Dermal Sensitization QRA Approach for Fragrance Ingredient
Dermal Sensitization QRA Approach for Fragrance Ingredient
Dermal Sensitization QRA Approach for Fragrance Ingredient
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CITRAL<br />
• Hazard Identification<br />
• Guinea pig data - weak sensitizer [14]<br />
• Local Lymph Node Assay<br />
• EC 3 = 1414 µg/cm 2 [11]<br />
• LOEL<br />
• HRIPT: 3876 µg/cm 2 in EtOH 5/8<br />
• HMT: 2759 µg/cm 2 in pet. 29/150<br />
• Other Data<br />
• 1240 µg/cm 2 in pet. 0/50<br />
• 775 µg/cm 2 in EtOH 0/41<br />
• 338 µg/cm 2 in EtOH 0/40<br />
• Confirmatory HRIPT - NOEL<br />
• 1400 µg/cm 2 in 3:1 DEP:EtOH 0/101<br />
Api <strong>QRA</strong> Worksop Jan 2007
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