Abstract Book - PDF - San Antonio Breast Cancer Symposium

CTRC-AACR San Antonio Breast Cancer Symposium
PD03-06 Simvastatin radiosensitizes differentiated and stem-like breast
cancer cell lines and is associated with improved local control
in inflammatory breast cancer patients treated with postmastectomy
radiation
Lacerda L, Reddy J, Liu D, Larson R, Masuda H, Brewer T, Debeb B, Xu
W, Hortobagyi GN, Buchholz TA, Ueno NT, Woodward WA. Morgan
Welch Inflammatory Breast Cancer Research Program and Clinic, The
University of Texas MD Anderson Cancer Center, Houston, TX.
PD03-07 Statin-induced decrease in proliferation depends on HMG-CoA
reductase expression in breast cancer
Bjarnadottir O, Romero Q, Bendahl P-O, Rydén L, Rose C, Loman N,
Uhlén M, Jirström K, Grabau D, Borgquist S. Clinical Sciences, Lund
University, Lund, Sweden; School of Biotechnology, KTH - Royal
Institute of Technology, Stockholm, Sweden.
PD03-08 Statin use and improved survival outcome in primary
inflammatory breast cancer: retrospective cohort study
Brewer TM, Masuda H, Iwamoto T, Liu P, Kai K, Barnett CM,
Woodward WA, Reuben JM, Yang P, Hortobagyi GN, Ueno NT. The
University of Texas M.D. Anderson Cancer Center, Houston, TX;
Eastern Virginia Medical School, Norfolk, VA; Okayama University
Hospital, Okayama, Japan.
PD03-09 Statins and breast cancer risk: A follow-up analysis of the
Women’s Health Initiative Cohort
Desai P, Jay A, Wu C, Cauley JA, Manson J, Peters U, Agalliu I, Abdul-
Hussein M, Bock C, Budrys N, Chlebowski R, Cote M, Lane D, Luo J,
Martin L, Park H, Petrucelli N, Rosenberg CA, Thomas F, Wactawski-
Wende J, Simon MS. Providence Hospital Medical Center, Southfield,
MI; Wayne State University, Detroit, MI; Fred Hutchinson Cancer
Research Center, Seattle, WA; University of Pittsburgh, PA; Harvard
School of Medicine, Boston, MA; Albert Einstein College of Medicine,
Bronx, NY; Lakeland Regional Medical Center, MI; Karmanos Cancer
Institute, Wayne State University, Detroit, MI; University of Texas
Health Science Center San Antonio, TX; Los Angeles Biomedical
Research Institute at Harbor-UCLA Medical Center, Torrance, CA;
Stony Brook University Medical Center, Stony Brook, NY; West
Virginia University, Morgantown, WV; George Washington University,
Washington, DC; University of California, Irvine, CA; NorthShore
University Health System, Evanston, IL; University of Tennessee
Health Science Center, Memphis, TN; University at Buffalo, NY.
7:00 am–9:00 am
Poster Discussion 4: Local THERAPY Decision Making
and DCIS
Ballroom B
Viewing 7:00 am
Discussion 7:45 am
Richard Crownover, MD, PhD, Chair
UT Health Science Center
San Antonio, TX
John Benson, MD, PHD, MA, DM, FRCS, Discussant
Addenbrooke’s Hospital
Cambridge, UNITED KINGDOM
and
I-Tien Yeh, MD, Discussant
Virginia Hospital Center
Arlington, VA
PD04-01 Intra-operative ultrasound in breast-conserving surgery for
palpable breast cancer significantly improves both surgical
accuracy and cosmetic outcome while saving costs
Haloua M, Krekel N, Coupe V, van den Tol P, Meijer S. VU Medical
Center, Amsterdam, Nederland, Netherlands; Alkmaar Medical
Center, Alkmaar, Noord-Holland, Netherlands.
PD04-02 Accelerated hypofractionated versus conventional whole
breast radiotherapy for localised left-sided breast cancer: the
effect on long-term cardiac morbidity
Chan EK, Woods R, Virani S, Speers C, Wai ES, Nichol A, McBride ML,
Tyldesley S. British Columbia Cancer Agency, Vancouver Centre;
Vancouver General Hospital; British Columbia Cancer Agency,
Vancouver Island Centre; British Columbia Cancer Agency.
PD04-03 Is breast conservation therapy an option for young women
with operable breast cancer? Local recurrence rates in young
women following surgery: a single centre experience
Lewis CR, Smith R, Matthews A, Choo E, Lee C. Prince of Wales
Cancer Centre (POWCC), Randwick, NSW, Australia; Prince of Wales
Hospital, Randwick, NSW, Australia; NHMRC Clinical Trials Unit,
University of Sydney, NSW, Australia.
PD04-04 What is influencing breast conservation rates in the United
States? Data from the National Accreditation Program of
Breast Centers
Chagpar AB, Kaufman CS, Connolly J, Burgin C, Granville T,
Winchester D. Yale University School of Medicine, New Haven,
CT; Bellingham Breast Center; Beth Israel Deaconess, Boston, MA;
National Accreditation Center for Breast Centers; Pat Nolan Center
for Breast Health, Glenview, IL.
PD04-05 Molecular predictors for type of recurrence following
conservative treatment for DCIS
Sakr RA, Andrade VP, Chandarlapaty S, Giovanni C, Giri D, Heguy A,
De Brot M, Olvera N, Muhsen S, Koslow S, Van Zee KJ, Morrow M,
Rosen N, King TA. Memorial Sloan-Kettering Cancer Center,
New York.
PD04-06 Molecular phenotypes of DCIS predict invasive and DCIS
recurrence
Williams KE, Barnes NLP, Cheema K, Dimopoulos N, Bundred NJ,
Landberg G. The University of Manchester, Manchester, Greater
Manchester, United Kingdom.
PD04-07 The Ki-67 labeling index predicts the risk of recurrence of
DIN patients treated with radiotherapy following breast
conserving surgery
Pruneri G, Lazzeroni M, Guerrieri-Gonzaga A, Botteri E, Leonardi
MC, Rotmensz N, Serrano D, Varricchio C, Disalvatore L, Del Castillo
A, Viale G, Bonanni B. European Institute of Oncology, Milan, Italy;
European Institute of Oncology, Milan; University of Milan, School
of Medicine.
PD04-08 Cell cycle algorithm correlates with grade of DCIS and p53
status, allows elimination of ‘intermediate grade’ disease and
gives clinically meaningful information
Sainsbury R, Loddo M, Proctor I, Stoeber K, Williams G, Thorat M,
Cuzick J. University College London, United Kingdom; Wolfson
Institute of Preventative Medicine, Queen Mary College, London,
United Kingdom.
7:00 am–9:00 am
POSTER SESSION 2 & CONTINENTAL BREAKFAST
Exhibit Halls A-B
P2-01-01 Establishment and validation of circulating tumor
cell-based prognostic nomograms in 497 first-line metastatic
breast cancer patients
Giordano A, Reuben JM, Egleston BL, Hajage D, Hortobagyi GN,
Cristofanilli M, Pierga J-Y, Bidard F-C. The University of Texas MD
Anderson Cancer Center, Houston, TX; Fox Chase Cancer Center,
Philadelphia, PA; Institut Curie, Paris, France.
Cancer Res; 72(24 Suppl.) December 15, 2012 20s Cancer Research