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Swelling Index %w/w
% Microcapsules retained after
8th hour
Santhosh Kumar Mankala et al, J Adv Scient Res, 2011; 2(4): 34-45 43
Table 3: Drug content/Encapsulation Efficiency of formulations NSM 1 -NMM 6
Formulation
D:SA:P
ratio
Weight
Taken
(mg)
Theoretical
Drug content
(mg)
Practical
Drug Content
(mg)
Encapsulation
Efficiency (%)
NSM 1
2:2:1 100 40 36.55 ±2.254 91.375 ±5.126
NSM 2
2:3:1 100 33.33 30.98 ±1.975 93.878 ±4.356
NSM 3
2:4:1 100 28.57 25.36 ±1.991 90.571 ±4.198
NMM 4
2:2:1 100 40 34.58 ±2.321 86.45 ±6.124
NMM 5
2:3:1 100 33.33 30.24 ±1.012 91.636 ±2.448
NMM 6
2:4:1 100 28.57 22.65 ±3.165 80.892 ±7.275
*Mean ± S.D (n=3)
250
200
150
110.54
Swelling Index data of nateglinide mucoadhesive
microcapsules (Formulations NSM1-NMM6)
163.44
189.29
104.3
132.3
30
25
20
15
In vitro mucoadhesive wash of test results of nateglinide
mucoadhesive microcapsules after 8hours
(Formulations NSM1-NMM6) 24
18
22
20
18
20
100
57.89
10
50
5
0
NSM1 NSM2 NSM3 NMM4 NMM5 NMM6
Formulations
0
NSM1 NSM2 NSM3 NMM4 NMM5 NMM6
Formulation
Figure 5: Swelling Index histogram of nateglinide mucoadhesive
microcapsules NSM 1 -NMM 6
All physical parameters were found in the acceptable range.
The microencapsulation efficiency and swelling index were
found to be greater with Sod. CMC than in other formulations,
whereas mucoadhesive efficiency was found higher in
formulations with MC. All compositions were found
compatible in IR, DSC and XRD studies and thus are suitable
for extending the scope of work in this research area. The
drug release from the microcapsules was sustained over an
Figure 6: In vitro mucoadhesive wash off test results histogram
of nateglinide mucoadhesive microcapsules NSM 1 -NMM 6 after 8
h
extended period of time. The study states that release
depended on the core: coat ratio and type of mucoadhesive
agent, which got retarded as the coat material percentage got
increased. Microcapsules prepared using Sod. CMC showed
better sustained action, and formulation containing drug: SA:
Sod. CMC in the ratio 2:4:1 was found to be the best
formulation as it released the maximum drug up to 22 h.
Table 4: In Vitro Wash off Test Data of formulations NSM 1 -NSM 6
Formulation
(50
microcapsules)
% of microcapsules (±SD) adhering to tissue at (h)
Phosphate buffer, pH 7.4
1 2 4 8
NSM 1 52 ±4.66 44 ±2.66 34 ±2 18 ±3.33
NSM 2 68 ±5.33 56 ±4 44 ±3.33 22 ±2.66
NSM 3 82 ±5 68 ±4.33 58 ±4.66 20 ±1.66
NMM 4 52 ±3.33 44 ±4.33 34 ±2.66 18 ±3
NMM 5 62 ±2.66 56 ±2.66 43 ±3.33 24 ±3.66
NMM 6 76 ±4.66 62 ±4 48 ±2.66 20 ±2.66
*Mean ± S.D (n=3)
Journal of Advanced Scientific Research, 2011, 2(4)