Global Dialogue on Nanotechnology and the Poor ... - Nanowerk
Global Dialogue on Nanotechnology and the Poor ... - Nanowerk
Global Dialogue on Nanotechnology and the Poor ... - Nanowerk
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nanotechnology,<br />
water, & development<br />
In order to assist in <strong>the</strong> development of a coordinated research<br />
program to assess potential risks of nanoscale materials, <strong>the</strong> Internati<strong>on</strong>al<br />
Risk Governance Council has identified four overlapping generati<strong>on</strong>s of<br />
new nanotechnology products that have <strong>the</strong> potential for development<br />
between 2000 <strong>and</strong> 2020: passive nanostructures, active nanostructures,<br />
systems of nanosystems, <strong>and</strong> heterogeneous molecular nanosystems.<br />
Each generati<strong>on</strong> of products is marked by <strong>the</strong> creati<strong>on</strong> of commercial<br />
prototypes using systematic c<strong>on</strong>trol of <strong>the</strong> respective phenomena <strong>and</strong><br />
manufacturing processing.The rudimentary capabilities of<br />
nanotechnology today for systematic c<strong>on</strong>trol <strong>and</strong> manufacture at <strong>the</strong><br />
nanoscale are expected to evolve significantly in complexity <strong>and</strong> degree<br />
of integrati<strong>on</strong> by 2020. Most of <strong>the</strong> nanotechnologies for water<br />
purificati<strong>on</strong> available today are probably in <strong>the</strong> first, <strong>and</strong> possibly in <strong>the</strong><br />
sec<strong>on</strong>d, generati<strong>on</strong> of nanotechnology products. 107<br />
The main deficit of risk governance for <strong>the</strong> first generati<strong>on</strong> of passive<br />
nanostructures (e.g., nanoparticles, coatings, nanostructured materials)<br />
is <strong>the</strong> relatively low level of knowledge of <strong>the</strong> new properties <strong>and</strong><br />
functi<strong>on</strong>s <strong>on</strong> toxicity <strong>and</strong> bioaccumulati<strong>on</strong> <strong>and</strong> limited underst<strong>and</strong>ing of<br />
<strong>the</strong> nanomaterials’ exposure rates.The main deficit for <strong>the</strong> new<br />
generati<strong>on</strong>s of nanoproducts, (including active nanodevices, nano-bio<br />
applicati<strong>on</strong>s, <strong>and</strong> nanosystems is <strong>the</strong> uncertain/unknown evoluti<strong>on</strong> of<br />
<strong>the</strong> technology <strong>and</strong> human effects (e.g., health, changes at birth, brain<br />
underst<strong>and</strong>ing <strong>and</strong> cognitive<br />
issues, <strong>and</strong> human evoluti<strong>on</strong>)<br />
as well as a framework through<br />
which policies can address<br />
such uncertainties.<br />
To fill <strong>the</strong> gap in knowledge<br />
about nanomaterials, comm<strong>on</strong><br />
frameworks for risk research,<br />
risk assessment, <strong>and</strong> risk<br />
management, several<br />
organizati<strong>on</strong>s are developing<br />
applicable frameworks <strong>and</strong><br />
protocols. 108 Some of <strong>the</strong> critical<br />
issues <strong>and</strong> research needs that<br />
are relevant in <strong>the</strong> developing<br />
field of nanotoxicology 109 include<br />
<strong>the</strong> following:<br />
Need for detailed materials<br />
characterizati<strong>on</strong>;<br />
Need for realistic exposure<br />
scenarios;<br />
Need for methods to track<br />
nanomaterials in biological<br />
experiments;<br />
Organizati<strong>on</strong> / Publicati<strong>on</strong><br />
Internati<strong>on</strong>al Risk Governance<br />
Council<br />
Internati<strong>on</strong>al Organizati<strong>on</strong> for<br />
St<strong>and</strong>ardizati<strong>on</strong><br />
ASTM<br />
European Commissi<strong>on</strong>, Health<br />
& C<strong>on</strong>sumer Protecti<strong>on</strong><br />
Directorate-General, Scientific<br />
Committee <strong>on</strong> Emerging <strong>and</strong><br />
Newly Identified Health Risks<br />
Envir<strong>on</strong>mental Defense<br />
<strong>and</strong> DuP<strong>on</strong>t<br />
Az<strong>on</strong>ano.com<br />
Need for sensitive detecti<strong>on</strong> methods to determine dose<br />
metrics; <strong>and</strong><br />
Need to identify key indicators of toxicity.<br />
There is also a need to define a systematic <strong>and</strong> disciplined process<br />
that can be used to identify, manage, <strong>and</strong> reduce potential health,<br />
safety, <strong>and</strong> envir<strong>on</strong>mental risks of nanoscale materials across all<br />
lifecycle stages. DuP<strong>on</strong>t <strong>and</strong> Envir<strong>on</strong>mental Defense are developing<br />
such a framework, which will be pilot-tested <strong>on</strong> specific nanoscale<br />
materials or applicati<strong>on</strong>s of commercial interest to DuP<strong>on</strong>t. 110<br />
Fur<strong>the</strong>r complicating <strong>the</strong> research of envir<strong>on</strong>mental <strong>and</strong> human<br />
health issues is <strong>the</strong> lack of a nomenclature for <strong>the</strong> field. Currently, <strong>the</strong><br />
science is based <strong>on</strong> <strong>the</strong> size of nanoparticles but does not take into<br />
account <strong>the</strong> basic chemical structure, such as titanium or carb<strong>on</strong>, or<br />
<strong>the</strong> surface coating of <strong>the</strong> nanoparticles. 111 Several efforts are now<br />
under way to develop a comm<strong>on</strong> nomenclature, including projects<br />
by <strong>the</strong> <strong>Nanotechnology</strong> Technical Committee of <strong>the</strong> Internati<strong>on</strong>al<br />
Organizati<strong>on</strong> for St<strong>and</strong>ardizati<strong>on</strong> 112 <strong>and</strong> <strong>the</strong> ASTM Internati<strong>on</strong>al<br />
Committee E56 <strong>on</strong> <strong>Nanotechnology</strong>. 113<br />
Table 10: Examples of Existing Risk Governance Initiatives<br />
Title<br />
<strong>Nanotechnology</strong> Project<br />
ISO Launches Work <strong>on</strong><br />
<strong>Nanotechnology</strong> St<strong>and</strong>ards<br />
ASTM,Technical Committees<br />
Opini<strong>on</strong> <strong>on</strong> <strong>the</strong> Appropriateness<br />
of Existing Methodologies to<br />
Assess <strong>the</strong> Potential Risks<br />
Associated with Engineered<br />
<strong>and</strong> Adventitious Products of<br />
Nanotechnologies<br />
Envir<strong>on</strong>mental Defense <strong>and</strong><br />
DuP<strong>on</strong>t: <str<strong>on</strong>g>Global</str<strong>on</strong>g> <strong>Nanotechnology</strong><br />
St<strong>and</strong>ards of Care Partnership<br />
DuP<strong>on</strong>t, Envir<strong>on</strong>mental Defense<br />
Create Framework for<br />
<strong>Nanotechnology</strong><br />
Link<br />
http://www.irgc.org/irgc/projects/nanotechnology/<br />
http://www.iso.org/iso/en/commcentre/pressreleases/<br />
archives/2005/ Ref980.html<br />
http://www.astm.org/cgibin/SoftCart.exe/COMMIT/COMMITTEE/E56.htm?L+m<br />
ystore+gxyx8351+1115426305<br />
http://ec.europa.eu/health/ph_risk/committees/04_sceni<br />
hr/docs/scenihr_o_003b.pdf<br />
http://www.envir<strong>on</strong>mentaldefense.org/article.cfm?c<strong>on</strong>ten<br />
tID=4821<br />
http://www.az<strong>on</strong>ano.com/news.asp?newsID=1536<br />
107<br />
Internati<strong>on</strong>al Risk Governance Council,“<strong>Nanotechnology</strong> Project,” .<br />
108<br />
Ibid.; <strong>and</strong> Az<strong>on</strong>ano.com,“DuP<strong>on</strong>t, Envir<strong>on</strong>mental Defense Create Framework for <strong>Nanotechnology</strong>,” October 12, 2005, .<br />
109<br />
R. H. Hurt et al.,“Toxicology of Carb<strong>on</strong> Nanomaterials: Status,Trends, <strong>and</strong> Perspectives <strong>on</strong> <strong>the</strong> Special Issue," Carb<strong>on</strong>,Vol. 44, Issue 6 , pp. 1028 – 1033, 2006; A. Nel et al.,“Toxic<br />
Potential of Materials at <strong>the</strong> Nanolevel,” Science,Vol. 311, No. 576, 2006, pp. 622 – 627; G. Oberdorster et al. “Principles for Characterizing <strong>the</strong> Potential Human Health Effects from<br />
Exposure to Nanomaterials: Elements of a Screening Strategy,” Particle <strong>and</strong> Fibre Toxicology,Vol. 2, No. 8, 2005, .<br />
110<br />
Envir<strong>on</strong>mental Defense,“Envir<strong>on</strong>mental Defense <strong>and</strong> DuP<strong>on</strong>t: <str<strong>on</strong>g>Global</str<strong>on</strong>g> <strong>Nanotechnology</strong> St<strong>and</strong>ards of Care Partnership,” October 11, 2005,<br />
.<br />
111<br />
Goldman <strong>and</strong> Coussens, op. cit.<br />
112<br />
Internati<strong>on</strong>al Organizati<strong>on</strong> for St<strong>and</strong>ardizati<strong>on</strong>,“ISO Launches Work <strong>on</strong> <strong>Nanotechnology</strong> St<strong>and</strong>ards,” November 16, 2005,<br />
.<br />
113<br />
ASTM,Technical Committees, .<br />
32