Annual Review - St Vincent's University Hospital

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St. Vincent’s Healthcare Group Limited - Annual Review 2008 Education and Research Centre Research Activities Changes to our research team in 2008 In 2008, Adriana Michielsen joined our team to embark on her Ph.D. studies which will examine how defects in the immune system may be important in controlling treatment response in colorectal cancer patients. This work is funded by an IRCSET grant for 3 years. Eoin Slattery and Danny Cheriyan have also begun their MD research work. Eoin is investigating how cigarette smoking has a protective role in Ulcerative Colitis. Eoin has been awarded an Abbott Newman Fellowship (UCD) to conduct this work. In collaboration Prof. Paul Murphy (NUI, Galway), Danny is analysing the action of newly synthesised anti-angiogenetic compounds using our human tumour explant tissue model. National and international talks in 2008 Jacintha O’Sullivan: University of Washington, Seattle ‘Predicting treatment response using a novel tumour explant tissue model’. Sheeona Gorman: Irish Radiation Research Society (IRRS), Belfast. ‘Ex vivo bystander effects promote mitochondrial dysfunction and chromosomal bridge breakage fusion events in colorectal cancer’. Joe Marry: Clinical Plenary Session of the Irish Society of Gastroenterology, ‘Evaluating the effects of monoclonal antibody therapies on pro-angiogenic growth factors in individual colorectal cancer explants’. Edward Fox: Association for Cancer Research Annual Meeting, San Diego. ‘Mutator phenotype of sporadic human colon cancer’. Poster Presentations in 2008 Sheeona Gorman: IACR: Gamma ray-induced bystander effects in colorectal cancer: a specific study on anaphase bridge and micronuclei formations in unirradiated bystander cells. Sheeona Gorman: All Ireland Cancer Conference: Ex vivo bystander effects promote chromosomal instability through bridge breakage fusion events: telomere shortening and bridge formations coupled with mitochondrial dysfunction. Juliette Sheridan: All Ireland Cancer Conference: Survival of very elderly patients with colorectal cancer. Sheeona Gorman: ISG: Ex vivo bystander effects promote mitochondrial dysfunction and chromosomal bridge breakage fusion events in colorectal cancer. Joe Marry: AntiAngio2008, San Diego, CA. Evaluating the effects of monoclonal antibody therapies on proangiogenic growth factors in individual colorectal cancer explants. Garret Cullen: ISG: The effect of cigarette smoking on cell cycle kinetics and mitogen activated protein kinases in inflammatory bowel disease: implications for disease progression. Garret Cullen: Digestive Disease Week (DDW): Cigarette smoking in inflammatory bowel disease: cell cycle arrest may explain the divergent effects in Crohn’s disease and ulcerative colitis Edward Fox: Association for Cancer Research Annual Meeting. Mutator phenotype of sporadic human colon cancer. Research Collaborators: Prof. Peter Rabinovitch, University of Washington, Seattle, USA Prof. Larry Loeb, University of Washington, Seattle, USA Dr Orla Howe, Dr. Fiona Lyng, DIT, Kevin Street Dr. Dermot Leahy, Conway Institute, UCD Prof. Martin Tenniswood, Notre Dame, Indiana Dr. Cormac Taylor & Dr. Katrina Comferford, Conway Institute, UCD Dr. Amanda McCann, Conway Institute, UCD Prof. Kevin Malone, St Vincents University Hospital, Dublin Dr. Ursula Fearon & Dr Doug Veale, Rheumatology, S.V.U.H. Prof Walter Kolch, Beatson Institute, Glasgow Prof Patrick Johnson, Almac, Craigavon, Belfast. Dr. Elizabeth Ryan, Trinity College Dublin. 36 Return to Contents Return to ERC Contents
St. Vincent’s Healthcare Group Limited - Annual Review 2008 Education and Research Centre Research Activities Breast Cancer Research Principal Investigator: Professor Joe Duffy Researchers: Dr Aisling Pierce, Dr Eadaoin McKiernan, Dr Siun Walsh, Dr Neil O’Brien (currently visiting scientist in the lab of Drs Denis Slamon, University of California at Los Angeles) Collaborators (Local): Professor John Crown, Mr Enda McDermott, Mr Denis Evoy, Dr Liam Gallagher Steve Pennington (UCD), Professor (UCD), Professor F Martin Dr Norma O’Donovan (UCD), (DCU) Collaborators (International): Drs Denis Slamon, University of California at Los Angeles; Dr Stan Krajewski, Burnham Institute, La Jolla; Prof Fred Sweep, Nijmegen; Prof Nils Brunner, Copenhagen, Prof Manfred Schmitt, Munich. Research Focus The overall aim of the Breast Cancer Research Group is to develop new molecular markers to aid the early diagnosis of breast cancer, help with prognosis and predict likely response or resistance to specific therapies. Dr Siun Walsh is investigating new therapeutic targets for the treatment of an aggressive subtype of breast cancer, known as the triple-negative subtype. Triplenegative breast cancers are so named as they lack expression of estrogen receptor (ER), progesterone receptor (PR) and do not exhibit overexpression or amplification of the HER-2 gene. Consequently, targeted therapy is currently unavailable for this subgroup of patients. Although triple-negative cancers represent a relatively small minority of invasive breast cancers (15- 20%), they are responsible for a disproportionate number of breast cancer deaths. There is thus an urgent need to identify novel targets and to develop therapeutic strategies that will improve the prognosis for this sub-group of breast cancer patients. Aisling Pierce is involved in using proteomics and glycomics for the early detection of breast cancer. She is also investigating the potential role for the breast-specific gene, mammaglobin, in the formation of breast cancer. Eadaoin McKiernan is attempting to identify new markers for predicting the metastatic potential of newly diagnosed breast cancers. This work is being carried out as part of a HRB-funded Programme Grant. Invited Presentations at International Meetings Duffy MJ, 2ndMultidisciplinary Cancer Symposium, Uludag, Turkey, Title of Presentation: Personalised Treatment for Cancer: How Biomarkers Can Help. Duffy MJ, 36th International Society for Oncology and Biomarkers Conference, Tokyo, Title of Presentation, The Future of Tumor Markers: New Technologies and New Approaches. Duffy MJ, 14th Hamburg Symposium on Tumor Markers, Hamburg, Title of Presentation, Conformities and Inconsistencies in the Use of Tumor Markers Duffy MJ, All-Ireland Cancer Conference, Dublin, Title of Presentation, uPA and PAI-1 as Validated Biomarkers in Breast Cancer: From Pilot Studies to Recommendation for Clinical Use. 37 Return to Contents Return to ERC Contents
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