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Vascular Healing Following PCB Use<br />

De Novo vs. ISR Applications<br />

Can we extrapolate the data gathered from ISR trials towards the<br />

development of DCB technologies aimed to treat de novo lesions?<br />

In-Stent Restenosis<br />

• Ballooning inside of a stent.<br />

• Quiescent disease state.<br />

• Mature neointima.<br />

De-Novo (+Stent)<br />

Emerging • Disrupting DCB a plaque.<br />

Trial Designs<br />

• Active disease state.<br />

DES<br />

Market<br />

• Presence of necrotic tissue.<br />

• Smaller degree of injury induced. • Higher degree of injury.<br />

• No additional material left behind.<br />

• Stent left behind.<br />

• Plaque drug uptake?<br />

• Best mechanism of delivery?<br />

• Pre, post, crimped stent?<br />

• Stent healing in vivo?<br />

ISR<br />

De Novo

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