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(3) Local Tissue Effects (Safety)<br />

Vascular Healing According to Dose<br />

1= Minimal<br />

2= Slight<br />

3= Moderate<br />

2.5<br />

4= Marked<br />

2<br />

5= Massive<br />

15 1.5<br />

1 1<br />

Mean Sc core<br />

1<br />

0.5<br />

Uncoated 0<br />

Delayed Endothelialization<br />

2.17<br />

1.75<br />

Mean Score<br />

2.5<br />

2<br />

1.5<br />

1<br />

0.5<br />

0<br />

Fibrin (Endothelial + Medial)<br />

Control 2x 4x 6x Control 2x 4x 6x<br />

1<br />

1.2<br />

1.7<br />

1.95<br />

Cotavance<br />

(1x)<br />

Cotavance<br />

(6x)<br />

Mean<br />

Score<br />

3<br />

2.5<br />

2<br />

1.5<br />

1<br />

0.5<br />

0<br />

IEL Rupture<br />

Presence Amorphous Material<br />

2.5 3.5<br />

2.87<br />

2 2<br />

3<br />

1.62<br />

2.5<br />

1.87<br />

2<br />

15 1.5<br />

1<br />

1<br />

0.5 0<br />

0<br />

Control 2x 4x 6x Control 2x 4x 6x<br />

Score<br />

Mean<br />

Histology picture obtained from CVPath

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