How Is TB Transmitted ?

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2) Transmission of Drug-resistant Mtb • Public Health is important • What about Biology ? • <strong>Is</strong> drug-resistance costly (to the bug) ? • Studies in E. coli suggest “fitness cost” • MDR / XDR-<strong>TB</strong> associated with HIV • Are XDR strains less “fit” ?
Fitness: The Experimental Approach RIF S RIF R Conditioning Competition no RIF CFU measurements @ baseline & endpoint RIF
Page 1 and 2: How Is TB Transmitted ? Sébastien
Page 3 and 4: The Global Diversity of Mtb Global
Page 5 and 6: Global TB Burden by Mtb Lineage Est
Page 7 and 8: “Out-of-Africa” of M. tuberculo
Page 9 and 10: Where Is TB Now? Global TB 2005 Est
Page 11: XDR-TB in the
Page 15 and 16: Clinical Isolates with Acquired RIF
Page 17 and 18: Clinical Frequency of rpoB Mutation
Page 19 and 20: Population-based Molecular Epidemio
Page 21 and 22: INH R Mutation and RFLP Clustering
Page 23 and 24: Does Strain Lineage Impact Propensi
Page 25 and 26: 2) Transmission of Drug-resistant M
Page 27: Acknowledgments ISB, Seattle • Pe

How Is TB Transmitted ?

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