How Is TB Transmitted ?
How Is TB Transmitted ?
How Is TB Transmitted ?
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Fitness Cost of Rifampicin-Resistant Mtb<br />
Lab-derived<br />
mutants:<br />
Mean relative fitness<br />
1<br />
0.9<br />
0.8<br />
0.7<br />
0.6<br />
0.5<br />
0.4<br />
0.3<br />
0.2<br />
0.1<br />
0<br />
S531L H526Y H526D S531W H526R S522L Q513L H526P R529Q<br />
rpoB mutation<br />
Clinical<br />
strains:<br />
Mean relative fitness<br />
1.3<br />
1.2<br />
1.1<br />
1<br />
0.9<br />
0.8<br />
0.7<br />
0.6<br />
0.5<br />
0.4<br />
0.3<br />
0.2<br />
0.1<br />
0<br />
1 2 3 4 5 6 7 8 9 10<br />
S531L<br />
<strong>Is</strong>olate pair<br />
other rpoB<br />
Gagneux et al. Science 2006
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