CURRICULUM VITAE Eric J. Lenze, M.D. - Institute for Public Health

3/26/13
CURRICULUM VITAE
Eric J. Lenze, M.D.
BIOGRAPHICAL
Citizenship:
Email:
Business
Address:
U.S.
lenzee@ wustl.edu
660 S. Euclid Ave., Campus Box 8134
St. Louis, MO 63110
Business Phone: (314) 362-1671
Present Position:
Professor, Department of Psychiatry, Washington University School of
Medicine
UNDERGRADUATE
1990
Washington University
St. Louis
EDUCATION AND TRAINING
B.A.
Biology and Philosophy
GRADUATE
1994
Washington University School of Medicine
St. Louis
M.D.
POST-GRADUATE
1998
1999
1999-2001
Barnes-Jewish Hospital/Washington University
Medical School
University of Pittsburgh Medical Center
Western Psychiatric Institute and Clinic
University of Pittsburgh Medical Center
Western Psychiatric Institute and Clinic
Resident, Psychiatry
Clinical Fellow, Geriatric
Psychiatry
Research Fellow, Intervention
Research Center for Late-Life
Mood Disorders
2001-2005
2005
APPOINTMENTS AND POSITIONS
Assistant Professor, Department of Psychiatry, Western Psychiatric Institute and
Clinic, University of Pittsburgh Medical Center
Assistant Professor, Department of Physical Medicine & Rehabilitation, University of
Pittsburgh Medical Center
1

2006-2007
2007-2011
2011-present
Associate Professor, Departments of Psychiatry and Physical Medicine &
Rehabilitation, University of Pittsburgh Medical Center
Associate Professor, Department of Psychiatry, Washington University School of
Medicine
Professor, Department of Psychiatry, Washington University School of Medicine
CERTIFICATION AND LICENSURE
1994-1998,
2007-present
MD Licensure, Missouri
1998-2008 MD Licensure, Pennsylvania
2000-present Certified, American Board of Psychiatry and Neurology (recertified 2010)
2002-present
Certified, Geriatric Psychiatry
HONORS AND AWARDS
1990 Phi Beta Kappa
1996-1998
American Association for Geriatric Psychiatry award and honorary fellowship
(Sponsor: Bristol-Meyer Squibb)
1997 Eli Robins award for excellence in clinical ability, research, and teaching
1999 Stepping Stones award in geriatric psychiatry (Sponsor: Bayer)
2000
2001
George Winokur Clinical Award (Sponsor: American Academy of Clinical
Psychiatrists)
Member-in-Training Award for best unpublished research paper (Sponsor: American
Association for Geriatric Psychiatry)
2002 International College of Geriatric Psychopharmacology travel fellowship
2005-present
Best Doctors in America
2012 Resident Mentoring award from Washington University Department of Psychiatry
EDITORIAL RESPONSIBILITIES
2004-2009 Editorial Board, Annals of Clinical Psychiatry
2006-2011 Editorial Board, American Journal of Geriatric Psychiatry
2009-present
Editorial Board, Journal of the American Geriatrics Society
2

Reviewer for Acta Psychiatrica Scandinavica, Aging and Mental Health, American
Journal of Geriatric Psychiatry, American Journal of Psychiatry, Annals of Internal
Medicine, Archives of General Psychiatry, Biological Psychiatry, Comprehensive
Psychiatry, Current Psychiatry, Depression and Anxiety, Drugs and Aging, Expert
Opinion on Drug Safety, International Journal of Geriatric Psychiatry, International
Psychogeriatrics, Journal of Affective Disorders, Journal of the American Geriatric
Society, Journal of the American Medical Association, Journal of Clinical Psychiatry,
Journal of Psychiatric Research, Journal of Psychiatry and Clinical Neurosciences,
Journal of Psychosomatic Research, Mental Health & Aging, Neurobiology of Aging,
Neurorehabilitation & Neural Repair, Pain Medicine, Perceptual and Motor Skills,
Psychiatric Genetics, Psychiatry Research, Psychological Reports, Social Science &
Medicine, and Stress.
Triage editor, American Journal of Geriatric Psychiatry
ad hoc
Other service:
University of Pittsburgh Institutional Review Board, 2002-2007
Study sections:
NIMH SRSP (2009-2010), NIMH ACISR/DCISR (2007). NIH Adult Psychopathology
and Disorders of Aging (2009, 2010), ZRG1: Mental Health Epidemiology (2010),
Canadian Institute for Health (2008), Netherlands Organisation for Health Research
and Development (2006, 2010), ZRG1 PSE (2011), ZAT1 HS-10 Clinical Studies of
Complementary and Alternative Medicine (2012)
NIMH ITVA standing member (2012-2016)
Veterans Administration:
Appointment, VA-Pittsburgh, 2002-2004
Reviewer, VA merit awards, 2004
Reviewer, HSR&D's Evidence-based Synthesis Program, “Performance
characteristics of self-report instruments for diagnosing Generalized Anxiety and
Panic Disorders in primary care”
MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES
1995-1998 Eastern Missouri Psychiatric Society
1995-present
1996-present
1999-present
American Psychiatric Association (General Member)
American Association for Geriatric Psychiatry
Anxiety Disorders Association of America
2000-2009 American Association for Clinical Psychiatry
2001-present
Pennsylvania Psychiatric Society
2002-2005 International College of Geriatric Psychopharmacology
MAJOR INVITED LECTURES
3

1. Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic,”
Grand Rounds, Department of Psychiatry, Washington University, May 1998
2. "Results of a Resident Satisfaction Survey," Grand Rounds, Department of Psychiatry,
Washington University, May 1998
3. “Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic,”
George Winnokur award presentation, American Association of Clinical Psychiatry annual
meeting, November 2000
4. “Developing Your Research Career,” American Association for Geriatric Psychiatry annual
meeting, February 2001
5. “Effects of Therapeutic Sleep Deprivation on Speed of Antidepressant Response in Elderly
Depressed Patients,” International College of Geriatric Psychoneuropharmacology annual
meeting, Barcelona, October 2002
6. “Persistent Depression in Elderly Persons is Associated with Cognitive Decline: Longitudinal
Findings from the Cardiovascular Health Study,” AAGP annual meeting, Honolulu, March 2003
7. “Anxiety Disorders in Late Life” Symposium chairman, ICGP annual meeting, San Juan, PR,
December 2003
8. “Treatment of Geriatric Anxiety Disorders: Results from a Placebo-Controlled Study of
Citalopram,” ICGP annual meeting, San Juan, PR, December 2003
9. “New Research in Late-Life Generalized Anxiety Disorder” Symposium chairman, AAGP annual
meeting, Baltimore, MD, February 2004
10. “Pharmacologic Management of Late-Life Generalized Anxiety Disorder,” AAGP annual meeting,
Baltimore, MD, February 2004
11. “The Interface of Late-Life Depression and Physical Rehabilitation,” AAGP annual meeting,
Baltimore, MD, February 2004
12. “Cognitive and Affective Factors as Predictors of Hip Fracture Recovery in the Elderly,” AACP
annual meeting, Ft. Lauderdale, FL, March 2004
13. “Gene-Environment Interactions in Late Life Mental Disorders,” NCDEU meeting, Phoenix, AZ,
June 2004
14. “5-HTTLPR as a risk gene for late-life depression after hip fracture: implications for
depression prevention.” ICGP annual meeting, Basel, Switzerland, October 2004
15. “Treatment of anxiety in late life.” AAGP annual meeting, San Diego, CA, March 2005
16. “Pharmacotherapy for late-life anxiety: results of a 32-week study with citalopram.” ADAA
annual meeting, Seattle, WA, March 2005
17. “Late-life depression and medical illness.” APA annual meeting, Atlanta, GA, May 2005.
18. “Somatic symptoms in late-life anxiety: treatment issues in primary care.” ABCT annual
meeting, Washington, DC, November 2005.
19. Chair of symposium, “Developing your research career”, AAGP annual meeting, San Juan,
PR, March 2006.
20. Chairman of symposium and speaker, “New research on late-life anxiety disorders”, AAGP
annual meeting, San Juan, PR, March 2006.
21. Chairman of symposium and speaker, “New opportunities for preventing depression in late
life”, AAGP annual meeting, San Juan, PR, March 2006.
22. “Medication management of late-life anxiety disorders”, ADAA annual meeting, Miami, FL,
March 2006.
23. “How to treat in the absence of scientific evidence: a focus on anxiety disorders in the
4

elderly”, APA annual meeting, Toronto, ON, May 2006
24. “The impact of medical comorbidity on mood and anxiety disorders in the elderly patient”,
APA annual meeting, Toronto, ON, May 2006
25. “Anxiety disorders”, Geriatric Psychopharmacology course, APA annual meeting, Toronto,
ON, May 2006
26. “New research on late-life anxiety disorders”, Nevada Psychiatric Association annual
meeting, February 2007
27. “Anxiety and depression in late life”, Wellcome Trust Neuroscience and Mental Health
Meeting, March 2007
28. “Late life anxiety treatment: safety and tolerability”, American Medical Directors’ Association
annual meeting, March 2007
29. “Medication management of late-life anxiety disorders”, Anxiety Disorders Association of
America annual meeting, St Louis, March 2007
30. “Medical rehabilitation as a treatment for late-life depression”, UCSD, August 2007
31. “Anxiety disorders in late life”, UCSD Grand Rounds, August 2007
32. “Pharmacogenetics of escitalopram efficacy in late-life Generalized Anxiety Disorder”,
NCDEU annual meeting, May 2008
33. “Treating depression in older adults: the upside (and downside) of psychotropics”, KUMC
talk, Kansas City, MO, June 2009.
34. Chairman of symposium and speaker, “Biology and treatment response in older adults with
Generalized Anxiety Disorder”, AAGP annual meeting, Honolulu, HI, March 2009
35. “Pharmacogenetics of SSRI response in late life Generalized Anxiety Disorder: can we move
towards personalized medicine?”, AAGP annual meeting, Honolulu, HI, March 2009
36. “Pharmacotherapy of Generalized Anxiety Disorder in older adults”, ADAA annual meeting,
Albuquerque, NM, March 2009.
37. “Treating anxiety disorders and depression in older adults,” St Louis University Grand
Rounds (Psychiatry), St Louis, MO, June 2009.
38. Chairman of symposium and speaker, “Anxiety disorders in older adults”, AAGP annual
meeting, Savannah, GA, March 2010.
39. Chairman of symposium and speaker, “Genetics in geriatric psychiatry”, AAGP annual
meeting, Savannah, GA, March 2010.
40. Keynote speaker and invited grand rounds, “Anxiety disorders in older adults”, University of
Toronto/Centre for Addiction and Mental Health, Toronto, ON, April 2010.
41. “Mental health aspects of stroke rehabilitation”, St Louis University Annual Stroke
Symposium, St Louis, MO, June 2010.
42. “Anxiety disorders in older adults”, University of Kentucky 27 th Annual Summer Series on
Aging, Lexington, KY, June 2010.
43. “Generalized Anxiety Disorder in older adults”, ADAA-sponsored webinar, October 27, 2010.
44. “Translational research in late-life anxiety”, invited discussant, AAGP annual meeting, San
Antonio, TX, March 2011.
45. “Late-life anxiety disorders”, Symposium director and speaker, ADAA annual meeting, New
Orleans, LA, March 2011.
46. “Pharmacogenetics of late-life anxiety disorders”, ADAA annual meeting, New Orleans, LA,
March 2011.
5

47. “New treatment targets for late-life depression and anxiety disorders”, ECNP annual meeting,
Paris, September 2011.
48. “Treating stress and improving cognition in older adults”, Department of Aging, University of
Florida, September 2011.
49. “Anxiety disorders”, Geriatric Psychiatry review course, AAGP annual meeting, Washington
DC, March 2012
50. “Enhanced medical rehabilitation”, AAGP annual meeting, Washington DC, March 2012.
51. “Developing new rehabilitation interventions”, Rehabilitation Research Network keynote
speaker, Pittsburgh, PA May 2012.
52. “Cognitive dysfunction: the symptom of depression that nobody understands”, ECNP annual
meeting, Vienna, October 2012
CONSULTING RELATIONSHIPS AND BOARD MEMBERSHIPS
2004-2005: Board, American Association of Clinical Psychiatrists
2005-2011: Co-chair, Research Committee, American Association for Geriatric Psychiatry
2011: Program Chair, American Association for Geriatric Psychiatry
2011-present: Chair, Research Committee, American Association for Geriatric Psychiatry
2005-present: Member and chair (2006-present) of Data and Safety Monitoring Board for AgeWise
and AgeWise II programs (NIA-sponsored program grants), University of Pittsburgh
2007-2011: Consultant, Fox Learning Systems (small business)
2008-present: Scientific Council, Anxiety Disorders Association of America
2009-present: DSM-V lifespan committee; head of workgroup on anxiety disorders and aging
2010-present: Chair, Data and Safety Monitoring Board for DASH (NHLBI) study (Ken Freedland, PI),
Washington University
2011-present: Chair, DSM-V lifespan committee
Governmental:
RESEARCH SUPPORT
Role Years Grant Title and role
Past Funding:
PI 1999 Seed money grant: Combination pharmacotherapy of
depressed elderly patients in acute rehabilitation (PI)
Source and
amount
Internal
$10,000
PI 2001-
2006
K23 MH64196: Depression Treatment in Medically
Rehabilitating Elderly
NIMH
$848,933
6

Consultant
2008-
2010
Co-I 2004-
2009
PI 2004-
2010
SBIR Phase 2: Web-based stroke health education (PI:
Debra Fox, Fox Learning Systems)
R01 MH059395: Improving Quality of Primary Care for
Anxiety Disorders (PI: Bruce Rollman, MD)
R01 MH070547: Pharmacotherapy of Late Life
Generalized Anxiety Disorder
NINDS
NIMH
NIMH
$1,365,000
PI
2009-
2011
R34 MH083868 Enhanced Acute Medical
Rehabilitation for Late-Life Depression After Hip
Fracture
NIMH
$684,000
PI
2010-
2011
R01 MH074596S Supplement to Risk Genes for Late
Life Depression After Hip Fracture
NIMH
$63,840
Current Funding:
PI
2007-
2012
R01 MH074596 Risk Genes for Late Life Depression
After Hip Fracture
NIMH
$1,686,938
PI
2009-
2014
R01 MH083648 Incomplete Response in Late-Life
Depression: Getting to Remission
NIMH
$2,143,501
coordinating
site PI
2011-
2014
Collaborative R34 Mindfulness-Based Stress Reduction
and Cognitive Function in Stress and Aging
NCCAM
$602,000
Consultant
2009-
2013
R01HD055525 Donepezil to Promote Functional
Recovery Post-Stroke (PI: Ellen Whyte, MD)
NICHD
Non-governmental:
Role Years Grant Title and role
Source and
amount
Past Funding:
PI 2000 Investigator-initiated project: Treatment of anxiety
disorders in elderly subjects: a controlled study with
citalopram
PI 2003 Investigator-initiated project: Galantamine for the
Treatment of Post-Stroke Cognitive Impairment in the
PI 2004-
2005
PI 2006-
2008
PI 2007
Medical Rehabilitation Setting
Investigator-initiated project: Donepezil for the
Treatment of Post-Stroke Cognitive Impairment in the
Medical Rehabilitation Setting
Investigator-initiated project: Memantine for the
enhancement of rehabilitation efficacy and prevention of
major depressive disorder in older adults
A multi-center, open-label study in healthy volunteers
and patients with affective and anxiety disorders to
characterize the regional distribution of [ 11 C] ABP688 in
brain by PET
Forest
Laboratories
$97,175
Janssen
Pharmaceuticals
$90,000
Pfizer
Pharmaceuticals
$68,000
Forest
Laboratories
$149,884
Novartis
$482,123
Current Funding:
7

PI
2008-
2011
Investigator-initiated project: Escitalopram and
Cognitive Behavioral Therapy for maintenance of
response in late life Generalized Anxiety Disorder
Forest
$152,000
Co-I
2009-
2012
CARE program (PI: Consuelo Wilkins, M.D.)
Barnes Jewish
Hospital
Foundation
PI
2011-
2012
Ketamine for treatment-resistant depression
Sidney R. Baer
Foundation
$200,000
PI
2011-
2012
Cardiometabolic effects of antipsychotics
Johnson &
Johnson
$144,000
PI
2011-
2013
Glycine transporter inhibitor for schizophrenia (site for
phase 3 study)
Roche
1998-2007
CLINICAL TITLE AND RESPONSIBILITIES
Medical Staff, Western Psychiatric Institute and Clinic, University of Pittsburgh
Medical Center
1998-2002 Medical Staff, Presbyterian SeniorCare Nursing Home
1998-2000 Medical Staff, Redstone Highlands Nursing Home
2000-2006 Consulting Staff, UPMC Rehabilitation Hospital
2001-2002 Consulting Staff, UPMC South Side Hospital
2002-2006 Consulting Staff, UPMC Shadyside Hospital and UPMC St Margaret’s Hospital
2007-present
2010-present
Medical Staff, Barnes-Jewish Hospital
Medical Staff, Barnes-Jewish Extended Care
8

Courses:
1. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
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TEACHING ACTIVITIES
Cell Biology
Teaching Assistant
1988
One Semester
Undergraduate students
Approx. 100
Washington University, St. Louis, MO
Interview Skills and Mental Status Exam
One-hour lectures as part of introduction to psychiatry course
1996-1997 inclusive
Eight
Third-year Medical Students
Approx. 30
Washington University, St. Louis, MO
Depression in Primary Care
One-hour Lecture, informal
1997-1998 inclusive
Four times per year
Third-year Medical Students and Non-Psychiatric Residents
Four
Washington University, St. Louis, MO
Anxiety Disorders
Lecture as part of psychiatry course
1998
Once
Occupational Therapy Students
100
Washington University, St. Louis, MO
Neuropsychiatry
Introduction to neuropsychiatry lecture as part of residency course
curriculum
1998-1999 inclusive
Twice
Psychiatry PGY1 Residents
10
University of Pittsburgh School of Medicine
Problem-based Learning Course Instructor
Lecture and discussion on depression, anxiety disorders as part of
psychiatry curriculum
1999-2003
Four per year
Second-year Medical Students
10-12
University of Pittsburgh School of Medicine
9

7. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
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13. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
Late-life depression treatment
One-hour lecture as part of residency course curriculum
2000-present
Three times per year
PGY-2 Residents
10
University of Pittsburgh School of Medicine
Geriatric Psychiatry in rehabilitation settings
One-hour lecture as part of residency course curriculum
2001-present
Once per year; 1 hour per year
Geriatric Fellows
4-5
University of Pittsburgh School of Medicine
Geriatric Anxiety Disorders
One-hour lecture as part of residency course curriculum
2000-present
Twice per year
Residents
4-8
Benedum Geriatric Center, University of Pittsburgh
Generalized Anxiety Disorder
One-hour lecture as part of residency course curriculum
2003-present
Once per year
Residents
12
University of Pittsburgh School of Medicine
Clinical Neuroscience Elective
90 minute lecture plus 2-3 hours of group discussions
2004
once
4 th year medical students
10
University of Pittsburgh School of Medicine
Anxiety Disorders in Late Life
60 minute lecture
2004
once
advanced practice nurses
10
University of Pittsburgh School of Medicine
Anxiety Disorders
60 minute lecture
2007
once
1 st year medical students
147
University of Pittsburgh School of Medicine
10

14. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
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20. Course Name:
Description:
Year:
No. of Times:
To Whom:
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Where:
Geriatric psychiatry clinical rounds
Weekly interactive seminar
2008-present
Monthly
PGY1 psychiatry residents
4-5
Washington University School of Medicine
Psychiatry small group seminar
Interactive seminar and case discussion
2008-2009
Once yearly
1 st year medical students
15-20
Washington University School of Medicine
Psychiatry residency seminar
2-hour introduction to geriatric psychiatry
2009-present
Once yearly
PGY1 psychiatry residents
8-10
Washington University School of Medicine
Anxiety disorders in older adults
1-hour presentation to ADRC
2009
Once
ADRC faculty, staff, residents, and students
50-60
Washington University School of Medicine
Anxiety disorders in older adults
1-hour talk
2010-present
Once yearly
all psychiatry residents
35-40
Washington University School of Medicine
Depression in older adults
1-hour talk
2010-present
Once yearly
all psychiatry residents
35-40
Washington University School of Medicine
Advanced Resident’s Seminar (discussant)
90 minute discussion of published research studies
2010-present
One to three times yearly
PGY3/4 psychiatry residents
16-20
Washington University School of Medicine
11

21 Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
22 Course Name:
Description:
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25. Course Name:
Description:
Year:
No. of Times:
To Whom:
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Where:
Introduction to clinical research
90 minute talk
2010
Once
PGY2 psychiatry residents
9-10
Washington University School of Medicine
Post-stroke depression
60 minute talk
2010
Once
Physical Medicine & Rehabilitation residents
8-10
Washington University School of Medicine
Geriatric psychiatry
Director of rotation
2010-present
Weekly
all PGY2 psychiatry residents
up to10
Washington University School of Medicine
Late-life depression
Lecture to pain management trainees
2010-present
Once yearly
Residents and faculty in pain management
~10
Washington University
Geriatric psychopharmacology
2.5 hour lecture for psychology course (head: Brian Carpenter, Ph.D.)
2010
Once
Advanced psychology graduate students
6+
Washington University
Late-life depression: a clinical trials perspective
1-hour presentation to ADRC
2010
Once
ADRC faculty, staff, residents, and students
50-60
Washington University School of Medicine
Behavioral disturbances in dementia
1-hour talk
2010
Once
All psychiatry residents
35-40
Washington University School of Medicine
12

26. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
Late-life depression and anxiety: a clinical trials perspective
1-hour talk
2011
Once
All clinical psychology staff and graduate students
50-60
Washington University
27. Course Name:
Description:
Year:
No. of Times:
To Whom:
No. of Students:
Where:
Antidepressants, antipsychotics in older adults
2 1-hour talks
2011-present
Yearly
Neurology residents and medical students
30-40
Washington University
Department of Psychiatry, Resident Supervision
Clinical Preceptor, Benedum Geriatric Center, 1999-2007.
Examiner, Mock Oral Boards, 2001-2003.
Examiner, Clinical Practice Examination, 2008-present
Geriatric Psychiatry Attending Rounds, 2008-2010
Geriatric Rotation Course Director and supervisior in outpatient geropsych clinic, 2010-present
Weekly 1:1 Psychotherapy supervision (during one-month geriatrics rotation) to all PGY2 residents,
2011-present.
Research mentorship of Marcie Shea, 2011-2012, for PGY4 research rotation
Research mentorship of Chad Sylvester, M.D., Ph.D., PGY2, in research rotation, 2010-2011.
Psychotherapy supervision: Courtney Johnson, PGY2, 2010
Psychotherapy supervision: Marcie Shea, PGY3, 2011
Psychotherapy supervision: Chad Sylvester, PGY2, 2011
Department of PM&R Research Conference, University of Pittsburgh
Depression in Medical Rehabilitation, October 2001.
Postdoctoral Fellow
Mentorship of Rose Mantella, Ph.D., University of Pittsburgh, 1/05-12/07 (T32MH019886)
Translational research in geriatric depression and anxiety
Medical Student Supervision
Mentorship of Helen Dorra, University of Pittsburgh, summer 2000-spring 2001
Research resulted in publication of original research in peer-reviewed journal
Mentorship of Jin Joo, University of Pittsburgh, summer 2001-spring 2004
Research resulted in publication of 2 original research articles in peer-reviewed journals,
presentation at national meeting, and American Geriatrics Society award
Mentorship of Alison Deluca, University of Pittsburgh, fall 2003-spring 2004
Research resulted in publication of original research in peer-reviewed journal
Co-mentor of James Krings, Doris Duke fellow (Primary Mentor: Jay Piccirrillo, M.D.), 2011-2012.
Other Supervision
Mentorship of Stephen Blank, University of Pittsburgh, undergraduate, summer-fall 2004
Research resulted in publication of original research in peer-reviewed journal
Research mentorship of Alexandre Dombrovski, M.D., 2005-2007 (resulted in publication of original
research in peer-reviewed journal)
13

Mentorship of Carmen Andreescu, M.D., Assistant Professor of Psychiatry, University of Pittsburgh,
2007-present (mentor during research fellowship; now K23 consultant)
Mentor and dissertation committee member, Maya Matheny, MD/PhD student, University of
Maryland, 208-present
Dissertation committee member, Steve Balsis, PhD student in Psychology, Washington University
K30 mentor, Chris Rosnick, Ph.D., Assistant Professor of Psychology, SIUE, 2008-present
Mentorship of Aliza Smazik, OTD student, research externship, 2010.
Mentorship (as consultant) to Erin Foster, OTD, Instructor of Occupational Therapy on K23 (funded
2011).
Mentor/sponsor to Ginger Nicol, M.D., Instructor of Psychiatry, on K23MH092435: Measurement of
cardiometabolic risk in children (2011-present).
Co-mentor and co-sponsor of NRSA for Cheri Levinson, PhD student in Psychology, Washington
University (funded 2011-present).
Mentor to Lauren Garfield, Ph.D., T32 post-doctoral research fellow (2011-2012).
Research mentorship to Pilar Christancho, M.D., Instructor in Psychiatry (2011-present).
Practicum supervisor for Michelle Voegtle, undergraduate at SIUE, 2011-2012.
Mentor to Kerri Rawson, Ph.D., T32 post-doctoral research fellow (2012-present).
Other University Service
Barnes-Jewish Foundation/Institute for Clinical and Translational Science study section, 2009,,
2010, and 2011 study sections
Institute for Clinical and Translational Science K30 reviewer, 2010 and 2011
14

Peer-Reviewed Original Research Articles:
BIBLIOGRAPHY
1. Pepose JS, Laycock KA, Miller JK, Chansue E, Lenze EJ, Gans LA, Smith ME (1992):
Reactivation of latent herpes virus by excimer laser photokeratectomy. American Journal of
Ophthalmology 114: 45-50.
2. Lenze E, Miller AR, Munir ZB, Pornnoppadol C, North CS (1999): Psychiatric symptoms
endorsed by somatization disorder patients in a psychiatric clinic. Annals of Clinical Psychiatry
11: 73-79.
3. Lenze EJ, Cross D, McKeel D, Neuman RJ, Sheline YI (1999): White matter hyperintensities
and gray matter lesions in healthy depressed subjects. American Journal of Psychiatry 156:
1602-1607.
4. Lenze EJ, Sheline YI (1999): Absence of striatal volume differences between depressed
subjects with no comorbid medical illness and matched comparison subjects. American Journal
of Psychiatry 156: 1989-1991.
5. Lenze EJ, Mulsant BH, Shear MK, Schulberg HC, Dew MA, Begley AE, Pollock BG, Reynolds
CF (2000): Comorbid anxiety disorders in depressed elderly patients. American Journal of
Psychiatry 157(5): 722-728.
6. Lenze EJ, Rogers JC, Martire LM, Mulsant BH, Rollman BL, Dew MA, Schulz R, Reynolds CF
(2001): The association of late-life depression and anxiety with physical disability: a review of
the literature and prospectus for future research. American Journal of Geriatric Psychiatry
9:113-135.
7. Lenze EJ, Mulsant BH, Shear, MK, Alexopoulos GS, Frank E, Reynolds CF (2001): Comorbidity
of depression and anxiety disorders in later life. Depression and Anxiety 14: 86-93.
8. Lenze EJ, Miller MD, Dew MA, Martire LM, Begley AE, Schulz R, Frank E, Reynolds CF (2001):
Subjective health measures and acute treatment outcomes in geriatric depression. International
Journal of Geriatric Psychiatry 16(12): 1149-1155.
9. Lenze EJ, Dew MA, Mazumdar S, Begley AE, Cornes C, Miller MD, Imber SD, Frank E, Kupfer
DJ, Reynolds CF (2002): Combined pharmacotherapy and psychotherapy as maintenance
treatment for late life depression: effects on social adjustment. American Journal of Psychiatry
159(3): 466-468.
10. Harman JS, Rollman BL, Hanusa BH, Lenze EJ, Shear MK: Physician office visits of adults for
anxiety disorders in the United States: 1985-1998 (2002). Journal of General Internal Medicine
17: 165-172. PMCID: PMC1495023
11. Joo JH, Lenze EJ [Corresponding Author], Mulsant BH, Begley AE, Weber E, Stack JA,
Mazumdar S, Reynolds CF, Pollock BG (2002): Risk factors for falls during treatment of late-life
depression. Journal of Clinical Psychiatry 63(10): 936-941.
12. Miller MD, Lenze EJ, Dew MA, Whyte E, Weber E, Begley AE, Reynolds CF (2002): Effect of
cerebrovascular risk factors on depression treatment outcome in later life. American Journal of
Geriatric Psychiatry 10(5): 592-598.
13. Dorra HH, Lenze EJ [Corresponding Author], Kim Y, Mulsant BH, Munin MC, Dew MA,
Reynolds CF (2002): Effect of psychiatric problems on rehabilitation outcome in elderly patients
with hip fracture. International Journal of Psychiatry in Medicine 32: 249-259.
14. Lenze EJ, Mulsant BH, Dew MA, Shear MK, Houck PR, Pollock BG, Reynolds CF (2003). Good
treatment outcomes in late-life depression with comorbid anxiety. Journal of Affective Disorders
77: 247-254.
15

15. Lenze EJ, Munin MC, Quear T, Dew MA, Rogers JC, Begley AE, Reynolds CF (2004): The
Pittsburgh Rehabilitation Participation Scale: Reliability and Validity of a Clinician-Rated
Measure of Participation in Acute Rehabilitation. Archives of Physical Medicine and
Rehabilitation 85: 380-384.
16. Lenze EJ, Munin MC, Dew MA, Rogers JC, Seligman K, Mulsant BH, Reynolds CF (2004):
Adverse effects of depression and cognitive impairment on rehabilitation participation and
recovery after hip fracture. International Journal of Geriatric Psychiatry 19: 465-471.
17. Lenze EJ, Munin MC, Quear T, Dew MA, Rogers JC, Begley AE, Reynolds CF (2004):
Significance of Poor Patient Participation in Physical and Occupational Therapy for Functional
Outcome and Length of Stay. Archives of Physical Medicine and Rehabilitation 85:1599-1601.
18. Lenze EJ, Mulsant BH, Shear MK, Dew MA, Miller MD, Pollock BG, Houck P, Tracey B,
Reynolds CF (2005): Efficacy and tolerability of citalopram in the treatment of late life anxiety
disorders: Results from an 8-week, placebo-controlled trial. American Journal of Psychiatry 162:
146-150.
19. Lenze EJ, Mulsant BH, Mohlman J, Shear MK, Dew MA, Schulz R, Miller MC, Tracey B,
Reynolds CF (2005): Generalized Anxiety Disorder in late life: lifetime course and comorbidity
with Major Depressive Disorder. American Journal of Geriatric Psychiatry 13: 77-80.
20. Munin MC, Seligman K, Dew MA, Quear T, Skidmore E, Gruen G, Reynolds CF, Lenze EJ
(2005): Effect of rehabilitation site on functional recovery after hip fracture. Archives of Physical
Medicine and Rehabilitation 86: 367-372.
21. Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, Rogers JC, Quear T,
Houck P, Reynolds CF (2005): Association of the serotonin transporter gene-linked polymorphic
region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. American
Journal of Geriatric Psychiatry 13: 428-432.
22. Lenze EJ, Schulz R, Martire LM, Zdaniuk B, Glass T, Kop WJ, Jackson SA, Reynolds CF
(2005): The course of functional decline in older people with persistently elevated depressive
symptoms: longitudinal findings from the Cardiovascular Health Study. Journal of the American
Geriatrics Society 53: 569-575.
23. Lenze EJ, Karp JF, Mulsant BH, Blank S, Shear MK, Houck PR, Reynolds CF (2005): Somatic
symptoms in late-life anxiety: Treatment issues. Journal of Geriatric Psychiatry and Neurology
18: 89-96.
24. Deluca AK, Lenze EJ [Corresponding Author], Mulsant BH, Butters MA, Karp JF, Dew MA,
Pollock BG, Shear MK, Houck PR, Reynolds CF (2005): Comorbid anxiety disorder in late-life
depression: Association with memory decline over four years. International Journal of Geriatric
Psychiatry 20: 848-854.
25. Drayer RA, Mulsant BH, Lenze EJ, Rollman BL, Dew MA, Kelleher K, Karp JF, Begley A,
Schulberg HC, Reynolds CF (2005): Somatic symptoms of depression in elderly patients with
medical comorbidities. International Journal of Geriatric Psychiatry 20: 973-982.
26. Joo JH, Solano FX, Mulsant BH, Reynolds CF, Lenze EJ (2005): Predictors of adequacy of
depression management in the primary care setting. Psychiatric Services 56: 1524-1528.
27. Blank S, Lenze EJ [Corresponding Author], Mulsant BH, Dew MA, Karp JF, Shear MK, Houck
PR, Miller MD, Pollock BG, Tracey B, Reynolds CF (2006): Outcomes of late-life anxiety
disorders during 32 weeks of citalopram treatment. Journal of Clinical Psychiatry 67: 468-472.
28. Reynolds CF, Dew MA, Pollock BG, Mulsant BH, Frank E, Miller MD, Houck PR, Mazumdar S,
Butters MA, Stack JA, Schlernitzauer MA, Whyte EM, Gildengers A, Karp JF, Lenze EJ, Szanto
K, Bensasi S, Kupfer DJ (2006): Maintenance treatment of major depression in old age. New
England Journal of Medicine 354: 1130-1138.
16

29. Munin MC, Begley AE, Skidmore ER, Lenze EJ (2006): Influence of rehabilitation site on hip
fracture recovery in community dwelling subjects at six-month follow-up. Archives of Physical
Medicine and Rehabilitation 87: 1004-1006.
30. Karp JF, Reynolds CF, Butters MA, Dew MA, Mazumdar S, Begley AE, Lenze EJ, Weiner DK
(2006): The relationship between pain and mental flexibility in older adult pain clinic patients,
Pain Medicine 7: 444-452. PMCID: PMC2946642
31. Tew JD, Mulsant BH, Houck PR, Lenze EJ, Whyte EM, Miller MD, Stack JA, Bensasi S,
Reynolds CF (2006): Impact of prior treatment exposure on response to antidepressant
treatment in late-life. American Journal of Geriatric Psychiatry 14: 957-965.
32. Lenze EJ, Munin MC, Skidmore ER, Dew MA, Rogers JC, Whyte EM, Quear T, Begley AE,
Reynolds CF (2007): Onset of depression in elderly persons after hip fracture: implications for
prevention and early intervention of late-life depression. Journal of the American Geriatrics
Society 55: 81-86.
33. Andreescu C, Lenze EJ [Corresponding Author], Dew MA, Begley AE, Mulsant BH,
Dombrovski AY, Pollock BG, Stack J, Miller MD, Reynolds CF (2007): Effect of comorbid anxiety
on treatment response and relapse risk in late-life depression: controlled study. British Journal
of Psychiatry 190: 344-349.
34. Lenze EJ, Skidmore ER, Dew MA, Butters MA, Rogers JC, Begley AE, Reynolds CF, Munin MC
(2007): Does depression, apathy, or cognitive impairment reduce the benefit of inpatient
rehabilitation facilities for elderly hip fracture patients? General Hospital Psychiatry 29: 141-146.
NIHMS19786 PMCID: PMC1853243
35. Dew MA, Whyte EM, Lenze EJ, Houck PR, Mulsant BH, Pollock BG, Stack JA, Bensasi S,
Reynolds CF (2007): Recovery from major depression in older adults receiving augmentation of
antidepressant pharmacotherapy. American Journal of Psychiatry 164: 892-899.
36. Mantella R, Butters MA, Dew MA, Mulsant BH, Tracey B, Shear MK, Reynolds CF, Lenze EJ
(2007): Cognitive impairment in late life Generalized Anxiety Disorder. American Journal of
Geriatric Psychiatry 15: 673-679.
37. Dombrovski A, Mulsant BH, Houck P, Mazumdar S, Lenze EJ, Andreescu C, Cyranowski JM,
Reynolds CF (2007): Residual symptoms and recurrence during maintenance treatment of latelife
depression. Journal of Affective Disorders 103(1-3): 77-82. PMCID: PMC2680091
38. Saghafi R, Brown C, Butters MA, Cyranowski J, Dew MA, Frank E, Gildengers A, Karp JF,
Lenze EJ, Lotrich F, Martire L, Mazumdar S, Miller MD, Mulsant BH, Weber E, Whyte E, Morse
J, Stack J, Houck PR, Bensasi S, and Reynolds CF (2007): Predicting six-week treatment
response to escitalopram pharmacotherapy in late-life major depressive disorder. International
Journal of Geriatric Psychiatry 22: 1141-1146.
39. Koenig K, Whyte EM, Munin MC, O’Donnell L, Skidmore ER, Penrod L, Lenze EJ (2007):
Stroke-related knowledge and health behaviors among post-stroke patients in inpatient
rehabilitation. Archives of Physical Medicine and Rehabilitation 88: 1214-1216.
40. Dombrovski A, Lenze EJ, Dew MA, Mulsant BH, Houck P, Reynolds CF (2007): Maintenance
Treatment for Old-Age Depression Preserves Health-Related Quality of Life: A Randomized,
Controlled Trial of Paroxetine and Interpersonal Psychotherapy. Journal of the American
Geriatrics Society 55: 1325-1332.
41. Karp JF, Whyte EM, Lenze EJ, Dew MA, Begley A, Miller MD, Reynolds CF (2008): Rescue
pharmacotherapy with duloxetine for SSRI-nonresponders in late-life depression: outcome and
tolerability. Journal of Clinical Psychiatry 69: 457-463. PMCID: PMC2846083.
42. Lenze EJ, Shardell M, Ferrell RE, Orwig D, Yu-Yahiro J, Hawkes W, Fredman L, Miller R,
Magaziner J (2008): Association of serotonin-1A and 2A receptor promoter polymorphisms with
depressive symptoms and functional recovery in elderly persons after hip fracture. Journal of
Affective Disorders 111(1): 61-66. PMCID: PMC2610462
17

43. Mehta M, Whyte EM, Lenze EJ, Perera S, Huang W, Studenski S (2008): Depressive
symptoms in late life: associations with apathy, resilience and disability vary between young-old
and old-old. International Journal of Geriatric Psychiatry 23:238-43.
44. Mantella RC, Butters MA, Amico JA, Mazumdar S, Rollman BL, Begley AE, Reynolds CF, Lenze
EJ (2008): Salivary cortisol is associated with diagnosis and severity of late-life Generalized
Anxiety Disorder. Psychoneuroendocrinology 33:773-81. PMCID: PMC2766671
45. Skidmore ER, Koenig KL, Munin MC, Whyte EM, O’Donnell L, Penrod L, Lenze EJ (2008): Do
Clinical Rehabilitation Education Programs Really Improve Stroke-Related Knowledge?
American Journal of Physical Medicine & Rehabilitation 87:637-641.
46. Whyte EM, Lenze EJ [Corresponding Author], Butters MA, Skidmore E, Koenig K, Dew MA,
Penrod L, Mulsant BH, Pollock BG, Cabacungen L, Begley AE, Reynolds CF, Munin MC (2008):
An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in
elderly cognitively impaired stroke patients. Cerebrovascular Diseases 26:317-321. PMCID:
PMC2914451
47. Andreescu C, Rollman B, Belnap B, Shear MK, Mazumdar S, Houck P, Lenze EJ (2008):
Generalized Anxiety Disorder Severity Scale (GADSS) validation in older adults. American
Journal of Geriatric Psychiatry 16: 813-818. NIHMS82635 PMCID: PMC2803316
48. Lenze EJ, Rollman BL, Shear MK, Dew MA, Pollock BG, Ciliberti C, Costantino M, Snyder S,
Shi P, Spitznagel E, Andreescu C, Butters MA, Reynolds CF (2009). Escitalopram for older
adults with Generalized Anxiety Disorder: a randomized-controlled trial. JAMA 301 (5): 296-303.
PMCID: PMC2840403
49. Coley KC, Scipio TM, Ruby C, Lenze EJ, Fabian TJ (2009). Aripiprazole Prescribing Patterns
and Side Effects in Elderly Psychiatric Inpatients. Journal of Psychiatric Practice 15:150-153.
50. Sheffrin M, Driscoll HC, Lenze EJ, Mulsant BH, Pollock BG, Miller MD, Butters MA, Dew MA,
Reynolds CF (2009): Pilot Study of Augmentation With Aripiprazole for Incomplete Response in
Late-Life Depression: Getting to Remission. Journal of Clinical Psychiatry 70(2): 208-213.
PMCID: PMC2886714
51. Weiss BJ, Calleo JS, Kunik ME, Rhoades HW, Novy D, Lenze EJ, Stanley MA (2009): The
Utility of the Generalized Anxiety Disorder Severity Scale with Older Adults in Primary Care.
Depression and Anxiety 26(1): E10-15. PMCID: PMC2709998
52. Lenze EJ, Munin MC, Dew MA, Marin RS, Butters MA, Skidmore ER, Whyte EM, Begley AE,
Reynolds CF (2009): Apathy after hip fracture: a potential target for intervention to improve
functional outcomes. Journal of Neuropsychiatry and Clinical Neurosciences 21(3): 271-8.
PMCID: PMC2752427
53. Talkowski JB, Lenze EJ, Munin MC, Harrison C, Brach J (2009): Patient Participation and
Physical Activity during Rehabilitation and Future Functional Outcomes in Patients following Hip
Fracture. Archives of Physical Medicine and Rehabilitation 90: 618-622.
54. Andreescu C, Lenze EJ, Mulsant BH, Wetherell JL, Begley AE, Mazumdar S, Reynolds CF
(2009): High worry severity is associated with poorer acute and maintenance efficacy of
antidepressants in late-life depression. Depression and Anxiety 26(3): 266-272. PMCID:
PMC2680149
55. Porensky EK, Dew MA, Karp JF, Skidmore ER, Rollman B, Shear MK, Lenze EJ (2009): The
burden of late-life generalized anxiety disorder: Effects on disability, health-related quality of life,
and healthcare utilization. American Journal of Geriatric Psychiatry 17(6): 473-482 PMCID:
PMC3408215
56. Lotrich FE, Lenze EJ (2009): Gene-environment interactions and depression. Letter to the
editor, JAMA 302: 1859-1860.
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57. Karp JF, Dew MA, Houck PR, Lotz MJ, Lenze EJ, Skidmore E, Reynolds CF (2009): Use of the
Late Life Function and Disability Instrument to Assess Disability in Major Depression. Journal of
the American Geriatrics Society. 57: 1612-1619. PMCID: PMC2854008
58. Andreescu C, Butters M, Lenze EJ, Venkatraman VK, Nable M, Reynolds CF 3rd, Aizenstein HJ
(2009): fMRI activation in late-life anxious depression: a potential biomarker. International
Journal of Geriatric Psychiatry 24(8): 820-828. PMCID: PMC2722439
59. Skidmore ER, Whyte EM, Becker JT, Holm MB, Butters MA, Dew MA, Lenze EJ (2010).
Cognitive and affective predictors of rehabilitation participation after stroke. Archives of Physical
Medicine and Rehabilitation 91: 203-207. PMCID: PMC2824912
60. Reynolds CF, Dew MA, Martire LM, Miller MD, Cyranowski JM, Lenze EJ, Whyte EM, Mulsant
BH, Pollock BG, Karp JF, Gildengers A, Szanto K, Dombrovski AY, Andreescu C, Butters MA,
Morse JQ, Houck PR, Bensasi S, Mazumdar S, Stack JA, Frank E (2010): Treating Depression
to Remission in Older Adults: A Controlled Evaluation of Combined Escitalopram with
Interpersonal Psychotherapy versus Escitalopram with Depression Care Management.
International Journal of Geriatric Psychiatry 25:1134-1141. PMCID: PMC3004217
61. Lenze EJ, Mantella RC, Shi P, Goate AM, Nowotny P, Butters MA, Andreescu C, Thompson
PA, Rollman BL (2011): Elevated cortisol in older adults with Generalized Anxiety Disorder is
reduced by treatment: a placebo-controlled evaluation of escitalopram. American Journal of
Geriatric Psychiatry 19: 482-490. PMCID: PMC3424606
62. Lenze EJ, Goate AM, Nowotny P, Dixon D, Shi P, Bies RR, Lotrich FK, Rollman BL, Shear MK,
Thompson PA, Andreescu C, Pollock BG (2010). Relation of serotonin transporter genetic
variation to efficacy of escitalopram for Generalized Anxiety Disorder in older adults. Journal of
Clinical Psychopharmacology 30:672-677. PMCID: PMC3059101
63. Wetherell JL, Stoddard JA, White KS, Kornblith SJ, Nguyen H, Andreescu C, Zisook S, Lenze
EJ (2011): Augmenting Antidepressant Medication with Modular CBT for Geriatric Generalized
Anxiety Disorder. International Journal of Geriatric Psychiatry 26: 869-875.
64. Reynolds CF, Butters MA, Lopez O, Pollock BG, Dew MA, Mulsant BH, Lenze EJ, Holm M,
Rogers JC, Mazumdar S, Houck PR, Begley AE, Anderson S, Karp JF, Miller MD, Whyte EM,
Stack J, Gildengers A, Szanto K, Bensasi S, Kaufer DI, Kamboh MI, DeKosky ST (2011):
Maintenance treatment of depression in old age: a randomized, placebo-controlled evaluation of
the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Archives
of General Psychiatry, 68: 51-60. PMCID: PMC3076045
65. Andreescu C, Gross JJ, Lenze E, Dunfee-Edelman K, Snyder S, Tanase C, Aizenstein H
(2011): Altered Cerebral Blood Flow Patterns Associated with Pathologic Worry in the Elderly,
Depression and Anxiety 28 (3): 202-9. PMCID: PMC3225118
66. Butters MA, Bhalla RK, Andreescu C, Wetherell JL, Mantella RC, Begley AE, Lenze EJ (2011):
Neuropsychological functioning in older adults with Generalized Anxiety Disorder. British
Journal of Psychiatry 199: 211-218.
67. Matheny ME, Miller RR, Shardell MD, Hawkes WG, Lenze EJ, Magaziner J, Orwig DL (2011):
Inflammatory cytokine levels and depressive symptoms in older women in the year after hip
fracture. Journal of the American Geriatrics Society, 59: 2249-2255, 2011. PMCID:
PMC3245645
68. Lenze EJ, Dixon D, Mantella RC, Dore PM, Andreescu C, Reynolds CF, Newcomer JW, Butters
MA (2012): Treatment-related alteration of cortisol predicts change in neuropsychological
function during acute treatment of late-life anxiety disorder. International Journal of Geriatric
Psychiatry 27: 454-462.
69. Lenze EJ, Host HH, Hildebrand M, Morrow-Howell N, Carpenter B, Freedland KE, Baum CA,
Binder EF (2011): Enhanced Medical Rehabilitation is feasible in a skilled nursing facility:
preliminary data on a novel treatment for older adults with depression. American Journal of
Geriatric Psychiatry, epub.
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70. Mohlman J, Bryant C, Lenze EJ, Stanley MA, Gum A, Flint A, Beekman AT, Wetherell JL, Thorp
SR, Craske MG (2012): Improving recognition of late life anxiety disorders in DSM-V:
Observations and recommendations of the Advisory Committee to the Lifespan Disorders Work
Group. International Journal of Geriatric Psychiatry 27: 549-556.
71. Lenze EJ, Skidmore ER, Begley AE, Newcomer J, Butters MA, Whyte EM (2011): Memantine
for late-life depression and apathy after a disabling medical event: a double-blind, placebocontrolled,
12-week pilot study. International Journal of Geriatric Psychiatry 27(9):974-980.
72. Hildebrand MW, Host HH, Binder EF, Carpenter B, Freedland KE, Morrow-Howell N, Baum CM,
Dore P, Lenze EJ (2012): Measuring treatment fidelity in a rehabilitation intervention study.
American Journal of Physical Medicine and Rehabilitation 91(8):715-24.
73. Lenze EJ (2012): Reversal of SSRI-associated urinary retention with mirtazapine augmentation
(letter). Journal of Clinical Psychopharmacology; 32(3): 434.
74. Lenze EJ, Dixon D, Nowotny P, Lotrich FE, Dore P, Pollock BG, Hinrichs AL, Butters MA
(2013): Escitalopram reduces attentional performance in anxious older adults with highexpression
genetic variants at serotonin 2A and 1B receptors. International Journal of
Neuropsychopharmacology 16(2): 279-288.
75. Sylvester C, Corbetta M, Raichle M, Rodebaugh TL, Sheline YI, Schlagger B, Zorumski C,
Lenze EJ (2012): Functional network dysfunction in anxiety and anxiety disorders. Trends in
Neurosciences 35: 527-535. PMCID: PMC3432139
76. Lenze EJ, Host HH, Hildebrand MW, Morrow-Howell N, Carpenter B, Freeland KE, Baum CA,
Dixon D, Dore P, Wendleton L, Binder EF (2012): Enhanced Medical Rehabilitation increases
therapy intensity and engagement and improves functional outcomes in post-acute rehabilitation
of older adults: a randomized controlled trial. Journal of the American Medical Director’s
Association 13(8): 708-712.
77. Rodebaugh TL, Levinson CA, Lenze EJ (2013): A high-throughput clinical assay for testing drug
facilitation of exposure therapy. Depression and Anxiety (epub).
78. Shea MO, Garfield L, Teitelbaum S, Civitelli R, Dixon D, Mulsant BH, Reynolds CF, Lenze EJ
(2013): Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated
with increased marker of bone resorption. Osteoporosis International (epub).
79. Rosnick C, Butters MA, Rawson K, Lenze EJ (2013): Association of cortisol with
neuropsychological assessment in older adults with Generalized Anxiety Disorder. Aging and
Mental Health (epub).
80. Joel I, Begley AE, Mulsant BH, Lenze EJ, Mazumdar S, Dew MA, Blumberger D, Butters MA,
Reynolds CF: Dynamic prediction of treatment response in late-life depression. American
Journal of Geriatric Psychiatry in press.
81. Wetherell JL, Petkus AJ, White KS, Nguyen H, Kornblith S, Andreescu C, Zisook S, Lenze EJ:
Antidepressant medication augmented with cognitive behavioral therapy for Generalized Anxiety
Disorder in older adults. American Journal of Psychiatry in press.
Peer-Reviewed Invited Papers:
1. Lenze EJ, Mulsant BH, Shear MK, Houck P, Reynolds CF (2002): Anxiety symptoms in elderly
patients with depression: what is the best approach to treatment? Drugs and Aging 19(10):753-
60.
2. Lenze EJ, Shear MK, Mulsant BH, Reynolds CF (2002): Anxiety disorders in late life: an
evolving picture. CNS Spectrums 7(11): 805-810.
3. Lenze EJ (2003): Comorbidity of depression and anxiety in the elderly. Current Psychiatry
Reports 5(1): 62-67.
20

4. Lenze EJ, Holm MB, Rogers JC, Reynolds CF (2003): Combining pharmacotherapy and
psychotherapy in the rehabilitative and maintenance treatment of late-life depression. Directions
in Psychiatry 23 (1): 43-54.
5. Lenze EJ, Pollock BG, Shear MK, Mulsant BH, Bharucha A, Reynolds CF (2003): Treatment
considerations for anxiety in the elderly. CNS Spectrums 8 (12 Suppl 3): 6-13.
6. Mulsant BH, Whyte E, Lenze EJ, Lotrich F, Karp JF, Pollock BG, Reynolds CF (2003):
Achieving long-term optimal outcomes in geriatric depression and anxiety. CNS Spectrums 8
(12 Suppl 3): 35-46.
7. Whyte EM, Dew MA, Gildengers A, Lenze EJ, Bharucha A, Mulsant BH, Reynolds CF (2004):
Time course of response to antidepressants in late-life major depression: Therapeutic
Implications. Drugs and Aging 21(8):531-554.
8. Shear K, Roose SP, Lenze EJ, Alexopoulos GS. Depression in the elderly: the unique features
related to diagnosis and treatment. CNS Spectrums 2005 10 (8 Suppl 10):1-13.
9. Wetherell JL, Lenze EJ, Stanley MA (2005): Evidence-based treatment of geriatric anxiety
disorders. Psychiatric Clinics of North America 28: 871-896.
10. Karp JF, Lenze EJ, Solai LK, Rosen J, Reynolds CF (2006): Preventing depression in older
adults. Clinical Neuropsychiatry: Journal of Treatment Evaluation 3: 69-80.
11. Reynolds CF, Dew MA, Lenze EJ, Whyte EM (2007): Preventing depression in medical illness:
a new lead? Archives of General Psychiatry 2007; 64(8): 884-885.
12. Lenze EJ, Mulsant BH: Biomarkers in geriatric psychiatry (2007). American Journal of Geriatric
Psychiatry 2007; 15: 827-831.
13. Lenze E, Sheffrin M, Driscoll HC, Mulsant BH, Pollock BG, Dew MA, Lotrich F, Devlin B, Bies R,
Reynolds CF (2008): Incomplete response in late-life depression: Getting to remission.
Dialogues in Clinical Neuroscience 10: 419-430. PMCID: PMC3181898
14. Lenze EJ, Wetherell JL (2009): Bringing the bedside to the bench, and then to the community: a
prospectus for intervention research in late-life anxiety disorders. International Journal of
Geriatric Psychiatry 24: 1-14.
15. Wolitsky-Taylor K, Castriotta N, Lenze EJ, Stanley MA, Craske MG (2010): Anxiety disorders in
older adults: a comprehensive review. Depression and Anxiety 27: 190-211.
16. Lenze EJ, Wetherell JL (2011): Anxiety disorders. New developments in old age. American
Journal of Geriatric Psychiatry 19: 301-304.
17. Lenze EJ: Treating depression in older adults with dementia (2011). Journal of the American
Geriatrics Society 59: 754-755.
18. Lenze EJ, Wetherell JL: A lifespan view of anxiety disorders. Dialogues in Clinical
Neuroscience, 13: 381-399, 2011. PMCID: PMC3263387
19. Andreescu C, Lenze EJ (2012): Anxiety-depression comorbidity: bête noire or quick fix? British
Journal of Psychiatry 200: 179-181.
20. Bryant C, Mohlman J, Stanley MA, Gum A, Flint A, Beekman A, Wetherell JL, Thorp S, Lenze
EJ: Anxiety disorders in older adults: looking to DSM5 and beyond…” American Journal of
Geriatric Psychiatry, in press.
21. Rodebaugh TL, Lenze EJ: Lessons learned from D-cycloserine: the promise and limits of drug
facilitation of psychotherapy. Journal of Clinical Psychiatry, in press.
22. Szanto K, Conwell Y, Duberstein P, Epstein-Lubow G, Bruce ML, Lenze EJ: Suicide Prevention
and Older Adults: Roadblocks and Recommendations. Psychiatric Services, in press.
Book chapters:
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1. Lenze EJ, Shear MK: Anxiety Disorders. MacMillon Encyclopedia of Aging, pp 75-79.
2. Lenze EJ: Anxiety. Springer Encyclopedia of Aging, Version 4, 2006.
3. Reynolds CF, Brown C, Cruz M, Detlefsen EG, Hall D, Homrok K, Kilbourne A, Lee B, Lenze E,
Miller MD, Mulsant BH, Palmer J, Post EP, Shevchik G, Solano FX, Spence-Jones G, South-Paul
J. Depression in old patients. Current Diagnosis and Treatment in Family Medicine 2004, pp
531-537.
4. Lenze EJ, Wetherell JL. Anxiety disorders. Chapter for American Psychiatric Press Textbook on
Geriatric Psychiatry, 4 th Edition, 2008, pp367-383.
5. Lenze EJ. Anxiety Disorders in the elderly. Chapter for American Psychiatric Press Textbook on
Anxiety Disorders, 2 nd Edition, 2009.
6. Lenze EJ, Wetherell JL, Andreescu C. Anxiety disorders. Chapter for American Psychiatric
Press Textbook on Geriatric Neuropsychiatry, 3 rd edition, 2011.
7. Lenze EJ, Wetherell JL, Andreescu C. Anxiety disorders. Chapter for American Psychiatric
Publishing Essentials of Geriatric Neuropsychiatry, 2 nd edition, 2012.
8. Stoddard J, Wetherell JL, Lenze EJ. Treating mood disorders using combined psychotherapy and
medication in older adults. The Oxford Handbook of Clinical Geropsychology, in press.
9. Petkus A, Lenze EJ, Wetherell JL. Anxious Depression: Application of a Unified Model of
Emotional Disorders to Older Adults. In Late-life Mood Disorders, Lavretsky, Sajatovic, and
Reynolds (editors), Oxford Press 2013,
10. Gebara MA, Lenze EJ. Depression and anxiety in the older adult. Washington University Manual
for Geriatrics, in press.
11. Lenze EJ, Wetherell JL, Andreescu C. Anxiety Disorders. Chapter for American Psychiatric Press
Clinical Handbook on Geriatric Neuropsychiatry, in press.
12. Lenze EJ. Planning grants. Chapter for Research in Physical Medicine and Rehabilitation:
Methods, Management, and Statistics (Flora Hammond, James Malec, Todd Nick editors), in
press.
13. Lenze EJ, Whyte J. Treatment development. Chapter for Research in Physical Medicine and
Rehabilitation: Methods, Management, and Statistics (Flora Hammond, James Malec, Todd Nick
editors), in press.
Other publications:
1. Lenze EJ: Sleep complaints in the elderly. Geriatric Psychiatry News 1998
2. Lenze EJ: Common difficulties in the assessment and reporting of resident behaviors with mental
disorders. Primary Instructor: Ideas and Expectations for Quality of Care 11/99.
3. Lenze EJ: Disability and mortality associated with depression in elderly nursing home patients.
Issues in Depression 2000, 2 (2): 6-7.
4. Lenze EJ. “Anxiety disorders in the elderly”. ASCP Model Psychopharmacology Curriculum, 4 th
Edition, American Society of Clinical Psychopharmacology, Glen Oaks, NY, 2006.
5. Lenze EJ. Anxious depression in late life. Psychiatric Times, August 2007.
6. Lenze EJ. “Anxiety disorders in the elderly”. Glick ID, Balon R, Zisook S, et al., ASCP Model
Psychopharmacology Curriculum, 5 th Edition, American Society of Clinical Psychopharmacology,
Glen Oaks, NY, 2008.
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7. Lenze EJ. The treatment of late-life anxiety: efficacy and tolerability. Long-term care Interface
(2008 supplemental publication), pp5-8.
8. Lenze EJ. Anxiety disorders. American Geriatric Society, Geriatrics Review Syllabus: A core
curriculum in geriatric medicine, 7 th edition.
9. Lenze EJ (2010): Editor and introduction to special report on geriatric mental health, Psychiatric
Times.
10. Lenze EJ: Anxiety disorders. American Geriatric Society, Geriatrics Review Syllabus: A core
curriculum in geriatric medicine, 8 th edition, 2013.
11. Lenze EJ: Anxiety Disorders. In Flaherty E, Resnick B, eds. Geriatric Nursing Review Syllabus: A
Core Curriculum in Advanced Practice Geriatric Nursing. 3rd ed. New York: American Geriatrics
Society; 2011.
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