Survey track-related courses
Survey track-related courses
Survey track-related courses
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Lecture <strong>courses</strong> Master <strong>track</strong> Transport Physics October 2011<br />
● 10 ECTS<br />
● 17 ECTS<br />
● 14 ECTS<br />
compulsory <strong>courses</strong> Master programme Applied Physics<br />
3AP15 Electrodynamics (3 ECTS)<br />
3AP16 Computational Physics (4 ECTS)<br />
2DN40 Complex Analysis (3 ECTS)<br />
<strong>track</strong>-<strong>related</strong> <strong>courses</strong><br />
8 ECTS compulsory <strong>courses</strong>:<br />
3T100 Advanced Fluid Dynamics (4 ECTS)<br />
3T340 Micro- and Nanofluidics (4 ECTS)<br />
9 ECTS <strong>track</strong>-<strong>related</strong> elective <strong>courses</strong> (see below)<br />
free elective <strong>courses</strong><br />
Track-<strong>related</strong> <strong>courses</strong> taught by lecturers of the groups in Transport Physics:<br />
Quarter 1<br />
3T340 Micro- and Nanofluidics *<br />
3T350 Statistical Fluid Mechanics and Chaos **<br />
3T220 Chaos (only in academic year 2011-2012)<br />
(Darhuber/Harting/Huinink)<br />
(Toschi/vdWater)<br />
(van de Water/Toschi)<br />
Quarter 2<br />
3T360 Hydrodynamic Stability **<br />
3T280 Turbulent Flow Phenomena<br />
3F240 NMR/MRI<br />
(Kamp/vdWiel/Clercx)<br />
(Trieling/vdWiel/vSteenhov)<br />
(Kopinga)<br />
Quarter 3<br />
3T100 Advanced Fluid Dynamics *<br />
3T370 Experimental Methods in Transport Physics<br />
3T380 Advanced Computational Fluid Dynamics<br />
3T390 Atmospheric Physics<br />
(van Heijst)<br />
(Darhuber/Trieling/vdWater)<br />
(Toschi/Clercx/Harting/others)<br />
(Boersma/vdWiel)<br />
Quarter 4<br />
3T250 Geophysical Fluid Dynamics<br />
3F250 Transport in Porous Media<br />
(van Heijst)<br />
(Pel)<br />
* <strong>track</strong>-compulsory course (4 ECTS)
** starts in the academic year 2012-2013
3T100 Advanced Fluid Dynamics 4 ECTS<br />
Lecturer:<br />
Prof. GertJan van Heijst<br />
Objectives<br />
The student learns about the role of vorticity in viscous and inviscid flows. Specific goals<br />
are:<br />
• to analyse mechanisms of production of vorticity and redistribution through<br />
diffusion;<br />
• to analyse and model different coherent vortex structures.<br />
In the second part of the lecture course the student learns how irrotational flows can be<br />
described by applying complex function theory. Specific goals are:<br />
• to apply concepts of complex function theory to flows around solid bodies and to<br />
calculate forces on these;<br />
• to apply the theory of conformal mapping.<br />
Contents<br />
In this course some important fundamental aspects of fluid mechanics will be discussed<br />
which one often encounters both in theoretical problems and in industrial applications.<br />
The first part of the course concentrates on the subject of 'vortex dynamics'. Topics like<br />
vortex theorems, vorticity production and diffusion, coherent vortices in 2D flows and 3D<br />
vortex structures will be discussed. The second part of the course concentrates on the<br />
application of 'complex function theory' in fluid dynamics (complex flow potential,<br />
Milne-Thomson circle theorem, forces on bodies in potential flows, and conformal<br />
mapping).
3T280 Turbulent Flow Phenomena 3 ECTS<br />
Lecturers:<br />
Dr. Ruben Trieling<br />
Prof. Anton van Steenhoven (W)<br />
Dr. Bas van de Wiel<br />
Objectives<br />
The student obtains basic knowledge about the theory of turbulent flow phenomena.<br />
Specific goals are:<br />
• to analyse stability/instability of laminar flows;<br />
• to gain understanding of the basic phenomenological theory of turbulence;<br />
• to analyse the statistical properties of turbulence using statistical procedures;<br />
• to characterize turbulent flows using the concepts of correlation functions and<br />
spectra;<br />
• to analyse the structure of turbulent flows near walls;<br />
• to analyse the production, transport and dissipation of energy in turbulent flows;<br />
• to apply the concept of vorticity to turbulent flows;<br />
• to be familiar with numerical techniques <strong>related</strong> to turbulence modelling.<br />
Contents<br />
Many flows in nature and in industrial situations are turbulent. This course serves as an<br />
introduction in the theory of such turbulent flow phenomena. Since turbulent flows<br />
emerge as a result of instability processes of laminar flows, the course starts with stability<br />
analysis. Subsequently, the following subjects are considered: general features of<br />
turbulence including statistical properties and spectra, the structure of turbulent flows<br />
near walls, some aspects of vorticity and the energy budget, closure models, introduction<br />
to numerical techniques such as k- modelling and LES, and turbulent diffusion.
3T250 Geophysical Fluid Dynamics 3 ECTS<br />
Lecturer:<br />
Prof. GertJan van Heijst<br />
Objectives<br />
The student learns about the effects of background rotation and density stratification on<br />
incompressible fluid flow. Specific goals are:<br />
• to analyse complex flow phenomena by using the concept `potential vorticity’;<br />
• to analyse basic dynamic balances and the role of viscous effects (Ekman<br />
boundary layers);<br />
• to gain understanding of basic mechanisms of varying kinds of wave phenomena<br />
in rotating and/or stratified fluids;<br />
• to analyse stability/instability of flows.<br />
Contents<br />
This course focusses on some basic features of the dynamics of large-scale geophysical<br />
flows as met in oceans and planetary atmospheres, which are essentially affected by<br />
background rotation and density stratification of the medium. Topics that are discussed:<br />
geostrophic flow, conservation of potentical vorticity, Ekman boundary layers, spin-up,<br />
wind-driven ocean circulation, Boussinesq approximation, waves in rotating and<br />
stratified fluids, density currents, geostrophic adjustment, barotropic and baroclinic<br />
instability, aspects of 2D turbulence ad dynamics of coherent vortex structures. A<br />
laboratory course ‘geophysical fluid dynamics’ is organized with experimental and<br />
computer sessions, in which students can investigate some dynamical features of rotating<br />
and stratified flows in the laboratory and by numerical simulations.
3T390 Atmospheric Physics 3 ECTS<br />
Lecturers:<br />
Dr. Folkert Boersma<br />
Dr. Bas van de Wiel<br />
Objectives<br />
The objective of the course is to show how simple principles of physics can be applied to<br />
describe a complex system as the atmosphere, and how one can reduce the complex<br />
system to build models. The second objective is to convey a basic but current knowledge<br />
of atmospheric composition in terms of air pollution and greenhouse gas concentrations,<br />
and their effects, along with an appreciation for the research that led to this knowledge.<br />
Contents<br />
This course introduces students to a basic knowledge of physics and transport in the<br />
atmosphere, relevant for understanding air pollution and the greenhouse effect. The<br />
course starts with some basics on the structure of the atmosphere. Subsequently simple<br />
atmospheric concepts are introduced that help explain the horizontal and vertical<br />
transport of atmospheric constituents, using the concept of lifetime of a species.<br />
Atmospheric transport in all dimensions is discussed: geostrophic flow, the general<br />
circulation, vertical transport, and turbulence. We conclude the course with examining<br />
the role that atmospheric constituents play in controlling the temperature of the Earth.<br />
Exercises are an essential part of the course, and students are encouraged to work through<br />
them. These exercises demonstrate and apply <strong>related</strong> concepts to current issues in<br />
atmospheric research, and they often tell important stories based on research papers.
3T340 Micro- and Nanofluidics 4 ECTS<br />
Lecturers:<br />
Prof. Anton Darhuber<br />
Dr. Jens Harting<br />
Dr. Henk Huinink<br />
Objectives<br />
This course will provide students with an overview of micro- and nanofluidics, i.e.<br />
aspects of fluid mechanics, heat- and mass transfer at small length scales where surface<br />
and interface effects dominate the dynamics. The students will gain insight into the forces<br />
and physical mechanisms that determine and are available for transport at micro- and<br />
nanoscales. Although the course does not focus on microfabrication and device design, it<br />
will provide students with a basis for estimating quantities such as stresses exerted by<br />
liquids on microscopic objects, flow velocities and mixing efficiencies. These skills will<br />
facilitate the identification of the best-suited transport mechanism for a specific system in<br />
the context of fundamental research or industrial R&D.<br />
Contents<br />
1. Length scales:<br />
- The transition from the molecular to the continuum picture<br />
2. The predominance of viscous friction and interfacial effects:<br />
- The Stokes equation and corresponding boundary conditions<br />
3. Surface forces:<br />
- Liquids in contact with other phases: surface tension, Van der Waals & Casimir<br />
forces, contact angles, superhydrophobic surfaces<br />
4. Mixing:<br />
- Brownian motion and diffusion<br />
- Micromixing and chaotic advection<br />
5. Applications:<br />
- Transport in porous media<br />
- Biological systems, lipid membranes and vesicles
3T350 Statistical Fluid Mechanics and Chaos 3 ECTS<br />
Lecturers:<br />
Prof. Federico Toschi<br />
Prof. Willem van de Water<br />
Objectives<br />
[no learning objectives have been formulated yet]<br />
Contents<br />
Many flow regimes in Nature or in industrial applications display unpredictable behavior.<br />
This course serves as an introduction to chaos and to modern techniques for the study of<br />
the statistical properties of fluid flows in chaotic regime. To begin with, we will study the<br />
basis of chaos: the disordered behavior of nonlinear dynamical systems. Even very<br />
simple but nonlinear systems can display chaotic and unpredictable behaviour. The<br />
emphasis will be on a scaling description, a concept beautifully illustrated by fractals.<br />
Regarding chaotic fluids the focus will be on both Eulerian and Lagrangian chaos.<br />
Central to the course is the exposure to the modern literature. During one half of the<br />
course basic concepts are introduced, and in the other half each participant presents an<br />
article on chaos or chaotic flows that appeared in recent years in Physical Review Letters.<br />
Of course, adequate coaching is offered.<br />
Recommended prior knowledge:<br />
3T280 Turbulent Flow Phenomena
3T360 Hydrodynamic Stability 3 ECTS<br />
Lecturers:<br />
Dr. Leon Kamp<br />
Dr. Bas van de Wiel<br />
Prof. Herman Clercx<br />
Objectives<br />
The student learns how to analyse the (in)stability of flows by some basic analysis<br />
techniques, including nonlinear theory.<br />
Contents<br />
• Introduction: basics and fundamental concepts, what is (in)stability, mechanisms<br />
of instability.<br />
• Techniques and methods to investigate hydrodynamic stability (laboratory<br />
experiments, numerical simulations, linear and weakly nonlinear theory, normal<br />
mode analysis, bifurcation and chaos, strongly nonlinear theory, development of<br />
instabilities in space and time).<br />
• Kelvin-Helmholtz instability.<br />
• Capillary instability of a jet (Rayleigh's theory).<br />
• Rayleigh-Bénard convection.<br />
• Centrifugal instability (swirling flows, Couette flow, Görtler instability).<br />
• Stability of parallel flows (inviscid; Rayleigh's stability problem, viscous; Orr-<br />
Sommerfeld problem, stratification; generalization of Kelvin-Helmholtz<br />
instability, Rayleigh-Taylor instability, baroclinic instability).<br />
Book: Introduction to Hydrodynamic Stability by P.G. Drazin
3T370 Experimental Methods in Transport Physics 3 ECTS<br />
Lecturers:<br />
Prof. Anton Darhuber<br />
Dr. Ruben Trieling<br />
Prof. Willem van de Water<br />
Objectives<br />
This course will provide students with an overview of experimental methods in fluid<br />
mechanics and their modern technological implementations. The students will gain<br />
insight into the underlying physical mechanisms, the capabilities regarding temporal and<br />
spatial resolution and accuracy as well as the strengths and limitations of the methods.<br />
The course will provide students with a basis for selecting the optimal technique for a<br />
certain measurement problem in the context of academic research or industrial R&D.<br />
Contents<br />
Three general categories of methods will be discussed:<br />
1) Measurement techniques for large-scale flows such as particle image velocimetry<br />
(PIV), particle <strong>track</strong>ing velocimetry (PTV), hot-wire anenometry, laser-induced<br />
fluorescence (LIF), laser-Doppler anemometry (LDA).<br />
2) Measurement methods for micro- and nanofluidic systems such as tensiometry, surface<br />
topography and film-thickness metrology (interferometric and ellipsometric techniques),<br />
2D- and 3D-optical microscopy and resolution-enhancement techniques, flow metrology<br />
and manipulation using optical tweezers.<br />
3) Experimental methods for the characterization of transport in porous media:<br />
techniques for measuring porosity and permeability as well as multicomponent and<br />
multiphase heat- and mass transfer, such as nuclear magnetic resonance (NMR) imaging<br />
and x-ray tomography.
3T380 Advanced Computational Fluid Dynamics 3 ECTS<br />
Lecturers:<br />
Prof. Federico Toschi<br />
Prof. Herman Clercx<br />
Dr. Jens Harting<br />
Dr. Jan ten Thije Boonkkamp<br />
Prof. Ronny Keppens (KU Leuven)<br />
Objectives<br />
The course provides an introduction to advanced computational methods useful to<br />
investigate fluid flows from the micro to the macro-scales under laminar and turbulent<br />
flow regime.<br />
Contents<br />
The course will present an overview of several complementary computational methods<br />
(particles-based methods like Stochastic Rotation or Dissipative Particle Dynamics,<br />
mesoscopic methods like Lattice Boltzmann and spectral methods). The first part of the<br />
course is common and provides a general background on advanced techniques for<br />
computational fluid dynamics and their mathematical foundations. In the second part<br />
there is the possibility to choose to specialize either on large-scales (e.g. turbulence and<br />
MHD) or on small-scales (micro, nano-fluidics and multiphase flows) flows.<br />
Recommended prior knowledge:<br />
2DN08 Numerical Methods<br />
3CC80 Computational Physics<br />
Related <strong>courses</strong>:<br />
3T220 Chaos<br />
3T280 Turbulent Flow Phenomena<br />
3P270 Computational Plasma Physics<br />
3NC10 Mathematical Methods in Physics<br />
3T340 Micro- and Nanofluidics
3T220 Chaos 3 ECTS<br />
Lecturers:<br />
Prof. Willem van de Water<br />
Prof. Federico Toschi<br />
Objectives<br />
(have not been formulated)<br />
Contents<br />
Chaos is the disordered behavior of nonlinear systems with just a few degrees of<br />
freedom: very simple but nonlinear systems. We will see why the route to chaos is often<br />
universal. This universality can be expressed in terms of a renormalisation theory, which<br />
embodies the invariance of the dynamics under a change of scale. We will discuss the<br />
Feigenbaum–Cvitanovic renormalization equation for the route to chaos through period<br />
doublings. Next, we will walk the road to chaos along the golden mean in the case of<br />
competition of nonlinear oscillators.<br />
Fluids are described by (nonlinear) partial differential equations, which can be viewed as<br />
many dynamical systems glued together and talking to each other. We will discuss<br />
synchronization in these systems. More general, we will explore the dynamics of weakly<br />
nonlinear systems described by partial differential equations. We will also discuss how<br />
the path of fluid parcels can be chaotic, and how concepts of chaos can be applied to<br />
these chaotic flows.<br />
Throughout these subjects, the emphasis is on a scaling description. A theory of scales is<br />
beautifully illustrated by the concept of fractals. It is possible to give a thermodynamic<br />
description of these strange things.<br />
Central to the course is the exposure to the modern literature. During one half of the<br />
course basic concepts are introduced, and in the other half each participant presents an<br />
article on chaos and nonlinear fluids which appeared in the past year in Physical Review<br />
Letters. Adequate coaching is offered.<br />
Recommended prior knowledge:<br />
3T280 Turbulent Flow Phenomena
3F240 NMR/MRI 3 ECTS<br />
Lecturer:<br />
Prof. Klaas Kopinga<br />
Objectives<br />
• Understanding the basic principles of Nuclear Magnetic Resonance (NMR).<br />
• Understanding NMR-based imaging techniques (MRI).<br />
• Have knowledge of frequently used MRI pulse sequences.<br />
• Understanding measurements of flow and diffusion using MRI<br />
Contents<br />
In this course the basics of Nuclear Magnetic Resonance (NMR) and Magnetic<br />
Resonance Imaging (MRI) will be introduced. Most of the phenomena will be described<br />
in terms of semi-classical models; quantum-mechanical models will only be used when<br />
strictly necessary. The following topics will be considered: Mathematics of NMR, Spin<br />
Physics, NMR Spectroscopy, Fourier Transforms, Imaging Principles, the k-space,<br />
Fourier Transform Imaging Principles, Basic Imaging Techniques, Spectroscopic<br />
Imaging, Imaging Hardware, Image Presentation, Image Artifacts and Advanced Imaging<br />
Techniques. Some attention will be given to measurements of flow and diffusion with<br />
MRI.
3F250 Transport in Porous Media 3 ECTS<br />
Lecturer:<br />
Dr. Leo Pel<br />
Objectives<br />
This course is a first introduction and provides a basic theoretical background for<br />
modelling transport phenomena engaged in various engineering projects. Subjects are:<br />
porosity, capillary pressure, permeability, transport in saturated materials, absorption and<br />
drying, oil/water transport, moisture and ion transport.<br />
Contents<br />
The transport of, e.g., water, oil in porous media is studied in various disciplines, e.g.,<br />
civil engineering, building physics, chemical engineering, reservoir engineering and soil<br />
science. In all these disciplines, problems are encountered in mass and heat are<br />
transported through a porous material. In these disciplines many models have been<br />
develop to describe the transport processes in porous media. It is beyond the scope of this<br />
course to go into the details of these various theories. This course is a first introduction<br />
and provides a basic theoretical background for modelling transport phenomena engaged<br />
in various engineering projects The discussion in this course will be limited to the<br />
transport in the isothermal situations.<br />
Subjects are: porosity, capillary pressure, permeability, transport in saturated materials,<br />
absorption and drying, oil/water transport, moisture and ion transport.
Master <strong>track</strong> Transport Physics<br />
Other relevant elective lecture <strong>courses</strong>:<br />
2DN41 Aeroacoustics<br />
(Rienstra/Hirschberg)<br />
3CS01 Percolation, Fractals and Scaling in Condensed Matter (Michels)<br />
3CS02 Nonequilibrium Thermodynamics and Statistical Mechanics (van der Schoot)<br />
3CS03 Theory of Liquids<br />
(Clercx/Toschi)<br />
3P110 Introduction to Plasma Physics<br />
(van de Sanden)<br />
3S390 Biosensors for Medical Diagnostics<br />
(van IJzendoorn)<br />
4P060 Fundamentals of Gas Dynamics<br />
(Smeulders/Hirschberg)<br />
4P510 Renewable Energy Sources<br />
(van Noort/Kramer/<br />
van de Sanden/Creatore)<br />
4P540 Multiphase Flow with Heat Effects<br />
(van der Geld)<br />
4P630 Application of FEM to Heat and Flow Problems (Rindt)<br />
4P700 Turbo Machinery<br />
(de Lange)<br />
4P710 Micro Heat Transfer<br />
(Frijns)<br />
4P720 Wind Energy<br />
(van Esch)<br />
8W090 Cardiovascular Fluid Mechanics<br />
(van de Vosse/Bogaerds)<br />
8W150 Multi-fluid Mechanics<br />
(Anderson/Meijer)<br />
8W270 Fluid Biomechanics<br />
(van de Vosse/Bogaerds)
2DN41 Aero-acoustics 3 ECTS<br />
Lecturers:<br />
Dr. Sjoerd Rienstra / Prof. Mico Hirschberg<br />
Objectives<br />
Introduction to acoustics and flow-acoustics.<br />
Contents<br />
Aeroacoustics is the study of sound generation by flows. The basic concepts of acoustics<br />
are introduced. We consider acoustics of pipes and of free field. Then we focus on the<br />
theory of Lighthill for sound generation by flows and the vortex-sound theory. Theory is<br />
illustrated as much as possible by examples of applications (speech production, whistling,<br />
woodwind musical instruments, turbine sound, aircraft noise, ...).
3CS01<br />
Lecturer:<br />
Percolation, Fractals and Scaling in Condensed Matter<br />
(caput Theoretical Physics)<br />
1 ECTS<br />
Prof. Thijs Michels<br />
Objectives<br />
No learning objectives have been stated yet for this course<br />
Contents<br />
Many materials of practical relevance are, by nature or by design, disordered in their<br />
microstructure: concrete, reinforced or conductive composites, porous catalysts,<br />
polymeric semiconductors, sandbeds, fractured rocks, biotissue, etc. Often the disordered<br />
structure at the mesoscale between the scale of the constituent molecules and that of the<br />
specimen has the property or designed function of transporting something through the<br />
material: charge, mass, momentum or energy. The physics underlying this material<br />
function is intimately <strong>related</strong> to the mesoscale morphology, in particular to the presence<br />
of network-like sample-spanning pathways through the material. A fundamental<br />
framework to understand the relation between material microstructure and transport<br />
property is provided by the theoretical concepts of percolation, fractals and scaling. This<br />
Caput Theoretical Physics provides a short mathematical introduction in these three<br />
fundamental concepts. They are illustrated in the application to DC and AC conduction<br />
through random composites and in the growth mechanism of fractal pathways.
3CS02<br />
Lecturer:<br />
Non-equilibrium Thermodynamics and Statistical<br />
Mechanics (caput Theoretical Physics)<br />
2 ECTS<br />
Prof. Paul van der Schoot<br />
Objectives<br />
No learning objectives have been stated yet for this course<br />
Contents<br />
Thermodynamics and statistical mechanics provide a powerful theoretical framework for<br />
understanding how materials or collections of molecules behave in a state of equilibrium,<br />
e.g., under what conditions certain types of molecule choose to be in a gaseous state or to<br />
condense into liquid, liquid-crystallin, plactic, or crystalline states of aggregation.<br />
Equilibrium states of materials are characterised by a total absence of their properties on<br />
time. However, if materials are suddenly brought under altered thermodynamic<br />
conditions of, say, pressure, volume or temperature, they ideally move towards their new<br />
equilibrium state with progressing time. Such non-equilibrium processes are described by<br />
non-equilibrium extensions of classical thermodynamics and statistical mechanics, the<br />
fundamentals of which will be discussed in the course. Practical applications will focus in<br />
particular on diffusive transport processes involving mass and heat, as well as phase<br />
ordering kinetics, including spinodal decomposition, nucleation and growth, and latestage<br />
coarsening.
3CS03 Theory of Liquids (caput Theoretical Physics) 2 ECTS<br />
Lecturers:<br />
Prof. Herman Clercx / Prof. Federico Toschi<br />
Objectives<br />
No learning objectives have been stated yet for this course<br />
Contents<br />
Liquids lack the long-range order typical for solids. Collisional processes and short-range<br />
correlations distinguish liquids from dilute gases. Therefore, no idealized models<br />
comparable with the perfect gas or the harmonic solid are available for even simple<br />
liquids. During the last half of the 20th century a rapid progress has been made in our<br />
understanding of the microscopic structure and the dynamics of simple liquids. With<br />
advances in experiments (light and neutron scattering), theoretical analysis (statistical<br />
mechanics, kinetic theory of strongly cor<strong>related</strong> systems) and numerical tools (Molecular<br />
Dynamics and Monte Carlo simulations) a rather clear and complete picture emerged on<br />
the properties of simple atomic liquids. Since the last few decades a variety of more<br />
complicated systems are being studied: ionic, molecular and polar liquids, liquid metals,<br />
liquid-vapor interfaces, liquid crystals, and colloidal suspensions. In this lecture we will<br />
address the basic theory of the liquid state based on a statistical mechanical description of<br />
liquids. Topics that will be discussed include static properties of liquids, distribution<br />
function theories, perturbation theory and inhomogeneous fluids. We will conclude with<br />
an outlook to more complex fluids.
3S390 Biosensors for medical diagnostics 3 ECTS<br />
Lecturer:<br />
Dr. Leo van IJzendoorn<br />
Objectives<br />
Obtaining sufficient knowledge to be able to read and understand recent literature on<br />
biosensors as well as obtaining the basic knowledge required to start (experimental)<br />
research on biosensors.<br />
Contents<br />
In this course, new developments will be discussed in the design of biosensors that can<br />
measure extremely low concentrations of proteins or nucleic acids (picomolar) in a small<br />
volume (microliter) of body fluid (e.g. blood, saliva, urine). At present, a strong<br />
worldwide research competition is ongoing to apply (new) physical detection principles<br />
in fast and compact biosensors that can be used in ‘point-of-care’ applications. After a<br />
short introduction in biochemistry for physicists, this course will start with the principles<br />
of molecular recognition through the use of various types of immunoassays.<br />
Subsequently the kinetics of the molecular recognition will be discussed which is, inside<br />
the biosensor, determined by a combination of reaction kinetics, convection and<br />
diffusion. Next, the physical detection principles of the new sensors will be addressed:<br />
1. magnetic detection applying the Giant Magnetic Resistance or Hall effects<br />
2. electrical detection methods (impedance spectroscopy)<br />
3. optical detection techniques applying fluorescence, chemiluminescence and<br />
surface plasma resonance.<br />
A critical evaluation of the sensitivity of different technologies will be given on the basis<br />
of recent literature.
4P060 Fundamentals of Gas Dynamics 3 ECTS<br />
Lecturers:<br />
Prof. David Smeulders / Prof. Mico Hirschberg<br />
Objectives<br />
Basic knowledge of quasi-one-dimensional steady and unsteady gasdynamics.<br />
Contents<br />
Gas dynamics is that part of fluid mechanics in which fluid compressibility, characterised<br />
by the speed of sound, is important. The following subjects will be discussed during the<br />
course: one-dimensional propagation of waves in tubes, distortion of waves with a high<br />
amplitude. The formation of almost discontinuous pressure-waves, characterized by a<br />
large change in velocity and thermodynamic state, the so-called shock waves. The<br />
possibility to create well-defined shock waves in a laboratory using a shock tube and its<br />
use for studying physical and chemical properties of gases. The correspondence between<br />
waves in gases and waves in traffic density on a highway. Steady compressible flow in<br />
tubes of varying diameter.