Dr. Ulfert Hornemann - School of Pharmacy - University of Wisconsin ...

Dr. Ulfert Hornemann
School of Pharmacy
University of Wisconsin-Madison
425 N. Charter Street
Madison, WI 53706-1515
PHONE: 608 / 263-1447
FAX: 608 / 262-3997
email: ULHornemann@pharmacy.wisc.edu
PUBLICATIONS
1. Nichtverwertung von 4-Hydroxy-tryptophan bei der Biosynthese der Mutterkornalkaloide
Eine Ueberpruefung, H. G. Floss, U. Mothes, D. Onderka and U. Hornemann, Z.
Naturforschg., 20b, 134-135 (1965).
2. Chanoclavines and the Biosynthesis of Ergot Alkaloids. H. G. Floss, U. Hornemann, N.
Schilling, D.Groger and D. Erge, Chem. Comm., 105-106 (1967).
3. Biosynthesis of Ergot Alkaloids. Evidence for Two Isomerizations in the Isoprenoid Moiety
during the Formation of Tetracyclic Ergolines. H. G. Floss, U. Hornemann, N. Schilling, K.
M. Kelley, D. Groger and D. Erge, J. Amer. Chem. Soc., 90, 6500-6507 (1968).
4. Thin-layer Chromatographic Separation of Some Indolic Methyl Esters Including
Indoleisopropionic Acid Methyl Ester. U. Hornemann and H. G. Floss, Anal. Biochem., 26,
469-471 (1969).
5. Biosynthesis of Indoleisopropionic Acid by Claviceps. Biological C-Methylation Involving
an Intact Methyl Group. U. Hornemann, M. K. Speedie, K. M. Kelley, L. H. Hurley and H.
G. Floss, Arch. Biochem. Biophys., 131, 430-437 (1969).
6. Biosynthesis of the Antibiotic Indolmycin by Streptomyces griseus. C-Methylation at the b
carbon Atom of the Tryptophan Side Chain. U. Hornemann, L. H. Hurley, M. K. Speedie,
H. G. Guenther and H. G. Floss, Chem. Comm., 245-246 (1969).
7. Tryptophan Metabolism, Protein and Alkaloid Synthesis in Saprophytic Cultures of the Ergot
Fungus (Claviceps sp.). H. Kaplan, U. Hornemann, K. M. Kelley and H. G. Floss, Lloydia,
32, 489-497 (1969).
8. Isolation and Absolute Configuration of Indolmycenic Acid, An Intermediate in The
Biosynthesis of Indolmycin by Streptomyces griseus. U. Hornemann, L. H. Hurley, M. K.
Speedie and H. G. Floss, Tetrahedron Letters, 2255-2258 (1970).
9. Demonstration of a C-Methylating Enzyme in Cell-free Extracts of Indolmycin-Producing
Streptomyces griseus. U. Hornemann, M. K. Speedie, L. H. Hurley and H. G. Floss,
Biochem. Biophys. Res. Comm., 39, 594-599 (1970).
10. Studies on the Biosynthesis of the Mitomycin Antibiotics by Streptomyces verticillatus. U.
Hornemann and J. C. Cloyd, Chem. Comm., 301-302 (1971).
11. The Biosynthesis of Indolmycin. U. Hornemann, L. H. Hurley, M. K. Speedie and H. G.
Floss, J. Amer. Chem. Soc., 93, 3028-3035 (1971).
12. Mitomycin Biosynthesis by Streptomyces verticillatus. Incorporation of the Amino-group of
D-( 15 N)-Glucosamine into the Aziridine Ring of Mitomycin B. U. Hornemann and M. J.
Aikman, Chem. Comm., 88-89 (1973).
Dr. Ulfert Hornemann Page 1
School of Pharmacy, University of Wisconsin-Madison, 425 N. Charter St., Madison, WI 53706-1515

13. Synthesis of 2-Amino-2-deoxy-D-glucose- 15 N and 2-Amino-2-deoxy-L-glucose-2- 14 C. U.
Hornemann, Carbohydrate Res., 28, 171-174 (1973).
14. D-Glucosamine and L-Citrulline, Precursors in Mitomycin Biosynthesis by Streptomyces
verticillatus. U. Hornemann, J. P. Kehrer, C. S. Nunez and R. L. Ranieri, J. Amer. Chem.
Soc., 96, 320-322 (1974).
15. Precursors in Mitomycin Biosynthesis by Streptomyces verticillatus. U. Hornemann, J. P.
Kehrer, C. S. Nunez, R. L. Ranieri and Y. K. Ho, Develop. Industr. Microbiol., 15, 82-91
(1974).
16. Synthesis of L-Arabinose-5-phosphate, 5-O-Carbamoyl-D Arabinose and 6-O-Carbamoyl-Dglucose.
M. M. A. Abd El-Rahman and U. Hornemann, Carbohydrate Res., 38, 355-358
(1974).
17. Pyruvic Acid and D-Glucose as Precursors in Mitomycin Biosynthesis by Streptomyces
verticillatus. U. Hornemann, J. P. Kehrer and J. H. Eggert, Chem. Comm., 1045-1046
(1974).
18. S-Adenosylmethionine: Indolepyruvate-3-methyltransferase. M. K. Speedie, U. Hornemann
and H. G. Floss, in Methods in Enzymology, Vol. 43, Antibiotics (J. H. Hash, ed.), p. 498-
502, Academic Press, New York, 1975.
19. Isolation and Characterization of Tryptophan Transaminase and Indolepyruvate C-Methyltransferase:
Enzymes Involved in Indolmycin Biosynthesis in Streptomyces griseus. M. K.
Speedie, U. Hornemann and H. G. Floss, J. Biol. Chem., 250, 7819-7825 (1975).
20. Utilization of the Intact Carbamoyl Group of L-[NH 2 CO- 13 C, 15 N]-Citrulline in Mitomycin
Biosynthesis by Streptomyces verticillatus. U. Hornemann and J. H. Eggert, J. Antibiot., 28,
841-843 (1975).
21. Further Studies on the Biosynthesis of the Antibiotic Indolmycin in Streptomyces griseus. L.
Zee, U. Hornemann and H. G. Floss, Biochem. Physiol. Pflanzen, 168, 19-25 (1975).
22. Oxidative Amination of Toluhydroquinone. S. C. Srivastava and U. Hornemann, Angew.
Chem. Int. Ed. Engl., 15, 109-110 (1976).
23. Studies on the Mode of Action of the Mitomycin Antibiotics. Reversible Conversion of
Mitomycin C into 7-Aminomitosane-9a-Sodium Sulfonate. U. Hornemann, Y. K. Ho, J. K.
Mackey, Jr. and S. C. Srivastava, J. Amer. Chem. Soc., 98, 7069-7074 (1976).
24. Synthesis of 3-Substituted-2,4-Dimethyl-6-Pyrrolidine-1, 4-Benzoquinones, A. B. Daruwala
and U. Hornemann, Org. Prep. Proced. Int., 9, 19-25 (1977).
25. Isolation and Characterization of Desepoxy-4,5-didehydro-methylenomycin A, A Precursor
of the Antibiotic Methylenomycin A in SCPl + Strains of Streptomyces coelicolor A3 (2), U.
Hornemann and D. A. Hopwood, Tet. Lett., 2977-2978 (1978).
26. High Pressure Liquid Chromatography of the Antibiotics Mitomycin A, B and C and of Polar
Mitomycin C Conversion Products. S. C. Srivastava and U. Hornemann, J. Chromatogr.,
161, 393-395 (1978).
27. Nitroalkane Oxidation by Streptomyces, M. R. Dhawale and U. Hornemann, J. Bacteriol.,
137, 916-924 (1979).
28. Studies on the Biosynthesis of the Antibiotic Streptozotocin by Streptomyces achromogenes
var streptozoticus. Feeding Experiments with Carbon-14 and Tritium Labeled Precursors. S.
Singaram, R. S. Lawrence and U. Hornemann, J. Antibiot., 32, 379-385 (1979).
29. A Convenient Method for Shortening the Sugar Chain; Degradation of D-Glucose into D-
Arabinose. M. A. E. Sallam, S. Singaram and U. Hornemann, Carbohydr. Res., 73, 320-322
(1979).
Dr. Ulfert Hornemann Page 2
School of Pharmacy, University of Wisconsin-Madison, 425 N. Charter St., Madison, WI 53706-1515

30. Formation of 1-Ethylxanthyl-2,7-Diaminomitosene and 1,10-Diethylxanthyl-2,7-Diaminodecarbomoylmitosene
in Aqueous Solution upon Reduction-Reoxidation of Mitomycin C in the
Presence of Potassium Ethylxanthate. U. Hornemann, P. J. Keller and J. F. Kozlowski, J.
Amer. Chem., Soc., 101, 7121-7124 (1979).
31. Role of D-[4- 14 C]Erythrose and [3- 14 C]Pyruvate in the Biosynthesis of the meta-CC 6 N Unit
of the Mitomycin Antibiotics in Streptomyces verticillatus. U. Hornemann, J. H. Eggert and
D. P. Honor, J. C. S. Chem. Commun., 11-13 (1980).
32. Utilization of Cibacron Blue 3G-A Sepharose 6B in the Isolation and Enrichment of Pyruvate
Phosphate, Dikinase, Alanine Dehydrogenase and Phosphoenolpyruvate Carboxylase from
Mitomycin-Producing Streptomyces verticillatus. K. L. Redman and U. Hornemann, J.
Antibiot., 33, 863-877 (1980).
33. U. Hornemann and D. A. Hopwood, Biosynthesis of Methylenomycin A, in Antibiotics, IV,
Biosynthesis, Ed. J. W. Corcoran, Springer, New York, 123-131 (1981).
34. U. Hornemann, Biosynthesis of the Mitomycins, in Antibiotics, IV, Biosynthesis, Ed. J. W.
Corcoran, Springer, New York, 295-312 (1981).
35. U. Hornemann, Nitrogen-Nitrogen Bond Containing Antibiotics: Biosynthesis of Streptozocin,
in Antibiotics, IV, Biosynthesis, Ed. J. W. Corcoran, Springer, New York, 313-324
(1981).
36. The 13 C-NMR Spectrum of Mitomycin C: Reassignment. P. J. Keller and U. Hornemann, J.
Nat. Prod., 46, 569-571 (1983).
37. Reactions of Mitomycin C with Potassium Ethyl Xanthate in Neutral Aqueous Solution. U.
Hornemann, K. Iguchi, P. J. Keller, H. M. Vu, J. F. Kozlowsky and H. Kohn, J. Org. Chem.,
48, 5026-5033 (1983).
38. U. Hornemann, Mitomycins, in Handbook of Microbiology, 2nd Edition, Eds. A. I. Laskin,
H. A. Lechevalier, Vol. V: Microbiological Products, CRC Press, Boca Raton, 619-621
(1984).
39. Lack of Influence of the Carbamoyl Group on the Stereochemistry of the Acid-Catalyzed
Opening of the Aziridine Ring of the Mitomycins and of Congeners. U. Hornemann, P. J.
Keller, and K. Takeda, J. Med. Chem., 28, 31-36 (1985).
40. Stereochemical Relationship between Mitomycins A, B and C. U. Hornemann and M. J.
Heins, J. Org. Chem., 50, 1301-1302 (1985).
41. Spectinomycin Resistance and Associated DNA Amplification in Streptomyces achromogenes
subsp. rubradiris. U. Hornemann, C.J. Otto, G.G. Hoffman, and A.C. Bertinuson,
J. Bacteriol., 169, 2360 (1987).
42. DNA Amplification in Streptomyces achromogenes subsp. rubradiris is Accompanied by a
Deletion, and the Amplified Sequences are Conditionally Stable and can be Eliminated by
two Pathways. U. Hornemann, C.J. Otto, and X.Y. Zhang, J. Bacteriol., 171, 5817 (1989).
43. U. Hornemann, X.Y. Zhang and C.J. Otto, "Transferable Streptomyces DNA Amplification
and Coamplification of Foreign DNA Sequences", J. Bacteriol., 175, 1126 - 1133 (1993).
44. U. Hornemann, and X.Y. Zhang, "Transferable Streptomyces DNA Amplification - an
Example of Involvement of an ori site", Biotechnologya, 7/8, 120-125 (1995). Meeting
report written for: Proceedings of the Ninth Symposium on the Biology of Actinomycetes,
Moscow, 1994.
45. O. M. Cholewa and U. Hornemann, “Laminated Dialysis Cassette”, BioTechniques, 25, 212
(1998).
Dr. Ulfert Hornemann Page 3
School of Pharmacy, University of Wisconsin-Madison, 425 N. Charter St., Madison, WI 53706-1515