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April 2007 - Division of Biology and Medicine - Brown University

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Images In <strong>Medicine</strong><br />

Malignant Gastric Ulcer on Multidetector Row CT<br />

<strong>and</strong> Endoscopy<br />

Brian D. Midkiff, MD, MPH, Philip A. McAndrew, MD, <strong>and</strong> William W. Mayo-Smith, MD<br />

This 78-year-old Caucasian woman presented with epigastric<br />

pain for which endoscopy was performed. Direct<br />

endoscopic visualization demonstrated a suspicious,<br />

solitary ulcer <strong>of</strong> the posterior body <strong>and</strong> thickened folds<br />

<strong>of</strong> the antrum. Multidetector row CT examination <strong>of</strong><br />

the abdomen with intravenous <strong>and</strong> low-density oral contrast<br />

material showed a gastric mass at the posterior midbody<br />

with a large central ulcer (arrow) as well as inflammatory<br />

thickening <strong>of</strong> the gastric antrum (arrowhead) <strong>and</strong><br />

no evidence <strong>of</strong> local invasion or nodal disease. Biopsy<br />

performed at endoscopy demonstrated a low-grade marginal<br />

zone B-cell lymphoma.<br />

Lymphoma involves the stomach more frequently<br />

than any other segment <strong>of</strong> the gastrointestinal tract. Primary<br />

gastric lymphoma is usually confined to the stomach<br />

<strong>and</strong> regional nodes <strong>and</strong> is most commonly a non-<br />

Hodgkin lymphoma <strong>of</strong> B-cell origin. On cross-sectional<br />

imaging, gastric lymphoma typically presents as diffuse<br />

wall thickening. However, it may also manifest as focal<br />

disease or malignant ulceration, as seen in this case. Primary<br />

gastric lymphomas may be high-grade or lowgrade.<br />

Low-grade tumors, such as lymphoma <strong>of</strong> mucosa-associated<br />

lymphoid tissue (MALT), follow a more<br />

indolent clinical course <strong>and</strong> are associated with 5-year<br />

survival rates <strong>of</strong> up to 60%.<br />

Low-density oral contrast material <strong>and</strong> intravenous<br />

contrast material aid in visualization <strong>of</strong> the bowel mucosa<br />

at multidetector CT. In this patient, low-density<br />

oral contrast allowed superb CT characterization <strong>of</strong> the<br />

gastric mass <strong>and</strong> malignant ulcer. The CT image shown,<br />

which was obtained using a 64 detector row scanner,<br />

demonstrates findings which correlate well with the endoscopic<br />

images. The large mass, central ulcer, <strong>and</strong> antral<br />

wall thickening are well seen. When used appropriately,<br />

low-density oral contrast material aids in the CT<br />

investigation <strong>of</strong> mucosal pathology, including evaluation<br />

for depth <strong>of</strong> disease, perforation, local invasion <strong>and</strong> distant<br />

metastatic disease.<br />

REFERENCES<br />

Horton, KM, Fishman, EK. Current role <strong>of</strong> CT in imaging <strong>of</strong> the stomach.<br />

Radiographics 2003; 23:75-87.<br />

Ba-Ssaalamah A, et al. Dedicated multidetector CT <strong>of</strong> the stomach.<br />

Radiographics 2003; 23:625-44.<br />

CORRESPONDENCE<br />

Brian D. Midkiff, MD, MPH<br />

e-mail: Bmidkiff@lifespan.org<br />

Brian D. Midkiff, MD, MPH, is a radiology resident in the Department<br />

<strong>of</strong> Diagnostic Imaging, Warren Alpert Medical School <strong>of</strong><br />

<strong>Brown</strong> <strong>University</strong>,<br />

Philip A. McAndrew, MD, is an attending physician at Rhode<br />

Isl<strong>and</strong> Hospital, Warren Alpert Medical School <strong>of</strong> <strong>Brown</strong> <strong>University</strong><br />

William W. Mayo-Smith, MD, is a Pr<strong>of</strong>essor in the Department<br />

<strong>of</strong> Diagnostic Imaging, Warren Alpert Medical School <strong>of</strong> <strong>Brown</strong> <strong>University</strong>.<br />

VOLUME 90 NO. 4 APRIL <strong>2007</strong><br />

133

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