Discovery of Potent HIV-1 Capsid Assembly Inhibitors
Discovery of Potent HIV-1 Capsid Assembly Inhibitors
Discovery of Potent HIV-1 Capsid Assembly Inhibitors
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CAIs reduce virus yield or infectivity<br />
Proviral clone used to transfect 293 cells <strong>Inhibitors</strong> applied to virus<br />
producing cells at 50XEC 50 analysis performed 48h post-transfection<br />
Infectivity assay<br />
cytoplasm<br />
virions<br />
Titre (x10 5 /mL)<br />
1.4<br />
1.2<br />
1.0<br />
0.8<br />
0.6<br />
0.4<br />
0.2<br />
0<br />
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