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Discovery of Potent HIV-1 Capsid Assembly Inhibitors

Discovery of Potent HIV-1 Capsid Assembly Inhibitors

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<strong>Capsid</strong> <strong>Assembly</strong> Assay (CAA)<br />

In the context <strong>of</strong> CA-NC, nucleic acid enhances<br />

the formation <strong>of</strong> capsid-like complexes in vitro<br />

CA-NC<br />

+<br />

probe<br />

B<br />

B<br />

B<br />

Streptavidin<br />

<strong>Assembly</strong> phase wash detect<br />

Boehringer Ingelheim - CROI 2010 3

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