Discovery of Potent HIV-1 Capsid Assembly Inhibitors
Discovery of Potent HIV-1 Capsid Assembly Inhibitors
Discovery of Potent HIV-1 Capsid Assembly Inhibitors
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<strong>HIV</strong>-1 <strong>Capsid</strong> <strong>Assembly</strong> and Maturation<br />
MA CA NC p6<br />
<strong>HIV</strong> protease<br />
MA MA CA<br />
NC<br />
p6<br />
p6<br />
Gag polyprotein<br />
Cleavage products<br />
<strong>HIV</strong> protease<br />
Immature virions<br />
(non-infectious)<br />
Mature virions<br />
(infectious)<br />
• <strong>Assembly</strong> and optimal<br />
stability <strong>of</strong> the core is<br />
crucial for viral replication<br />
and infectivity<br />
Boehringer Ingelheim - CROI 2010<br />
• Purified CA can assemble into<br />
core-like particles in vitro<br />
EM <strong>of</strong> capsid tubes<br />
assembled in vitro<br />
2
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