Download - American Head and Neck Society
Download - American Head and Neck Society
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Oral Papers<br />
cartilage invasion; however, close observation following medical<br />
therapy is required to identify recurrent disease. In comparison, patients<br />
undergoing TL with postoperative RT or CRT demonstrated markedly<br />
better local control. For patients with cartilage invasion, a prospective<br />
trial comparing response to medical therapy versus surgical therapy in<br />
patients with T4 laryngeal carcinoma is needed.<br />
S021<br />
DETERMINANTS OF LONG-TERM SPEECH AND SWALLOWING<br />
OUTCOMES FOLLOWING CHEMORADIOTHERAPY FOR<br />
LOCOREGIONALLY ADVANCED HEAD AND NECK CANCER. K W<br />
Mouw, PhD, D J Haraf, MD, K M Stenson, MD, E E Cohen, MD, E Blair,<br />
MD, M E Witt, RN MS, E E Vokes, MD, J K Salama, MD; The University<br />
of Chicago.<br />
Purpose: To identify factors that influence long-term speech <strong>and</strong><br />
swallowing function in patients treated with induction chemotherapy<br />
(IndCT) followed by combined chemoradiotherapy (CRT) for<br />
locoregionally advanced head <strong>and</strong> neck cancer (HNC). Materials <strong>and</strong><br />
Methods: A cohort of 221 patients was treated with IndCT followed by<br />
combined (CRT) for locoregionally advanced HNC between 1995 <strong>and</strong><br />
2002 at the University of Chicago. Of the 184 patients not excluded for<br />
early death or locoregional failure, 163 (88.6%) were assigned a speaking<br />
score of 1-4 at an average of 34.9 months (range=1.5-68) following the<br />
completion of treatment, <strong>and</strong> 166 (90.2%) were assigned a swallowing<br />
score of 1-4 at an average of 34.5 months (range=1-76) following<br />
completion of treatment. Speaking <strong>and</strong> swallowing scores are based on<br />
the validated McMaster scale for head <strong>and</strong> neck radiotherapy outcomes,<br />
with a score of 1 indicating normal function <strong>and</strong> higher scores reflecting<br />
increasing speech <strong>and</strong> swallowing morbidity. Results: Patients received<br />
one of three radiation therapy (RT) dosing schemes during treatment,<br />
<strong>and</strong> there was a trend towards better speech <strong>and</strong> swallowing scores with<br />
decreasing overall RT doses. Swallowing scores did not vary significantly<br />
based on location of the primary site, whereas speaking scores were<br />
significantly worse in patients with a larynx or hypopharynx primary<br />
site compared to the oral cavity or oropharynx (P