Sample Size and Power
Sample Size and Power
Sample Size and Power
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Phase II Designs<br />
• Screening of new therapies<br />
• Not to prove ‘final’ efficacy, usually<br />
– Efficacy based on surrogate outcome<br />
• Sufficient activity to be tested in a<br />
r<strong>and</strong>omized study<br />
• Issues of safety still important<br />
• Small number of patients (still may be<br />
in the hundreds total, but maybe less<br />
than 100/arm)
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