09.11.2014 Views

solvent-abuse-pakistan

solvent-abuse-pakistan

solvent-abuse-pakistan

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Section one<br />

1.2 Solvent Abuse<br />

Defining Solvent Abuse has proven to be a<br />

far more arduous task than it has been for<br />

most other drugs. In broader terms <strong>solvent</strong><br />

<strong>abuse</strong> or more accurately called Volatile<br />

Substance Abuse (VSA) has been defined as<br />

the “deliberate inhalation of gases, chemical<br />

fumes or vapours for mind-altering and<br />

recreational purposes in order to get a “high”<br />

similar to the intoxication produced by<br />

alcohol”. Solvents are chemicals that change<br />

from liquid form into gases or vapours at<br />

ordinary room temperatures. Their <strong>abuse</strong><br />

potential is directly related to their ability to<br />

produce intoxication and repeated <strong>abuse</strong> may<br />

result in psychological dependence or other<br />

harmful health effects. The prevalence and<br />

public health effects of volatile substance<br />

<strong>abuse</strong> are often underestimated and local<br />

knowledge of the phenomenon is inadequate.<br />

The wide range of organic <strong>solvent</strong>s available<br />

in many common products further complicates<br />

the situation. Compounds such as diethyl<br />

ether, chloroform and nitrous oxide have been<br />

deliberately inhaled for recreational purposes<br />

since the early 1800s. Solvents from<br />

adhesives such as glues, (notably toluene),<br />

typewriter correcting fluids and thinners (1,1,1-<br />

trichloroethane), hydrocarbons such as those<br />

found in cigarette lighter refills [forms of<br />

liquefied petroleum gas (LPG), largely butane],<br />

aerosol propellants, halocarbon fire<br />

extinguishers and gases such as nitrous oxide<br />

are among the compounds or products which<br />

may be <strong>abuse</strong>d in this way. Petrol and its byproducts<br />

(gasoline) as well as Acetone<br />

(propanone) have also been reported to be<br />

<strong>abuse</strong>d, especially in developing communities.<br />

While the inhalation of volatile substances<br />

for mind-altering and recreational purposes is<br />

a long-standing problem in the developed<br />

world, the phenomenon appears to be of a<br />

recent origin in most countries in Asia and the<br />

Pacific region. Research has shown that VSA<br />

is primarily an adolescent phenomenon, with<br />

the highest levels of prevalence reported<br />

among 15 and 16 year olds. VSA gives rise to<br />

dose-related effects similar to those of other<br />

hypno sedatives. Small doses can rapidly lead<br />

to euphoria and other disturbances of<br />

behaviour similar to those caused by ethanol<br />

(alcohol), and may also induce delusions and<br />

hallucinations<br />

. 19,20,21,22,23,24.<br />

Inhalants can be breathed in through the<br />

nose or the mouth in a variety of ways, such<br />

as:<br />

<br />

<br />

<br />

<br />

“Sniffing” or “snorting” fumes from<br />

containers;<br />

“Bagging”sniffing or inhaling fumes<br />

from substances sprayed or<br />

deposited inside a plastic or paper<br />

bag;<br />

“Huffing” from an inhalant-soaked rag<br />

stuffed in the mouth;<br />

Spraying aerosols directly into the<br />

nose or mouth.<br />

Inhaled chemicals are rapidly absorbed<br />

through the lungs into the bloodstream and<br />

quickly distributed to the brain and other<br />

organs. Research has shown that the<br />

chemical substances found in inhalants<br />

produce acute effects similar to subanaesthetic<br />

concentrations of general<br />

anaesthetics, as well as to the effects of<br />

classical CNS depressant drugs, such as<br />

alcohol and the barbiturates. This is<br />

characterized by a rapid high that resembles<br />

alcohol intoxication with initial excitation<br />

followed by drowsiness, dis-inhibition, lightheadedness<br />

and agitation. Nearly all <strong>abuse</strong>d<br />

inhalants (other than nitrites) produce a<br />

pleasurable effect by depressing the CNS.<br />

There is evidence that toluene, a <strong>solvent</strong><br />

found in many commonly <strong>abuse</strong>d inhalants<br />

including glue, paint and nail polish removers,<br />

activates the brain's dopamine system. The<br />

dopamine system has been known to play a<br />

role in the rewarding effects of many drugs of<br />

<strong>abuse</strong>. Nitrites, in contrast, dilate and relax<br />

blood vessels rather than acting as<br />

anaesthetic<br />

agents. For<br />

the<br />

anaesthetics,<br />

evidence<br />

suggests<br />

that<br />

enhancement<br />

of<br />

GABAenergic<br />

inhibition may<br />

be an<br />

important<br />

cellular target for<br />

their acute effects, just as it is for alcohol and<br />

25,26<br />

other depressant drugs.<br />

Within minutes of inhalation, the user<br />

experiences intoxication along with other<br />

effects similar to those produced by alcohol.<br />

Alcohol-like effects may include slurred<br />

speech, an inability to coordinate movements,<br />

euphoria, and dizziness. In addition, users<br />

may experience light-headedness,<br />

hallucinations, and delusions, e.g., a feeling<br />

that they can fly. Because intoxication lasts<br />

4<br />

5

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!