Medical and Biological Sciences XXVI/2 - Collegium Medicum ...

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Julia Feit et. al.
individuals, who are not carriers of the virus, does not
differ statistically significantly from drug addicts who
are HIV positive.
putamen) and functionally being a central structure of
the limbic system and reward system [19].
However, increasing the motor performance of
HIV(+) individuals may be influenced by many
pharmacokinetic factors.
Antiviral medicines often interact with methadone
due to the complex metabolism which may lead to
intensified adverse events including reduction or
potentiating of the effectiveness of methadone.
The pharmacokinetic properties of the same drug
can vary considerably between patients due to genetic
factors or comorbidities including liver damage
associated with HCV and HBV infection. Those are
very common in this group of patients. All of these
medications interact with methadone and antiviral
drugs [20, 21, 22, 23].
Fig. 3. The comparison of execution time TMT A test before
and after the administration of a single dose of
methadone in the group of HIV(+)
Ryc. 3. Porównanie czasu wykonania testu TMT A przed i po
podaniu metadonu w grupie osób HIV(+)
DISCUSSION
The study aimed to verify the effect of a single dose
of methadone on the motor skills of HIV(+) persons
addicted to opioids in comparison to HIV(-) ones. In
addition, the TMT test examined whether its values
depend on the dose of methadone taken and the
duration of treatment.
It was found that there are statistically significant
differences both in the speed of TMT A test
completion and in the duration of methadone
treatment.
However, this does not mean that there is
a correlation between these results, because the
duration of the treatment may be associated with a
virus carrier status, which is associated with the risk of
loss of life, and what therefore motivates people in this
group for a systematic substitution therapy.
The time of completion of the TMT A test in
subjects from both groups may be related to the
influence of psychoactive substances in the nervous
centers [18,9]. It was found that in people addicted to
psychoactive substances, structural and functional
changes take place in the ventral striatum. The major
part of which is the nucleus accumbens anatomically a
part of the striatum (including caudate nucleus and
CONCLUSION
Based on the analysis of the test results in opioid
addicted subjects, who are participants of the
methadone program, before and after the
administration of a therapeutic dose of methadone, it
can be concluded that the adoption of a therapeutic
dose of methadone statistically significantly increases
psychomotor performance.
The size of methadone dose does not influence the
study results. The duration of treatment, which is
statistically significantly longer in HIV(+) individuals,
can be determined by a life-threatening risk in this
group. A single dose of methadone statistically
significantly affects motor functions of HIV(+)
subjects.
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