Bryan Kolb: Factors influencing Prefrontal Cortical Development and ...

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Factors altering PFC development The developing PFC is altered by many Pre- and postnatal events including: 1. gonadal hormones 2. stress 3. Sensory and motor experience 4. . Psychoactive drugs 5. Social relationships, including play 6. Cognitive experience
Drug-induced behavioural sensitization The phenomenon whereby there is an escalating behavioral response to repeated administration of a constant dose of a psychomotor stimulant such as amphetamine, cocaine, or nicotine.
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Factors Influencing Prefrontal Cort
Page 3 and 4:
OBJECTIVES 1. Understand organizati
Page 5 and 6:
What is the PFC?
Page 7 and 8: How does the PFC do its job? The pr
Page 9 and 10: Rhesus Monkey Stipple area: MD proj
Page 11 and 12: What does the PFC do? Temporal orga
Page 17 and 18: Examples of deficits of temporal co
Page 19 and 20: Key Points 1. The emergence of PFC
Page 21: Correlation between brain growth an
Page 24 and 25: Developmental Surprises 1. The OFC
Page 26 and 27: The Cortical Neuron Brain Plasticit
Page 28 and 29: Arnold Scheibel’s Story Cell Stru
Page 30 and 31: The principles of brain organizatio
Page 32 and 33: Differences in Cortical plasticity
Page 34 and 35: Gonadal hormones change more than t
Page 36 and 37: Factors altering PFC development Th
Page 38 and 39: Adult Stress Altered PFC organizati
Page 40 and 41: So what? The changed structure of t
Page 42 and 43: Turning Gold into Lead Examples of
Page 44 and 45: Why? For at least some of the outco
Page 46 and 47: Romanian Communist Policy:1966 decr
Page 50 and 51: Getting to the brain via the skin P
Page 52 and 53: How does this work? Skin and brain
Page 54 and 55: Does experience have the same effec
Page 56 and 57: Complex housing alters spine densit
Page 61 and 62: Similar Results are seen in mPFC bu
Page 63 and 64: Thus, Psychoactive drugs are chroni
Page 65 and 66: Is this just about stimulants? NO!!
Page 67 and 68: Are there long-term consequences? 1
Page 69 and 70: How might the changes be related to
Page 71 and 72: Drugs and later experience Drug Tre
Page 73 and 74: What about prenatal effects? Accord
Page 77 and 78: All mammals have play behaviour wit
Page 79 and 80: Sibling play = more complex OFC Adu
Page 81 and 82: Parents change us too… All mammal
Page 85 and 86: What about other developmental Diso
Page 87 and 88: What about other developmental Diso
Page 89 and 90: FAST vs SLOW Although there Are no
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Bryan Kolb: Factors influencing Prefrontal Cortical Development and ...

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