BIOQUELL Clarus L2 (609K) - APEX Laboratory Equipment Company

Bioquell | Clarus L2
• Hydrogen peroxide vapour (HPV) bio-decontamination
technology, capable of 6-log sporicidal reduction
• Fixed or mobile configurations for equipment,
enclosures and rooms up to 75m 3
• Fast, validatable bio-decontamination cycles
• PLC controlled allowing simple integration with
facilities and equipment
• Excellent material compatibility including
sensitive electronics

Bioquell Clarus L2 multi-function HPV generator
The Bioquell Clarus L2 is a second generation hydrogen peroxide vapour
(HPV) generator, replacing Bioquell’s widely used Clarus L HPV generator.
The Clarus L2 offers enhanced functionality and is able to bio-decontaminate
both enclosures and rooms/laboratories up to 75m 3 . The Clarus L2 has
enhanced HPV delivery and control, as well as an improved user interface
using touch screen controls.
• Accurate measurement of the amount of hydrogen peroxide vaporised
• Simple menu-driven user interface to set cycle parameters and access
to bio-decontamination parameters
• Graphical display of bio-decontamination cycle progress tracking critical
parameters in real time
• Communications port allows integration to building management system
(BMS) or related systems and equipment
• Data logging option allowing data export into Excel ® format
• Multiple language options
• Bioquell dual circuit technology for fast and efficient
bio-decontamination cycles
• No requirement for room dehumidification prior to cycles
Operation
Easy to clean and safe bottle loading mechanism with built-in drip
tray and wipe clean mechanism. Housing accepts Bioquell 0.5 ltr
and 1 ltr hydrogen peroxide solution allowing multiple cycles
without intervention.
A thermal printer allows for hard copy data recording. Each stage of the
cycle is recorded and printed.

Bioquell hydrogen peroxide solution
• Bioquell hydrogen peroxide is specified and
approved for use with Bioquell HPV generators
• Approved for use as a biocide by regulatory
bodies (BPD, EPA)
• Selected for optimal biocidal effectiveness
Optional accessories include:
• Remote control with room gassing distribution facility
• Sensor pack - integrated hydrogen peroxide
vapour sensor
• Data logging and archive with USB interface
• Hand-held HPV detector
• External aeration/catalyst unit to reduce cycle
times further
Validation and service
Fully validatable to comply with requirements of
GMP using GAMP compliant software. Bioquell
provides complete service including:
• Installation and integration
• Preventative maintenance plans
• Extensive field-based service
engineer network
• IQ/OQ/PQ documentation
and execution
• Bio-decontamination cycle
development services
• Ongoing MQ and RQ support*
*Provided as part of a preventative maintenance plan

Materials of external construction
Temperature
Operating 15°C to 35°C
Storage -15°C to 50°C
Relative humidity
Operating
Storage
Top moulding – polypropylene
Side panels – polyurethane coated aluminium
75% RH maximum
95% RH (non-condensing)
Power requirement AC 220 – 240V 50 Hz (Euro) 6 amps
AC 110 – 120V 60 Hz (USA) 12 amps
AC 90 – 110V 50/60 Hz (Japan) 12 amps
Power consumption
Power supply
Operating position
Pollution degree environment 2
Dimensions (WxHxD)
Weight
Maximum H 2
O 2
liquid volume
H 2
O 2
liquid concentration
Hose pipes
Gas hose connections
Control system
Airflow rate
Gassing
Conditioning/aeration
Temperature of supply gas at outlet
H 2
O 2
liquid injection rate
Refrigeration system off coil temperature
Condensate removal
1300W
Installation category II
Upright only
515 x 1140 x 705mm
80 kg
1 litre
30-35% w/w Bioquell hydrogen peroxide (stored at 2-8°C)
1.5 inch nominal bore
male/female
Camlock fittings 1.5 inch
Siemens ® S7 PLC
(GAMP compliant software)
Controlled at 25 m 3 /hr
Controlled at 25 m 3 /hr at 750Pa external pressure
75°C maximum
Inlet air HEPA filter efficacy 99.997%
Gassing & dehum circuit HEPA filter efficacy 99.997%
Pressurisation system flow rate
Pressurisation system range
Noise
1.5 to 6 g/min (gassing); 0 or 1.5 to 6 g/min (dwell)
Approx 2°C (from 20°C return)
Evaporation to atmosphere
100 l/min (max)
+200 to -200 Pa
Less than 60 dBA at 1 metre (free field)
Features in brief
• Dual circuit technology for optimum cycle times
• Closed circuit operation
• Siemens ® colour touch screen
• GAMP compliant software
• Compact and highly portable design
• Easily cleanable external surface
• Volt-free contacts for external signals
• Integral thermal paper printer
• Remote start/stop
• Simple connection, flexible supply/return hoses
and pressure monitoring
• Supply return hoses (2mtrs long)
• Cycle edit and store facility for new applications
• Effective against a wide range of micro-organisms
• Hydrogen peroxide vapour gas sensor
• Utilises 30-35% w/w Bioquell hydrogen peroxide
solution in 0.5 ltr or 1 ltr
• Maximum enclosure bio-decontamination 75m 3

Hydrogen peroxide vapour (HPV) technology
HPV concentration
1
2
3
Inactivation of micro-organisms
t=0*
GASSING DWELL AERATION
TIME
* Conditioning phase not shown (vaporiser reaches temperature)
Note: “features” on graph change e.g. depending on size of
chamber (& related temperature effect)
4
5
Schematic of Bioquell HPV concentration/time graph
1. HPV introduced – initial rapid increase in HPV concentration
2. HPV saturation/“dew point” achieved – onset of rapid bio-decontamination
3. HPV gassing plateau – sustained micro-condensation effecting bio-deactivation
4. Dwell period (contact time)
5. Aeration – removal of HPV from the atmosphere typically by catalytic
conversion to water vapour and oxygen, leaving no residues
Schematic of dew point and Bioquell kill dynamics
1. Injection of HPV into the enclosure starts (t=0)
2. Only slight decline in biological indicator population prior to dew point
3. Rapid micro-biological kill occurs immediately after saturation/“dew point” is achieved –
process optimised to achieve reliable 6-log sporicidal reduction on all exposed surfaces
4. Onset of micro-condensation correlates with rapid bio-deactivation
5. Bio-deactivation achieved via micro-condensation (invisible layer) of hydrogen
peroxide (2-6µm)
* Typical BI: Tyvek ® pouched 6-log
Geobacillus stearothermophilus spores
Key benefits of HPV
• Excellent material compatibility
including sensitive electronics
• Environmentally friendly -
“residue-free” (breaks down to
water vapour and oxygen)
• Effective against a wide range
of micro-organisms
• High level disinfection achieved
(6-log sporicidal reduction)
HPV applications
• GMP cleanrooms
• Aseptic processing
• Biologics
• Biomedical
• Biosafety/security
• Material transfer chambers
• Ambient decontamination of
autoclaves/freeze driers
• Robotic enclosures
• Safety cabinets/isolators
Key features and benefits of the Clarus L2 HPV generator
FEATURES
Optimised cycle performance producing fast and effective
bio-decontamination
Flexible multi-use generator
Critical condition monitoring with alarm set points for
‘Alert’ or ‘Action’
Advanced software and Siemens ® PLC controls for ease of
use and operation
BENEFITS
Minimal process downtime – no need for preconditioning,
process operates with ambient environment
Can bio-decontaminate rooms and enclosures up to 75m 3 .
Small footprint requiring minimal floor space
Compatible with GMP and GLP requirements
Simple integration into a building management system
(BMS) or the Clarus PORT rapid decontamination
transfer chamber

Other unique bio-decontamination
solutions from Bioquell
Bioquell RBDS rapid facility bio-decontamination service
A unique bio-decontamination service from Bioquell
for zones, rooms and buildings:
• “Infinitely scalable” – no room or building too large
• Emergency, scheduled, contract or new-build
• Rapid deployment by highly trained Bioquell technicians
Bioquell Material Transfer Solutions
Bio-decontamination chambers:
• Material transfer incorporating HPV bio-decontamination
at ambient temperature
• Rapid bio-decontamination leading to fast material transfer
• Inflatable door seals for reliable, safe operation
Bioquell Z HPV generator
State-of-the-art bio-decontamination equipment offering:
• Large scale room/zone bio-decontamination
• Parametric cycle control
• Simple to operate “plug and play”
Disclaimer: Bioquell UK Ltd or its affiliates, distributors, agents or licensees
(together “Bioquell”) reserves the right to change the specification of
the Bioquell Clarus L2 without notice. In addition, Bioquell makes no
claims as to the guarantee of sterilisation using these products; however,
Bioquell recommends that customers ensure that the requisite level of
bio-decontamination is achieved using standard biological indicators such as
6-log Geobacillus stearothermophilus spores; and the Bioquell Clarus L2, subject
to appropriate cycle development, is designed to be able to provide such levels of
bio-deactivation.
Your local distributor:
Clarus / Bioquell / RBDS are registered trade marks of Bioquell UK Ltd.
© Bioquell UK Ltd (2010). All rights reserved.
For further information on Bioquell’s technology:
E: info@bioquell.com
W: www.bioquell.com
Bioquell UK Ltd
T: +44 (0)1264 835 835
Bioquell Ireland
T: +353 (0)61 603 622
Bioquell Inc
T: +1 (215) 682 0225
Bioquell SAS
T: +33 (0)1 43 78 15 94
Bioquell Asia Pacific Pte Ltd
T: +65 6592 5145
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