BIOQUELL Clarus L2 (609K) - APEX Laboratory Equipment Company

Hydrogen peroxide vapour (HPV) technology
HPV concentration
1
2
3
Inactivation of micro-organisms
t=0*
GASSING DWELL AERATION
TIME
* Conditioning phase not shown (vaporiser reaches temperature)
Note: “features” on graph change e.g. depending on size of
chamber (& related temperature effect)
4
5
Schematic of Bioquell HPV concentration/time graph
1. HPV introduced – initial rapid increase in HPV concentration
2. HPV saturation/“dew point” achieved – onset of rapid bio-decontamination
3. HPV gassing plateau – sustained micro-condensation effecting bio-deactivation
4. Dwell period (contact time)
5. Aeration – removal of HPV from the atmosphere typically by catalytic
conversion to water vapour and oxygen, leaving no residues
Schematic of dew point and Bioquell kill dynamics
1. Injection of HPV into the enclosure starts (t=0)
2. Only slight decline in biological indicator population prior to dew point
3. Rapid micro-biological kill occurs immediately after saturation/“dew point” is achieved –
process optimised to achieve reliable 6-log sporicidal reduction on all exposed surfaces
4. Onset of micro-condensation correlates with rapid bio-deactivation
5. Bio-deactivation achieved via micro-condensation (invisible layer) of hydrogen
peroxide (2-6µm)
* Typical BI: Tyvek ® pouched 6-log
Geobacillus stearothermophilus spores
Key benefits of HPV
• Excellent material compatibility
including sensitive electronics
• Environmentally friendly -
“residue-free” (breaks down to
water vapour and oxygen)
• Effective against a wide range
of micro-organisms
• High level disinfection achieved
(6-log sporicidal reduction)
HPV applications
• GMP cleanrooms
• Aseptic processing
• Biologics
• Biomedical
• Biosafety/security
• Material transfer chambers
• Ambient decontamination of
autoclaves/freeze driers
• Robotic enclosures
• Safety cabinets/isolators
Key features and benefits of the Clarus L2 HPV generator
FEATURES
Optimised cycle performance producing fast and effective
bio-decontamination
Flexible multi-use generator
Critical condition monitoring with alarm set points for
‘Alert’ or ‘Action’
Advanced software and Siemens ® PLC controls for ease of
use and operation
BENEFITS
Minimal process downtime – no need for preconditioning,
process operates with ambient environment
Can bio-decontaminate rooms and enclosures up to 75m 3 .
Small footprint requiring minimal floor space
Compatible with GMP and GLP requirements
Simple integration into a building management system
(BMS) or the Clarus PORT rapid decontamination
transfer chamber