Asian Journal of Pharmacodynamics and Pharmacokinetics ...

Asian Journal of
Pharmacodynamics and
Pharmacokinetics
ISSN 1608-2281
Copyright by Hong Kong Medical Publisher
Publisher Homepage: www.hktmc.com
Asian Journal of Pharmacodynamics and Pharmacokinetics
Information for Authors
www. hktmc.com /ajdmpk
Aims and Scope
Asian Journal of Pharmacodynamics and
Pharmacokinetics, an international journal, is the official
publication of Hong Kong Medical Publisher. The
publication is sponsored by Hong Kong International
Traditional Medical Association and Chinese
Pharmacological Society, in association with the Drug
Metabolism Committee of Chinese Pharmacological
Society and Tianjin Pharmacological Society. The Journal
is published and distributed by Hong Kong Medical
Publisher.
The Journal’s purposes are to provide a forum for
the studies on metabolism and pharmacokinetic of drugs
and xenobiotics (specifically, nature products, herbal
medicines and biotech-pharmaceuticals), including
metabolism, bio-transformation, metabolite analysis,
experimental and clinical pharmacokinetics,
bioavailability, bioequivalence, toxicokinetics,
pharmacokinetic- pharmacodynamic research,
pharmacokinetic models and statistical programs,
application of new methods and techniques in metabolism
and pharnmacokinetics, as well as experimental and
clinical pharmacology, and drug safety evaluation.
The Journal’s purposes are also to provide a foster
communication between educational, research, industrial,
medical, and governmental personnel engaged in drug
metabolism and pharmacokinetics, pharmacological,
toxicological and clinical studies.
Manuscripts are accepted for consideration with the
understanding that they have not been published
elsewhere and are not concurrently under review
elsewhere. Papers that have been given at scientific
meetings are accepted for consideration.
Publication data
Asian Journal of Pharmacodynamics and
Pharmacokinetics is published quarterly on March, June,
September and December; one annual volume contains
four issues of 80 pages each.
The full texts of papers are published in web-edition.
The website is www. hktmc.com.cn/ajdmpk. All of
papers are read and downloaded from this website.
Manuscript Submission
Manuscript should be sent to Editorial Committee by
E-mail to asianjdmpk@163.com or to Professor
Chang-Xiao Liu, Academic Editor-in-Chief of Asian
Journal of Pharmacodynamics and Pharmacokinetics.
Computer Floppy Disks
Some savings are realized when a floppy disk of the
manuscript is available to the typesetter. Therefore, when
it is convenient to do so, authors are requested to provide
a floppy disk containing a single copy of the manuscript
file. Authors should indicate what word processing
system was used to create the manuscript file.
Style
Keep the manuscript as terse as possible.
Sources Manuscripts, including references, are to
be prepared according to the AMA Manual of Style.
Dorlan’s Illustrated Medical Dictionary should be used
for spelling of medical terms, and Webster’s Third New
International or College dictionaries for spelling and
hyphenation of non-medical terms. Use concise, not
redundant; use short (American), not long (British)
spellings. Avoid complicated compound complex
sentences. Delete unnecessary wording.
Numbers Use numerals for all units of measure
and time except days, hours, and minutes; and for all
numbers greater than nine. Spell out the numbers one
through nine only for general usage and for quantities of
days, hours, and minutes less than or equal to nine. Spell
out numbers, symbols, and figures beginning a sentence.
Abbreviations Only standard abbreviations, as
listed in the AMA Manual of Style may be used without
definition. Terms appearing frequently within a paper
may be abbreviated, but should be spelled out at first
citation, with the abbreviation following in parentheses.
Examples: pharmacokinetics (PK), ranitidine (Ran),
ginseng saponin (GS), Ginkgo biloba extract (GbE),
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volume of distribution (Vd), Calcium calmodilin
dependent protein kinase (CCDPK).
Manuscript Preparation
Type the manuscript on white bond paper (A4) with
broad margins. Use double spacing through out. Organize
the manuscript in the order indicated below, with the page
number typed in the upper right-hand corner of each page.
Title Page Page 1 should include: (1) the title of
the article (80 characters maximum); (2) full name(s) of
author(s); (3) affiliations (job title, department,
institution,city, and state or country) indicating which
authors are associated with which affiliations; and (4)
Footnotes may include the name and address of the author
to whom reprint requests are to be sent, and
correspondence to which author, phone, Fax, and E-mail,
as well as source of financial support..
Abstract and Key Words Page 2 should include
the title of the article followed by the abstract, which
should be about 200 words. The abstract should
summarize the main points of the article. The abstract in
structured form consists of Aim (the purpose of the study),
Methods (basic proedures), Results (main findings with
main data) and Conclusions. Following the abstract, list
4-8 key words for indexing.
Text
Papers should be organized in the following format:
Introduction, Materials and methods, Results, discussion,
and references.
Introduction
summarizes the rationale and gives a concise
background. Use references to provide the most salient
background rather than an exhaustive review. The last
sentence should state tersely your purpose to do this study.
An uncommon or new compound should be identified by
the chemical name and structural formula.
Materials and methods
Materials International Nonproprietary Names
(INN) or generic names should be employed whenever
possible. If necessary, the proprietary name may be added
once, in parentheses. The first letter of the drug name
should be small for INN or generic names, but capitalized
for proprietary names. Manufacturers and specifications
should be given for main drugs, chemicals, and
instruments. The drug administration schedule should be
identified, includes dose and route of administration.
Scientific name for all microorganism, plants, and
animals should be given. The sex, age, and actually
measured body weights of tested animals or humans
should be expressed as mean, standard deviation, and
total range.
Methods: Offer technical information to allow the
experiments to be repeated. Describe new methods or
modifications and identify the unusual instruments and
procedures in sufficient detail. The routes of
administration may be abbreviated, eg, intraarterial (ia),
intracerebroventricular (icv), intragastric gavage (ig),
intramuscular (im), intraperitoneal (ip), intravenous (iv),
per os (po), subcutaneous (sc). Dosage is expressed as per
kg ( in animals).
Statistical Methods: Statistical methods should be
described to verify the results. Give number of
observations and subjects. Report losses to observations,
such as dropouts from the study. Only homogeneous data
can be averaged. The standard deviation (s) is much
preferred to standard error (s x ).
Suitable techniques should be chosen for the
statistical treatments, eg, t test (group or paired
comparisons), chi-squqre test, Ridit, probit, logit,
regression, correlation, analysis of variance (ANOVA),
analysis of covariance, etc.
Effective digits are determined by the precision of
the measuring instruments. Do not include more digits
than are justified by the accuracy of the determinations.
Results
Simple data may be set forth in text with no need of
tables or figures. Described results should be
understandable and clear. The word “significantly” should
be replaced by its synonyms, if it indicates, or the p value,
if it indicates statistical significance. The tables and
figures should be prepared according to following
principles. Summarize or emphasize the results followed
by tables or figures. Reserve extensive interpretations of
the results for the discussion section.
Tables: Each table should have a brief title. Type
each table on separate sheet. If the table must exceed one
page, duplicate all headings on the second sheet. Number
tables in the order in which they are cited in the text.
Define all abbreviations and indicate the units of
measurement for all values. Explain all empty spaces or
dashes. If data from any other source, published or
unpublished, are used, obtain a permission letter for their
use and cite the source in the legend.
Figures: Figures should be professionally drawn in
black ink and, if possible, submitted as glossy,
high-contrast black-and-white photographs between three
and six inches in width. Letters, numbers, and symbols
should be clear throughout, and should be large enough to
remain legible when reduced for publication. In general,
the size is height: width = 2;3. Be sure that all spelling is
correct, that there are no broken letters or uneven type,
and that abbreviations used are consistent with those in
the text. The data for drawing the figures should be typed
on separate sheets and submitted along with the figures.
Quantity and unit: Physical quantity is printed in
italic type. A subscript that represents a symbol for a
physical quantity is printed in italic type. A solidus (/)
shall not be followed by a multiplication sign or a
division sign unless parentheses are inserted to avoid any
ambiguity. In complicated cases negative powers or
parentheses shall be used. SI units must be used.
Discussion
Discussion should deal with interpretations of your
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esults. Emphasize any new and important aspects and
relate your results to other studies. Discuss the
shortcomings in your experiments. New hypotheses and
recommendations may be proposed when warranted.
End with a brief conclusion, which ought to be linked
with the goal stated in introduction.
Acknowledgments
Acknowledgments may briefly include (1)
contributors that do not warrant authorship; (2) technical
help; and (3) financial or material support.
References
Type references double-spaced and number them
consecutively in the order in which they are first
mentioned in text, not alphabetically. The references
should conform to the style recommended in the AMA
Manual of Style. References in text, tables, and legends
are identified by Arabic numerals typed parenthetically.
Authors are responsible for the accuracy and
completeness of the references.
For journal articles, include: (1) author name(s) of
all authors; (2) title; (3) journal title abbreviated as it
appears in the Index Medicus or spelled out if it is not
listed; (4) year of publication; (5) volume number; (6)
issue; and (7) inclusive page numbers.
For books, list: (1) author name(s); (2) title,
including number of editions; (3) chapter title if
appropriate; (4) editor; (5) place of publication, publisher,
and year published; (6) volume number and (7) page
numbers if appropriate.
For Conference proceedings and conference papers,
list: (1) author name(s) of all authors; (2) title; (3) Name
of Conference proceedings or Conference Paper
Collection; (4) year, month, data, place (Country, city); (5)
place of publication, publisher, and year published; (6)
volume number and (7) inclusive page numbers.
Unpublished observations and personal
communications should not appear in the references.
Manuscripts that have been accepted for publication but
have not yet been published may appear in the references:
include authors, manuscript title, and name of journal
followed by “in press” in parentheses.
Sample references
1. Abraham BK, Adithan C, Usha Kiran P, Asad M,
Koumaravelou K. Genetic polymorphism of CYP2D6 in
kamataka and andhra pradesh population in india. Acta
Pharmacol Sin 2000; 21: 494-8.
2. Liu CX. Studies on Drug Metabolism and
pharmacokinetics in China. ISSX Newsletter 1990; 9(2):
1-2.
3. Milton AS. Prostaglandins and fever. In: Sharma HS,
Westman J, editors. Progress in brain research; v 115. Brain
function in hot environment. Amsterdam: Elsevier; 1998;
129-39.
4. Wnag LCK. Current drug safety testing in USA.
Proccedings of International Symposium on Traditional
Medicines and Modren Pharmacology; 1987 May 2-4;
Beijing, China. Beijing: Chinese Pharmacological Society;
1987; 257-61.
5. World Health Organization. Good manufacturing practices
for pharmaceutical products. Annex 1. Thirty-second
Report of the WHO Expert Committee on Specifications
for pharmaceutical preparation. WHO Technical Report
Series N.823. Geneva, Switzerland: World Health
Organization.
6. Guo FK, Li YL, Wu SG. Antisense IRAK-2 oligonucleotide
inhibits interleukin-1-induced nuclear factor-kB activiation
in vitro. Acta Pharmacol Sin 2000; 21: in press.
Editor’s Note
The instruction for manuscript preparation assume
certain resources are available to the author. Although
compliance with these instructions will increase the
probability of publication in the Journal, authors should
not be discouraged in submitting manuscripts that do not
completely comply with these instructions. If an author
feels his/her manuscript is worthy of publication in the
Journal, he/she should do as much as possible to comply,
then submit it to the editor. If the editor and editorial
board agree on its desirability for publication, the
Editorial Office will assist in satisfying the publisher’s
manuscript preparation requirements.
Review and Publication Process
Manuscripts are examined by the Editor and in most
cases by reviewers. Decisions of the Editor are final. All
material accepted for publication is subject to copyediting.
Authors will receive page proofs before publication, and
should answer all queries and carefully check all editorial
changes at this point.
The first author of each article will freely receive 4
copies of the complete issue.
Copyright Protection
The submission of the manuscript by author means
that the authors automatically agree to assign exclusive
copyright to Hong Kong Medical Publisher once this
manuscript is accepted for publication. The work should
not be published elsewhere in any forms without written
permission of the Publisher. The paper published in Hong
Kong Medical Publisher is protected by copyright, which
covers the translation rights and exclusive right to
reproduce and distribute all of the articles published in
Hong Kong Medical Publisher.
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