Asian Journal of Pharmacodynamics and Pharmacokinetics ...

Asian Journal of Pharmacodynamics and PharmacokineticsInformation for Authorswww. hktmc.com.cn/ajdmpkAims and ScopeAsian Journal of Pharmacodynamics andPharmacokinetics, an international journal, is the officialpublication of Hong Kong Medical Publisher. Thepublication is sponsored by Hong Kong InternationalTraditional Medical Association and ChinesePharmacological Society, in association with the DrugMetabolism Committee of Chinese PharmacologicalSociety and Tianjin Pharmacological Society. The Journal ispublished and distributed by Hong Kong Medical Publisher.The Journal’s purposes are to provide a forum for thestudies on metabolism and pharmacokinetic of drugs andxenobiotics (specifically, nature products, herbal medicinesand biotech-pharmaceuticals), including metabolism,bio-transformation, metabolite analysis, experimental andclinical pharmacokinetics, bioavailability, bioequivalence,toxicokinetics, pharmacokinetic- pharmacodynamicresearch, pharmacokinetic models and statistical programs,application of new methods and techniques in metabolismand pharnmacokinetics, as well as experimental and clinicalpharmacology, and drug safety evaluation.The Journal’s purposes are also to provide a fostercommunication between educational, research, industrial,medical, and governmental personnel engaged in drugmetabolism and pharmacokinetics, pharmacological,toxicological and clinical studies.Manuscripts are accepted for consideration with theunderstanding that they have not been published elsewhereand are not concurrently under review elsewhere. Papersthat have been given at scientific meetings are accepted forconsideration.Publication dataAsian Journal of Pharmacodynamics andPharmacokinetics is published quarterly on March, June,September and December; one annual volume contains fourissues of 80 pages each.The full texts of papers are published in web-edition.The website is www. hktmc.com.cn/ajdmpk. All of papersare read and downloaded from this website.Manuscript SubmissionManuscript should be sent to Editorial Committee byE-mail to asianjdmpk@163.com or to ProfessorChang-Xiao Liu, Academic Editor-in-Chief of AsianJournal of Pharmacodynamics and Pharmacokinetics 308Anshan West Road, Tianjin, 300193, China. Submit twohigh-quality copies of the manuscript including tables andfigures.Computer Floppy DisksSome savings are realized when a floppy disk of themanuscript is available to the typesetter. Therefore, when itis convenient to do so, authors are requested to provide afloppy disk containing a single copy of the manuscript file.Authors should indicate what word processing system wasused to create the manuscript file.StyleKeep the manuscript as terse as possible.Sources Manuscripts, including references, are tobe prepared according to the AMA Manual of Style.Dorlan’s Illustrated Medical Dictionary should be used forspelling of medical terms, and Webster’s Third NewInternational or College dictionaries for spelling andhyphenation of non-medical terms. Use concise, notredundant; use short (American), not long (British)spellings. Avoid complicated compound complex sentences.Delete unnecessary wording.Numbers Use numerals for all units of measure andtime except days, hours, and minutes; and for all numbersgreater than nine. Spell out the numbers one through nineonly for general usage and for quantities of days, hours, andminutes less than or equal to nine. Spell out numbers,symbols, and figures beginning a sentence.Abbreviations Only standard abbreviations, aslisted in the AMA Manual of Style may be used withoutdefinition. Terms appearing frequently within a paper maybe abbreviated, but should be spelled out at first citation,with the abbreviation following in parentheses. Examples:pharmacokinetics (PK), ranitidine (Ran), ginseng saponin(GS), Ginkgo biloba extract (GbE), volume of distribution(Vd), Calcium calmodilin dependent protein kinase(CCDPK).Manuscript PreparationType the manuscript on white bond paper (A4) withbroad margins. Use double spacing through out. Organizethe manuscript in the order indicated below, with the pagenumber typed in the upper right-hand corner of each page.Title Page Page 1 should include: (1) the title of thearticle (80 characters maximum); (2) full name(s) ofauthor(s); (3) affiliations (job title, department,78

institution,city, and state or country) indicating whichauthors are associated with which affiliations; and (4)Footnotes may include the name and address of the authorto whom reprint requests are to be sent, and correspondenceto which author, phone, Fax, and E-mail, as well as sourceof financial support..Abstract and Key Words Page 2 should includethe title of the article followed by the abstract, which shouldbe about 200 words. The abstract should summarize themain points of the article. The abstract in structured formconsists of Aim (the purpose of the study), Methods (basicproedures), Results (main findings with main data) andConclusions. Following the abstract, list 4-8 key words forindexing.TextPapers should be organized in the following format:Introduction, Materials and methods, Results, discussion,and references.Introductionsummarizes the rationale and gives a concisebackground. Use references to provide the most salientbackground rather than an exhaustive review. The lastsentence should state tersely your purpose to do this study.An uncommon or new compound should be identified bythe chemical name and structural formula.Materials and methodsMaterials International Nonproprietary Names (INN)or generic names should be employed whenever possible. Ifnecessary, the proprietary name may be added once, inparentheses. The first letter of the drug name should besmall for INN or generic names, but capitalized forproprietary names. Manufacturers and specifications shouldbe given for main drugs, chemicals, and instruments. Thedrug administration schedule should be identified, includesdose and route of administration. Scientific name for allmicroorganism, plants, and animals should be given. Thesex, age, and actually measured body weights of testedanimals or humans should be expressed as mean, standarddeviation, and total range.Methods: Offer technical information to allow theexperiments to be repeated. Describe new methods ormodifications and identify the unusual instruments andprocedures in sufficient detail. The routes of administrationmay be abbreviated, eg, intraarterial (ia),intracerebroventricular (icv), intragastric gavage (ig),intramuscular (im), intraperitoneal (ip), intravenous (iv), peros (po), subcutaneous (sc). Dosage is expressed as per kg( in animals).Statistical Methods: Statistical methods should bedescribed to verify the results. Give number of observationsand subjects. Report losses to observations, such asdropouts from the study. Only homogeneous data can beaveraged. The standard deviation (s) is much preferred tostandard error (s x ).Suitable techniques should be chosen for the statisticaltreatments, eg, t test (group or paired comparisons),chi-squqre test, Ridit, probit, logit, regression, correlation,analysis of variance (ANOVA), analysis of covariance, etc.Effective digits are determined by the precision of themeasuring instruments. Do not include more digits than arejustified by the accuracy of the determinations.ResultsSimple data may be set forth in text with no need oftables or figures. Described results should beunderstandable and clear. The word “significantly” shouldbe replaced by its synonyms, if it indicates, or the p value, ifit indicates statistical significance. The tables and figuresshould be prepared according to following principles.Summarize or emphasize the results followed by tables orfigures. Reserve extensive interpretations of the results forthe discussion section.Tables: Each table should have a brief title. Type eachtable on separate sheet. If the table must exceed one page,duplicate all headings on the second sheet. Number tablesin the order in which they are cited in the text. Define allabbreviations and indicate the units of measurement for allvalues. Explain all empty spaces or dashes. If data from anyother source, published or unpublished, are used, obtain apermission letter for their use and cite the source in thelegend.Figures: Figures should be professionally drawn inblack ink and, if possible, submitted as glossy, high-contrastblack-and-white photographs between three and six inchesin width. Letters, numbers, and symbols should be clearthroughout, and should be large enough to remain legiblewhen reduced for publication. In general, the size is height:width = 2;3. Be sure that all spelling is correct, that thereare no broken letters or uneven type, and that abbreviationsused are consistent with those in the text. The data fordrawing the figures should be typed on separate sheets andsubmitted along with the figures.Quantity and unit: Physical quantity is printed initalic type. A subscript that represents a symbol for aphysical quantity is printed in italic type. A solidus (/) shallnot be followed by a multiplication sign or a division signunless parentheses are inserted to avoid any ambiguity. Incomplicated cases negative powers or parentheses shall beused. SI units must be used.DiscussionDiscussion should deal with interpretations of yourresults. Emphasize any new and important aspects andrelate your results to other studies. Discuss theshortcomings in your experiments. New hypotheses andrecommendations may be proposed when warranted.End with a brief conclusion, which ought to be linked withthe goal stated in introduction.AcknowledgmentsAcknowledgments may briefly include (1) contributorsthat do not warrant authorship; (2) technical help; and (3)financial or material support.ReferencesType references double-spaced and number themconsecutively in the order in which they are first mentionedin text, not alphabetically. The references should conform to79

the style recommended in the AMA Manual of Style.References in text, tables, and legends are identified byArabic numerals typed parenthetically.Authors are responsible for the accuracy andcompleteness of the references.For journal articles, include: (1) author name(s) of allauthors; (2) title; (3) journal title abbreviated as it appearsin the Index Medicus or spelled out if it is not listed; (4)year of publication; (5) volume number; (6) issue; and (7)inclusive page numbers.For books, list: (1) author name(s); (2) title, includingnumber of editions; (3) chapter title if appropriate; (4)editor; (5) place of publication, publisher, and yearpublished; (6) volume number and (7) page numbers ifappropriate.For Conference proceedings and conference papers,list: (1) author name(s) of all authors; (2) title; (3) Name ofConference proceedings or Conference Paper Collection; (4)year, month, data, place (Country, city); (5) place ofpublication, publisher, and year published; (6) volumenumber and (7) inclusive page numbers.Unpublished observations and personalcommunications should not appear in the references.Manuscripts that have been accepted for publication buthave not yet been published may appear in the references:include authors, manuscript title, and name of journalfollowed by “in press” in parentheses.Sample references1. Abraham BK, Adithan C, Usha Kiran P, Asad M,Koumaravelou K. Genetic polymorphism of CYP2D6 inkamataka and andhra pradesh population in india. ActaPharmacol Sin 2000; 21: 494-8.2. Liu CX. Studies on Drug Metabolism andpharmacokinetics in China. ISSX Newsletter 1990; 9(2):1-2.3. Milton AS. Prostaglandins and fever. In: Sharma HS,Westman J, editors. Progress in brain research; v 115.Brain function in hot environment. Amsterdam: Elsevier;1998; 129-39.4. Wnag LCK. Current drug safety testing in USA.Proccedings of International Symposium on TraditionalMedicines and Modren Pharmacology; 1987 May 2-4;Beijing, China. Beijing: Chinese PharmacologicalSociety; 1987; 257-61.5. World Health Organization. Good manufacturingpractices for pharmaceutical products. Annex 1.Thirty-second Report of the WHO Expert Committee onSpecifications for pharmaceutical preparation. WHOTechnical Report Series N.823. Geneva, Switzerland:World Health Organization.6. Guo FK, Li YL, Wu SG. Antisense IRAK-2oligonucleotide inhibits interleukin-1-induced nuclearfactor-kB activiation in vitro. Acta Pharmacol Sin 2000;21: in press.Editor’s NoteThe instruction for manuscript preparation assumecertain resources are available to the author. Althoughcompliance with these instructions will increase theprobability of publication in the Journal, authors should notbe discouraged in submitting manuscripts that do notcompletely comply with these instructions. If an authorfeels his/her manuscript is worthy of publication in theJournal, he/she should do as much as possible to comply,then submit it to the editor. If the editor and editorial boardagree on its desirability for publication, the Editorial Officewill assist in satisfying the publisher’s manuscriptpreparation requirements.Review and Publication ProcessManuscripts are examined by the Editor and in mostcases by reviewers. Decisions of the Editor are final. Allmaterial accepted for publication is subject to copyediting.Authors will receive page proofs before publication, andshould answer all queries and carefully check all editorialchanges at this point.The first author of each article will freely receive 4copies of the complete issue.Copyright ProtectionThe submission of the manuscript by author meansthat the authors automatically agree to assign exclusivecopyright to Hong Kong Medical Publisher once thismanuscript is accepted for publication. The work should notbe published elsewhere in any forms without writtenpermission of the Publisher. The paper published in HongKong Medical Publisher is protected by copyright, whichcovers the translation rights and exclusive right toreproduce and distribute all of the articles published inHong Kong Medical Publisher.80