Regulatory Response to BCS in Japan BCS : æ¥æ¬ã«ããã ... - NIHS
Regulatory Response to BCS in Japan BCS : æ¥æ¬ã«ããã ... - NIHS
Regulatory Response to BCS in Japan BCS : æ¥æ¬ã«ããã ... - NIHS
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100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
Dissolution Predicted Observed<br />
pH 1<br />
0 20 40 60<br />
.<br />
.<br />
A<br />
E<br />
Convolution<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
0 5 10 15 20 25<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
Normal<br />
subjects<br />
0<br />
0 5 10 15 20 25<br />
% dissolved<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
0 20 40 60<br />
Time (m<strong>in</strong>)<br />
pH 7<br />
Metronidazole Tablets<br />
Concentration (ug/ml)<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
0 5 10 15 20 25<br />
Time (h)<br />
Concentration (ug/ml)<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
Achlorhydric<br />
subjects<br />
0 5 10 15 20 25<br />
Time (h)<br />
Ogata. Int.J.Pharm.Ther.Tox.<br />
23, 277, 1985.
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