Antiphospholipid Syndrome.

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APASS substudy of WARS Patients with cerebral arterial events • Study: ASA (low dose) vs Warfarin (INR 1.4-2.8) • Major findings: aPL did not predict recurrence ASA and Warfarin equal efficacy • Limitations: Single measure of aCL (any level) LAC testing not optimal Mean age 62.5 years Females (42%)
A Systematic Review Of Secondary Thromboprophylaxis In Patients With aPL Recommendations • APS first venous event: Warfarin, INR:2.0 - 3.0 • APS recurrent venous event, arterial event: Warfarin, INR: > 3.0 • VTE event and single positive aPL: Warfarin, INR: 2.0 - 3.0 • Stroke and single positive aPL: ASA (low dose) Similar to treatment non-SLE population (Ruiz-Irastorza, G et al: Arthritis Care & Res 2007; 57:1487)
Page 1 and 2: Antiphospholipid Syndrome Dr. John
Page 3 and 4: Antiphospholipid Syndrome Objective
Page 5 and 6: (Hanly JG CMAJ 2003;168(13):1675)
Page 7 and 8: Phospholipid-binding Proteins • I
Page 9 and 10: Lupus Anticoagulant International C
Page 11 and 12: Antiphospholipid Antibodies (aPL)
Page 13 and 14: Antiphospholipid Syndrome Classific
Page 15 and 16: Antiphospholipid Syndrome Pathogeni
Page 21 and 22: Thrombosis and aPL Antibodies • S
Page 23 and 24: Recurrent Thrombotic Events Initial
Page 25 and 26: Thrombosis and aPL Antibodies Facto
Page 27 and 28: Treatment of APS • Obstetric mani
Page 29 and 30: Secondary Prevention of Thrombotic
Page 31 and 32: Management Of Thrombosis In APS INR
Page 33 and 34: A Comparison Of Two Intensities Of
Page 35 and 36: A Randomized Clinical Trial Or High
Page 38 and 39: Management of Antiphospholipid Anti
Page 40 and 41: APASS substudy of WARS Patients wit
Page 45 and 46: Catastrophic Antiphospholipid Syndr
Page 47 and 48: Prevention of Thrombosis in APS Oth
Page 50 and 51: Antiphospholipid Syndrome Historica
Page 52 and 53: Antiphospholipid Syndrome Historica
Page 54 and 55: IgG Anticardiolipin Antibodies
Page 56 and 57: Animal Models of Antiphospholipid S
Page 58 and 59: Placentae In BALB/C Mice Infused Wi
Page 60 and 61: 2 -glycoprotein I • Physiologic r
Page 62: Annexin V, Antiphospholipid Antibod
Page 68 and 69: Inhibition of C5 Activation Prevent
Page 70 and 71: Association of Autoantibodies to Nu
Page 72 and 73: Antiphospholipid Syndrome Embolic M
Page 74 and 75: Antiphospholipid Syndrome Obstetric
Page 76 and 77: Antiphospholipd Syndrome and Pregna
Page 78: Acknowledgements • John Fisk •

Antiphospholipid Syndrome.

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