Is treating Blood pressure alone enough to protect your

Caduet … Early Improvements in Arterial Wall
Compliance
AVALON-AWC AWC * study strongly
suggests that a greater early
vascular benefit can be
obtained from simultaneous
treatment with amlodipine and
atorvastatin, vs. either agent
alone, in patients with
hypertension and
dyslipidemia.
11.70%
19.30%
1.30%
3.10%
Placebo Atorvastatin Amlodipine Caduet 5/10
Effect of treatment on small artery compliance (c2) At week 8,
1- Cohn JN. AVALON-AWC: Arterial Wall Compliance in the Atorvastatin and Amlodipine in Patients With Elevated Lipids and Hypertension Trial. Am J
Hypertens 2009; 22:137-44.
Caduet … Reversal of LDL-induced Endothelial Dysfunction
Endothelial dysfunction contributes to mechanisms of atherogenesis and its
clinical manifestations, including coronary artery disease. 1
Effect of Caduet ®1
100%
90%
80%
60%
40%
20%
0%
‐20%
‐40%
‐60%
% increase in NO ¤
% d ti i i ONOO º
‐50%
Caduet partially restored the NO level of LDL*-induced dysfunctional
endothelium. 1
Effect of Caduet may be enhanced by antioxidant properties related to their
intermolecular actions in the cell membrane and an increase in the
expression and coupling of endothelial nitric oxide synthase. 1
¤ NO: Nitric Oxide,
º ONOO-: Cytotoxic Peroxynitrite
*LDL: Low-density Lipoprotein
1- Mason RP. A rationale for combination therapy in risk factor management: a mechanistic perspective. The American Journal of
Medicine. 2005; 118(12A): 54S-61S.