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UK: Miller <strong>et</strong> <strong>al</strong>.<br />

Based on Nation<strong>al</strong> Childhood Enceph<strong>al</strong>opathy Study<br />

(NCES), 1976-1979<br />

770 cases of acute enceph<strong>al</strong>opathy in “previously<br />

apparently neurologic<strong>al</strong>ly norm<strong>al</strong>” children<br />

– 16 had received measles vaccine 7 to 14 days prior<br />

– similar proportion in controls (RR 1.85; 95% CI 0.9 - 3.7)<br />

10-year follow-up of 594 (77%) cases<br />

– including 11/16 with measles vaccine<br />

– 3/11 died or had neurologic<strong>al</strong>, education<strong>al</strong>, or behavior<strong>al</strong><br />

dysfunction<br />

– similar proportion in controls (RR 0.84; 95% CI 0.2, 3.5)

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