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Conclusions Wakefield hypothesis – focused on 3-way relationship among MMR, atypical autism with regression, and non-specific colitis – based on “attribution” of cause by physicians and parents Other epidemiologic studies – focused on 2-way relationship between MMR and PDD or IBD – different outcomes and sometimes different exposures – difficulties of studying rare outcomes Epidemiological evidence reviewed here is inadequate to accept or reject a causal relationship between MMR and autism
MMR and autism evidence model MMR Measles vaccine Measles infection PDD Autism Atypical autism w/ regression (CDD?) Non-specific colitis IBD CD, UC
Page 1 and 2: Epidemiologic Studies of MMR Vaccin
Page 3 and 4: Disclaimer GW authors are not exper
Page 5 and 6: Epidemiology of autism Prevalence o
Page 7 and 8: Epidemiology of bowel disease Etiol
Page 9 and 10: The Wakefield study Urinary methylm
Page 11 and 12: The Wakefield study Authors conclud
Page 13 and 14: The epidemiologic challenge Gatheri
Page 15 and 16: UK: Miller et al. Based on Nationa
Page 17 and 18: NE Thames (UK): Taylor et al. Chil
Page 19 and 20: NE Thames (UK): Taylor et al. Timin
Page 21 and 22: Sweden: Gilberg and Heijbel Childr
Page 23 and 24: Studies of MMR and bowel disease Co
Page 25 and 26: Olmstead County, MN: Pardi et al.
Page 27 and 28: UK: Thompson et al. Study of childr
Page 29 and 30: CA, OR, WA: Davis et al. Vaccine Sa
Page 31: Summary: MMR and IBD Limited eviden
Page 35: Disclaimer GW authors are not exper

et al - Georgetown University

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