Modified Terminalia randii gum as a binder in metronidazole tablet formulation

Binder
Conc
of
binde
r
Bulk density
(g/ml)
Modified terminalia randii gum as a binder in metronidazole tablet formulation
Table 1: Micromeritic Properties of Granules
Tapped
density
(g/ml)
Flow rate
(g/sec)
Angle
repose
( O )
of
Carr’s
index
( O / O )
Hausner
ratio
Contro 0.00 0.483±0.00 0.523±0.01 3.95±0.44 35.24±0.21 7.62±1.77 1.07±0.01 445
Mean
granule size
µm
PVP 1.00 0.416±0.20 0.450±0.00 4.74±0.52 36.74±0.56 7.41±1.28 1.08±0.01 485
2.00 0.396±0.18 0.430±0.00 5.90±0.56 37.35±0.21 7.53±1.33 1.08±0.01 515
3.00 0.416±0.19 0.430±0.00 6.63±0.57 36.62±0.21 3.10±1.33 1.03±0.01 585
5.00 0.410±0.18 0.453±0.00 7.88±0.60 36.00±0.21 9.54±1.13 1.10±0.01 710
ATR 1.00 0.427±0.00 0.433±0.00 5.20±0.41 48.86±0.56 1.55±1.34 1.01±0.01 755
2.00 0.410±0.00 0.430±0.00 5.73±0.31 48.57±0.52 4.65±0.00 1.05±0.00 765
3.00 0.400±0.01 0.440±0.01 7.22±0.29 49.63±0.14 9.09±0.20 1.09±0.00 770
5.00 0.407±0.00 0.417±0.01 9.78±0.47 49.22±0.42 2.32±4.02 1.02±0.04 860
The release properties of the tablets were assessed using disintegration and dissolution times (t 50 and t 80
i.e. time required for 50% and 80% of the drug to be released respectively). The disintegration time of tablets is
the rate limiting step in dissolution and consequently absorption of the active ingredient. The British
Pharmacopoeia [13], states that uncoated tablets must disintegrate within 15 minutes. All the formulations
disintegrated in less than 15 minutes. The result of the release properties are presented in Table 2. The
disintegration time was observed to increase with increase in concentration of binder.Formulations containing
ATR at 5 % w/w had significantly lower (p0.05) in the dissolution time.
Table 2: Tablet Properties
Binder
PVP
ATR
Concentration
(% w/w)
Friability
(%)
Crushing
strength
(N)
CSFR
Disintegration
time
(Min)
T 50
(min)
T 80
(min)
0.00 0.36±0.01 18.58±2.97 51.61 0.03±0.00 2.35 4.45
1.00 0.53±0.03 27.46±3.80 51.81 0.07±0.01 2.35 4.50
2.00 0.48±0.01 59.54±3.45 124.04 0.14±0.01 2.52 4.75
3.00 0.44±0.01 96.68±3.88 219.72 0.38±0.06 2.75 5.25
5.00 0.45±0.04 104.88±3.57 233.07 0.79±0.02 2.80 5.75
1.00 0.69±0.02 22.56±2.86 32.70 0.07±0.02 2.25 5.25
2.00 0.40±0.01 26.58±2.78 66.45 0.22±0.01 1.85 3.75
3.00 0.30±0.02 39.56±3.00 131.87 0.31±0.00 2.35 5.35
5.00 0.36±0.02 31.72±3.45 88.11 0.38±0.05 2.55 5.75
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