Modified Terminalia randii gum as a binder in metronidazole tablet formulation

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Binder Conc of binde r Bulk density (g/ml) Modified terminalia randii gum as a binder in metronidazole tablet formulation Table 1: Micromeritic Properties of Granules Tapped density (g/ml) Flow rate (g/sec) Angle repose ( O ) of Carr’s index ( O / O ) Hausner ratio Contro 0.00 0.483±0.00 0.523±0.01 3.95±0.44 35.24±0.21 7.62±1.77 1.07±0.01 445 Mean granule size µm PVP 1.00 0.416±0.20 0.450±0.00 4.74±0.52 36.74±0.56 7.41±1.28 1.08±0.01 485 2.00 0.396±0.18 0.430±0.00 5.90±0.56 37.35±0.21 7.53±1.33 1.08±0.01 515 3.00 0.416±0.19 0.430±0.00 6.63±0.57 36.62±0.21 3.10±1.33 1.03±0.01 585 5.00 0.410±0.18 0.453±0.00 7.88±0.60 36.00±0.21 9.54±1.13 1.10±0.01 710 ATR 1.00 0.427±0.00 0.433±0.00 5.20±0.41 48.86±0.56 1.55±1.34 1.01±0.01 755 2.00 0.410±0.00 0.430±0.00 5.73±0.31 48.57±0.52 4.65±0.00 1.05±0.00 765 3.00 0.400±0.01 0.440±0.01 7.22±0.29 49.63±0.14 9.09±0.20 1.09±0.00 770 5.00 0.407±0.00 0.417±0.01 9.78±0.47 49.22±0.42 2.32±4.02 1.02±0.04 860 The release properties of the tablets were assessed using disintegration and dissolution times (t 50 and t 80 i.e. time required for 50% and 80% of the drug to be released respectively). The disintegration time of tablets is the rate limiting step in dissolution and consequently absorption of the active ingredient. The British Pharmacopoeia [13], states that uncoated tablets must disintegrate within 15 minutes. All the formulations disintegrated in less than 15 minutes. The result of the release properties are presented in Table 2. The disintegration time was observed to increase with increase in concentration of binder.Formulations containing ATR at 5 % w/w had significantly lower (p0.05) in the dissolution time. Table 2: Tablet Properties Binder PVP ATR Concentration (% w/w) Friability (%) Crushing strength (N) CSFR Disintegration time (Min) T 50 (min) T 80 (min) 0.00 0.36±0.01 18.58±2.97 51.61 0.03±0.00 2.35 4.45 1.00 0.53±0.03 27.46±3.80 51.81 0.07±0.01 2.35 4.50 2.00 0.48±0.01 59.54±3.45 124.04 0.14±0.01 2.52 4.75 3.00 0.44±0.01 96.68±3.88 219.72 0.38±0.06 2.75 5.25 5.00 0.45±0.04 104.88±3.57 233.07 0.79±0.02 2.80 5.75 1.00 0.69±0.02 22.56±2.86 32.70 0.07±0.02 2.25 5.25 2.00 0.40±0.01 26.58±2.78 66.45 0.22±0.01 1.85 3.75 3.00 0.30±0.02 39.56±3.00 131.87 0.31±0.00 2.35 5.35 5.00 0.36±0.02 31.72±3.45 88.11 0.38±0.05 2.55 5.75 31
Modified terminalia randii gum as a binder in metronidazole tablet formulation Figure 3: Plots of percentage metronidazole released against time in formulations containing 5% w/w ATR and PVP IV. CONCLUSION The data obtained from this study indicates that acetylated Terminalia randii gum could be substituted for polyvinyl pyrrolidoneas a binder in tablet formulations, especially where a tablet that is not “too strong” but with similar release property is required. REFERENCES [1] K. OforiKwakye, Y. Asantewaa and S. Lugrie kipo.Physicochemical and Binding Properties of cashew tree gum in metronidazo letablet formulations.Int.J Pharm Pharm Sci, 2( 4), 2010, 105109 [2] H. Rahim, M. A Khan, A. Badshah, K.A Chishti, S. Khan and M. Junaid. Evaluation of Prunusdomestica gum as a novel tablet binder. BJPS, 50(1), 2014, 195-202. [3] R. Kumar, S.R. Patil, M. B. Patil, M. S. Paschapur, R. Mahalaxmi Isolation and evaluation of the emulsifying properties of tamarind seed polysaccharide on castor oil emulsion. Der Pharmacia Lettre, 2 (1), 2010, 518-527 [4] V. Rana, P. Rai, A.K. Tiwary, R.S. Singh, J.F. Kennedy and C.J.Knill. Modified gums: Approaches and applications in drug delivery. Carbohydrate Polymers, 83, 2011, 1031-1047. [5] G. Dodi, D. Hritcu and M. I. Popa. Carboxymethylation of guar gum: Synthesis and characterization. Cellulose Chem. Technol., 45 (3-4), 2011, 171-176 [6] B.R. Sharma, V. Kumar and P.L. Soni. Ceric ammonium nitrate-initiated graft copolymerization of acrylamide onto Cassia tora gum. J Appl. Polymer Sci. 90, 2002.3250-3255. [7] P. Goyal, V.Kumar and P. Sharma. Graft copolymerisation of acrylamide onto tamarind kernel powder in the presence of ceric ion. J Appl. Polymer Sci.108, 2008a, 3696-3701. [8] O.A Bamiro, V.R Sinha, R. Kumar, O.A Odeku. Characterization and evaluation of Terminalia randii gum as a binder in carvedilol tablet formulation. Acta Pharm Sci. 52, 2010, 254-262. [9] S. Esezobo and V. Ambujan. An evaluation of starch obtained from Plantain-Musa Paradisiaca-As a binder and disintegrant for compressed tablets. J Pharm Pharmacol, 34,1982, 761-765. [10] M. Luangtanan-Anan and J.T. Fell. Bonding mechanisms in tableting. Int J Pharm. 60, 1990, 197-202 [11] J.I Wells, Tablet testing, in J. Swarbick, J.C Boylan (14 Ed), Encyclopedia of Pharmaceutical Technology(Marcel Dekker, New York 1997) 401-418. [12] G.S Banker and N.R Anderson, Tablets, in L. Lachman, H.A Liberman special Indian (Ed), The Theory and practice of Industrial Pharmacy (CBS Publishers and Distributor, New Dehli, 2009) 293-345 [13] British Pharmacopoaeia (BP). The Commission Office London. 2009; 111: 6578 – 6585 [14] O.A.Odeku and O.AItiola. Evaluation of the effects of Khaya gum on the mechanical and release properties of paracetamol tablet formulation. Drug Dev Ind Pharm 29,2003, 311-320. 32
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