2007 Annual Report - The Department of Surgery - University of ...

RESEARCH PROGRAMS
SELECTED FEDERAL GRANTS
The Department of Surgery has a long and notable history
in biomedical research, as exemplified by our own Nobel
Laureate Dr. Charles B. Huggins. This tradition continues
today with fundamental, translational and clinical
research programs. The field of surgery and, by extension, surgical research is
unique in that it focuses not only on the treatment of disease, but also on the physical
manipulation of the body. From a past focused primarily on injury repair and removal of diseased
tissue, surgery in the present has engaged in the renovation of the body through
organ and tissue transplantation as well as device implantation. As a result, the Department
of Surgery is uniquely positioned to be an interface between biomedical research, clinical
practice and technological development.
Section Name Title of Research
Cardiac Gupta, Mahesh P. The Role of PARP-SIR2 Signaling in Heart Failure
Cardiac Gupta, Mahesh P. Histone Deacetylases in Pathogenesis of Heart Failure
General Alverdy, John Pseudomonas Effects on the Gut Barrier from Surgery
General Fichera, Alessandro Timing of Rectal Cancer Response to Chemoradiation
General Jaskowiak, Nora T. National Surgical Adjuvant Breast and Bowel Project
(NSABP) Co-STAR (Study of Tamoxifen and Raloxifene) Study
General McKee, Mark D. CEA-Directed Cancer Treatment with Gene-Modified T Cells
General Nishimura, Micheal I. Animal Model for Her-2/neu Specific TCR Gene Transfer
General Nishimura, Micheal I. Tumor Recognition by TCR Transduced CD4+ & CD8+ T Cells
General Nishimura, Micheal I. Autoimmune Vitiligo as a Road Map to Melanoma Therapy
General Posner, Mitchell C. American College of Surgeons Oncology Group-Chair,
Gastrointestinal Committee
General Silverstein, Jonathan C. Advanced Biomedical Tele-Collaboration Testbed in Surgery,
Anesthesia, and Emergency Medicine
Direct
7,726
50,174
100,613
14,125
178
125,549
36,308
5,186
2,379
13,740
486,904
Indirect
4,133
26,843
53,016
7,416
18
10,034
8,071
2,645
1,273
7,259
255,624
FY 07 Total
11,859
77,017
153,629
21,541
,195
135,583
44,379
7,831
3,652
20,998
742,528
This year, the Department of Surgery created an Office of Surgical Research (OSR) headed
by Karl Matlin, PhD, Vice-Chairman for Research, with an advisory panel of senior departmental
investigators. For the first time, OSR centralizes and facilitates management of
pre-award research grants and clinical trials, research facilities and academic research
activities. It also provides research training for graduate students, residents and postdoctoral
fellows as well as faculty development on the research promotional tracks.
Neuro Frim, David M. Hydrocephalus, Intracranial Pressure, and Neurocognition
Neuro Lesniak, Maciej S. Targeted Adenoviral Gene Therapy for Malignant Glioma
Neuro MacDonald, Robert Loughlin Unruptured Intracranial Aneurysms: Neurologic Outcome
Ortho Haydon, Rex C. BMP6-Mediated Osteogenesis
Ortho He, Tong-Chuan Regulation of Beta-Catenin Signaling by Tyrosine Phosphorylation
Ortho Martell, John Acetabular Bone Loss Following Hip Arthroplasty
Ortho Ojakangas, Catherine Cerebral Mechanisms of Skill Learning in Humans
153,541
25,652
1,197
99,002
67,321
4,422
129,993
80,570
2,052
628
7,920
36,017
2,322
10,399
234,111
27,704
1,825
106,922
103,337
6,744
140,393
One of the important goals of OSR is to create
programs that enhance research activities within the
Department. Along this line, OSR started a weekly
departmental research seminar in the spring of 2007
to improve communications among investigators.
Initially, most of the speakers were faculty members.
However, OSR will extend invitations to speakers
from regional and national institutions during the
fall of 2007.
A second initiative organizes investigators into surgical
research interest groups whose membership
transcends boundaries of clinical sections. The group
will focus on research activities in the department
including: faculty recruitment, laboratory renovation,
creation and expansion of shared resources as well as
interactive mentoring of surgeon investigators and
basic scientists.
Finally, efforts are underway to develop the
Department’s engineering capabilities through
collaborations with neighboring institutions, such as
Argonne National Laboratory and Illinois Institute
of Technology. Engineering expertise is already
being supplemented through the Department’s
recent appointment of Joel Collier, PhD, a tissue
engineer/materials scientist.
Plastics Lee, Raphael Membrane Sealing: Biopolymers for Tissue Electroporation
Plastics Lee, Raphael Non-Ionizing Research: Electrical Stimulation of Biological Tissues (1)
Plastics Lee, Raphael Non-Ionizing Research: Electrical Stimulation of Biological Tissues (2)
Transplant Chong, Anita S. Spleen Regulation of Beta-Cell Regeneration
Transplant Chong, Anita S. Graft Rejection and Accommodation by Anti-Gal mABs (1)
Transplant Chong, Anita S. Stem Cells for Tolerance Induction
Transplant Chong, Anita S. Graft Rejection and Accommodation by Anti-Gal mABs (2)
Transplant Garfinkel, Marc R. Combined Effects for Improved Tissue Dissociation
Transplant Harland, Robert Transplantation in People with HIV Infection (1)
Transplant Harland, Robert Transplantation in People with HIV Infection (2)
Transplant Millis, J. Michael Studies of Pediatric Liver Transplantation
Transplant Thistlethwaite, J. Richard Immunosuppression Withdrawal in Liver Transplant Recipients
Workscope: Planning Grant for Clinical Trial of Immunosuppression
Withdrawal in Liver Transplant Recipients
Research Matlin, Karl S. Cell-Matrix Interactions in Epithelial Polarization
Research Zegers, Mirjam Regulation of Epithelial Contact Inhibition by Rac Effector Proteins
73,179
241,637
126,892
52,851
88,460
56,173
16,460
48,550
42,807
9,765
8,852
125,563
9,028
27,073
37,847
128,772
67,887
28,275
46,441
29,491
6,616
25,974
22,474
5,224
4,648
65,660
4,830
14,484
111,026
370,409
194,780
81,126
134,901
85,664
23,076
74,524
65,281
14,989
13,500
191,223
13,858
41,557
Urology Rinker-Schaeffer, Carrie W. Prostate Cancer Metastatic Colonization: Role of MKK4
72,317
36,882
109,199
Urology Rinker-Schaeffer, Carrie W. Post-Transcriptional Regulation of MKK4-A Stress Signaling Kinase
Implicated in the Regulation of Metastatic Growth
1,686
886
2,572
Urology Rinker-Schaeffer, Carrie W. Societal Interactions in Ovarian Cancer Metastases:
A Quorum Sensing Hypothesis
113,295
60,613
173,908
Urology Steinberg, Gary MVAC in Organ-Confined Bladder Cancer Based on p53 Status
240
,126
366
Urology Zagaja, Gregory Neoadjuvant Anti-Angiogenesis Therapy for Prostate Cancer
17,564
9,396
26,960
Vascular Bassiouny, Hisham Biomechanical Mechanisms and Venous Intimal Hyperplasia
129,686
45,734
175,421
Vascular Bassiouny, Hisham A Multinode Sonic and Ultrasonic Diagnostic Imaging Method
2,224
1,190
3,414
Vascular Bassiouny, Hisham MR Determination of Carotid Atherosclerosis Progression 0,0
18,571
7,726
26,297
Vascular Weichselbaum, Ralph R. Gene Therapy for Extension of Vein Graft Patency 0,0
16,625
7,232
23,856
2,623,509
1,174,648
3,798,156
12 | UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERY
ANNUAL REPORT 2007 | 13