DEPARTMENT OF SURGERY 2008 ANNUAL REPORT - The ...

TABLE OF CONTENTSLetter from the Chairman 1Shaping Patient Care 4Training Future Leaders 8Pioneering New Discoveries 12Building Healthy Communities 16Section Descriptions 18Cardiac and Thoracic Surgery | General Surgery | Neurosurgery |Ophthalmology and Visual Science | Orthopaedic Surgery andRehabilitation Medicine | Otolaryngology-Head and Neck Surgeryand Dentistry | Pediatric Surgery | Plastic and ReconstructiveSurgery | Transplantation | Urology | Vascular Surgery andEndovascular TherapySelected Honors 30Surgery by the Numbers 32Sponsored Research 33Current Residents, Fellows and Graduates 37Publications 40Development 62I AM PLEASED TO SHARE WITH YOU THE 2008 ANNUALREPORT OF THE UNIVERSITY OF CHICAGO DEPARTMENTOF SURGERY. This report highlights our many accomplishments andstrengths, and provides a window into a world that is continuously moving andgrowing. As leaders and innovators in the field of surgery, we are constantly1ANNUAL REPORT 2008transforming our approach to clinical care, research and education to enhanceour endeavors and shape the future of surgical practice.Once again, the University of Chicago Medical Center received acclaim fromU.S. News & World Report (July 2008), including Honor Roll status as one ofthe 18 best hospitals in the United States. Additionally, many of our programsranked in the top 25, including: digestive disorders (#6), endocrinology (#11),cancer (#18), neurology and neurosurgery (#19), heart and heart surgery (#20),kidney disease (#22), ear, nose and throat (#22).

4UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYSHAPING PATIENT CAREAdvancing surgical care has always been the hallmarkof the University of Chicago Department of Surgery.Our predecessors’ pioneering work includes: DallasB. Phemister, MD, who in the 1930s proved that mostcases of surgical shock are caused by loss of blood;Charles B. Huggins, MD, who oversaw the firstorchiectomy to treat advanced prostate cancer in 1939;as well as Christoph Broelsch, MD, who performedthe first successful living-donor transplant in 1989.The Department continues to transform patient careusing comprehensive knowledge, sophisticated surgicaltechniques and revolutionary technology to provide thebest treatment and outcomes for patients.As part of a unified “Chicago” approach to emergingtechnologies, the Department is grounding newtechniques in outcomes research to find the mostappropriate applications of minimally invasive surgery.In this approach, faculty discuss with each patient theentire range of options available, striving to provide theright treatment to the right patient at the right time.The Department is a recognized leader in endoscopyand minimally invasive surgery, the practice ofperforming surgical procedures through tiny incisions.Minimally invasive surgery offers many benefits overtraditional techniques, including: less pain, shorterhospital stays, quicker return to normal activities,minimal scarring, reduced recovery time and less injuryto tissue.Due to the increase in volume of minimally invasivesurgical procedures, the Department purchased a secondda Vinci Surgical System, a high tech, computerenhancedsystem. Many faculty have long been usingthe robot. Oncologic urologic surgeons, as an example,have been performing robotic procedures since 2002.They have developed the largest experience in Illinoisto manage prostate, bladder and kidney cancer usinglaparoscopic and robotic techniques.Among this group, pediatric urologist Mohan S.Gundeti, MD, performed the first-ever robotic-assistedaugmentation cystoplasty with appendicovesicostomy(Mitrofanoff). This is a reconstructive surgery forpatients with a neurogenic bladder utilizing about12–14 inches of the small intestine to increase thesize of the bladder. The tip of the appendix, a hollowmuscular tube, is then connected between the bladderand the skin of the lower abdomen to allow patients todrain the bladder. He invited his colleague, GregoryZagaja, MD, to assist on this complex procedure.In the past year, Hisham Bassiouny, MD, has begunto use the robotic system to treat aortoiliac occlusivedisease and abdominal aortic aneurysm, a conditionwhich results from the expansion of a weakened aortaand can be fatal if the aorta ruptures. An investigationaldevice exemption (IDE) from the FDA is under reviewfor broader use of this technology in the minimallyinvasive treatment of abdominal aortic disease.As a leader in robotic and minimally invasive cardiacsurgery, the Department is on the cutting edge of newtechnology. Sudhir Srivastava, MD, has collaborativerelationships with various companies to build newdevices related to robotic cardiac surgery. Of particularnote, he spent time in the lab developing a newimaging camera that is integrated into the roboticcamera allowing the surgeon to see how well the graftis working during surgery. Typically, the surgeonwould finish the graft and the patient would have aCT-Angiogram following the operation to assess itseffectiveness. This new technology would allow thesurgeon to identify and repair any problems before theoperation has concluded and the chest is closed.Head and Neck Cancer surgeons Elizabeth Blair,MD, Louis Portugal, MD, and Kerstin Stenson, MD,work closely with radiation and medical oncology toprovide function-sparing multimodality treatment andreconstruction for patients with head and neck cancer.They treat patients with all stages and types of head andneck cancers, including: cancers of the sinuses, mouth,Marco Patti, MD, pictured in the new Motility Laboratory, is aworld renowned surgeon who focuses exclusively on surgicaltechniques in treating benign and malignant esophageal diseases.tongue, tonsils, pharynx (throat), larynx (voice box),salivary glands, upper esophagus, and advanced headand neck skin cancers. Dr. Stenson, Head and NeckProgram Director, has developed surgical approachesfor patients with recurrent head and neck cancer aswell as functional reconstructions. Additionally, Dr.Blair has developed a new high risk oral cancer clinicand has ongoing clinical trials investigating noveltechnologies for early detection of oral cancer. Dr.Portugal specializes in the latest diagnostic, treatmentand surgical techniques for head and neck disorders.In particular, he performs transnasal esophagoscopy,a minimally invasive technique, to examine theesophagus and perform biopsies.Plastic surgeon David H. Song, MD, performsmicrosurgical breast reconstruction with DIEP (deepinferior epigastric perforator flap), an innovativetechnique that uses skin and fat but no muscle for breastreconstruction. This allows patients to recover andreturn to normal activities sooner and has less effect onabdominal strength. In addition, with the recent5ANNUAL REPORT 2008

6UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYrecruitment of Julie E. Park, MD, a plastic surgeon withextensive training in reconstructive microsurgery andbreast reconstruction, the Department will have thelargest center for perforator breast reconstruction in thegreater Chicago area.The sports medicine program provides state-ofthe-artclinical care for athletes of all ages and skilllevels, from professional players and school athletes to“weekend warriors.” Michael Terry, MD, providesmedical coverage for the Chicago Blackhawks, whileSherwin Ho, MD, provides medical coverage for theU.S. national women’s indoor volleyball team. Dr.Ho recently traveled with the team to the World Cupin Japan and the 2008 Summer Olympics in Beijing.Most recently, the Section has recruited J. MartinLeland III, MD, who specializes in sports medicineinjuries and previously provided medical coverage forthe Philadelphia Eagles, Philadelphia Phillies and thePhiladelphia Marathon.Many of the Department’s sections have expanded theirpractices to outpatient settings, surgery centers andoffice locations throughout the greater Metropolitanarea, including the western suburbs (PediatricSurgery), southern suburbs (Orthopaedics and OHNS),as well as Weiss Memorial Hospital (Ophthalmology,Vascular Surgery, Plastic Surgery, Urology andOrthopaedics).Increasingly, patient care is becoming amultidisciplinary experience. The Center forGastrointestinal Oncology, under the direction ofMitchell C. Posner, MD (Surgical Oncology), Hedy L.Kindler, MD (Medical Oncology), and Irving Waxman,MD (Interventional Gastroenterology), continuesto provide expertise in the diagnosis, treatment andmanagement of a variety of complex cancers of thedigestive system, including: rectal cancers, pancreaticcancer, liver cancer, esophageal cancer, gastrointestinalstromal tumors (GIST) and stomach cancers. Throughinnovative surgical procedures and medical treatments,physicians offer patients the highest chances of successagainst their disease. Some of the procedures include:minimally invasive esophagectomy; gastrectomy;pancreatectomy; hepatic resection; rectal resection;diagnostic and therapeutic endoscopy for pancreatic,hepatobiliary, and esophageal cancers; and gene therapyfor upper GI cancers.Most recently, the University of Chicago MedicalCenter opened the Center for Esophageal Diseases, oneof the few centers in the United States solely dedicatedto diagnosing and treating disorders of the esophagus.These include: gastroesophageal reflux disease(GERD), Barrett’s esophagus, esophageal achalasia,paraesophageal hernia, esophageal diverticulum,cancers of the esophagus as well as submucosal tumorsof the esophagus. Directing this Center is Marco Patti,MD, who was recruited this past year for his extensiveexpertise in the surgical treatment of esophagealdisorders. Additionally, a Motility Laboratory is part ofthe Center for Esophageal Diseases. In this laboratory,state-of-the-art equipment is used to diagnose motilitydisorders and assess the severity of gastroesophagealreflux disease.For its advanced expertise and experience, theTransplant Center at the University of Chicago MedicalCenter received full unconditional accreditation for allsolid organ programs from the Centers for Medicareand Medicaid Services. Under the leadership of J.Michael Millis, MD, it was the second center in the cityand among the first twenty centers in the country toreceive this designation. The Transplant Center has thelargest heart transplant program in the state of Illinoisand the most experienced multi-organ transplantcenter in the Midwest. The Center performed the firstsuccessful heart/liver/kidney transplant in the worldin addition to being the first program to successfullyperform a heart/kidney/pancreas transplant.In neurosurgery, the Pediatric Neurosciences Center,under the leadership of David Frim, MD, continuesto offer a wide range of expertise from neurosurgery,neurology, neuro-oncology and neurogenetics to treatpediatric neuro-disorders, emphasizing hydrocephalusand congenital anomalies of the nervous system,epilepsy, and brain and spine tumors. The sectionrecently recruited Ann Marie Flannery, MD, aninternationally recognized pediatric neurosurgeonwith expertise in minimally invasive endoscopicneurosurgery, craniofacial surgery and brain tumorsurgery.7ANNUAL REPORT 2008Right: Giuliano Testa, MD, Director of Liver Transplant and HepatobiliarySurgery, (right) is seen here reviewing an ultrasound tolocalize a cancerous tumor prior to performing the liver resection.

TRAINING FUTURE LEADERS8UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYSurgical education and training is moving beyond thetraditional model of “see one, do one, teach one” andtransforming into a “practice before performance”model that delves into the technological realm ofvirtual environments and surgical simulation.The University of Chicago Department of Surgeryhas inaugurated a state-of-the-art Laparoscopic SkillsLaboratory with an associated Minimal Access Surgery(MAS) curriculum to enhance training in minimallyinvasive surgery. The new technology allows residentsto become proficient in the basic skills and cognitiveknowledge required to perform laparoscopic surgicalprocedures prior to entering the operating room.However, “the broader, long-term goal is to establisha pattern of self-directed practice and continuousperformance improvement that can be applied toMAS as well as to the adoption of other novel surgicaltechniques, technologies and knowledge,” says VivekPrachand, MD, who has led the efforts to develop theLab.The Lab features both inanimate and virtual realitysimulators to allow residents to develop the skills usedin laparoscopic surgery. These simulators include:• EndoTower — a virtual reality laparoscope simulatorused to train residents and medical students incamera navigation• LapTrainer with Simuvision — inanimate trainersused for the majority of task practice• ProMIS — a hybrid virtual reality trainer thatmeasures speed, accuracy and efficiency ofstandardized tasks using actual laparoscopicinstrumentation to provide residents with feedbackon their performanceThe curriculum is designed to develop proficiencyusing a combination of lectures, computer-based selfstudy,faculty-mentored training sessions and deliberatepractice sessions at which trainees work at their ownpace. Assessment of trainee progress compared tobaseline performance will take place using simulatorbasedand validated expert-based performance metrics.Prior to beginning PGY-3, residents will demonstratecompetency by obtaining certification from theFundamentals of Laparoscopic Surgery program jointlydeveloped by the Society of American Gastrointestinaland Endoscopic Surgeons (SAGES) and the AmericanCollege of Surgeons (ACS). FLS Certification willbe prerequisite for active participation in advancedlaparoscopic procedures in the OR.Residents will benefit from the expertise andmentorship of surgical faculty from across theDepartment, including general surgery, urology,thoracic surgery, pediatric surgery, and transplantation.Some of the faculty includes: John Alverdy, MD;Alessandro Fichera, MD; Mark Ferguson, MD; MohanGundeti, MD; Robert Harland, MD; Donald Liu, MD;Sangtae Park, MD; Marco Patti, MD; Vivek Prachand,MD; Arieh Shalhav, MD; and Kevin Zorn, MD.Left: NorthShore University HealthSystem in Evanston, IllinoisRight: Vivek Prachand, MD, (right) trains third year medicalstudent Rebecca Wolsky (left) on the Endo Tower, a trainingsystem that simulates a laparoscopic camera used during surgery.In another technological innovation, the Departmentopened the Dennis and Claire Nardoni SurgicalConference Center. This new facility is an interactive,multimedia, educational meeting and conferencecenter with state-of-the-art technology and remarkablecross-communication capabilities including videoconferencing and live feed connections to the operatingrooms. The Conference Center was designed toenhance educational and collaborative interactions bothinternally and externally for students, residents andfaculty.Along with technology, collaborative relationships aretransforming education and providing diverse trainingopportunities for medical students, residents andfellows. The University of Chicago Pritzker School ofMedicine and NorthShore University HealthSystem,previously known as Evanston NorthwesternHealthcare, have agreed on an academic affiliationthat will make the NorthShore hospital locations inEvanston, Glenbrook and Highland Park the primaryoff-site learning environment for University of Chicagomedical students and residents.9ANNUAL REPORT 2008ProMIS is a cutting edge technology system that simulates theenvironment within the abdominal cavity to assist students andresidents in understanding the mechanics of laparoscopic surgery.

10UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYThis new affiliation pairs the strengths of the Universityof Chicago Medical Center, which has a sharp focuson complex care, biomedical science and distinguishedprograms, with those of the NorthShore system, whichis one of the most fully integrated, multi-hospital,research and primary care organizations in the country.Both institutions share a commitment to the highestlevels of patient care and medical research, yet exposestudents and residents to different patient populations,hospital environments and operational systems.The Department’s graduate medical educationprograms continue to be robust and competitivewith all core programs receiving four or five yearaccreditation cycles. Interest in post-graduate surgicaltraining programs remained at a high level as theDepartment continued its successes in the nationalintern and resident matching program. As an example,the Department received 1,013 applications for thegeneral surgery program from graduating medicalstudents around the country. During the 2008-09recruitment season, the Department’s six first-yeargeneral surgery residents matched in the top third ofthe highly competitive match list. This recruitmentsuccess has been equally strong in the Department’sother training programs in Cardiac and ThoracicSurgery, Neurosurgery, Ophthalmology and VisualScience, Orthopaedic Surgery, Otolaryngology-Headand Neck Surgery, Pediatric Surgery, Plastic Surgery,Transplantation, Urology, and Vascular Surgery andEndovascular Therapy.As part of the Department’s commitment to educationand training, many faculty have taken on additionalteaching responsibilities in the University of ChicagoPritzker School of Medicine. Karl Matlin, PhD, forexample, has taken on the role of Course Directorof Molecular and Cell Biology. His outstandingleadership and innovative teaching has resulted in thecourse receiving its highest rating since 2005. MichaelKathleen Goss, PhD, gives a presentation on the Department’svast research opportunities to new surgical residents.Simon, MD, and Colleen Ross, PhD, markedlyexpanded surgical faculty participation in the HumanMorphology course, bringing to life the value of grossanatomy to the practice of medicine.Bringing together technology and anatomy,Jonathan Silverstein, MD, MS, has served as theCourse Director of “Immersive Virtual Anatomy”through the Biological Sciences Division. Studentslearn fine anatomic details of the human bodyfrom high-resolution clinical volumetric data (e.g.,computed tomography and magnetic resonance) viahigh-performance, interactive stereo visualizationsystems based on computer gaming boards. Studentshave responded favorably to this course, which hasconsistently received outstanding evaluations andenrollment requests from more than 40 students for acourse originally designed for seven. Due to this highdemand, Dr. Silverstein taught concurrent sessionsin two rooms using simultaneous immersive displaysand video communications, allowing an enrollmentof 17 students. Eventually, Dr. Silverstein hopes toexpand this course across multiple sites including otheruniversities.Moving beyond anatomy, the Department iscommitted to the education and practice of surgicalethics. As an example, J. Terry Ernest, MD, PhD, isLeft: This image is from an immersive hepatic surgery educationalenvironment to help students better understand the liver anatomy.Right: Lazar Greenfield, MD, (speaker from the University ofMichigan, on the left), and Peter Angelos, MD, PhD, (second fromleft) at the weekly surgical ethics seminar series.teaching a bioethics course designed specifically forophthalmologists to encourage students to look intothemselves and others to evaluate their own beliefs andvalues as part of their lifelong process of growth andlearning.On a larger scale, the Department has collaborated withthe University of Chicago MacLean Center for ClinicalMedical Ethics to develop the first formal SurgicalEthics Fellowship Program with an accompanyingseminar series. The one-year surgical ethics fellowshipprogram, directed by Peter Angelos, MD, PhD,provides ethics training in research, teaching andclinical ethics consultations for a junior or mid-careersurgeon.Throughout the year, the program hosts a weeklyseminar featuring local and national scholars in thefield of surgical ethics. These lectures cover several bigthemes, including: surgical innovation and surgicalresearch, commercialization of intellectual property insurgical innovation, solid organ and composite tissuetransplantation, and the surgeon-patient relationship.Already, several of the surgery faculty, residentsand fellows have participated in the program. Theyincluded: Tina Desai, MD, Giuliano Testa, MD, JavadHekmat-Panah, MD, Jateen Prema, MD, and AmyLehman, MD.11ANNUAL REPORT 2008

12UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYPIONEERING NEW DISCOVERIESGroundbreaking research has always been thecornerstone of the University of Chicago Departmentof Surgery, from Alexis Carrel, MD, the 1912 NobelPrize winner for vascular suturing and organtransplantation, to Charles B. Huggins, MD, the1966 Nobel Prize winner for hormonal treatmentof prostate cancer. Moving forward today, theDepartment is pursuing new avenues of research thatfoster discovery and transform the field of surgery.Carrie Rinker-Schaeffer, PhD, in collaboration withJohn Alverdy, MD, and Bonnie Bassler, MD, (PrincetonUniversity), is working on a novel line of research thatapplies a concept from microbiology to cancer metastasis.They are currently investigating whether cancer cellsforming a metastatic colony exhibit behavior thatresembles bacterial quorum sensing, a process in whicha single bacterium finds and communicates with otherbacteria through local chemical messages and allows thebacteria to interact as a collective group rather than asindividual units.Should this prove to be the case in cancer behavior, itwould represent a unique departure from current theory,which assumes that cancer cells work alone and thatmetastatic disease is caused by the most deadly cells. Givencurrent statistics that 560,000 Americans will die this yearfrom cancer (most from metastatic disease), understandingthis cellular process could eventually translate into thedevelopment of targeted antimetastatic therapies andimproved outcomes for patient survival.Also in the tradition of innovative research, ChristopherSkelly, MD, has been investigating the role of a neurovirulenceattenuated Herpes simplex virus (HSV-1) to preventarterial restenosis (the process by which arteries reclogafter treatment due to an unregulated growth andmovement of cells in the vessel). Most recently, he testedthe effects of a genetically-engineereed R7020 herpesvirus on the carotid artery following balloon angioplasty(a procedure to open narrow or blocked blood vessels ofthe heart) and ligation-induced blood flow reduction.Dr. Skelly found that the R7020 virus preferentiallyblocks the arterial restenosis caused by smooth musclecells, while allowing the endothelial cell layer to re-form.He further showed that the R7020 prevents the activationof cell death. These have resulted in a first-authorpublication in the Proceedings of the National Academy ofSciences as well as a new NIH K08 award. Additionally,with nearly one million Americans newly diagnosed withsymptomatic peripheral vascular occlusive disease andone million angioplasty and stent procedures performedannually, this research could potentially translate intotreatment to prevent injury to the arteries and thus,reduce the need for further intervention.With the goal of moving promising treatments frombenchside to bedside, the Laboratory of Molecular andRegenerative Medicine has been established to discovernovel techniques to regenerate human tissues usingcombinations of synthetic materials, cultured cells andgene delivery to treat a variety of human diseases.Although in the early stages, some of the initial researchthemes of this group include: musculoskeletal regenerativemedicine; craniofacial bone biology and healing; novelbiomaterials design; wound healing and vascular biology;biomechanics and bioimaging as well as immune andinflammatory responses to engineered tissues.Materials science provides the basic foundation andbuilding blocks in the early phases of tissue regeneration.Joel Collier, PhD, develops novel synthetic biomaterialsfrom polymers and peptides (components of proteins) and13ANNUAL REPORT 2008Above left: New biomaterials are designed and synthesized inthe Collier lab using a variety of chemical and biological techniques,including using a peptide synthesizer, pictured here.Above right: Joel Collier, PhD, (right) and postdoctoral scholarJai Rudra, PhD, (left) conduct an assay to investigate the biocompatibilityof newly developed biomaterials.Left: Angiogram demonstrating stenosisof the left femoral arteryMiddle: Carrie Rinker-Schaeffer, PhD,(right) and graduate student ShaheenaKhan (left) are using fluorescentmicroscopy to model quorum sensingin cancer cells.Right: Human islets

Daniel Mass, MD, (right) with hand fellow Ruth Baer, MD, (left) on theirvolunteer trip in Lima, Peru.16UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYBUILDING HEALTHY COMMUNITIESCommitted to transforming the health andwell-being of patients, the University ofChicago Department of Surgery is creatingpositive changes in communities here andacross the world.Locally, the Department is developing ways toparticipate in the Urban Health Initiative, a partnershipbetween the University of Chicago Medical Centerand community doctors, clinics and hospitals toimprove the long-term health of South Side residentsin Chicago. These opportunities may include moreconvenient clinic sites for treatment of glaucoma, tonsilsand hernias.Globally, many faculty donate their time and advancedclinical expertise to treating patients living in countriesthat have little or no access to adequate health care, letalone surgical care. They are also equipping physiciansin these countries with the latest surgical techniquesand knowledge to continue treating more patients.Mark Greenwald, MD, Susan Ksiazek, MD, andresident Megan Collins, MD, consulted with colleagueson patients and observed surgery while on a volunteertrip in Warsaw, Poland. Meanwhile, their colleague,Michael Saidel, MD, traveled to Ethiopia to conductresearch in trachoma, a leading cause of infectiousblindness worldwide with an incidence reaching 40percent of children in parts of Africa.In addition, faculty members have traveled to theCaribbean and Latin America. David Song, MD, anactive volunteer and member of the Board of Directorsfor the Medical Aid for Children of Latin America,travels annually to the Dominican Republic with ateam of plastic surgery residents to provide free surgicalcare for children with congenital deformities, suchas cleft lips and palates, burn scar contractures andother correctable physical deformities. Dr. Song’s teamtypically examines over 900 patients and treats over 200patients each trip.Over the past two years, Bassem Mora, MD, MBA,has volunteered his time and worked with local cardiacsurgeons in both the Dominican Republic and Syriato perform corrective and palliative operations forcongenital heart disease. He has taken a number ofUniversity of Chicago practitioners on those trips,including pediatric intensivists, anesthesiologists,perfusionists and nurses from Comer Children’sHospital.Through the auspices of Health Volunteers Overseas,Daniel Mass, MD, and hand fellow Ruth Baer, MD,treated hand patients in Lima, Peru. Hand problemsin this country range from carpal tunnel to complexuntreated trauma and congenital hand anomalies. Drs.Mass and Baer were able to perform approximately20 procedures, including a pollicization, severalmuscle transfers for brachial plexus palsies, traumareconstructions after crush injuries as well as tendontransfers for nerve palsies. Another component of thistrip involved training local physicians interested inhand surgery. Topics ranged from rheumatoid arthritis,tendon transfers, wrist arthroscopies, distal radiusfractures, trauma reconstruction and replantation.Top left: Bassem Mora, MD, MBA, (right) withone of his patients in the Dominican Republic.Top right: David Song, MD, (left) withJoan Matthews, MD, (right) and one of theirpatients in the Dominican Republic.Bottom left and right: Valluvan Jeevanandam, MD,volunteers at a charity hospital in Puthaparthi,India.Heading east, Valluvan Jeevanandam, MD, travels afew times a year to a charity hospital in Puthaparthi,India (near Bangalore) for a period of two to threeweeks providing free cardiac surgery, with an emphasison complex cases. On these trips, he typicallyperforms about 20 charity cases per week. Without Dr.Jeevanandam’s help, most patients cannot afford the carethey need, often face a life expectancy of less than oneyear and have no other treatment options.While surgical treatment is a vital aspect of this trip,Dr. Jeevanandam realized that training and educationcould produce more good work. “Initially, I startedperforming operations for charity, but then I realizedthat more substantial gains would be produced if Ihelped the surgeons expand their skills and knowledgebase,” says Dr. Jeevanandam. “By teaching them to dothe more complex surgeries, they are able to serve manymore patients than I can on my own.”17ANNUAL REPORT 2008

The Section of Cardiac and Thoracic SurgeryThe Section of Cardiac and Thoracic Surgery continues•Wickii Vigneswaran, MD, named President of theSECTION DESCRIPTIONSto be a leader in robotic and minimally invasivesurgery. The clinical faculty provide treatment for themost complex cases, with particular specialization inheart, lung and heart/lung transplants, ventricularassist device implants, complex cardiac reconstruction,minimally invasive valvular and arrhythmia surgeries,malignancies, esophageal diseases, as well as highriskpulmonary resection.Section Highlights and Accomplishments•Ranked among the top 20 programs for heart surgeryby U.S. News & World Report (July 2008)•••International College of Surgeons, US Section, andappointed to the Board of Trustees for the AmericanCollege of Chest Physicians’ Chest FoundationValluvan Jeevanandam, MD, provided free cardiac surgerywhile educating practitioners on techniques at a charityhospital in India for two to three weeks, during whichhe performed roughly 20 charity cases per weekBassem Mora, MD, MBA, traveled to the DominicanRepublic in April 2008 on a medical mission to treatpediatric cardiac surgery patientsWorked to implement an ACGME cardiothoracicresidency program in collaboration with NorthShoreUniversity HealthSystem19ANNUAL REPORT 2008•Participated in an exclusive clinical trial for the Heart-Cardiac and Thoracic Surgery 19 | General Surgery 20 | Neurosurgery 21 |Ophthalmology and Visual Science 22 | Orthopaedic Surgery andRehabilitation Medicine 23 | Otolaryngology–Head and Neck Surgeryand Dentistry 24 | Pediatric Surgery 25 | Plastic and Reconstructive•Ware device, a third generation ventricular assist deviceproviding cutting-edge treatment for patients withheart failureStarted a new clinical trial with Quark Pharmaceuticalsin which patients are given an RNA inhibitor toprevent renal failure after cardiac surgerySurgery 26 | Transplantation 27 | Urology 28 | Vascular Surgery andEndovascular Therapy 29•Sudhir Srivastava, MD, worked on the developmentof a new imaging camera, integrated into the roboticcamera, that will allow surgeons to visualize the patencyof an anastomosis interoperativelyFACULTYProfessor of Surgery:Assistant Professor of Surgery:Mark Ferguson, MDShahab Akhter, MD •Valluvan Jeevanandam, MDBassem Mora, MD, MBA •Jai Raman, MD, PhDSudhir Srivastava, MD •VALLUVAN JEEVANANDAM, MDSection ChiefProfessor of SurgeryWickii Vigneswaran, MDAssociate Professor of Surgery:Mahesh Gupta, PhDPostdoctoral Scholar:Ravi Sundaresen Nagalingam, PhDVinodkumar Pillai, PhD• denotes new faculty

The Section of General SurgeryThe Section of NeurosurgeryThe Section of General Surgery focuses on a variety• Opened the Dennis and Claire Nardoni SurgicalThe Section of Neurosurgery builds upon its rich•The Brain Tumor Center continues to offer a20UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYof diseases and complex conditions, with particularexpertise in cancer treatment, endocrine surgery,hepatobiliary and pancreatic surgery, esophagealdisorders, inflammatory bowel disease and obesitysurgery. The Section has expertise in applying minimallyinvasive surgical techniques to treat many of thesedisease processes. Fueled by clinical research, theSection has designed and participated in numerousclinical trials to ask critical questions related to improvingtreatment for pancreatic, esophageal, gastric, colorectaland breast cancer, and inflammatory bowel disease.Section Highlights and Accomplishments• Rated as one of the Top 10 Cancer and GastrointestinalCenters in America• Recruited Marco Patti, MD, an internationally knowngastrointestinal surgeon with expertise in the surgicaltreatment of esophageal disorders• Recruited Konstantin Umanskiy, MD, a specialist in thetreatment of colon and rectal diseases• Jose Guevara-Patiño, MD, PhD, received fundingfrom the National Institutes of Health and the AmericanCancer Society to investigate the development ofimmunological strategies to eliminate cancer cellsConference Center, a state-of-the-art, multimedia,interactive facility designed to enhance educationaland collaborative interactions internally/externallyfor students, residents and faculty• Received funding from the Michael Rolfe PancreaticCancer Foundation to support Kevin Roggin’s, MD,research in early detection and prevention of pancreaticcancer. Dr. Roggin has also been named a fellow ofthe University of Chicago Pritzker School of MedicineAcademy of Distinguished Medical Educators• Vivek Prachand, MD, led the development of a newLaparoscopic Simulation Laboratory and MinimalAccess Surgery Curriculum for surgical residents andfellows. The Lab features state-of-the-art technologyto train residents in basic/advanced skills and cognitiveknowledge required for laparoscopic surgery• Increased from four to five clinical services that haveeach been given a designation to commemoratehistorically significant University of Chicago surgeons,including: Dallas B. Phemister, MD, Lester R. Dragstedt,MD, Edwin L. Kaplan, MD, Donald F. Ferguson, MD,and George E. Block, MD• Nora Jaskowiak, MD, has been inducted into the AlphaOmega Alpha Honor Medical Society by the Universityof Chicago Pritzker School of Medicine• Alessandro Fichera, MD, received approval from the Americanlegacy of excellence in clinical care, research andeducation. The faculty use their clinical expertise andadvanced neurosurgical technology to provide themost effective and up-to-date treatment for the entirespectrum of neurosurgical disease, including: neurovascularsurgery, neuro-oncology, surgical epilepsy,spinal surgery, pediatric neurosurgery, as well asfunctional and stereotactic neurosurgery. Along withdelivering the best medical care, the Section is activelyinvolved in clinical and basic science investigations tocreate new knowledge that will advance the fields ofneurosurgery and the neurosciences.Section Highlights and Accomplishments•Ranked among the top 19 Neurosurgery/Neurologyprograms by U.S. News & World Report (July 2008)• Recruited Ann Marie Flannery, MD, an internationallyrecognized pediatric neurosurgeon with expertisein minimally invasive endoscopic neurosurgery, craniofacialsurgery and brain tumor surgery. Dr. Flannery alsospecializes in the surgical treatment of congenital spineanomalies and brachial plexus injuries•••coordinated, multidisciplinary approach to the careof adult and pediatric patients with tumors of thecentral nervous systemThe Pediatric Neurosciences Center in ComerChildren’s Hospital has united physicians and nursesfrom neurosurgery, neurology, neuro-oncology andneurogenetics to treat pediatric neuro-disorders,emphasizing hydrocephalus and congenital anomalies ofthe nervous system, epilepsy, and brain and spine tumorsThe University of Chicago Adult Epilepsy programcollaborated with brain imaging experts to investigateways to improve surgical epilepsy treatment withless invasive diagnostic techniques and moreeffective surgeryThe Neurosurgery Residency Program continues toeducate a group of physician-scientists who will advancethe future of academic neurosurgery and make a lastingcontribution to the care of neurosurgical patients21ANNUAL REPORT 2008Society of Colorectal Surgeons to establish a fellowship incolorectal surgery and will serve as program directorMITCHELL C. POSNER, MDSection ChiefThomas D. Jones Professor ofSurgeryFACULTYProfessor of Surgery:John Alverdy, MDPeter Angelos, MD, PhDEdwin L. Kaplan, MDJeffrey B. Matthews, MDMarco Patti, MD •Mitchell C. Posner, MDAssociate Professor of Surgery:Roger Hurst, MDMark McKee, MDJonathan Silverstein, MD, MSAssistant Professor of Surgery:Alessandro Fichera, MDJose Guevara-Patiño, MD, PhDNora Jaskowiak, MDVivek Prachand, MDKevin Roggin, MDKonstantin Umanskiy, MD •Stephan Wyers, MDInstructor of Surgery:Eugene Choi, MD •Clinical Associate Professor ofSurgery:Mark Connolly, MDClinical Assistant Professorof Surgery:Asha Chhablani, MDResearch Associate (AssistantProfessor of Surgery):Olga Zaborina, PhDPostdoctoral Scholar:David Fink, MDJames McCracken, PhD• denotes new facultyDAVID FRIM, MD, PhDSection ChiefRalph Cannon Professorof NeurosurgeryFACULTYProfessor of Surgery:Ann Marie Flannery, MD •David Frim, MD, PhDJavad Hekmat-Panah, MDRichard Penn, MDV. Leo Towle, MD *Associate Professor of Surgery:Frederick Brown, MDMaciej Lesniak, MDSaeid Mojtahedi, MD *Jordan Rosenblum, MD *Assistant Professor of Surgery:Fernando Goldenberg, MD *Axel Rosengart, MD *Bakhtiar Yamini, MDClinical Associate Professorof Surgery:Leonard Kranzler, MDResearch Associate (AssistantProfessor of Surgery):Catherine Ojakangas, PhDIlya Ulasov, DVM, PhDPostdoctoral Scholar:Cleo Rolle, PhD* denotes secondary appointment• denotes new faculty

The Section of Ophthalmology and Visual ScienceThe Section of Orthopaedic Surgery and Rehabilitation MedicineThe Section of Ophthalmology and Visual Science•Seenu Hariprasad, MD, has enrolled his first patient inThe Section of Orthopaedic Surgery and Rehabilitation•Sherwin Ho, MD, traveled with the U.S. national22UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYprovides comprehensive medical and surgicaltreatment of eye diseases. Some of the services theyoffer include: cataract surgery with lens implantation,corneal transplantation plus refractive surgery,vitreo-retinal surgery, special treatment of diabeticretinopathy and age-related retinal degeneration,eye plastic surgery, strabismus surgery and neuroophthalmology.Section Highlights and Accomplishments• Michael Saidel, MD, uses state-of-the-art techniquesin performing Descemet’s Stripping EndothelialKeratoplasty (DSEK). He was the first to performthis procedure at the University of Chicago. He alsohas research interests in keratoconus, ocular infectiousdisease and conflict of interest issues related to ophthalmology.He has ongoing research in Ethiopia ontrachoma, a leading cause of infectious blindness worldwidewith an incidence reaching 40 percent of childrenin parts of Africa••••a newly initiated multicenter clinical trial investigatinga novel treatment for retinal vein occlusion, a conditionthat often times results in severe vision loss whichcurrently has a large unmet need in terms of treatmentMark Greenwald, MD, Susan Ksiazek, MD, and residentMegan Collins, MD, consulted with colleagues onpatients and observed surgery while on a volunteer tripin Warsaw, PolandJ. Terry Ernest, MD, PhD, has designed a bioethics coursespecifically for ophthalmologists to encourage studentsto look into themselves and others to evaluate their ownbeliefs and values as part of a lifelong process of growthand learningMichael Grassi, MD, in conjunction with Dingcao Cai,PhD, has established the Krill Retinal DegenerationClinic to carry out specialized retinal function testing,such as the electroretinogram (ERG) as well as genetictesting for patients with retinitis pigmentosa and otherretinal degenerative conditionsLouise Sclafani, OD, received the Optometrist ofthe Year Award, the highest honor bestowed by theIllinois Optometric Association based on service inthe community, to the visual welfare of the publicand to optometryMedicine continues to be a cohesive academic unit witha clinical and basic science faculty dedicated to the careof patients, education of students, residents and fellows,as well as the creation of new knowledge in the clinicaland basic science of musculoskeletal diseases.Section Highlights and Accomplishments• Recruited J. Martin Leland III, MD, an orthopaedicsurgeon with a special interest in sports medicineinjuries. Prior to coming to the University ofChicago, Dr. Leland provided medical coverage forthe Philadelphia Eagles, Philadelphia Phillies andthe Philadelphia Marathon.• Kris Alden, MD, joined the Bone and Joint Programat Weiss Memorial Hospital• Terrance D. Peabody, MD, named President of theMusculoskeletal Tumor Society• David Manning, MD, established an “Early Walk”program, a multifaceted program for modern hip andknee arthroplasty that includes minimally invasivesurgery joint replacement, specialized anesthetictechniques, multimodal pain management and rapidrecover physical therapy program•••••women’s indoor volleyball team to the World Cup inJapan and the 2008 Summer Olympics in BeijingTong-Chuan He, MD, PhD, received the Three GorgesFriendship Award, which is given to foreign experts whohave made significant scientific, social and economiccontributions to the development of Chongqing, ChinaRex Haydon, MD, PhD, selected as an AmericanOrthopaedic Association ABC Traveling Fellow for2009. Fellows travel for five weeks touring Australia,New Zealand, South Africa and the United KingdomRobert Bielski, MD, organized an orthopaedic reviewcourse for the University of Chicago pediatric residentsRoderick Birnie, MD, named President of the ChicagoSociety for Surgery of the HandDaniel Mass, MD, and hand fellow Ruth Baer, MD,volunteered in Lima, Peru to treat patients and trainlocal physicians who have an interest in hand surgery23ANNUAL REPORT 2008Purnendu Gupta, MDInstructor of Surgery:FACULTYTong-Chuan He, MD, PhDAnn Zmuda, MD *MARK GREENWALD, MDInterim Section ChiefProfessor of SurgeryProfessor of Surgery:J. Terry Ernest, MD, PhDMark Greenwald, MDRima McLeod, MDSteven Shevell, PhD *Associate Professor of Surgery:Louise Sclafani, ODAssistant Professor of Surgery:Michael Grassi, MDSeenu Hariprasad, MDSusan Ksiazek, MDMarcus Marcet, MD •Michael Saidel, MDClinical Assistant Professorof Surgery:Rama Jager, MD, MBAClinical Associate:Chris Albanis, MDRobert Folberg, MDJames Green, MDValerie Kattouff, MDJeffrey Nichols, MDA. Gwendolyn Noble, MDThomas Patrianakos, MDPostdoctoral Scholar:Sudha Ramalingam, PhD* denotes secondary appointment• denotes new facultyTERRANCE D. PEABODY, MDSection ChiefThe Simon and Kalt FamiliesProfessor of SurgeryFACULTYProfessor of Surgery:Henry Finn, MDDaniel P. Mass, MDAnthony Montag, MD *Terrance D. Peabody, MDMichael Simon, MDProfessor Emeritus of Surgery:Bruce Reider, MDAssociate Professor of Surgery:Holly Benjamin, MD *Sherwin Ho, MDJohn Martell, MDBrian Toolan, MDAssistant Professor of Surgery:Robert Bielski, MDRoderick Birnie, MDRex Haydon, MD, PhDJ. Martin Leland III, MD •Hue Luu, MDDavid Manning, MDChristopher Sullivan, MDMichael Terry, MDClinical Associate Professor of Surgery:Michelle Gittler, MDClinical Assistant Professor of Surgery:Mary Lawler, MDGayle Spill, MDLisa Thornton, MDClinical Associate:Kris Alden, MD •Sung-Lana Kim, MDEdward Park, MDSuzan Rayner, MDPostdoctoral Scholar:Guo-Wei Zuo, PhDPostdoctoral Fellow:Yang Bi, MDBai-Cheng He, MD, PhDYi Wang, MD, PhD* denotes secondary appointment• denotes new faculty

The Section of Otolaryngology-Head and Neck Surgery and DentistryThe Section of Pediatric Surgery24UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYThe Section of Otolaryngology–Head and NeckSurgery (OHNS) and Dentistry diagnoses and treatsthe full range of Ear, Nose and Throat (ENT) disordersusing the most advanced surgical and non-surgicaltechniques, with subspecialties in chronic nasal andsinus disorders, olfaction, head and neck cancer,minimally invasive surgery, allergies, hearingdisorders, and speech language and voice disorders.Section Highlights and Accomplishments• Ranked among the top 22 ENT programs in thecountry and the best in Illinois by U.S. News &World Report (July 2008)•Minimally invasive surgery of the skull base has beenfurther developed with our neurosurgical colleagues• Head and neck cancer surgeons have applied functionsparingmultimodality treatment and reconstruction forpatients with head and neck cancer• Elizabeth Blair, MD, has developed a new High RiskOral Cancer Clinic and has ongoing clinical trials ofnovel technologies for early detection of oral cancers•Fuad Baroody, MD, and Robert Naclerio, MD, haveworked to understand the paradox of how an intranasal•••••••steroid can relieve the eye symptoms associated withseasonal allergic rhinitisDana Suskind, MD, has built a strong clinical team totreat children needing cochlear implants. She has alsoinitiated the integration of surgeons into the medicalstudents’ anatomy course. Nedra Joyner, MD, and JayantPinto, MD, have also contributed to this courseCompleted clinical trials of novel therapies for chronicsinus disease (Anti-IgE)Utilized medical simulation of airway emergencies toteach professionalism in OHNSEllen MacCracken, MS, has used Flexible EndoscopicEvaluation of Swallowing (FEES) testing for patientswith swallowing disorders. This test provides betteranatomical information and detects subtle abnormalitiesJayant Pinto, MD, obtained funding to study theolfactory loss in agingUtilized transnasal esophagoscopy, a minimallyinvasive technique, to examine the esophagus andperform biopsiesDentists continue to develop novel techniques toimprove dental implantsThe Section of Pediatric Surgery at the University ofChicago continues to provide comprehensive care fordiverse surgical problems in infants and children. Thisincludes congenital, neoplastic, infectious and otheracquired conditions of the gastrointestinal system, theblood and vascular system, the integument, the diaphragmand thorax (exclusive of heart), the endocrineglands, the genitourinary system, and the head andneck. The Section continues to be the national andinternational leader in minimally invasive pediatricsurgery and performs over 4,000 operations each year.Section Highlights and Accomplishments• Continues to manage the largest and busiest Extra-Corporeal Membrane Oxygenation (ECMO) programin the Chicago area• Michael Morowitz, MD, received the Junior FacultyResearch Fellowship by the Surgical Infection Societyto study the relationship between NEC and changes inintestinal bacteria• Successfully implemented an ACGME-accreditedpediatric fellowship program that is recognized as aleader in teaching minimally invasive surgery to bothsurgical residents and pediatric surgical fellows.The Section currently has its first two fellows••Expanded its service and outreach to the WesternSuburbs. The Section partners with Edward Hospital,Advocate Good Samaritan Hospital and AdventistHinsdale HospitalThe Pediatric Surgery program has received nationaland local media coverage for the complex proceduresthe surgeons perform. An example of this attentionis the coverage Donald Liu, MD, PhD, received forthe operation he performed on Bella Mia Craig.Baby Bella was born with a giant omphalocele, a rarecondition in which several of her abdominal organswere developing outside her body. Dr. Liu was ableto migrate these organs, including her liver and bowel,into the abdominal cavity, which allowed for asuccessful closure.25ANNUAL REPORT 2008FACULTYROBERT NACLERIO, MDSection ChiefProfessor of SurgeryOHNSProfessor of Surgery:Fuad Baroody, MDJacquelynne Corey, MDErnest Mhoon, MDRobert Naclerio, MDAssociate Professor of Surgery:Elizabeth Blair, MDDaniel Martin, PhDLouis Portugal, MDKerstin Stenson, MDDana Suskind, MDAssociate Professor of SurgeryEmeritus:Raul Hinojosa, MDAssistant Professor of Surgery:Jayant Pinto, MDMiriam Redleaf, MDClinical Professor of Surgery:Anthony Geroulis, MDClinical Associate:Nedra Joyner, MDResearch Associate (AssistantProfessor of Surgery):Adam Markaryan, PhDPostdoctoral Scholar:Rania Esteite, MDShilpy Sharma, PhDDENTISTRYProfessor of Surgery:Joseph Toljanic, DDSAssociate Professor of Surgery:Christopher Smith, DDSClinical Associate:Russell Baer, DDSDONALD C. LIU, MD, PhDSection ChiefMary Campau Ryerson ProfessorFACULTYProfessor of Surgery:Donald C. Liu, MD, PhDDavid Yousefzadeh, MD *Associate Professor of Surgery:Mindy Statter, MDAssistant Professor of Surgery:Michael Morowitz, MD •Clinical Associate:Arnold Coran, MD* denotes secondary appointment• denotes new faculty

The Section of Plastic and Reconstructive SurgeryThe Section of TransplantationThe Section of Plastic and Reconstructive Surgery•Russell R. Reid, MD, PhD, has developed a newThe Section of Transplantation has expertise in•Our liver surgeons have more combined experience in26UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYprovides compassionate and superior healthcare andadvances plastic surgery through innovative research,while training the future leaders of plastic surgery ina collegial setting. The Section provides a broad rangeof surgical services to people suffering from thecompromising effects of injury or disease as well asto those wishing to modify a certain physical feature.This includes the field of complex microsurgicalreconstruction of the head/neck, extremity and breast.Section Highlights and Accomplishments• David H. Song, MD, has conducted research to investigatethe clinical outcomes of mastectomy reconstruction,immediate lumpectomy reconstruction and the impactof regenerative tissue matrices on long-term outcomes.This work has been publicized by international breastsymposia, Vogue and local television• Recruited Julie E. Park, MD, a plastic surgeon withextensive training in reconstructive microsurgery andbreast reconstruction with a keen interest in outcomesresearch. With the addition of Dr. Park, the Section willbe the largest center for perforator breast reconstructionin the greater Chicago area••••research laboratory in Craniofacial Biology andDevelopment, funded by the Bernard G. SarnatEndowment. This lab focuses on discovering innovativebone regeneration techniques using mesenchymalstem cells and applying these discoveries to commonclinical problems that affect the craniofacial skeleton(craniosynostosis, cleft lip and palate, skeletal deficiency)Ginard I. Henry, MD, in collaboration with JonathanSilverstein, MD, MS, has examined techniquesto enhance and increase reconstructive surgicaltechniques using three-dimensional virtual surgeryin vivo radiographyRaphael C. Lee, MD, ScD, DSc (hon), went on amission trip to the United Nations Educational,Scientific and Cultural Organization (UNESCO)Center in Fianarantsoa, MadagascarLawrence J. Gottlieb, MD, was invited to the first annualcombined China-American Society of ReconstructiveMicrosurgery meeting as a panelist and lecturer discussinghis work with chimera perforator flaps for head andneck reconstructionLawrence S. Zachary, Director of Plastic SurgeryServices at Weiss Memorial Hospital, continues tobuild one of the largest programs in post-bariatricbody contouring in the Chicago areathe areas of heart, kidney, liver, lung and pancreastransplantation as well as complex surgical proceduresinvolving multi-organ transplants. The Section hasa long history of firsts in transplantation and iscontinually seeking out new and innovative ways toadvance the science of transplantation. Considereda leader in the field, the Section has the largestheart transplant program in Illinois and the mostexperienced multi-organ transplant center inthe Midwest.Section Highlights and Accomplishments• Received full, unconditional accreditation from theCenters of Medicare and Medicaid Services for allsolid organ programs. It was the second center inthe city and among the first twenty centers in theUnited States to receive this designation• Performed the first successful heart/liver/kidneytransplant in the world in addition to beingthe first program to successfully perform aheart/kidney/pancreas transplant•••••••living donor pediatric liver transplants than any othercenter in the countryDiabetes research efforts are directed at an IRBapproved,state-funded clinical trial involving islet celltransplantationAnita Chong, PhD, has ongoing research focusedon defining therapeutic approaches to enhance isletcell regeneration, and control and reverse autoimmunediabetesAbdominal Transplant Fellowship accredited by theAmerican Society of Transplant Surgeons. This two yearfellowship provides a focused experience and intensetraining dedicated to both kidney and liver transplantAbdominal transplant has incorporated the da VinciSurgical System for complex hepatobiliary andhepatectomy patients. This has resulted in improvedoutcomes and fewer complicationsThe Heart Transplant Team participated in a clinical trialevaluating the Transmedics Organ Care System, an organpreservation device that minimizes the cold ischemictime that a heart must endure during a transplant runEngaged in national and international ethics programs toimprove the field of transplant ethicsPartnered with local hospitals to improve access totransplant in those areas that have an underservedpatient population27ANNUAL REPORT 2008FACULTYDAVID H. SONG, MDSection ChiefAssociate Professor of SurgeryFACULTYProfessors of Surgery:Lawrence J. Gottlieb, MDRaphael C. Lee, MD, ScD, DSc (hon)Associate Professor of Surgery:David H. Song, MDLawrence S. Zachary, MDAssistant Professor of Surgery:Ginard I. Henry, MDJulie E. Park, MD •Russell R. Reid, MD, PhDClinical Associate Professor ofSurgery:Gary Burget, MDClinical Assistant Professor ofSurgery:McKay McKinnon, MDClinical Associate:Peter Geldner, MDJulius Few, MDLoren Schechter, MDDavid Teplica, MD, MFAPostdoctoral Scholar:Hongfeng Chen, PhD• denotes new facultyJ. MICHAEL MILLIS, MDSection Chief, Professor of SurgeryDirector, The University of ChicagoTransplant CenterProfessor of Surgery:Anita Chong, PhDJ. Michael Millis, MDLainie Ross, MD *J. Richard Thistlethwaite, Jr., MD, PhDAssociate Professor of Surgery:Robert C. Harland, MDGiuliano Testa, MDAssistant Professor of Surgery:Marc Garfinkel, MDAssociate:James Williams, MDResearch Associate (AssistantProfessor of Surgery):Jinwen Ding, MD, PhDDengping Yin, MD, PhDPostdoctoral Scholar:Tongmin Wang, MD, PhD* denotes secondary appointment

The Section of UrologyThe Section of Vascular Surgery and Endovascular TherapyThe Section of Urology is now the leading institution•Oncologic urologic surgeons are developing the largestThe Section of Vascular Surgery and Endovascular•Hisham Bassiouny, MD, started using the da Vinci28in Illinois for minimally invasive management ofurologic cancer and benign urologic disease. Theexperience in Illinois managing prostate, bladder andkidney cancer using laparoscopic and robotic techniquesTherapy has a long history of outstanding achievementin patient care, education and research in theSurgical System to treat abdominal aortic aneurysm, acondition in which the aorta expands and becomes weak29UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYSection continues to provide compassionate,comprehensive tertiary care with specialization inurologic oncology, reconstruction, female urology,stone disease and pediatric urology. Locally andregionally, the Section has the highest volume ofcomplex urologic oncology, reconstructive urologyand minimally invasive procedures, includingrobotically-assisted laparoscopic prostatectomy cases.Section Highlights and Accomplishments• Recruited Mohan S. Gundeti, MD, who performedthe first robotic-assisted bladder augmentation usingbowel segments• Recruited Scott Eggener, MD, a urologic surgeonwith specialization in the care of patients withurologic cancers, utilizing surgical, medical andnon-interventional approaches• Recruited Kevin Zorn, MD, who specializes inminimally invasive and general urology, both on-siteand at Weiss Memorial Hospital•••••Urologic oncology and minimally invasive surgeryprograms continue to train two clinical fellows andone research fellow per yearProvides an annual national course for Board review inUrology and robotic surgery trainingUrologic surgeons utilized robotic systems to operate onthe most complex cases and develop novel proceduresUrologic surgeons investigated new methods ofpreserving kidney function during surgeryThe Urology Research Laboratory investigated the basicscientific mechanisms of cancer metastasis as well as themolecular events involved in bladder cancer formationand progressionbroad spectrum of vascular disease. The Section’sfaculty is involved in the non-invasive evaluation andmedical management of patients with a variety ofvascular problems including arterial occlusive disease,venous disorders, and thoracoabdominal and arterialaneurysms. The basic science laboratories havepioneered research in the causes of atherosclerosis,the physiology of blood flow in vein grafts and theeffect of ischemia and reperfusion on various organs.Section Highlights and Accomplishments• The Section changed its name to the Section ofVascular Surgery and Endovascular Therapy to reflectthe evolution of the vascular surgery discipline toincorporate minimally invasive catheter-directedendovascular interventions.• Utilizes a state-of-the-art non-invasive vascularlaboratory for reliable detection and quantificationof arterial and venous disease as well as advancedoperative and endovascular interventions•••••Christopher Skelly, MD, received an NIH K08 Awardfor his innovative research on “Herpes Simplex VirusTherapy for the Treatment of Neointimal Hyperplasia"Tina Desai, MD, completed the University of ChicagoMacLean Center for Clinical Medical Ethics SurgicalEthics Fellowship Program and is developing a programto explore ethical considerations in clinical decisionmaking. Dr. Desai also accepted an invitation to jointhe MacLean Center FacultyGiancarlo Piano, MD, named the Director of the Centerof Venous Disease at Weiss Memorial HospitalCollaborated with Endovascular Therapy, VascularMedicine and Interventional Radiology to create theUniversity of Chicago Center for Vascular TherapyParticipated in the design and development of UCAST,The University of Chicago Aortic Specialty Team,with colleagues from Cardiac and Thoracic Surgery,Cardiology, Cardiovascular Anesthesia and InterventionalRadiology. UCAST offers state-of-the-art diagnosticimaging and cutting-edge intervention for complexaortic reconstructionsANNUAL REPORT 2008•ACGME-accredited vascular surgery fellowshipprogram provides hands-on training in vascular surgery,endovascular and laparorobotic intervention as well ascertification in non-invasive vascular diagnosisFACULTYP. Allan Klock, MD *Professor of Surgery:Edwin Posadas, MD *Arieh Shalhav, MDCarrie Rinker-Schaeffer, PhDARIEH SHALHAV, MDSection Chief, Fritz and Mary LeeDuda Family Professor, Director ofMinimally Invasive UrologyWalter Stadler, MD *Gary D. Steinberg, MDAssociate Professor of Surgery:Gregory Bales, MDKate Feinstein, MD *Glenn Gerber, MDGregory Zagaja, MDAssistant Professor of Surgery:Hikmat Al-Ahmadie, MD *Scott Eggener, MD •Mohan S. Gundeti, MD •Kevin Zorn, MD •Clinical Associate:Stephen Nold, MDSangtae Park, MDPostdoctoral Scholar:Victoria Robinson, PhDSergey Shikanov, PhD* denotes secondary appointment• denotes new facultyHISHAM BASSIOUNY, MDSection ChiefProfessor of SurgeryFACULTYProfessor of Surgery:Hisham Bassiouny, MDProfessor Emeritus of Surgery:Seymour Glagov, MDAssistant Professor of Surgery:Tina Desai, MDGiancarlo Piano, MDChristopher Skelly, MDLecturer:Victor Bernhard, MD

SELECTED HONORS 2007-200830UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYCardiac AND Thoracic SurgeryMark Ferguson, MDVisiting Professor, University of Nebraska, “Risk assessmentand risk reduction in thoracic surgery”Honorary member, Colegio Brasileiro de CirurgiaDigestivaChicago’s Top Doctors, Chicago magazineVisiting Professor, North Shore – Long Island JewishMedical Center, “Implications of Risk ManagementTechniques in Thoracic Surgery,” New YorkVisiting Professor, Japan Esophageal Society 62ndAnnual Meeting, “Pulmonary Complications afterEsophagectomy: Etiology and Prevention Strategies,”Tokyo, JapanVisiting Professor, Kagoshima University, “DecisionMaking in Surgery: Impact of Risk Management Strategies,”Kagoshima, JapanValluvan Jeevanandam, MDChicago’s Top Doctors, Chicago magazineJaishankar Raman, MD, PhDVisiting Professor, Australasian Society of CardiothoracicSurgeons, Annual Meeting, “Facilitating Techniques inImproving Survival of Heart Failure Patients” and “WhichVAD is best – what we would like and what we have?”Visiting Professor, GKNM Hospital, “Live Surgery Symposiumon Surgery for Aortic Aneurysms,” Coimbatore,IndiaVisiting Professor, Asian Cardiovascular Surgery Society,“Surgical Treatment of Heart Failure and MinimallyInvasive Valve Surgery,” Bali, IndonesiaChicago’s Top Doctors, Chicago magazineSudhir Srivastava, MDVisiting Professor, Association of Thoracic andCardiovascular Surgeons of Asia, 18th Biennial Congress,“Totally Endoscopic Coronary Artery Bypass with RoboticAssistance: Past, Present, Future,” Bali, IndonesiaVisiting Professor, 18th World Congress—World Societyof Cardiothoracic Surgeons, “Beating Heart TECAB:Where Do We Stand Today?”Visiting Professor, International Symposium on RoboticCardiac Surgery, “Totally Endoscopic Coronary ArteryBypass,” Beijing, ChinaWickii Vigneswaran, MDU.S. Section President, International College of SurgeonsGeneral SurgeryJohn Alverdy, MDSara and Harold Lincoln Thompson Professor, TheUniversity of ChicagoPeter Angelos, MD, PhDBest Doctors in AmericaRobert Baker Golden Apple Award for Excellence inTeaching, The University of Chicago Department ofSurgeryChicago’s Top Doctors, Chicago magazineAlessandro Fichera, MDPresident, Chicago Society of Colon and Rectal SurgeonsFavorite Faculty Member, The University of ChicagoPritzker School of MedicineNora Jaskowiak, MDAlpha Omega Alpha Honor Society, The University ofChicago Pritzker School of MedicineFavorite Faculty Member, The University of ChicagoPritzker School of MedicineJeffrey B. Matthews, MD82nd Abraham Colles Lecture, Royal College of Surgeonsin Ireland, “Surgical Biodiversity,” Dublin, IrelandBest Doctors in America, IllinoisDistinguished Visiting Professor, Uniformed ServicesUniversity of the Health Sciences, “Chronic Pancreatitis:Recent Advances and Ongoing Challenges,” Bethesda,MDEisenberg Lecturer in Surgery Brigham and Women’sHospital, Harvard Medical School, “Chronic Pancreatitis:Recent Advances and Ongoing Challenges,” Boston, MAMark McKee, MDCharles B. Huggins Research Award, The University ofChicago Department of SurgeryMitchell C. Posner, MDAmerica’s Top DoctorsAmerica’s Top Doctors for CancerBest Doctors in AmericaChicago’s Top Doctors, Chicago magazineVivek Prachand, MDDesignated Surgeon, BC/BS IL Bariatric Center ofExcellenceKevin Roggin, MDAlpha Omega Alpha Honor Society, The University ofChicago Pritzker School of MedicineOutstanding Faculty Member, The University of ChicagoPritzker School of MedicineLeonard Tow Humanism in Medicine Faculty Award, TheUniversity of Chicago Pritzker School of MedicineNeurosurgeryFrederick Brown, MDChicago’s Top Doctors, Chicago magazineDavid Frim, MD, PhDRalph Cannon Professor of Neurosurgery, The Universityof ChicagoChicago’s Top Doctors, Chicago magazineJavad Hekmat-Panah, MDAlpha Omega Alpha Honor Society, The University ofChicago Pritzker School of MedicineMaciej Lesniak, MDAmerica’s Top Surgeons, Consumers’ Research Councilof AmericaAmerica’s Top Doctors, Castle Connolly Ltd.Outstanding New Investigator Award, American Societyof Gene TherapyOphthalmology AND VisualScienceSeenu Hariprasad, MDGuide to America’s Top Ophthalmologists, Consumers’Research Council of AmericaKeynote Speaker, All India Ophthalmological Society,65th Annual Meeting, Hyderabad, IndiaEditorial Board of the American Journal of Ophthalmology,Elsevier PublicationsKeynote Speaker, All India Ophthalmological Society,66th Annual Meeting, Bangalore, IndiaRama Jager, MD, MBAGuide to America’s Top Ophthalmologists, Consumers’Research Council of AmericaMarcus Marcet, MDLifelong Education for the Ophthalmologist RecognitionAward, American Academy of OphthalmologyPhysician’s Recognition Award, American MedicalAssociationRima McLeod, MDNominated, NIH Director’s Pioneer AwardJeffrey Nichols, MDOutstanding Teacher of the Year, Stroger Hospital ofCook CountyThomas Patrianakos, MDGuide to America’s Top Ophthalmologists, Consumers’Research Council of AmericaOutstanding Attending Teacher of the Year, StrogerHospital of Cook CountyMichael Saidel, MD“Best of the Meeting” Poster, American Academy ofOphthalmologyVisiting Professor, Aspen Cornea Society Lecture, “5years of Bacterial Keratitis at the University of Chicago,”Snowmass, ColoradoVisiting Professor, Chicago Corneal Society, “GlobalElimination of Trachoma by the Year 2020,” Chicago,IllinoisLouise Sclafani, DOChair, Contact Lens and Cornea Section, AmericanOptometric AssociationOptometrist of the Year Award, Illinois OptometricAssociationInducted into the National Academies of PracticeNominating Committee Member, American Academy ofOptometryTop Ten Females at the Forefront of Optometry, Reviewof OptometryOrthopaedic Surgery ANDRehabilitation MedicineHenry Finn, MDChicago’s Top Doctors, Chicago magazineMichelle Gittler, MDChicago’s Top Doctors, Chicago magazineRex Haydon, MD, PhDGerald S. Laros Resident Teaching Award, The Universityof ChicagoABC Traveling Fellowship, American OrthopaedicAssociationTong-Chuan He, MD, PhDThree Gorges Friendship AwardSherwin Ho, MDInduction into the Herodicus Society, Florence, ItalyChicago’s Top Doctors, Chicago magazineJohn Martell, MDVisiting Professor, AOA-ASG Traveling FellowshipLecture, The University of Chicago, “Biomedical ImagingInstitute Research Efforts”Daniel P. Mass, MDVisiting Professor, Nantong Medical College, “Mechanicsof Flexor Tendon Repairs,” Nantong, ChinaChicago’s Top Doctors, Chicago magazineAnthony Montag, MDFavorite Faculty Member, The University of ChicagoPritzker School of MedicineTerrance D. Peabody, MDPresident, The Musculoskeletal Tumor SocietyBruce Reider, MDHead of Delegation, American Orthopaedic Society forSports Medicine Traveling Fellowship to AsiaRovere Award for Outstanding Educator, AmericanOrthopaedic Society for Sports MedicineChicago’s Top Doctors, Chicago magazineVisiting Professor, San Diego Naval Medical Center/University of California San Diego, “Planning for PublicationGetting Your Research Published Manuscript WritingConflict of Interest in Medical Publishing”Michael Simon, MDChicago’s Top Doctors, Chicago magazineMichael Terry, MDWheeling High School Distinguished Alumni Award.Favorite Faculty Award, The University of ChicagoPritzker School of MedicineOtolaryngology–Head ANDNeck SurgeryFuad Baroody, MDBest Doctors in America DatabaseJacquelynne Corey, MDReviewer, American Journal of RhinologyVisiting Professor, University Hospital, Bangkok, ThailandVisiting Professor and Keynote Speaker, Turkish OtolaryngologySociety, “Immunotherapy in Allergic Rhinitis,”Ankara, TurkeyNedra Joyner, MDChairman of the Board of Trustees, National MedicalAssociationVisiting Professor, Southern Illinois University Schoolof Medicine, Departments of Internal Medicine andOtolaryngologyErnest Mhoon, MD“Outstanding Physicians” in Otorhinolaryngology inthe Chicago area, Chicago Consumer’s CheckbookMagazineChicago’s Top Doctors, Chicago magazineRobert Naclerio, MDBest Doctors in America DatabaseChicago’s Top Doctors, Chicago magazineWall of Fame, Baylor College of Medicine, Departmentof OtolaryngologyJayant Pinto, MDDennis W. Jahnigen Scholars Award, American GeriatricsSocietyKerstin Stenson, MDVisiting Professor, University of California San Francisco,“Current Concepts in Head and Neck Cancer: Challengingthe Dogma”Visiting Professor, Johns Hopkins University, “CurrentConcepts in Head and Neck Cancer: Challenging theDogma”Visiting Professor, University of Texas MD AndersonCancer Center, “Chemoradiotherapy for AdvancedStage Oral Cavity and Large Volume Laryngeal Cancers”Dana Suskind, MDBest Doctors in America DatabasePediatric SurgeryArnold Coran, MDDenis Brown Gold Medal Award, British Association ofPediatric SurgeonsSalzburg Award, The American Academy of PediatricsKimura Lecture, University of Iowa Medical School& Hospitals, “Therapeutic Options for Long-GapEsophageal Atresia”Visiting Professor, Phoenix Children’s Hospital,“Therapeutic Options for Long-Gap Esophageal Atresia/The Surgical Management of Ambiguous Genitalia inInfants and Children”Colodny Lecture, University of Vermont Medical School,“Therapeutic Options for Long-Gap Esophageal Atresia/Recent Advances in the Management of HirschsprungDisease”Michael Morowitz, MDJunior Faculty Research Fellowship Award, SurgicalInfection SocietyPlastic AND Reconstructive SurgeryLawrence J. Gottlieb, MDAmerican Society of Reconstructive MicrosurgeryDelegate, World Society of Reconstructive Microsurgery,Athens, GreeceAmerican Society of Reconstructive MicrosurgeryDelegate, 1st Joint Conference Chinese Society ofMicrosurgery, Shanghai, ChinaChairman of Masters Series, American Society ofReconstructive MicrosurgeryRaphael C. Lee, MD, ScD, DSc (Hon)Chairman, Quadrangle ClubFellow, American Association for the Advancement ofScienceFellow, Biomedical Engineering SocietyAmerica’s Top Surgeons, Consumers’ Research Councilof AmericaVisiting Professor, University of Copenhagen – HerlevHospital, “The role of the University Physician – Scientistin the age of Technology Transfer”Russell R. Reid, MD, PhDAdvocate Lutheran General Hospital Partners Endowment:Craniofacial DatabaseAO Craniomaxillofacial Faculty, AO North AmericaCrikelair Award for Best Medical Student Presentation(Shanshan Mou), Plastic Surgery Research Council, PI:“Enhanced Osteogenic Capacity of Bone PrecursorCells Co-Transduced with Human Telomerase and BoneMorphogenetic Protein 9.”David H. Song, MDVisiting Professor, University of California, San DiegoVisiting Professor, 7th Annual Chinese Society of Thoracicand Cardiac Surgeons, “Primary Rigid Sternal Fixation: ANew Paradigm for Cardiac Surgery”Annual Arthur G. Michel Award, Breast Cancer Networkof StrengthGuest of Honor, Korean Society of Plastic and ReconstructiveSurgeonsDistinguished Alumnus Award, University of California,RiversideSecond Prize for Presentation, Midwest Association ofPlastic Surgeons, PI for Neta Adler 2008. “PedicledThoracodorsal Artery Perforator Flap in Breast Reconstruction:Clinical Experience”Lawrence S. Zachary, MDChicago’s Top Doctors, Chicago magazineResearchJoel Collier, PhDCAREER Award, National Science FoundationSymposium Co-chair, “Designed MacromolecularAssemblies for Biomedical Applications” AmericanChemical Society 233rd National MeetingSymposium Co-chair, “Self-Assembling Biomaterials”,Society for Biomaterials Annual MeetingDiscussion Leader, Gordon Research Conference onBiointerface Science, Aussois, France.TransplantationMarc Garfinkel, MDOutstanding Oral Presentation for Faculty Research,Fourteenth Annual Charles B. Huggins Research Conference,The University of ChicagoRobert Harland, MDVisiting Professor, AAP National Conference and Exhibition,“Pancreas Transplantation in 2007”Visiting Professor, American Society for Parental andEnteral Nutrition (ASPEN) Annual Meeting, “RenalDysfunction after Transplantation Solid Organ”J. Michael Millis, MDInvited Speaker, 36th Annual Critical Care Congress“Artificial Liver Therapy.”Visiting Professor, Peking Union Medical College,“Pediatric Liver Transplantation”.Best Doctors in AmericaInvited Guest, Organ Transplant Committee – PeoplesRepublic of China, Beijing ChinaInvited Speaker, 1st Symposium on Brain Death, PeoplesRepublic of China, Beijing ChinaChicago’s Top Doctors, Chicago magazineLainie Ross, MD, PhDPolicy Statement: Minors as Living Solid-Organ Donorsfor the American Academy of PediatricsGiuliano Testa, MDRobert Baker Golden Apple Award “For Excellence inTeaching,“ The University of ChicagoJ. Richard Thistlethwaite, Jr., MD, PhDPresident, International Pediatric Transplant AssociationPolicy Statement: Minors as Living Solid-Organ Donorsfor the American Academy of PediatricsChicago’s Top Doctors, Chicago magazineUrologyScott Eggener, MDReviewer of the Month, European UrologyArieh Shalhav, MDFritz and Mary Lee Duda Family Professor, The Universityof ChicagoVascular Surgery ANDENDOVASCULAR THERAPYHisham Bassiouny, MDCharles C. Guthrie Award—Senior Author and MentorCharter Member, Atherosclerosis and Inflammation in theCardiovascular System (AICS) Study Section, NHLBI-NIHTina Desai, MDPresident, Peripheral Vascular Surgery Society31ANNUAL REPORT 2008

DEPARTMENT OF SURGERY BY THE NUMBERSSPONSORED RESEARCH32UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYCLINICAL ACTIVITYCASES VISITS RVUsCardiac AND Thoracic 1,155 2,957 91,190General Surgery 2,671 14,344 72,046Neurosurgery 1,165 4,571 32,766Ophthalmology AND Visual Science 829 18,734 N/AOrthopaedics 3,333 23,060 99,621Otolaryngology–Head AND Neck Surgery(OHNS) AND Dentistry2,346 19,905 53,583Pediatric Surgery 1,195 1,909 20,618Plastic Surgery 1,131 6,471 41,710Transplantation 687 2,135 27,649Urology 2,028 9,224 66,299Vascular Surgery 597 2,952 23,942Grand Total 17,137 106,262 529,424RESIDENTSEDUCATIONAL ACTIVITYFELLOWSGeneral Surgery 50 Maxillofacial Prosthetics 1Neurosurgery 11 Ophthalmology AND Visual Science 2Ophthalmology AND VisualScienceRESEARCH ACTIVITY73 Active GrantsOver 650 Peer-reviewed publications$7.6 Million in Federal Funding$10.4 Million in Total Grant Funding8 Orthopaedic Surgery 4Orthopaedic Surgery 16 Otolaryngology–Head AND NeckSurgery (OHNS) AND DentistryOHNS AND Dentistry 9 Pediatric Surgery 2Plastic Surgery 6 Plastic Surgery 1Urology 10 Surgical Oncology 3Transplantation 2Urology 3Vascular Surgery 2Total Residents 110 Total Fellows 211Cardiac AND Thoracic SurgeryShahab Akhter, MDMyocardial Regulation of BETAARK1 by Protein Kinase C(Federal & Non-federal)Mahesh P. Gupta, PhDThe Role of PARP-SIR2 Signaling in Heart Failure(Federal)Histone Deacetylases in Pathogenesis of Heart Failure(Federal)Valluvan Jeevanandam, MDThe Role of Cardio Protection During Ischemia(Non-federal)Clinical Trial of the On-X Valve Using Low DoseAnticoagulation(Clinical Trial)Anticoagulation Strategy With Bioprosthetic ValvesPost-Operative Event Registry(Clinical Trial)Prospective, Multi-Center, Safety and Effectiveness of the OrganCare System Device for Cardiac Use(Clinical Trial)Wickii Vigneswaran, MDCALGB 140503: A Phase III Randomized Trial Of LobectomyVersus Sublobar Resection For Small (≤ 2 CM) Peripheral Non-Small Cell Lung Cancer(Clinical Trial)General SURGERYJohn Alverdy, MDPseudomonas Effects on the Gut Barrier from Surgery(Federal)In Vitro and In Vivo Efficacy of GMI-1051, A GlycomimeticCompound Active Against the PA-I and PA-II Lectins ofP. Aeruginosa(Non-federal)Peter Angelos, MD, PhDAmerican College of Surgeons Oncology GroupEthics Committee(Federal)Alessandro Fichera, MDTiming of Rectal Cancer Response to Chemoradiation (Federal)A Prospective, Observational, Multicenter Study Assessing EarlyPostoperative Recovery Following Laparoscopic Partial LargeBowel Resection(Clinical Trial)Jose Guevara-Patiño, PhDDisparate Suppression of Naïve Effector and Memory T Cells inTumor-Bearing Hosts(Federal)Functional Profiling of Tumor-Induced Immune Suppression(Non-federal)Rescuing Adoptively Transferred T Cells After Surgical Excisionof Melanoma(Non-federal)Jeffrey B. Matthews, MDSalt Transport in Surgical Diarrheal Disease(Federal)Mark D. McKee, MDCEA Directed Cancer Treatment with Gene-Modified T Cells(Federal)Tolerance and the T Cell Response to Self-Antigen in the Tumor-Bearing Host(Non-federal)Mitchell C. Posner, MDAmerican College of Surgeons Oncology Group (ACSOG)—Chair, GI Committee(Federal)TNFerade Biologic with 5-FU and Radiation Therapy forFirst-line Treatment of Unresectable Locally AdvancedPancreatic Cancer(Clinical Trial)Kevin K. Roggin, MDDevelopment of a Novel Molecular “Fingerprinting” to Aidthe Early Detection of Premalignant and Invasive MalignantPancreatic Cystic Neoplasms(Non-federal)Jonathan C. Silverstein, MD, MSBiomedical Tele-Collaboration Testbed in Surgery, Anesthesia andEmergency Medicine(Federal)NEUROSURGERYDavid M. Frim, MD, PhDHydrocephalus, Intracranial Pressure and Neurocognition(Federal)A Non-Significant Risk, Observational, Single Visit, PhysicianPreference Study of the Utility of the ShuntCheck forDetecting Cerebrospinal Fluid (CSF) Flow in AsymptomaticPatients with Ventriculo-peritoneal CSF Shunts(Clinical Trial)Maciej S. Lesniak, MDConditionally Replicative Adenoviral Vectors for MalignantGlioma(Federal)Development of an Adenoviral Vector with Chimeric Fiber forMalignant Glioma(Federal)Targeted Adenoviral Gene Therapy for Malignant Glioma(Federal & Non-federal)Novel Combination Treatments for Brain Tumors(Federal)The Role of Regulatory T Cells in Malignant Glioma(Non-federal)Development of Novel Oncolytic Virus for Malignant Glioma(Non-federal)Molecular Dynamics of Wound Angiogenesis and the Role of theEPH/EPHRIN System in Wound Angiogenesis(Non-federal)A Phase II/III Randomized Study of CDX-110 with Radiationand Temozolomide in Patients with Newly DiagnosedGlioblastoma Multiforme(Clinical Trial)Phase II, Multicenter, Exploratory Study, Evaluating the TreatmentEffect of Surgery plus Gliadel Wafer in Patients with MetastaticBrain Cancer(Clinical Trial)A Phase I/II Dose Escalation Study of Locally-AdministeredOncoGel in Subjects with Recurrent Glioma(Clinical Trial)Catherine Ojakangas, PhDCerebral Mechanisms of Skill Learning in Humans(Federal)33ANNUAL REPORT 2008

SPONSORED RESEARCH34UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYRichard Penn, MDCollaborative Research: Mathematical Optimization for TargetedMacromolecules Delivery to the Brain(Federal)Modeling, Monitoring and Control of Hydrocephalus(Federal)Bakhtiar Yamini, MDEnhancing Apoptosis in Glioma by Using TNF-Alpha, Temozolomideand Radiotherapy(Non-federal)Temozolomide and Nuclear Factor-KB in the Treatment ofMalignant Glioma(Non-federal)Investigation of the Role of NF Kappa Beta in the Treatmentof Malignant Glioma and Tumor Necrosis Factor(Non-federal)Ophthalmology AND Visual ScienceMichael Grassi, MDGenomic and Genetic Studies of Diabetic Retinopathy (Federal)Role of Wnt Signal in the Pathogenesis of Retinopathy ofPrematurity(Non-federal & Clinical Trial)Canonical Wnt Signaling in Diabetic Retinopathy(Non-federal)The Chicago Retinal Degeneration Consortium: Advancing aSystems-Based Approach to Understanding & Treating RetinalDegenerative Disease(Clinical Trial)Seenu Hariprasad, MDA Phase III, Multicenter, Randomized, Sham Injection-ControlledStudy of the Efficacy and Safety of Ranibizumab InjectionCompared With Sham in Subjects With Macular Edema Secondaryto Branch Retinal Vein Occlusion(Clinical Trial)A Phase III, Multicenter, Randomized, Sham Injection-ControlledStudy of the Efficacy and Safety of Ranibizumab InjectionCompared With Sham in Subjects With Macular Edema Secondaryto Central Retinal Vein Occlusion(Clinical Trial)A Randomized Controlled Study of the Safety, Tolerability andBiological Effect of Repeated Intravitreal Administration ofVEGF Trap in Patients with Neovascular Age-Related MacularDegeneration Clinical Evaluation of Anti-Angiogenesis in theRetina Intravitreal Trial AMD Phase 2 (CLEAR-IT AMD-2)(Clinical Trial)The SCORE Study: A Randomized Trial to Compare theEfficacy and Safety of Intravitreal Injection(s) of TriamcinoloneAcetonide with Standard Care to Treat Macular Edema AssociatedWith Central Retinal Vein Occlusion and Branch Retinal VeinOcclusion(Clinical Trial)A Six-month, Phase III, Multicenter, Randomized, Sham-Controlled Trial (With Six Months Open-Label Extension) toAssess the Safety and Efficacy of 700 ul and 350 ug DexamethasonePosterior Segment Drug Delivery System (DEX PS DDSApplicator System) in the Treatment of Patients with MacularEdema Following Central Retinal Vein Occlusion or BranchRetinal Vein Occlusion(Clinical Trial)A Randomized, Double-Masked, Parallel Group, Multi-Center,Dose-Finding Comparison of the Safety and Efficacy of ASI-001A0.5 µg/day and ASI-001B 0.2 µg/day Fluocinolone AcetonideIntravitreal Inserts to Sham Injection in Subjects With DiabeticMacular Edema(Clinical Trial)A 3-Year, Phase III, Multicenter, Masked, Randomized, Sham-Controlled Trial to Assess the Safety and Efficacy of 700µg and350µg Dexamethasone Posterior Segment Drug Delivery System(Dex PS DDS) Applicator System in the Treatment of Patientswith Diabetic Macular Edema(Clinical Trial)An Evaluation of Efficacy and Safety of Posterior JuxtascleralAdministrations of Anacortave Acetate for Depot Suspensionversus Sham Administration in Patients at Risk for DevelopingCNV due to Exudative Age Related Macular Degeneration(Clinical Trial)Rima McLeod, MDTreatment of Congenital Toxoplasmosis(Federal)Novel Apicomplexan Metabolism & Organelle Transit(Federal)Innate Immune Receptors for Toxoplasma Gondii(Federal)A Pilot Study of Toxoplasmosis, Schizophrenia and BipolarDisease: Clinical Follow-Up of Children with CongenitalToxoplasmosis with Beginning Analysis of Neuroimaging andHost-Parasite Genetics(Non-federal)Joel Pokorny, PhDPsychophysical Studies of Color Defective Vision(Federal)Michael A. Saidel, MDFinite Element Analysis Modeling of the Human AnteriorSegment in Surgery and Disease(Non-federal)Orthopaedic Surgery ANDRehabilitation MEDICINERex C. Haydon, MD, PhDBMP6 Mediated Osteogenesis(Federal)Effects of TGFB-2 and BMP14 Combination Therapy on RatAchilles Tendon Healing(Non-federal)The Use of Osteogenic BMPs to Augment Healing of CriticalSized Femoral Defects in a Rat Model(Non-federal)Tong-Chuan He, MD, PhDRegulation of Beta-Catenin Signaling by TyrosinePhosphorylation(Federal)Role of ID Helix-Loop-Helix Proteins in BMP9-Induced BoneFormation(Non-federal)Molecular Genetic Analysis of Beta Catenin Signaling in SoftTissue Sarcoma(Non-federal)Regulation of CTGF by Wnt/Beta-Catenin Signaling(Non-federal)Hue H. Luu, MDThe Role of Connective Tissue Growth Factor on BMP9-Induced Osteogenesis(Federal)The Role of S100A6 on Human Osteosarcoma Metastasis(Non-federal)Otolaryngology–Head AND Neck SurgeryFuad Baroody, MDMechanism of Action of Fluticasone Furoate in ChildhoodObstructive Sleep Apnea Syndrome (OSAS).(Clinical Trial)Safety and Efficacy Evaluation of Topical Moxidex OticSolution Compared to Moxifloxacin Solution in the Treatment ofAcute Otitis media with Otorrhea(Clinical Trial)Elizabeth Blair, MDA Model Curriculum to Improve Resident Feedback and ProfessionalismUsing Immersive Simulation(Non-federal)Adam Markaryan, PhDMitochondrial Deletions in Cochlear Tissues and Presbycusis(Non-federal)Robert Naclerio, MDEffects of Continuous Airway Pressure on the Ability to Heat andHumidify Air(Non-federal)Intranasal CO 2 for Allergic Rhinitis(Clinical Trial)Study FFU109047, A Combination of Fluticasone Furoate NasalSpray Versus Oral Fexofendine in the Treatment of SeasonalAllergic Rhinitis(Clinical Trial)Does the Response to a Nasal Decongestant Test Predict theOutcome to Treatment of Seasonal Allergic Rhinitis withNasonex(Clinical Trial)A Combination of Intranasal Steroid/Oxymetaxoline Leads toFaster Relief of Nasal Congestion Without Inducing RhinitisMedicamentosa(Clinical Trial)Intranasal Steroids Prevent Antigen-Induced Hyperresponsivenessof the Nasal Ocular Reflex(Clinical Trial)The Addition of Montelukast to Fluticasone in the Treatment ofPerennial Allergic Rhinitis(Clinical Trial)Effects of Anti-IgE Antibody Omalizumab (Xolair) on Patientswith Chronic Sinusitis and a Positive Allergen Test(Clinical Trial)Jayant Pinto, MDRegulatory T Cells in Chronic Rhinosinusitis(Non-federal)Age-Related Olfactory Decline: The Role of Genetic Factors(Non-federal)Treatment of Olfactory Dysfunction in SeasonalAllergic Rhinitis(Clinical Trial)Dana Suskind, MDCCEHPE Pilot(Federal)Plastic AND Reconstructive SurgeryRaphael C. Lee, MD, ScD, DSc (hon)Biopolymer Surfactants for Sealing Electroporated Membranes(Federal)Neurophysiological Mechanisms of Electro-MuscularIncapacitation (EMI)(Federal)Non-Ionizing Research: Electrical Stimulation ofBiological Tissues(Federal)Effect of Cutting Edge Sharpness on Healing Response(Non-federal)David H. Song, MDA Multicenter, Prospective, Open-Label Study to Assess theClinical Outcomes of LTM Use in Two-Stage BreastReconstruction Immediately Post-Mastectomy(Clinical Trial)A Multicenter, Prospective, Randomized, Blinded, ControlledStudy to Evaluate the Clinical Outcomes of AlloDerm 1.0 vs.AlloDerm 2.0 Use in Two-Stage Breast ReconstructionImmediately Post-Mastectomy(Clinical Trial)RESEARCHJoel Collier, PhDModular Biomaterials for Cell Sheet Regeneration(Federal)CAREER: Modular Assemblies for Controlling theCell-Material Interface(Federal)Designing ECM-Inspired Peptide Biomaterials for RegenerativeMedicine(Federal)Basement Membrance-Mimicking Biomaterials for EnhancingDevice Endothelialization(Non-federal)Karl S. Matlin, PhDCell-Matrix Interactions in Epithelial Polarization(Federal)Mirjam Zegers, PhDRegulation of Epithelial Contact Inhibition by RACEffector Proteins(Federal)RAC, Basement Membrance Assembly and Epithelial CellTransformation(Non-federal)TRANSPLANTATIONAnita S. Chong, PhDMechanistic Studies on Listeria Infection and Inhibition ofAllograft Tolerance(Federal)Spleen Regulation of Beta-Cell Regeneration(Federal)Graft Rejection and Accomodation by Anti-GAL MABS(Federal)Stem Cells for Tolerance Induction(Federal)Impact of Staph Aureus Infections on Allograft Tolerance(Non-federal)The Effect of Pioglitazone on Pancreatic Beta CellRegeneration(Non-federal)Bacterial Infections and Transplantation Tolerance(Non-federal)Marc R. Garfinkel, MDCombined Effects for Improved Tissue Dissociation(Federal)Study of a Novel Method of Islet Encapsulation(Non-federal)35ANNUAL REPORT 2008

SPONSORED RESEARCHCURRENT RESIDENTS, FELLOWS AND GRADUATES36UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYRobert Harland, MDSolid Organ Transplantation in HIV: Multi-Site Study(Federal)Phase II Randomized, Multicenter, Active Comparator-ControlledTrial to Evaluate the Safety and Efficacy of Coadministrationof CP-690, 550 and Mycophenolate Mofetil/MycophenolateSodium in De Novo Kidney Allograft Recipients (A3921030)(Clinical Trial)Prograf/FK778 and Prograf/MMF in de novo KidneyTransplant Recipients(Clinical Trial)A Phase Iib, Randomized, Multicenter, Open-Label,Concentration-Controlled, Safety Study of ISA247 andTacrolimus (Prograf) in De Novo Renal Transplant Patients(Clinical Trial)Study Assessing Fixed Dose vs. Concentration ControlledCellCept Regimens for Patients Following Single Irgan RenalTransplantation in Combination with Full Dose and ReducedDose Calcineurin Inhibitors(Clinical Trial)J. Michael Millis, MDStudies of Pediatric Liver Transplantation—Split EMMES(Federal)J. Richard Thistlethwaite Jr., MD, PhDImmune Tolerance Network—immunosuppression(Federal)Belatacept Conversion Trial in Renal Transplantation(Clinical Trial)Comparing Concentration-Controlled Certican ® in Two Doses(1.5 and 3.0 ms/d Starting Doses) with Reduced Neoral ® vs1.44g Myfortic ® with Standard Dose Neoral in de novo RenalTransplant Recipients(Clinical Trial)Belatacept Evaluation of Nephroprotection and Efficacy asFirst-Line Immunosuppression Trial—Extended Criteria Donors(BENEFIT- EXT)(Clinical Trial)A 4-Week, Multicenter, Double-Blind, Randomized, ParallelGroup Study to Compare the Gastrointestinal Safety andTolerability of Myfortic and MMF (CellCept)(Clinical Trial)Belatacept Evaluation of Nephroprotection and Efficacy asFirst-Line Immunosuppression Trial (BENEFIT)(Clinical Trial)UROLOGYGregory T. Bales, MDGeriatrics for Specialty Residents(Non-federal)AMS Transobturator Mal Sling System for the Treatment of MaleStress Urinary Incontinence(Clinical Trials)Glenn Gerber, MDDutasterind 0.5 mg Adminstered Orally Once Daily for 4 years toReduce the Risk of Biopsy-Detectable Prostate Cancer(Clinical Trials)Carrie W. Rinker-Schaeffer, PhDSocietal Interactions in Ovarian Cancer Metastases:Quorum-Sensing Hypothesis(Federal)ID of Effectors of MKK4-Mediated Suppression in OvarianCancer Metastatic Colonization(Non-federal)Molecular Mechanisms Controlling JNKK MetastasisSuppression Protein Function(Non-federal)Regulation of Prostate Cancer Metastatic Colonization: AQuorum-Sensing Hypothesis(Non-federal)Identification of Downstream Effectors & Biological Outcomes ofMKK4-Mediated Metastasis Suppression in Ovarian Cancer(Non-federal)Gary Steinberg, MDThe Detection of Bladder Cancer by Microsatellite Analysis(Federal)MVAC in Organ-Confined Bladder Cancer Based on P53 Status(Federal)Phase III, Open-Label, Multicenter Study of the Efficacy andSafety of MCC in the Treatment of Patients with Non-MuscleInvasive Bladder Cancer at High Risk for Progression and WhoAre Refractory to BCG(Clinical Trials)A Multicenter, Randomized Placebo-Controlled, Double Blind,Phase III Trial of Single-Dose Intravesical Eoquin as a SurgicalAdjuvant Instilled in the Early Postoperative Period in PatientsUndergoing Transurethral Resection for Noninvasive BladderCancer(Clinical Trials)Study of Alvimopan for the Management of Postoperative Ileus inSubjects Undergoing Radical Cystectomy(Clinical Trials)Clinical Utility of The Vysis UroVysion Test and the OptimalSurveillance Strategies for Patients with Transitional Cell Carcinomaof the Bladder(Clinical Trials)Study to Investigate the Efficacy and Safety of Aprotinin on TransfusionRequirements in Patients with Bladder Cancer UndergoingRadical or Total Cystectomy(Clinical Trials)Gregory Zagaja, MDPhase II Clinical Trial(Federal)Vascular Surgery AND EndovascularTherapyHisham Bassiouny, MDStructural and Molecular Determinants of CarotidAtherosclerotic Plaque Tissues(Non-federal)Tina Desai, MDClinical Evaluation of Efficacy and Safety of Fibrin Sealant VHS/D 500 S-APR for Hemostasis in Subjects Undergoing VascularSurgery(Clinical Trials)Stenting and Angioplasty with Protection in Patients atHigh-Risk for Endarterectomy(Clinical Trials)Positive Impact of Endovascular Options for Treating AneurysmsEarly (PIVOTAL)(Clinical Trials)Christopher Skelly, MDCTSA K12 Scholar Award(Federal)Prevention of Arterial Restenosis Utilizing a Neurovirulence-Attenuated Herpes Simplex Virus(Non-federal)Prevention of Arterial Restenosis Utilizing a HSV-1Eluting Stent(Non-federal)Resident/Fellow Name PGY Year Position After Leaving UC ProgramDentistry, Oral AND MaxillofacialResident Nelson Lo 1GENERAL SURGERYResident Rebecca Gibbons 1Resident Jeffrey Katz 1Resident Megan Miller 1Resident Melissa Ruiz 1Resident Jordan Stern 1Resident Marie Ziesat 1Resident Gina Degiovanni 1 PreliminaryResident Christopher Holbrook 1 PreliminaryResident Frank Primus 1 PreliminaryResident Erica Carlisle 2Resident Michelle Cowan 2Resident Andrea Olivas 2Resident Richelle Williams 2Resident Emily Ahmed 2rResident Eric Grossman 2rResident Samuel Kingsley 2rResident Amy Lehman 2rResident Kathleen Romanowski 2rResident Brian Bello 3Resident Vidas Dumasius 3Resident Christopher Kenney 3Resident Jason Long 3Resident Alizah Rotramel 3Resident John Seal 3Resident Trissa Babrowski 3rResident Lisa Spiguel 3rResident Jennifer Holder-Murray 4Resident John Hyngstrom 4Resident Gabriel Loor 4Resident Michael Shao 4Resident Cindy Wu 4Resident Kai Bickenbach 5Resident Mukta Katdare 5Resident Melissa Kirkwood 5Resident Trevor Reichman 5Resident Jula Veerapong 5Resident Tina Jenq 2008 Graduate Plastic Surgery Fellowship, Oregon Health & ScienceUniversity, Portland, ORResident James Mezhir 2008 Graduate Surgical Oncology Fellowship, Memorial Sloan-KetteringCancer Center, NYResident Adam M. Vogel 2008 Graduate Pediatric Surgery Fellowship, University of Texas, HoustonResident Amer Zureikat 2008 Graduate Surgical Oncology Fellowship, University of Pittsburgh, PANEUROSURGERYResident Mahua Dey 1Resident Ricky Wong 1Resident Nassir Mansour 1Resident Nabil Salib 2Resident Sherise Ferguson 3Resident Ippei Takagi 3Resident Joseph Hsieh 4Resident David Rosen 5Resident Michael Turner 5Resident Reza Yassari 6Resident Julian Mattiello 2008 GraduateOphthalmology AND Visual ScienceResident Mojica Giocondo 2Resident Rominder Momi 2Resident Ajay Singh 237ANNUAL REPORT 2008

CURRENT RESIDENTS, FELLOWS AND GRADUATESResident/Fellow Name PGY Year Position After Leaving UC ProgramResident/Fellow Name PGY Year Position After Leaving UC Program38UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYOphthalmology AND Visual Science (CONT)Resident Megan Collins 3Resident Anna Gabrielian 3Resident Geeta Belsare 4Resident Daniel Kiernan 4Resident Shuchi Patel 4Fellow Veeral Sheth 5Fellow Theodore Lin 6Resident Terry Alexandrou 2008 Graduate Private practice, ILResident Joann Chang 2008 Graduate Cornea & External Disease Fellowship,Moran Eye Center, UTResident Anthony Mazzulla 2008 Graduate Vitreo-Retinal Surgery Fellowship,Ochsner Clinic Foundation, LAFellow Richard Lin 2008 Graduate Palo Alto Veterans Administration Hospital,Stanford University, CAOrthopaedic Surgery and Rehabilitation MedicineResident Kashif Ali 1Resident James Cameron 1Resident Michael Chioffe 1Resident Jay Deimel 1Resident Reginald Alexander 2Resident Kyle Hazelwood 2Resident Thomas O’Hagan 2Resident Noah Shaftel 2Resident Michael Angeline 3Resident Waqas Hussain 3Resident Andre Ribeiro do Valle Spiguel 3Resident Robert Steffner 3Resident Balach Tessa 4Resident Fleck Erin 4Resident Rice Jaime 4Resident Atanda Alfred 5Resident Beal Matthew 5Resident Dairyko Gregory 5Resident Hussain Suleman 5Fellow Samer Attar 6Fellow Luis Carrilero 6Fellow Frank Corrigan 6Fellow Joshua Snyder 6Resident Samuel Coy 2008 Graduate Sports Medicine Fellowship,Steadman Hawkins Clinic, SCResident Justin Gent 2008 Graduate Sports Medicine Fellowship,San Diego Medical Center, CAResident Kirstina Olson 2008 Graduate Foot & Ankle Fellowship,Carolinas Medical Center, NCResident Andrew Trueblood 2008 Graduate Hand Fellowship, University of Cincinnati, OHFellow Raffi Avedian 2008 Graduate Assistant Professor, Stanford University, CAFellow Ruth Baer 2008 Graduate Everett Clinic, WAFellow Jonathan Shook 2008 GraduateFellow Michael Slimack 2008 Graduate Comprehensive Orthopaedics, WIOtolaryngology-Head AND Neck SurgeryResident Christian Soneru 1Resident Victoria Varga 1Resident Andrea Nath 2Resident Jonathan Sherman 2Resident David Brown 3Resident Chaaban Mohamad 3Resident William Johnson 4Resident Alexander Langerman 4Resident Mihir Bhayani 5Otolaryngology-Head AND Neck Surgery (CONT)Resident Janaki Emani 5Resident Mandana Namiranian 5Resident David Andrews 2008 Graduate Alaska Native Medical CenterPediatric SurgeryFellow Erika Newman 6Fellow Grace Mak 7Plastic SurgeryResident Jonathan Bank 1Resident Grant Kleiber 1Resident Matthew Greives 2Resident Trang Nguyen 2Resident Sara Dickie 3Resident Justine Lee 3Resident Aaron Pelletier 4Resident Michelle Roughton 4Resident Daniel Kwan 5Resident Iris Seitz 5Resident Amir Dorafshar 6Resident Eric Odessey 6Resident Michael DeWolfe 2008 Graduate Microsurgery Fellowship, University of ChicagoResident Charles Tseng 2008 Graduate Microsurgery Fellowship, University of California, Los AngelesSurgical OncologyFellow Emily Bellavance 6Fellow Galka Eva 7Fellow Sharman Rohit 8Fellow Paul Roach 2008 Graduate Military commitment, VATransplantFellow Bejon Maneckshana 6Fellow Inbo Shim 7Fellow Tiffany Anthony 2008 Graduate Methodist Hospital, TXUrologyResident Charles Chang 1Resident Olufenwa Famakinwa 1Resident Kyle Kiriluk 2Resident Alexandre Rosen 2Resident Gautam Jayram 3Resident Marcelo Orvieto 3Resident Michael Large 4Resident Mark Wille 4Resident Sujeet Acharya 5Resident Aimee Wiltz 5Resident Lambda Msezane 6Resident William Reynolds 6Fellow Tom Deklaj 7Fellow David Lifshitz 7Fellow Mark Katz 8Resident Edward Gong 2008 Graduate Pediatric Urology Fellowship,Boston Children’s HospitalResident Alvaro Lucioni 2008 Graduate Female Urology & Reconstructive Fellowship,Virginia Mason ClinicFellow Andrew Bernstein 2008 Graduate Private practice, NJFellow Michael Eng 2008 Graduate Transplant Fellowship, St. Vincent Medical Center,Los Angeles, CAVascular Surgery AND ENDOVASCULAR THERAPYFellow Timothy Wu 6Fellow John Carson 7Fellow Jateen Prema 2008 Graduate Kaiser Permanente, CA39ANNUAL REPORT 2008

PUBLICATIONS 2007–200840UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYCARDIAC AND THORACIC SURGERYShahab Akhter, MDPandalai PK, McLean KM, Bulcao CF, Duffy JY, D’Souza KM,Merrill WH, Pearl JM, Akhter SA. Acute beta-blockade preventsmyocardial beta-adrenergic receptor desensitization and preservesearly ventricular function after brain death. J Thorac CardiovascSurg 2008; 135(4):792–8D’Souza KM, Petrashevskaya NN, Merrill WH, Akhter SA.Inhibition of protein kinase C alpha improves myocardial betaadrenergicreceptor signaling and ventricular function in amodel of myocardial preservation. J Thorac Cardiovasc Surg2008; 135(1):172–9, 179.e1Mark Ferguson, MDCallender G, Ferguson MK. Paraesophageal hiatal hernia: optimalsurgical approach In: Ferguson MK, eds. Difficult Decisions inThoracic Surgery—An Evidence-Based Approach. London:Springer; 2007:343–349Spiguel L, Ferguson MK. Pneumonectomy or sleeve resectionfor management of lung cancer In: Ferguson MK, eds. DifficultDecisions in Thoracic Surgery—An Evidence-Based Approach.London: Springer; 2007:103–109Russell H, Ferguson MK. Management of N2 disease discoveredat thoracotomy for lung cancer resection In: Ferguson MK, eds.Difficult Decisions in Thoracic Surgery—An Evidence-BasedApproach. London: Springer; 2007:75–81Ferguson MK. Antireflux procedures. In: Kaiser, Kron, Spray,eds. Mastery of Cardiothoracic Surgery. Philadelphia: LippincottWilliams and Wilkins; 2007:121–130Ferguson MK. Thoracic Surgery Atlas. First ed. Philadelphia:Saunders; 2007.Ferguson MK, eds. Difficult Decisions in Thoracic Surgery:An Evidence-Based Approach 1st ed. London: Springer; 2007.Ferguson MK. Invited commentary. Ann Thorac Surg 2007;84(3):981Ferguson MK. The rationale for developing scoring systems forclinical practice. Thorac Surg Clin 2007; 17(3):343–51Konda VJ, Ross AS, Ferguson MK, Hart JA, Lin S, Naylor K,Noffsinger A, Posner MC, Dye C, Cislo B, Stearns L, Waxman I.Is the Risk of Concomitant Invasive Esophageal Cancer inHigh-Grade Dysplasia in Barrett’s Esophagus Overestimated?Clin Gastroenterol Hepatol 2007Jagadeeswaran R, Surawska H, Krishnaswamy S, et al. Paxillinis a target for somatic mutations in lung cancer: implications forcell growth and invasion. Cancer Res 2008; 68(1):132–42Choong NW, Vokes EE, Haraf DJ, Tothy PK, Ferguson MK,Kasza K, Rudin CM, Hoffman PC, Krauss SA, Szeto L, Mauer AM.Phase I study of induction chemotherapy and concomitantchemoradiotherapy with irinotecan, carboplatin, and paclitaxelfor stage III non-small cell lung cancer. J Thorac Oncol 2008;3(1):59–67Ferguson MK, Vigneswaran WT. Changes in patient presentationand outcomes for major lung resection over three decades. Eur JCardiothorac Surg 2008Ferguson MK, Vigneswaran WT. Diffusing capacity predictsmorbidity after lung resection in patients without obstructive lungdisease. Ann Thorac Surg 2008; 85(4):1158–65Ferguson MK, Lehman AG, Bolliger CT, Brunelli A. The roleof diffusing capacity and exercise tests. Thorac Surg Clin 2008;18(1):9–17Brunelli A, Ferguson MK, Rocco G, Pieretti P, Vigneswaran WT,Morgan-Hughes NJ, Zanello M, Salati M. A scoring systempredicting the risk for intensive care unit admission for complicationsafter major lung resection: a multicenter analysis. Ann ThoracSurg 2008; 86(1):213–8Mahesh Gupta, PhDGupta M, Sueblinvong V, Gupta MP. The single-strand DNA/RNA-binding protein, Purbeta, regulates serum response factor(SRF)-mediated cardiac muscle gene expression. Can J PhysiolPharmacol 2007; 85(3–4):349–59Paroni G, Fontanini A, Cernotta N, Foti C, Gupta MP, Yang XJ,Fasino D, Brancolini C. Dephosphorylation and Caspase ProcessingGenerate Distinct Nuclear Pools of Histone Deacetylase 4. MolCell Biol 2007Gupta MP. Factors controlling cardiac myosin-isoform shift duringhypertrophy and heart failure. J Mol Cell Cardiol 2007Pillai JB, Chen M, Rajamohan SB, Samant S, Pillai VB, Gupta M,Gupta MP. Activation of SIRT1, a class III histone deacetylase,contributes to fructose feeding mediated induction of the {alpha}-myosin heavy chain expression. Am J Physiol Heart Circ Physiol2008Gupta MP, Samant S, Smith SH, Shroff SG. HDAC4 and PCAFbind to cardiac sarcomeres and play a role in regulating themyofilament contractile activity. J Biol Chem 2008Valluvan Jeevanandam, MDAgarwal R, Jeevanandam V, Jolly N. Surgical treatment of a giantcoronary artery aneurysm: a modified approach. Ann Thorac Surg2007; 84(4):1392–4Bolotin G, Raman J, Williams U, Bacha E, Kocherginsky M,Jeevanandam V. Glutamine improves myocardial function followingischemia-reperfusion injury. Asian Cardiovasc Thorac Ann 2007;15(6):463–7Minhaj M, Patel K, Muzic D, Tung A, Jeevanandam V, Raman J,Chaney MA. The effect of routine intraoperative transesophagealechocardiography on surgical management. J Cardiothorac VascAnesth 2007; 21(6):800–4Bolotin G, Buckner GD, Campbell NB, Kocherginsky M, Raman J,Jeevanandam V, Maessen JG. Tissue-disruptive forces during mediansternotomy. Heart Surg Forum 2007; 10(6):487–92Jeevanandam V. Invited commentary. Ann Thorac Surg 2008;85(4):1354Te HS, Anderson AS, Millis JM, Jeevanandam V, Jensen DM. Currentstate of combined heart-liver transplantation in the United States. JHeart Lung Transplant 2008; 27(7):753–9Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J,Jeevanandam V, Kasza KE, Connor MF, Konczal DJ, Trevino S,Devarajan P, Murray PT. Urinary cystatin C as an early biomarkerof acute kidney injury following adult cardiothoracic surgery.Kidney Int 2008Sugeng L, Shernan SK, Salgo IS, Weinert L, Shook D, Raman J,Jeevanandam V, Dupont F, Settlemier S, Savord B, Fox J, Mor-Avi V,Lang RM. Live 3-dimensional transesophageal echocardiographyinitial experience using the fully-sampled matrix array probe.J Am Coll Cardiol 2008; 52(6):446–9Bassem Mora, MD, MBADiab KA, Cao QL, Mora BN, Hijazi ZM. Device closure ofmuscular ventricular septal defects in infants less than one yearof age using the Amplatzer devices: feasibility and outcome.Catheter Cardiovasc Interv 2007; 70(1):90–7Jaishankar Raman, MD, PhDJolly N, Garg RK, Raman J. Spontaneous resolution of a kink inan internal mammary artery bypass graft. Ann Thorac Surg 2007;84(2):676Raman J, Straus D, Song DH. Rigid plate fixation of the sternum.Ann Thorac Surg 2007; 84(3):1056–8Jolly N, Garg RK, Raman J, Hijazi ZM. Amplatzer(R) septaloccluder device for closure of aortic pseudoaneurysms. CatheterCardiovasc Interv 2007; 70(4):619–620Shah DP, Min JK, Raman J, Lodato JA, Van Kley D, Lang RM,Ward RP. Thrombus-in-transit: two cases and a review of diagnosisand management. J Am Soc Echocardiogr 2007; 1219(10):6–8Sudhir Srivastava, MDSrivastava S. Move over proteomics, here comes glycomics.J Proteome Res 2008; 7(5):1799Seurynck-Servoss SL, Baird CL, Miller KD, Pefaur NB, GonzalezRM, Apiyo DO, Engelmann HE, Srivastava S, Kagan J, RodlandKD, Zangar RC. Immobilization strategies for single-chainantibody microarrays. Proteomics 2008; 8(11):2199–2210Wickii Vigneswaran, MDVigneswaran WT, Bhorade S, Wolfe M, Pelletiere K, Garrity ER.Clinical pathway after lung transplantation shortens hospital lengthof stay without affecting outcome. Int Surg 2007; 92(2):93–8Ferguson MK, Vigneswaran WT. Diffusing capacity predictsmorbidity after lung resection in patients without obstructive lungdisease. Ann Thorac Surg 2008; 85(4):1158–64; discussion 1164–5Ferguson MK, Vigneswaran WT. Changes in patient presentationand outcomes for major lung resection over three decades.Eur J Cardiothorac Surg 2008; 33(3):497–501Jagadeeswaran R, Surawska H, Krishnaswamy S, et al. Paxillin isa target for somatic mutations in lung cancer: implications for cellgrowth and invasion. Cancer Res 2008; 68(1):132–42Brunelli A, Ferguson MK, Rocco G, Pieretti P, Vigneswaran WT,Morgan-Hughes NJ, Zanello M, Salati M. A scoring systempredicting the risk for intensive care unit admission for complicationsafter major lung resection: a multicenter analysis. Ann ThoracSurg 2008; 86(1):213–8DENTISTRY (OHNS)Russell Baer, DDSToljanic JA, Thor A, Baer R, Ekstrand K. Immediate fixedrestoration of implants in the atrophic edentulous maxilla. DentToday 2008; 27(6):56, 58, 60 passim; quiz 63Christopher Smith, DDSKhatami AH, Smith CR. “All-on-Four” immediate functionconcept and clinical report of treatment of an edentulous mandiblewith a fixed complete denture and milled titanium framework.J Prosthodont 2008; 17(1):47–51Joseph Toljanic, DDSFinne K, Rompen E, Toljanic J. Clinical evaluation of a prospectivemulticenter study on 1–piece implants. part 1: marginal bone levelevaluation after 1 year of follow-up. Int J Oral Maxillofac Implants2007; 22(2):226–34Toljanic JA, Thor A, Baer R, Ekstrand K. Immediate fixedrestoration of implants in the atrophic edentulous maxilla. DentToday 2008; 27(6):56, 58, 60 passim; quiz 63GENERAL SURGERYJohn Alverdy, MDMunoz DJ, Chen E, Fischer S, Roehrig M, Sanchez-Johnson L,Alverdy J, Dymek-Valentine M, le Grange D. Considerations for theuse of the Beck Depression Inventory in the assessment of weightlosssurgery seeking patients. Obes Surg 2007; 17(8):1097–101Alverdy JC. The re-emerging role of the intestinal microflora incritical illness and inflammation: why the gut hypothesis of sepsissyndrome will not go away. J Leukoc Biol 2007Munoz DJ, Lal M, Chen EY, Mansour M, Fischer S, Roehrig M,Sanchez-Johnsen L, Dymek-Valenitine M, Alverdy J, le Grange D.Why patients seek bariatric surgery: a qualitative and quantitativeanalysis of patient motivation. Obes Surg 2007; 17(11):1487–91Mitchell MT, Gasparaitis AE, Alverdy JC. Imaging findings inRoux-en-O and other misconstructions: rare but serious complicationsof Roux-en-Y gastric bypass surgery. AJR Am J Roentgenol2008; 190(2):367–73Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I,Fernandez H, Wang Y, Turner JR, Alverdy JC. Structure-FunctionAspects of PstS in Multi-Drug-Resistant Pseudomonas aeruginosa.PLoS Pathog 2008; 4(2):e4341ANNUAL REPORT 2008

PUBLICATIONS 2007–200842UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYMunoz DJ, Lal M, Chen EY, Mansour M, Fischer S, Roehrig M,Sanchez-Johnsen L, Dymek-Valenitine M, Alverdy J, le Grange D.Why Patients Seek Bariatric Surgery: A Qualitative and QuantitativeAnalysis of Patient Motivation. Obes Surg 2008Hickson J, Diane Yamada S, Berger J, Alverdy J, O’Keefe J, BasslerB, Rinker-Schaeffer C. Societal interactions in ovarian cancermetastasis: a quorum-sensing hypothesis. Clin Exp Metastasis 2008Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J. Depletionof intestinal phosphate after operative injury activates the virulenceof P aeruginosa causing lethal gut-derived sepsis. Surgery 2008;144(2):189–97Peter Angelos, MD, PhDSherman SI, Angelos P, Ball DW, et al. Thyroid carcinoma. J NatlCompr Canc Netw 2007; 5(6):568–621Terris DJ, Angelos P, Steward DL, Simental AA. Minimally invasivevideo-assisted thyroidectomy: a multi-institutional North Americanexperience. Arch Otolaryngol Head Neck Surg 2008; 134(1):81–4Vercler CJ, Angelos P. Communicating errors. Cancer Treat Res2008; 140:195–213Angelos P, Kapadia MR. Physicians and cancer patients: communicationand advance directives. Cancer Treat Res 2008; 140:13–28Ujiki M, Sturgeon C, Nayar R, Angelos P. Reply. World J Surg 2008Biffl WL, Spain DA, Reitsma AM, Minter RM, Upperman J, WilsonM, Adams R, Goldman EB, Angelos P, Krummel T, Greenfield LJ.Responsible development and application of surgical innovations:a position statement of the Society of University Surgeons. J AmColl Surg 2008; 206(6):1204–9Angelos P, Kodner I. Changing the diagnosis with retrospectivereview: a consideration of ethical issues. Surgery 2008; 144(1):99–100McGill J, Sturgeon C, Kaplan SP, Chiu B, Kaplan EL, Angelos P.How does the operative strategy for primary hyperparathyroidismimpact the findings and cure rate? A comparison of 800 parathyroidectomies.J Am Coll Surg 2008; 207(2):246–9Eugene Choi, MDChoi EA, Abdalla EK. Patient selection and outcome of hepatectomyfor noncolorectal non-neuroendocrine liver metastases.Surg Oncol Clin N Am 2007; 16(3):557–77Choi EA, Feig BW. Surgical resection in metastatic gastrointestinalstromal tumors. Curr Oncol Rep 2007; 9(4):303–8Mark Connolly, MDPodbielski FJ, Rodriguez HE, Zhu RY, Worley TA, FontaineJP, Connolly MM. Aortoesophageal fistula secondary to refluxesophagitis. Dig Surg 2007; 24(1):66–7Alessandro Fichera, MDMichelassi F, Katdare MV, Fichera A, Hurst RD. Surgical treatmentof Crohn’s disease. In: Fisher JE, Bland KI, eds. Mastery of Surgery.5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams &Wilkins; 2007Saha S, Fichera A, Bales G, Greenberg E, Kane S. Metastatic Crohn’sdisease of the bladder. Inflamm Bowel Dis 2007Aycock J, Fichera A, Colwell JC, Song DH. Parastomal HerniaRepair With Acellular Dermal Matrix. J Wound Ostomy ContinenceNurs 2007; 34(5):521–523Fichera A, Ragauskaite L, Silvestri MT, Elisseou NM, Rubin MA,Hurst RD, Michelassi F. Preservation of the Anal Transition Zone inUlcerative Colitis. Long-Term Effects on Defecatory Function.J Gastrointest Surg 2007Park SM, Rajapaksha TW, Zhang M, Sattar HA, Fichera A,Ashton-Rickardt PG, Peter ME. CD95 signaling deficient micewith a wild-type hematopoietic system are prone to hepaticneoplasia. Apoptosis 2007Fichera A, Peng SL, Elisseou NM, Rubin MA, Hurst RD. Laparoscopyor conventional open surgery for patients with ileocolonicCrohn’s disease? A prospective study. Surgery 2007; 142(4):566–71Beretta E, Boghi I, Fichera A, Mor E, Gregorini S, Frusca T. Twinpregnancy: not only a medical event. Minerva Ginecol 2007;59(6):571–8Dougherty U, Sehdev A, Cerda S, Mustafi R, Little N, Yuan W,Jagadeeswaran S, Chumsangsri A, Delgado J, Tretiakova M, JosephL, Hart J, Cohen EE, Aluri L, Fichera A, Bissonnette M. Epidermalgrowth factor receptor controls flat dysplastic aberrant crypt focidevelopment and colon cancer progression in the rat azoxymethanemodel. Clin Cancer Res 2008; 14(8):2253–62Khare S, Mustafi R, Cerda S, Yuan W, Jagadeeswaran S, DoughertyU, Tretiakova M, Samarel A, Cohen G, Wang J, Moore C, Wali R,Holgren C, Joseph L, Fichera A, Li YC, Bissonnette M. UrsodeoxycholicAcid Suppresses Cox-2 Expression in Colon Cancer: Rolesof Ras, p38, and CCAAT/Enhancer-Binding Protein. Nutr Cancer2008; 60(3):389–400Delgado JS, Mustafi R, Yee J, Cerda S, Chumsangsri A, DoughertyU, Lichtenstein L, Fichera A, Bissonnette M. Sorafenib TriggersAntiproliferative and Pro-Apoptotic Signals in Human EsophagealAdenocarcinoma Cells. Dig Dis Sci 2008Jose Guevara-Patiño, MD, PhDEngelhorn ME, Guevara-Patiño JA, Merghoub T, Liu C, FerroneCR, Rizzuto GA, Cymerman DH, Posnett DN, Houghton AN,Wolchok JD. Mechanisms of Immunization Against Cancer UsingChimeric Antigens. Mol Ther 2008Denman CJ, McCracken J, Hariharan V, Klarquist J, Oyarbide-Valencia K, Guevara-Patiño JA, Caroline Le Poole I. HSP70iAccelerates Depigmentation in a Mouse Model of AutoimmuneVitiligo. J Invest Dermatol 2008Roger Hurst, MDFichera A, Peng SL, Elisseou NM, Rubin MA, Hurst RD. Laparoscopyor conventional open surgery for patients with ileocolonicCrohn’s disease? A prospective study. Surgery 2007; 142(4):566–71Fichera A, Ragauskaite L, Silvestri MT, Elisseou NM, Rubin MA,Hurst RD, Michelassi F. Preservation of the anal transition zonein ulcerative colitis. Long-term effects on defecatory function. JGastrointest Surg 2007; 11(12):1647–53Edwin Kaplan, MDMezhir JJ, Melis M, Headley RC, Pai RK, Posner MC, KaplanEL. Successful palliation of hypercalcemia secondary to metastaticparathyroid cancer: an unusual indication for hepatic resection.J Hepatobiliary Pancreat Surg 2007; 14(4):410–3McGill J, Sturgeon C, Kaplan SP, Chiu B, Kaplan EL, Angelos P.How does the operative strategy for primary hyperparathyroidismimpact the findings and cure rate? A comparison of 800 parathyroidectomies.J Am Coll Surg 2008; 207(2):246–9Jeffrey B. Matthews, MDWray CJ, Lowy AM, Matthews JB, James LE, Mammen JM, ChoeKA, Hanto DW, Ahmad SA. Intraoperative margin re-resection forcolorectal liver metastases. J Surg Educ 2007; 64(3):150–7Matthews JB. Postoperative Outcomes in Patients With HepatocellularCarcinomas Resected With Exposure of the Tumor Surface—Invited Critique. Archives of Surgery 2007; 142(7):603Nair RR, Lowy AM, McIntyre B, Sussman JJ, Matthews JB, AhmadSA. Fistulojejunostomy for the management of refractory pancreaticfistula. Surgery 2007; 142(4):636–42Worrell RT, Merk L, Matthews JB. Ammonium transport in thecolonic crypt cell line, T84: Role for Rhesus Glycoproteins andNKCC1. Am J Physiol Gastrointest Liver Physiol 2007Matthews JB. The Revolution Will be Televised. J GastrointestSurg 2008Herreros de Tejada A, Chennat J, Miller F, Stricker T, Matthews JB,Waxman I. Endoscopic and EUS features of groove pancreatitismasquerading as a pancreatic neoplasm. Gastrointest Endosc 2008Mark McKee, MDMcKee MD. Pancreaticobiliary reflux and gallbladder cancer.J Surg Oncol 2007; 96(6):455–6McKee MD, Fichera A, Nishimura MI. T cell immunotherapy.Front Biosci 2007; 12:919–32Zureikat AH, McKee MD. Targeted therapy for solid tumors:current status. Surg Oncol Clin N Am 2008; 17(2):279–301Marco Patti, MDSweet MP, Nipomnick I, Gasper WJ, Bagatelos K, Ostroff JW,Fisichella PM, Way LW, Patti MG. The outcome of laparoscopicHeller myotomy for achalasia is not influenced by the degree ofesophageal dilatation. J Gastrointest Surg 2008; 12(1):159–65Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, HaysSR, Golden JA, Patti MG. Antireflux surgery for patients withend-stage lung disease before and after lung transplantation.Surg Endosc 2008; 22(2):495–500Meneghetti AT, Tedesco P, Galvani C, Gorodner MV, Patti MG.Outcomes after laparoscopic Nissen fundoplication are not influencedby the pattern of reflux. Dis Esophagus 2008; 21(2):165–9Raz DJ, Tedesco P, Herbella FA, Nipomnick I, Way LW, Patti MG.Side-to-side stapled intra-thoracic esophagogastric anastomosisreduces the incidence of leaks and stenosis. Dis Esophagus 2008;21(1):69–72Patti MG, Fisichella PM. Laparoscopic heller myotomy and dorfundoplication for esophageal achalasia. How I do it. J GastrointestSurg 2008; 12(4):764–6Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE,Kleinhenz ME, Hays SR, Patti MG. Lung transplantation inpatients with connective tissue disorders and esophageal dysmotility.Dis Esophagus 2008Fisichella PM, Raz D, Palazzo F, Niponmick I, Patti MG.Clinical, Radiological, and Manometric Profile in 145 Patientswith Untreated Achalasia. World J Surg 2008Palazzo F, Fisichella PM, Patti MG. Management of high-gradedysplasia. Curr Gastroenterol Rep 2008; 10(3):240–5Mitchell C. Posner, MDMezhir JJ, Melis M, Headley RC, Pai RK, Posner MC, KaplanEL. Successful palliation of hypercalcemia secondary to metastaticparathyroid cancer: an unusual indication for hepatic resection.J Hepatobiliary Pancreat Surg 2007; 14(4):410–3Veerapong J, Bickenbach KA, Shao MY, Smith KD, PosnerMC, Roizman B, Weichselbaum RR. Systemic Delivery of{gamma}134.5-Deleted Herpes Simplex Virus-1 Selectively Targetsand Treats Distant Human Xenograft Tumors That Express HighMEK Activity. Cancer Res 2007; 67(17):8301–6Smith KD, Shao MY, Posner MC, Weichselbaum RR. Tumorgenotype determines susceptibility to oncolytic herpes simplexvirus mutants: strategies for clinical application. Future Oncol 2007;3(5):545–556Posner MC. Brennan phenotype and its downstream expression.J Am Coll Surg 2007; 205(4 Suppl):S17–21Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE,Garofalo M, Nakamura S, Kufe DW, Posner MC, WeichselbaumRR. Diverse TNFalpha-induced death pathways are enhanced byinhibition of NF-kappaB. Int J Oncol 2007; 31(6):1519–28Posner MC, Niedzwiecki D, Venook AP, Hollis DR, Kindler HL,Martin EW, Schilsky RL, Goldberg RM. A Phase II ProspectiveMulti-institutional Trial of Adjuvant Active Specific ImmunotherapyFollowing Curative Resection of Colorectal Cancer HepaticMetastases: Cancer and Leukemia Group B Study 89903. Ann SurgOncol 2007Konda VJ, Ross AS, Ferguson MK, Hart JA, Lin S, Naylor K,Noffsinger A, Posner MC, Dye C, Cislo B, Stearns L, Waxman I.Is the Risk of Concomitant Invasive Esophageal Cancer in High-Grade Dysplasia in Barrett’s Esophagus Overestimated?Clin Gastroenterol Hepatol 2007Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC,Kron SJ, Weichselbaum RR. Resveratrol is an effective inducer ofCArG-driven TNF-alpha gene therapy. Cancer Gene Ther 200743ANNUAL REPORT 2008

PUBLICATIONS 2007–200844UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYVivek Prachand, MDPrachand V. Laparoscopic Duodenal Switch and Other Modalities.In: Soper NJ, Swanstrom LL, eds. Mastery of Endoscopic andLaparoscopic Surgery. 3rd ed. Philadelphia: Lippincott Williamsand Wilkins; 2007: in pressKeswani RN, Prachand VN, Te HS. Paraesophageal hernia: a rarepresentation of Marfan syndrome in adults. Gastrointest Endosc2007Alverdy JC, Prachand V. Patient Selection in Bariatric Surgery. In:Buchwald HC, Cowan G, Pories WJ, eds. Surgical Managementof Obesity. Philadelphia: Saunders Elsevier; 2007:471Jonathan Silverstein, MD, MSErberich SG, Silverstein JC, Chervenak A, Schuler R, Nelson MD,Kesselman C. Globus MEDICUS—Federation of DICOM MedicalImaging Devices into Healthcare Grids. Stud Health TechnolInform 2007; 126:269–78Silverstein JC, Walsh C, Dech F, Olson E, Papka ME, Parsad N,Stevens R. Immersive virtual anatomy course using a cluster ofvolume visualization machines and passive stereo. Stud HealthTechnol Inform 2007; 125:439–44Silverstein J, Selkov G, Salud L, Pugh C. Developing performancecriteria for the e-Pelvis simulator using visual analysis. Stud HealthTechnol Inform 2007; 125:436–8Wahl AO, Rademaker A, Kiel KD, Jones EL, Marks LB, Croog V,McCormick BM, Hirsch A, Karkar A, Motwani SB, Tereffe W, YuTK, Sher D, Silverstein J, Kachnic LA, Kesslering C, Freedman GM,Small W. Multi-Institutional Review of Repeat Irradiation of ChestWall and Breast for Recurrent Breast Cancer. Int J Radiat OncolBiol Phys 2007Silverstein JC, Walsh C, Dech F, Olson E, E M, Parsad N, StevensR. Multi-parallel open technology to enable collaborative volumevisualization: how to create global immersive virtual anatomyclassrooms. Stud Health Technol Inform 2008; 132:463–8Silverstein JC, Parsad NM, Tsirline V. Automatic perceptual colormap generation for realistic volume visualization. J Biomed Inform2008NEUROSURGERYDavid Frim, MD, PhDFerguson SD, Michael N, Frim DM. Observations regarding failureof cerebrospinal fluid shunts early after implantation. NeurosurgFocus 2007; 22(4):E7Kushen MC, Frim D. Placement of subdural electrode grids forseizure focus localization in patients with a large arachnoid cyst.Technical note. Neurosurg Focus 2007; 22(2):E5Williams MA, McAllister JP, Walker ML, Kranz DA, Bergsneider M,Del Bigio MR, Fleming L, Frim DM, Gwinn K, Kestle JR, LucianoMG, Madsen JR, Oster-Granite ML, Spinella G. Priorities forhydrocephalus research: report from a National Institutes ofHealth-sponsored workshop. J Neurosurg 2007; 107(5):345–357Sikorski CW, Iteld L, McKinnon M, Yamini B, Frim DM.Correction of sagittal craniosynostosis using a novel parietal bonefixation technique: results over a 10-year period. Pediatr Neurosurg2007; 43(1):19–24Bhayani MK, Maccracken E, Frim D, Baroody FM. Prolongedcricopharyngeal muscle spasm after resection of the cervical vagusnerve in a 15-year-old. Pediatr Neurosurg 2008; 44(1):71–4Foster KA, Frim DM, McKinnon M. Recurrence of synostosisfollowing surgical repair of craniosynostosis. Plast Reconstr Surg2008; 121(3):70e–76eTowle VL, Yoon HA, Castelle M, Edgar JC, Biassou NM, Frim DM,Spire JP, Kohrman MH. ECoG gamma activity during a languagetask: differentiating expressive and receptive speech areas. Brain2008Lacy M, Pyykkonen BA, Hunter SJ, Do T, Oliveira M, Austria E,Mottlow D, Larson E, Frim D. Intellectual Functioning in Childrenwith Early Shunted Posthemorrhagic Hydrocephalus. PediatrNeurosurg 2008; 44(5):376–381Maciej Lesniak, MDSonabend AM, Ulasov IV, Lesniak MS. Gene therapy trials forthe treatment of high-grade gliomas. Gene Ther Mol Biol 2007;11(A):79–92Ulasov IV, Zhu ZB, Tyler MA, Han Y, Rivera AA, Khramtsov A,Curiel DT, Lesniak MS. Survivin-Driven and Fiber-ModifiedOncolytic Adenovirus Exhibits Potent Antitumor Activity inEstablished Intracranial Glioma. Hum Gene Ther 2007Ulasov IV, Rivera AA, Han Y, Curiel DT, Zhu ZB, Lesniak MS.Targeting adenovirus to CD80 and CD86 receptors increases genetransfer efficiency to malignant glioma cells. J Neurosurg 2007;107(3):617–27Ulasov IV, Rivera AA, Nettelbeck DM, Rivera LB, Mathis JM,Sonabend AM, Tyler M, Wang M, Douglas JT, Lesniak MS. Anoncolytic adenoviral vector carrying the tyrosinase promoter forglioma gene therapy. Int J Oncol 2007; 31(5):1177–85Kushen MC, Sonabend AM, Lesniak MS. Current immunotherapeuticstrategies for central nervous system tumors. Surg OncolClin N Am 2007; 16(4):987–1004Paul CP, Everts M, Dent P, Fisher PB, Ulasov IV, Lesniak MS,Stoff-Khalili MA, Roth JC, Glasgow JN, Preuss MA, Dirven CM,Lamfers ML, Siegal GP, Zhu ZB, Curiel DT. Characterization ofInfectivity of Knob-Modified Adenoviral Vectors in Glioma.Cancer Biol Ther 2007; 7(3)Sonabend AM, Ulasov IV, Lesniak MS. Emerging role of new transgenicmouse models in glioma research. Expert Rev AnticancerTher 2007; 7(12 Suppl):S7–13Sonabend AM, Dana K, Lesniak MS. Targeting epidermal growthfactor receptor variant III: a novel strategy for the therapy ofmalignant glioma. Expert Rev Anticancer Ther 2007; 7(12Suppl):S45–50Lesniak MS. Advances in neuro-oncology: novel therapies andclinical trials. Expert Rev Anticancer Ther 2007; 7(12 Suppl):S1Sonabend AM, Velicu S, Ulasov IV, Han Y, Tyler B, Brem H,Matar MM, Fewell JG, Anwer K, Lesniak MS. A safety and efficacystudy of local delivery of interleukin 12 transgene by PPC polymerin a model of experimental glioma. Anticancer Drugs 2008;19(2):133–42Sonabend AM, Ulasov IV, Tyler MA, Rivera AA, Mathis JM, LesniakMS. Mesenchymal Stem Cells Effectively Deliver an OncolyticAdenovirus to Intracranial Glioma. Stem Cells 2008Andaloussi AE, Han Y, Lesniak MS. Progression of intracranialglioma disrupts thymic homeostasis and induces T-cell apoptosis invivo. Cancer Immunol Immunother 2008Tyler MA, Sonabend AM, Ulasov IV, Lesniak MS. Vector therapiesfor malignant glioma: shifting the clinical paradigm. Expert OpinDrug Deliv 2008; 5(4):445–58Sonabend AM, Rolle CE, Lesniak MS. The role of regulatory Tcells in malignant glioma. Anticancer Res 2008; 28(2B):1143–50Gui M, Peng H, Carew JD, Lesniak MS, Arfanakis K. A tractographycomparison between turboprop and spin-echo echo-planardiffusion tensor imaging. Neuroimage 2008Nandi S, Ulasov IV, Tyler MA, Sugihara AQ, Molinero L, HanY, Zhu ZB, Lesniak MS. Low-dose radiation enhances survivinmediatedvirotherapy against malignant glioma stem cells. CancerRes 2008; 68(14):5778–84Ulasov IV, Tyler MA, Rivera AA, Nettlebeck DM, Douglas JT,Lesniak MS. Evaluation of E1A double mutant oncolytic adenovectorsin anti-glioma gene therapy. J Med Virol 2008; 80(9):1595–603Richard Penn, MDLinninger AA, Somayaji MR, Erickson T, Guo X, Penn RD.Computational methods for predicting drug transport inanisotropic and heterogeneous brain tissue. J Biomech 2008Bakhtiar Yamini, MDSikorski CW, Iteld L, McKinnon M, Yamini B, Frim DM. Correctionof sagittal craniosynostosis using a novel parietal bone fixationtechnique: results over a 10-year period. Pediatr Neurosurg 2007;43(1):19–24Yamini B, Yu X, Dolan ME, Wu MH, Kufe DW, Weichselbaum RR.Inhibition of Nuclear Factor-{kappa}B Activity by TemozolomideInvolves O6-Methylguanine Induced Inhibition of p65 DNABinding. Cancer Res 2007; 67(14):6889–6898Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J,Bickenbach K, Weichselbaum RR. Adenovirally Delivered TumorNecrosis Factor-{alpha} Improves the Antiglioma Efficacy ofConcomitant Radiation and Temozolomide Therapy. Clin CancerRes 2007; 13(20):6217–23Ferguson SD, Foster K, Yamini B. Convection-enhanced deliveryfor treatment of brain tumors. Expert Rev Anticancer Ther 2007;7(12 Suppl):S79–85Rosen DS, Shafizadeh S, Baroody FM, Yamini B. Epidural abscesstreated with a medial supraorbital craniotomy through an incisionin the eyebrow. Case report. J Neurosurg Pediatrics 2008; 1(2):145–7OPHTHALMOLOGY AND VISUAL SCIENCEMichael Grassi, MDBenevento JD, Jager RD, Noble AG, Latkany P, Mieler WF, SautterM, Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C,McLeod R. Toxoplasmosis-associated neovascular lesions treatedsuccessfully with ranibizumab and antiparasitic therapy. ArchOphthalmol 2008; 126(8):1152–6Mark Greenwald, MDArun V, Noble AG, Latkany P, Troia RN, Jalbrzikowski J, Kasza K,Karrison T, Cezar S, Sautter M, Greenwald MJ, Mieler W, Mets MB,Alam A, Boyer K, Swisher CN, Roizen N, Rabiah P, Del MonteMA, McLeod R. Cataracts in congenital toxoplasmosis. J AAPOS2007; 11(6):551–4Zage PE, Reitman AJ, Seshadri R, Weinstein JL, Mets MB, Zeid JL,Greenwald MJ, Strauss LC, Goldman S. Outcomes of a two-drugchemotherapy regimen for intraocular retinoblastoma. PediatrBlood Cancer 2008; 50(3):567–72Seenu Hariprasad, MDHariprasad SM, Callanan D, Gainey S, He YG, Warren K. Cystoidand diabetic macular edema treated with nepafenac 0.1%. J OculPharmacol Ther 2007; 23(6):585–90Hariprasad SM, Mieler WF, Lin TK, Sponsel WE, Graybill JR.Voriconazole in the treatment of fungal eye infections: a reviewof current literature. Br J Ophthalmol 2008; 92(7):871–8Mojica G, Hariprasad SM, Jager RD, Mieler WF. Short-termintraocular pressure trends following intravitreal injections ofranibizumab (Lucentis) for the treatment of wet age-related maculardegeneration. Br J Ophthalmol 2008; 92(4):584Lin RC, Sanduja N, Hariprasad SM. Successful treatment of postoperativefungal endophthalmitis using intravitreal and intracameralvoriconazole. J Ocul Pharmacol Ther 2008; 24(2):245–8Vemulakonda GA, Hariprasad SM, Mieler WF, Prince RA, ShahGK, Van Gelder RN. Aqueous and vitreous concentrations followingtopical administration of 1% voriconazole in humans. ArchOphthalmol 2008; 126(1):18–22Hariprasad SM, Mieler WF, Grassi M, Green JL, Jager RD, MillerL. Vision-related quality of life in patients with diabetic macularoedema. Br J Ophthalmol 2008; 92(1):89–92Rama Jager, MD, MBAJager R, Mieler W, Miller J. Age-related Macular Degeneration.New England Journal of Medicine. 2008 Jun 12; 358(24):2606-17.Benevento J, Jager R, Noble A, Latkany P, Mieler WF, Sautter M,Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C,McLeod R; Toxoplasmosis Study Group.Toxoplasmosis-associatedneovascular lesions treated successfully with ranibizumab andantiparasitic therapy. Arch Ophthalmol. 2008 Aug; 126(8):1152-6.Mojica G, Hariprasad S, Jager R, Mieler W. Short-term intraocularpressure trends following intravitreal injections of ranibizumab(Lucentis) for the treatment of wet age-related macular degeneration.British Journal of Ophthalmology. 2008 Apr; 92(4):584.45ANNUAL REPORT 2008

PUBLICATIONS 2007–200846UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYHariprasad S, Mieler W, Grassi M, Green J, Jager R, Miller L.Vision-related quality of life in patients with diabetic macularoedema. British Journal of Ophthalmology. 2008 Jan; 92(1):89-92.Shukla D, Aiello L, Kolluru C, Baddela S, Jager R, Kim R. Relationof optical coherence tomography and unusual angiographicleakage patterns in central serous chorioretinopathy. Eye. 2008 Apr;22(4):592-6.Valerie Kattouff, MDBollinger KE, Kattouf V. Hypermetropia and Esotropia in MyotonicDystrophy JAAPOS 2008; 12(1):69–71Susan Ksiazek, MDKsiazek SM, Grover S, Mojica G, Fishman, G. Indocyanine GreenToxicity of the Retina Following Cataract Surgery: A Case ReportRetinal Cases & Bried Reports 2007Ksiazek SM. Ischemic Optic Neuropathy. In eds. Medlink Neurology;2007Marcus Marcet, MDvan Ginkel PR, Yang W, Marcet MM, Chow CC, Kulkarni AD,Darjatmoko S, Lindstrom MJ, Lokken J, Bhattacharya S, Albert DM.1 alpha-Hydroxyvitamin D2 inhibits growth of human neuroblastoma.J Neurooncol 2007; 85(3):255–62Rima McLeod, MDArun V, Noble AG, Latkany P, Troia RN, Jalbrzikowski J, Kasza K,Karrison T, Cezar S, Sautter M, Greenwald MJ, Mieler W, Mets MB,Alam A, Boyer K, Swisher CN, Roizen N, Rabiah P, Del MonteMA, McLeod R. Cataracts in congenital toxoplasmosis. J AAPOS2007; 11(6):551–4Welti R, Mui E, Sparks A, Wernimont S, Isaac G, Kirisits M,Roth M, Roberts CW, Botté C, Maréchal E, McLeod R.Lipidomic analysis of Toxoplasma gondii reveals unusual polarlipids. Biochemistry 2007; 46(48):13882–90Botté C, Saïdani N, Mondragon R, Mondragón M, Isaac G, Mui E,McLeod R, Dubremetz JF, Vial H, Welti R, Cesbron-Delauw MF,Mercier C, Maréchal E. Subcellular localization and dynamics of adigalactolipid-like epitope in Toxoplasma gondii. J Lipid Res 2008;49(4):746–62Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A,Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M, RoizenN, Cezar S, Remington J, Meier P, McLeod R. Longitudinal studyof new eye lesions in treated congenital toxoplasmosis. Ophthalmology2008; 115(3):553–559.e8Jamieson SE, de Roubaix LA, Cortina-Borja M, et al. Geneticand epigenetic factors at COL2A1 and ABCA4 influence clinicaloutcome in congenital toxoplasmosis. PLoS ONE 2008; 3(6):e2285Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, KirisitsM, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, QueenerSF, Liu SR, Jacobus DP, McLeod R. Novel Triazine JPC-2067-BInhibits Toxoplasma gondii In Vitro and In Vivo. PLoS Negl TropDis 2008; 2(3):e190Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, KuoA, Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M,Roizen N, Cezar S, Sautter M, Remington J, Meier P, McLeod R.Longitudinal Study of New Eye Lesions in Children withToxoplasmosis Who Were Not Treated During the First Year ofLife. Am J Ophthalmol 2008Benevento JD, Jager RD, Noble AG, Latkany P, Mieler WF, SautterM, Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C,McLeod R. Toxoplasmosis-associated neovascular lesions treatedsuccessfully with ranibizumab and antiparasitic therapy. ArchOphthalmol 2008; 126(8):1152–6Louise Sclafani, ODSclafani L. Contact Lens Fitting of Irregular Corneas ContactLens Specctrum 2007:33–40Sclafani L. Ask the Experts 38 Fascinating Questions My FamilyDoctor 2007:16Sclafani L. Recals Spin New Campaign for Contact Lens HygieneESCRS Eurotimes 2008; 13(4):48Sclafani L. New Options with Contact Lenses ESCRS Eurotimes2008; 13(3):32Sclafani L. Contact Lens for Allergy Season Primary CareOptometric News 2008ORTHOPAEDIC SURGERY AND REHABILITATIONMEDICINERobert Bielski, MDBielski RJ, Cunningham L, Horrigan JP, Londborg PD, Smith WT,Weiss K. Gepirone Extended-Release in the Treatment of AdultOutpatients With Major Depressive Disorder: A Double-Blind,Randomized, Placebo-Controlled, Parallel-Group Study. J ClinPsychiatry 2008:e1–e7Roderick Birnie, MDBirnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH,Berry PA, Hyde CF, Lewis JL, Stower MJ, Maitland NJ, CollinsAT. Gene expression profiling of human prostate cancer stem cellsreveals a pro-inflammatory phenotype and the importance ofextracellular matrix interactions. Genome Biol 2008; 9(5):R83Purnendu Gupta, MDDubois C, Bolt P, Gupta P, Wetzel F, Phillips F. Static versus dynamicplating for multilevel anterior cervical discectomy and fusion. SpineJ. 2007; 7(2):188–193Rex Haydon, MD, PhDLuo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, LuuHH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A protocolfor rapid generation of recombinant adenoviruses using the AdEasysystem. Nat Protoc 2007; 2(5):1236–47Lou J, Deng ZL, Lou X, Tang N, Song WX, Chen J, Shariff KA,Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A Protocolfor Rapid Generation of Recombinant Adenoviruses using theAdEasy System Nature Protocols 2007; 2(5):1236–1247Rosenfeld RM, Andes D, Bhattacharyya N, Cheung D, EisenbergS, Ganiats TG, Gelzer A, Hamilos D, Haydon RC, Hudgins PA,Jones S, Krouse HJ, Lee LH, Mahoney MC, Marple BF, Mitchell CJ,Nathan R, Shiffman RN, Smith TL, Witsell DL. Clinical practiceguideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137(3Suppl):S1–31Provencher MT, Bozic KJ, Haydon R, Lau JT, Vallier HA. AOA2005 John J. Fahey, MD, Memorial North American TravelingFellowship: Fellows’ Travel Diary. J Bone Joint Surg Am 2008;90(1):205–7Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J,Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH,Haydon RC, He TC. Regulation of osteogenic differentiationduring skeletal development. Front Biosci 2008; 13:2001–21Tang N, Song WX, Luo J, Haydon RC, He TC. OsteosarcomaDevelopment and Stem Cell Differentiation. Clin Orthop RelatRes 2008Wilson R, Bhuta T, Haydon R. Multiple simultaneous complicationsof acute otitis media in a child diagnosed with chronicgranulomatous disease: a case report. Ear Nose Throat J 2008;87(5):271–2, 279Tong-Chuan He, MD, PhDHaydon RC, Luu HH, He TC. Osteoblastic differentiationand osteosarcoma: a new perspective on oncogenesis. ClinicalOrthopaedics and Related Research 2007; 454:237–246Luo J, Chen J, Deng ZL, Luo X, Song WX, Sharff KA, Tang N,Haydon RC, Luu HH, He TC. Wnt signaling and human diseases:what are the therapeutic implications? Laboratory Investigation2007; 87:97–103Luu HH, Song WX, Luo X, Manning D, Luo J, Deng ZL, SharffKA, Montag AG, Haydon RC, He TC. The Distinct Roles ofBone Morphogenetic Proteins in Osteogenic Differentiation ofMesenchymal Stem Cells. Journal of Orthopaedic Research 2007;25(5):665–677Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, LuuHH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A Protocolfor rapid generation of recombinant adenoviruses using the AdEasysystem. Nature Protocols 2007; 2(5):1236–1247Zhang Y, Anderson DG, Phillips FM, Thonar EJ, He TC, PietrylaD, An HS. Comparative effects of bone morphogenetic proteinsand Sox9 overexpression on matrix accumulation by bovineanulus fibrosus cells: implications for anular repair. Spine 2007;32(23):2515–20Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH,Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effectsof Panax notoginseng and its major constituents on SW480 humancolorectal cancer cells. Int J Oncol 2007; 31(5):1149–56Li TJ, Song JN, Kang K, Tong SS, Hu ZL, He TC, Zhang BQ,Zhang CQ. RNA interference-mediated gene silencing of vascularendothelial growth factor in colon cancer cells. World J Gastroenterol2007; 13(40):5312–6Cho S, Bian J, Pelizzari CA, Chen CT, He TC, Pan X. Region-ofinterestimage reconstruction in circular cone-beam microCT. MedPhys 2007; 34(12):4923–33Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J,Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH,Haydon RC, He TC. Regulation of osteogenic differentiationduring skeletal development. Front Biosci 2008; 13:2001–21Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC,Kang Q, Wang Y, Du W, He TC, Yuan CS.Characterization of geneexpression regulated by American ginseng and ginsenoside Rg3 inhuman colorectal cancer cells. Int J Oncol 2008; 32(5):975–83Zhang Y, Phillips FM, Thonar EJ, Oegema T, An HS, Roman-BlasJA, He TC, Anderson DG. Cell therapy using articular chondrocytesoverexpressing BMP-7 or BMP-10 in a rabbit disc organ culturemodel. Spine 2008; 33(8):831–8Tang N, Song WX, Luo J, Haydon RC, He TC. OsteosarcomaDevelopment and Stem Cell Differentiation. Clin Orthop RelatRes 2008Luo X, Sharff KA, Chen J, He TC, Luu HH. S100A6 Expressionand Function in Human Osteosarcoma. Clin Orthop Relat Res2008Hue Luu, MDLuo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, LuuHH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A protocolfor rapid generation of recombinant adenoviruses using the AdEasysystem. Nat Protoc 2007; 2(5):1236–47Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J,Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH,Haydon RC, He TC. Regulation of osteogenic differentiationduring skeletal development. Front Biosci 2008; 13:2001–21Toolan BC, Bolt P, Clerk AN, Luu HH, Kang Q, Kummer JL, DengZL, Olson K, Primus F, Montag AG, He TC, Haydon RC. BMP-14Gene Therapy Increases Tendon Tensile Strength in a Rat Model ofAchilles Tendon Injury. J Bone Joint Surg Am 2008; 90(2):445–6Luo X, Sharff KA, Chen J, He TC, Luu HH. S100A6 Expressionand Function in Human Osteosarcoma. Clin Orthop Relat Res2008David Manning, MDDeng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J,Bennett E, Reid R, Manning D, Xue A, Montag AG. Regulation ofosteogenic differentiation during skeletal development. Front Biosci2008; 13:2001–21Brennan PC, Ryan J, Evanoff M, Toomey R, O’Beirne A, ManningD, Chakraborty DP, McEntee M. The impact of acoustic noisefound within clinical departments on radiology performance.Acad Radiol 2008; 15(4):472–6Manning DA, Lopez-Capel E, White ML, Barker S. Carbon isotopedetermination for separate components of heterogeneous materialsusing coupled thermogravimetric analysis/isotope ratio mass spectrometry.Rapid Commun Mass Spectrom 2008; 22(8):1187–119547ANNUAL REPORT 2008

PUBLICATIONS 2007–200848UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYManning DA. Where does all the helium that we use come from?Rapid Commun Mass Spectrom 2008; 22(11):1640–1642Wagner T, Lopez-Capel E, Manning D. Foreword. Rapid CommunMass Spectrom 2008; 22(11):1625 Lopez-Capel E, Krull ES, BolR, Manning DA. Influence of recent vegetation on labile andrecalcitrant carbon soil pools in central Queensland, Australia:evidence from thermal analysis-quadrupole mass spectrometryisotoperatio mass spectrometry. Rapid Commun Mass Spectrom2008; 22(11):1751–1758John Martell, MDWilkie JR, Giger ML, Engh CA, Hopper RH, Martell JM.Radiographic texture analysis in the characterization of trabecularpatterns in periprosthetic osteolysis. Acad Radiol 2008; 15(2):176–85Wilkie JR, Giger ML, Chinander MR, Engh CA, Hopper RH,Martell JM. Temporal radiographic texture analysis in the detectionof periprosthetic osteolysis. Med Phys 2008; 35(1):377–87Terrance Peabody, MDLewis VO, Wei A, Mendoza T, Primus F, Peabody T, Simon MA.Argon Beam Coagulation as an Adjuvant for Local Control ofGiant Cell Tumor. Clin Orthop Relat Res. 2007Ryan CW, Montag AG, Hosenpud JR, Samuels B, Hayden JB,Hung AY, Mansoor A, Peabody TD, Mundt AJ, Undevia S.Histologic response of dose-intense chemotherapy with preoperativehypofractionated radiotherapy for patients with high-risksoft tissue sarcomas. Cancer 2008Corby RR, Stacy GS, Peabody TD, Dixon LB. Radiofrequencyablation of solitary eosinophilic granuloma of bone. AJR Am JRoentgenol 2008; 190(6):1492–4Bruce Reider, MDReider B. Editorial: Announcing a Prize Competition: ReviewingSystematically Am J Sports Med 2007; 35:19–20Reider B. Editorial: Blighted Spring Am J Sports Med 2007;35(7):1057–8Reider B. After the honeymoon. Am J Sports Med 2007;35(8):1245–6Reider B. Total Recall. Am J Sports Med 2007; 35(9):1431–1432Reider B. Caveat injector. Am J Sports Med 2007; 35(10):1619–20Reider B. Passing the headline test. Am J Sports Med 2007;35(11):1807–8Reider B. Sound mind, sound body. Am J Sports Med 2007;35(12):1995–6Reider B. Six degrees of friendship. Am J Sports Med 2008;36(1):31–2Reider B. The next generation. Am J Sports Med 2008;36(2):233–4Reider B. Live long and prosper. Am J Sports Med 2008;36(3):441–2Reider B. Filling in the gaps. Am J Sports Med 2008; 36(4):635–7Reider B. Ecological misfits. Am J Sports Med 2008; 36(5):839–40Reider B. Found in translation. Am J Sports Med 2008; 36(6):1041–2Reider B. Toward a common language. Am J Sports Med 2008;36(7):1261–2Reider B. A popular cult. Am J Sports Med 2008; 36(8):1467–8Michael Simon, MDSimon MA, Rineberg BA, Herndon JH, Rorabeck CH, SpenglerDM, Tolo VT, Hanley EN, Weinstein SL. JBJS Trustees’ Commitmentto the Profession. J Bone Joint Surg Am 2008; 90–A(1):1Salsberg ES, Grover A, Simon MA, Frick SL, Kuremsky MA,Goodman DC. An AOA critical issue. Future physician workforcerequirements: implications for orthopaedic surgery education.J Bone Joint Surg Am 2008; 90(5):1143–59Michael Terry, MDBenjamin HI, Nikore V, Terry M. A complex knee injury in anadolescent football player: 1078: Med Sci Sports Exerc 2007; 39(5Suppl):S127Terry MA. Review of Practical Orthopedic Sports Medicineand Arthroscopy JAMA 2007; 298:230–231Brian Toolan, MDToolan BC. Surgical strategies: the lapidus procedure. Foot AnkleInt 2007; 28(10):1108–14Bolt PM, Coy S, Toolan BC. A comparison of lateral columnlengthening and medial translational osteotomy of the calcaneus forthe reconstruction of adult acquired flatfoot. Foot Ankle Int 2007;28(11):1115–23Toolan BC, Bolt P, Clerk AN, Luu HH, Kang Q, Kummer JL, DengZL, Olson K, Primus F, Montag AG, He TC, Haydon RC. BMP-14Gene Therapy Increases Tendon Tensile Strength in a Rat Model ofAchilles Tendon Injury. J Bone Joint Surg Am 2008; 90(2):445–6OTOLARYNGOLOGY–HEAD AND NECK SURGERYAND DENTISTRYFuad Baroody, MDBaroody FM. Interfacing medical and surgical management forchronic rhinosinusitis with and without nasal polyps. Clin AllergyImmunol 2007; 20:321–36Baroody FM. Mucociliary transport in chronic rhinosinusitis.Clin Allergy Immunol 2007; 20:103–19Baroody FM. Nasal and paranasal sinus anatomy and physiology.Clin Allergy Immunol 2007; 19:1–21Bhayani MK, Maccracken E, Frim D, Baroody FM. Prolongedcricopharyngeal muscle spasm after resection of the cervical vagusnerve in a 15-year-old. Pediatr Neurosurg 2008; 44(1):71–4De Benedetto A, Qualia CM, Baroody FM, Beck LA. FilaggrinExpression in Oral, Nasal, and Esophageal Mucosa. J InvestDermatol 2008Sahin-Yilmaz A, Baroody F, Markaryan A, Thompson K, Wall GM,Naclerio R. Effect of topical ciprofloxacin/dexamethasone ordexamethasone alone on acute Streptococcus pneumoniae rhinosinusitisin mice. Otolaryngol Head Neck Surg 2008; 138(3):340–6Naclerio RM, Pinto J, Detineo M, Baroody FM. Elucidating themechanism underlying the ocular symptoms associated with allergicrhinitis. Allergy Asthma Proc 2008; 29(1):24–8Rosen DS, Shafizadeh S, Baroody FM, Yamini B. Epiduralabscess treated with a medial supraorbital craniotomy through anincision in the eyebrow. Case report. J Neurosurg Pediatrics 2008;1(2):145–7Baroody FM, Mucha SM, Detineo M, Naclerio RM. Nasalchallenge with allergen leads to maxillary sinus inflammation.J Allergy Clin Immunol 2008Baroody FM, Foster KA, Markaryan A, deTineo M, Naclerio RM.Nasal ocular reflexes and eye symptoms in patients with allergicrhinitis. Ann Allergy Asthma Immunol 2008; 100(3):194–9Pinto JM, Schneider J, Perez R, Detineo M, Baroody FM, NaclerioRM. Serum 25-hydroxyvitamin D levels are lower in urban AfricanAmerican subjects with chronic rhinosinusitis. J Allergy ClinImmunol 2008Sahin-Yilmaz A, Baroody FM, DeTineo M, Cuttance G, MakinsonD, Pinto JM, Naureckas ET, Naclerio RM. Effect of changingairway pressure on the ability of the human nose to warm andhumidify air. Ann Otol Rhinol Laryngol 2008; 117(7):501–5Elizabeth Blair, MDSeiwert TY, Cohen EE, Haraf DJ, Stenson K, Blair EA, Mauer A,Dekker A, Vokes EE. A phase I trial of docetaxel based inductionand concomitant chemotherapy in patients with locally advancedhead and neck cancer. Cancer Invest 2007; 25(6):435–44Vokes EE, Seiwert E, Blair E, Cohen E, Salama J, Villaflor VM, WittM, Kovacevic M, Stenson K, and Haraf D. A phase I dose escalationstudy of Ad GV.EGR.TNF.11D (TNFFerade) with concurrentchemoradiotherapy in patients with recurrent head and neck cancer(HNC) J. Clin Oncol 2008; 26Javed A, Balabanov R, Arnason BG, Kelly TJ, Sweiss N, Pytel P,Walsh R, Blair EA, Stemer A, Lazzaro M, and Reder AT. MinorSalivary gland inflammation in Devic’s disease and longitudinallyextensive myelitis. Mult Scler. 2008Jacquelynne Corey, MDWheeler SM, Corey JP. Evaluation of upper airway obstruction—An ENT perspective. Pulm Pharmacol Ther 2007Sahin-Yilmaz AA, Corey JP. Rhinitis in the elderly. Clin AllergyImmunol 2007; 19:209–19Raul Hinojosa, MDMarkaryan A, Nelson EG, Hinojosa R. Detection of mitochondrialDNA deletions in the cochlea and its structural elements fromarchival human temporal bone tissue. Mutat Res 2008Markaryan A, Nelson EG, Tretiakova M, Hinojosa R. Technicalreport: immunofluorescence and TUNEL staining of celloidinembedded human temporal bone tissues. Hear Res 2008Adam Markaryan, PhDMarkaryan A, Nelson EG, Hinojosa R. Detection of mitochondrialDNA deletions in the cochlea and its structural elements fromarchival human temporal bone tissue. Mutat Res 2008Sahin-Yilmaz A, Baroody F, Markaryan A, Thompson K, Wall GM,Naclerio R. Effect of topical ciprofloxacin/dexamethasone ordexamethasone alone on acute Streptococcus pneumoniae rhinosinusitisin mice. Otolaryngol Head Neck Surg 2008; 138(3):340–6Baroody FM, Foster KA, Markaryan A, deTineo M, Naclerio RM.Nasal ocular reflexes and eye symptoms in patients with allergicrhinitis. Ann Allergy Asthma Immunol 2008; 100(3):194–9Markaryan A, Nelson EG, Tretiakova M, Hinojosa R. Technicalreport: immunofluorescence and TUNEL staining of celloidinembedded human temporal bone tissues. Hear Res 2008Ernest Mhoon, MDSigari F, Mhoon E, Montag A, Redleaf M. Pseudobifurcation ofthe vertical facial nerve in a temporal bone laboratory. OtolaryngolHead Neck Surg 2007; 137(3):513–4Robert Naclerio, MDPinto JM, Naclerio RM. Environmental and allergic factors inchronic rhinosinusitis. Clin Allergy Immunol 2007; 20:25–49Togias A, Naclerio RM. Cold air-induced rhinitis. Clin AllergyImmunol 2007; 19:267–81Sahin-Yilmaz A, Pinto JM, Detineo M, Elwany S, Naclerio RM.Familial Aggregation of Nasal Conditioning Capacity. J ApplPhysiol 2007Pinto JM, Naclerio RM. Environmental and allergic factors inchronic rhinosinusitis. New York, NY: Taylor and Francis; 2007.Stull DE, Krouse J, Meltzer EO, Roberts L, Kim S, Frank L,Naclerio R, Lund V, Long A. Development and validation of theCongestion Quantifier seven-item test (CQ7): a screening tool fornasal congestion. Value Health 2007; 10(6):457–65Bielory L, Katelaris CH, Lightman S, Naclerio RM. Treating theocular component of allergic rhinoconjunctivitis and related eyedisorders. MedGenMed 2007; 9(3):35Naclerio R, Kirtsreesakul V, Luxameechanporn T, Klemens J,Thompson K and Baroody F. Interaction of Allergic Rhinitis andBacterial Sinusitis in a Mouse Model. In: Holgate S, Marone G,Ring J, eds. Cellular and Molecular Targets in Allergy and ClinicalImmunology; 200749ANNUAL REPORT 2008

PUBLICATIONS 2007–200850UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYPinto LH, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J,Kedainis D, Siepka SM, Shimomura K, Song EJ, Husain A, LakserOJ, Mitchell RW, Dowell ML, Brown M, Camoretti-Mercado B,Naclerio R, Sperling AI, Levin SI, Turek FW, Solway J. Geneenvironmentinteractions in a mutant mouse kindred with nativeairway constrictor hyperresponsiveness. Mamm Genome 2008Pinto JM, Thanaviratananich S, Hayes MG, Naclerio RM, Ober C.A Genome-Wide Screen for Hyposmia Susceptibility Loci. ChemSenses 2008Naclerio R. Intranasal corticosteroids reduce ocular symptomsassociated with allergic rhinitis. Otolaryngol Head Neck Surg 2008;138(2):129–39Baroody FM, Foster KA, Markaryan A, deTineo M, Naclerio RM.Nasal ocular reflexes and eye symptoms in patients with allergicrhinitis. Ann Allergy Asthma Immunol 2008; 100(3):194–9Baroody FM, Mucha SM, Detineo M, Naclerio RM. Nasalchallenge with allergen leads to maxillary sinus inflammation.J Allergy Clin Immunol 2008; 121(5):1126–1132.e7Naclerio RM, Pinto J, deTineo M, Baroody FM. Elucidating themechanism underlying the ocular symptoms associated with allergicrhinitis. Allergy Asthma Proc 2008; 29(1):24–8Sahin-Yilmaz A, Baroody F, Markaryan A, Thompson K, Wall GM,Naclerio R. Effect of topical ciprofloxacin/dexamethasone ordexamethasone alone on acute Streptococcus pneumoniae rhinosinusitisin mice. Otolaryngol Head Neck Surg 2008; 138(3):340–6Bousquet J, Khaltaev N, Cruz AA et al. World Health Organization.GA (2) LEN. AllerGen. Allergic Rhinitis and its Impact on Asthma(ARIA) 2008 update (in collaboration with the World HealthOrganization, GA (2)LEN and AllerGen). Allergy 2008; 63(Suppl.86):8–160Pinto JM, Schneider J, Perez R, Detineo M, Baroody FM, NaclerioRM. Serum 25-hydroxyvitamin D levels are lower in urban AfricanAmerican subjects with chronic rhinosinusitis. J Allergy ClinImmunol 2008Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C. AGenomewide Screen for Chronic Rhinosinusitis Genes Identifiesa Locus on Chromosome 7q. Laryngoscope 2008Sahin-Yilmaz A, Baroody FM, DeTineo M, Cuttance G, MakinsonD, Pinto JM, Naureckas ET, Naclerio RM. Effect of changingairway pressure on the ability of the human nose to warm andhumidify air. Ann Otol Rhinol Laryngol 2008; 117(7):501–5Jayant Pinto, MDPinto JM, Naclerio RM. Environmental and allergic factors inchronic rhinosinusitis. Clin Allergy Immunol 2007; 20:25–49Pinto JM, Naclerio RM. Environmental and Allergic Factorsin Chronic Rhinosinusitis. In: Hamilos D, Baroody FM, eds.Chronic Rhinosinusitis Patterns of Illness, Pathophysiology andManagement. Marcel Dekker; 2007Sahin-Yilmaz A, Pinto JM, Detineo M, Elwany S, Naclerio RM.Familial Aggregation of Nasal Conditioning Capacity. J ApplPhysiol 2007Pinto JM, Thanaviratananich S, Hayes MG, Naclerio RM, Ober C.A Genome-Wide Screen for Hyposmia Susceptibility Loci. ChemSenses 2008Naclerio RM, Pinto J, Detineo M, Baroody FM. Elucidating themechanism underlying the ocular symptoms associated with allergicrhinitis. Allergy Asthma Proc 2008; 29(1):24–8Pinto JM, Schneider J, Perez R, Detineo M, Baroody FM, NaclerioRM. Serum 25-hydroxyvitamin D levels are lower in urban AfricanAmerican subjects with chronic rhinosinusitis. J Allergy ClinImmunol 2008Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C. AGenomewide Screen for Chronic Rhinosinusitis Genes Identifiesa Locus on Chromosome 7q. Laryngoscope 2008Sahin-Yilmaz A, Baroody FM, DeTineo M, Cuttance G, MakinsonD, Pinto JM, Naureckas ET, Naclerio RM. Effect of changingairway pressure on the ability of the human nose to warm andhumidify air. Ann Otol Rhinol Laryngol 2008; 117(7):501–5Louis Portugal, MDZender C, Luchette F, Portugal LG. Epistaxis In, eds. IRWIN ANDRIPPE’S INTENSIVE CARE MEDICINE. Lippincott Williams &Wilkins; 2008:1729–1734Miriam Redleaf, MDSigari F, Mhoon E, Montag A, Redleaf M. Pseudobifurcation ofthe vertical facial nerve in a temporal bone laboratory. OtolaryngolHead Neck Surg 2007; 137(3):513–4Redleaf MI, Pinto JM, Klemens JJ. Imaging case study: enlargedsuperior vestibular nerve canal with sensorineural hearing loss.J Laryngol Otol 2008:1–3Kerstin Stenson, MDLangerman A, Maccracken E, Kasza K, Haraf DJ, Vokes EE, StensonKM. Aspiration in chemoradiated patients with head and neckcancer. Arch Otolaryngol Head Neck Surg 2007; 133(12):1289–95Aycock JK, Stenson KM, Gottlieb LJ. The thoracoacromial trunk:alternative recipient vessels in reoperative head and neck reconstructivemicrosurgery. Plast Reconstr Surg 2008; 121(1):88–94Knab BR, Salama JK, Solanki A, Stenson KM, Cohen EE, Witt ME,Haraf DJ, Vokes EE. Functional organ preservation with definitivechemoradiotherapy for T4 laryngeal squamous cell carcinoma. AnnOncol 2008Salama JK, Stenson KM, Kistner EO, Mittal BB, Argiris A, Witt ME,Rosen F, Brockstein BE, Cohen EE, Haraf DJ, Vokes EE. Inductionchemotherapy and concurrent chemoradiotherapy for locoregionallyadvanced head and neck cancer: a multi-institutional phase IItrial investigating three radiotherapy dose levels. Ann Oncol 2008Cohn AB, Lang PO, Agarwal JP, Peng SL, Alizadeh K, Stenson KM,Haraf DJ, Cohen EE, Vokes EE, Gottlieb LJ. Free-flap reconstructionin the doubly irradiated patient population. Plast ReconstrSurg 2008; 122(1):125–32Dana Suskind, MDGeorges M, Suskind DL. Near-complete tracheal ring deformity:A case report. Ear Nose Throat J 2008; 87(7):405–7PEDIATRIC SURGERYArnold Coran, MDEhrlich PF; Coran, AG. Congenital Diaphragmatic Hernia. In:Kliegman, RM; Behrman, RE; Jenson, HB; Stanton, BF, eds. NelsonTextbook of Pediatrics. 18th ed. Philadelphia, PA: Elsevier Saunders;2007Ehrlich, PF; Coran, AG. Foramen of Morgagni Hernia. In: Kliegman,RM; Behrman, RE; Jenson, HB; Stanton, BF, eds. NelsonTextbook of Pediatrics. 18th ed. Philadelphia, PA: Elsevier Saunders;2007Ehrlich, PF; Coran, AG. Paraesophageal Hernia. In: Kliegman, RM;Behrman, RE; Jenson, HB; Stanton, BF, eds. Nelson Textbook ofPediatrics. 18th ed. Philadelphia, PA: Elsevier Saunders; 2007Ehrlich, PF; Coran, AG. Eventration of the Diaphragm. In: Kliegman,RM; Behrman, RE; Jenson, HB; Stanton, BF, eds. NelsonTextbook of Pediatrics. 18th ed. Philadelphia, PA: Elsevier Saunders;2007Teitelbaum DH, Coran, AG. Long-Term Results and Quality ofLife After Treatment of Hirschsprung’s Disease and Allied DisordersIn: Holschneider AM, Puri P, eds. Hirschsprung’s Disease and AlliedDisorders, 3rd Edition. 3rd ed. Leipzeig, Germany: Springer; 2007El-Sawaf MI, Coran AG, Teitelbaum, DH. Re-Operative Surgeryfor Hirschsprung’s DiseaseTeich S, Caniano DA, eds. Re-Operative Pediatric Surgery. Totowa,NY: Humana Press, Inc.; 2007Mogilner JG, Srugo I, Lurie M, Shaoul R, Coran AG, Shiloni E,Sukhotnik I. Effect of probiotics on intestinal regrowth andbacterial translocation after massive small bowel resection in a rat.J Pediatr Surg 2007; 42(8):1365–71Sukhotnik I, Agam M, Shamir R, Shehadeh N, Lurie M, Coran AG,Shiloni E, Mogilner J. Oral Glutamine Prevents Gut Mucosal Injuryand Improves Mucosal Recovery Following LipopolysaccharideEndotoxemia in a Rat. J Surg Res 2007; 143(2):379–384Sukhotnik I, Greenblatt R, Voskoboinik K, Lurie M, Coran AG,Mogilner JG. Relationship between time of reperfusion andE-selectin expression, neutrophil recruitment, and germ cellapoptosis after testicular ischemia in a rat model. Fertil Steril 2007Sukhotnik I, Coran AG, Greenblatt R, Brod V, Mogilner J, ShiloniE, Shaoul R, Bitterman H. Effect of 100% oxygen on E-selectinexpression, recruitment of neutrophils and enterocyte apoptosisfollowing intestinal ischemia-reperfusion in a rat. Pediatr SurgInt 2008; 24:29–35Sukhotnik I, Mogilner JG, Shaoul R, Karry R, Lieber M, Suss-TobyE, Ure BM, Coran AG. Responsiveness of intestinal epithelial cellturnover to TGF-alpha after bowel resection in a rat is correlatedwith EGF receptor expression along the villus-crypt axis. PediatrSurg Int 2008; 24:21–28Sukhotnik I, Meyer G, Nativ O, Coran AG, Voskoboinik K, ShiloniE, Mogilner JG. Effect of allopurinol on germ cell apoptosis followingtesticular ischemia-reperfusion injury in a rat. Pediatr Surg Int2008; 24:61–66Kessel A, Toubi E, Pavlotzky E, Mogilner J, Coran AG, Lurie M,Karry R, Sukhotnik I. Glutamine Attenuates Intestinal MucosalInjury Caused by LPS Endotoxemia through Down-Regulationor TLR-4 and MyD88 Expression J Clin Exp Immunol 2008;151:341–347Sukhotnik I, Srugo I, Mogilner JG, Lurie M, Coran AG, Shaoul R.Effect of lactulose on bacterial translocation and intestinal adaptationin a rat model of short bowel syndrome. J Pediatr GastroenterolNutr 2008; 46(5):507–13Sukhotnik I, Shehadeh N, Coran AG, Mogilner JG, Karry R,Shamian B, Ure BM, Shamir R. Oral insulin enhances cell proliferationand decreases enterocyte apoptosis during methotrexateinducedmucositis in the rat. J Pediatr Gastroenterol Nutr 2008;47(2):115–22Donald C. Liu, MD, PhDCarlisle EM, Mezhir JJ, Glynn L, Liu DC, Statter MB. The umbilicalmass: a rare neonatal anomaly. Pediatr Surg Int 2007; 23(8):821–4Mezhir JJ, Glynn L, Liu DC, Statter MB. Handlebar injuries inchildren: should we raise the bar of suspicion? Am Surg 2007;73(8):807–10Michael Morowitz, MDMorowitz M, Georgeson K, Holcomb G, Georgeson K,Ropthenberg A. Laparoscopic assisted pull-through forHirschsprung’s Disease, eds. Atlas of Pediatric Laparoscopyand Thoracoscopy. Philadelphia: Elsevier; 2008Mindy Statter, MDCarlisle EM, Mezhir JJ, Glynn L, Liu DC, Statter MB. The umbilicalmass: a rare neonatal anomaly. Pediatr Surg Int 2007; 23(8):821–4Mezhir JJ, Glynn L, Liu DC, Statter MB. Handlebar injuries inchildren: should we raise the bar of suspicion? Am Surg 2007;73(8):807–10Jackson CC, Munyikwa M, Bacha EA, Statter MB, Starr JP. CardiacBB gun injury with missile embolus to the lung. J Trauma 2007;63(4):E100–4PLASTIC AND RECONSTRUCTIVE SURGERYGary Burget, MDBurget GC, Walton RL. Optimal use of microvascular free flaps,cartilage grafts, and a paramedian forehead flap for aestheticreconstruction of the nose and adjacent facial units. Plast ReconstrSurg 2007; 120(5):1171–207; discussion 1208–1651ANNUAL REPORT 2008

PUBLICATIONS 2007–200852UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYLawrence J. Gottlieb, MDAycock JK, Stenson KM, Gottlieb LJ. The thoracoacromial trunk:alternative recipient vessels in reoperative head and neck reconstructivemicrosurgery. Plast Reconstr Surg 2008; 121(1):88–94Reynolds WS, Gottlieb LJ, Lucioni A, Rapp DE, Song DH, BalesGT. Vesicovaginal Fistula Repair with Rectus AbdominusMyofascial Interposition Flap. Urology 2008Dorafshar AH, Dickie SR, Cohn AB, Aycock JK, O’ConnorA, Tung A, Gottlieb LJ. Antishear therapy for toxic epidermalnecrolysis: an alternative treatment approach. Plast Reconstr Surg2008; 122(1):154–60Cohn AB, Lang PO, Agarwal JP, Peng SL, Alizadeh K, Stenson KM,Haraf DJ, Cohen EE, Vokes EE, Gottlieb LJ. Free-flap reconstructionin the doubly irradiated patient population. Plast ReconstrSurg 2008; 122(1):125–32Grevious MA, Paulius K, Gottlieb LJ. Burn scar contractures of thepediatric neck. J Craniofac Surg 2008; 19(4):1010–5Ginard I. Henry, MDHenry G. Essential for Students Plastic Surgery. Workgroup Editor2007; 7th EditionRaphael C. Lee, MD, ScD, DSc (hon)Lee RC. Plastic Surgery In: eds. World Book Encyclopedia. 2008Edition ed. World Book Corp.; 2007:553Ryan, CM and Lee RC. “Intensive Care Implications of ElectricShock Injury” Intl. Journal of Critical Care Medicine 2007Britt, Trunkey, and Feliciano, eds. “Electrical and Lightning Injuries”Acute Care Surgery: Principles and Practice New York, New York;2007.Mustafi D, Smith CM, Makinen MW, Lee RC. Multi-blockpoloxamer surfactants suppress aggregation of denatured proteins.Biochim Biophys Acta 2008; 1780(1):7–15Wicklund, A H; Ammar, A; Weitlauf, J C; Heilbronner, R L; Fink,J; Lee, R C; Kelley, K; Pliskin, N H. MMPI-2 Patterns in ElectricalInjury: A Controlled Investigation. Clinical Neuropsychology 2008;22(1):98–111Dalal ND, Lee RC. Treatment of burn injury by cellular repair.J Craniofac Surg 2008; 19(4):903–6McKay McKinnon, MDFoster K, McKinnon M, Frim D. Craniosynostosis—A Ten YearReview Plastic and Reconstructive Surgery 2007: In PressSikorski CW, Iteld L, McKinnon M, Yamini B, Frim DM. Correctionof sagittal craniosynostosis using a novel parietal bone fixationtechnique: results over a 10-year period. Pediatr Neurosurg 2007;43(1):19–24Foster KA, Frim DM, McKinnon M. Recurrence of synostosisfollowing surgical repair of craniosynostosis. Plast Reconstr Surg2008; 121(3):70e–76eRussell R. Reid, MD, PhDSelber J, Reid RR, Gershman B, Sonnad SS, Sutton LN, WhitakerLA, Bartlett SP. Evolution of Operative Techniques for the Treatmentof Single-Suture Metopic Synostosis. Ann Plast Surg 2007;59(1):6–13Reid RR. Facial growth and timing of surgical interventionClinics in Plastic Surgery 2007; 34(3):357–367Smartt JM, Reid RR, Singh DJ, Bartlett SP. True lambdoid craniosynostosis:long-term results of surgical and conservative therapy.Plast Reconstr Surg 2007; 120(4):993–1003Baker SB, Reid RR, Burkey B, Bartlett SP. Rapid maxillarydistraction protocol utilizing the halo distraction system and rigidinternal fixation. Cleft Palate Craniofac J 2007; 44(5):476–81Reid RR. Facial skeletal growth and timing of surgicalintervention. Clin Plast Surg 2007; 34(3):357–67Reid RR, Lee MJ, Lewis VL. Postauricular artery island flapfor subtotal ear reconstruction: expanding flap versatility basedon zones of regional perfusion. Plast Reconstr Surg 2008;121(4):213e–4eDeng ZL, Sharff KA, Tang N et al. (Reid RR 9th author).Regulation of osteogenic differentiation during skeletaldevelopment. Frontiers in Bioscience 2008; 13:2001–2021Smartt JM, Reid RR, Singh DJ, Bartlett SP. Regarding truelambdoid synostosis: long-term results of surgical and conservativetherapy: reply. Plast Reconstr Surg 2008; 122(2):673–4Selber J, Reid RR, Chike-Obi CJ, Sutton LN, Zackai EH,McDonald-McGinn D, Sonnad SS, Whitaker LA, Bartlett SP.The changing epidemiologic spectrum of single-suture synostoses.Plast Reconstr Surg 2008; 122(2):527–33Selber J, Reid RR, Chike-Obi CJ, Sutton LN, Zackai EH,McDonald-McGinn D, Sonnad SS, Whitaker LA, Bartlett SP.The changing epidemiologic spectrum of single-suture synostoses.Plast. Reconstr. Surg. 2008; 122(2): (2008):527–533.Selber J, Reid RR, Chike-Obi CJ, Sutton LN, Zackai EH,McDonald-McGinn D, Sonnad SS, Whitaker LA, Bartlett SP.The changing epidemiologic spectrum of single-suture synostoses.Plastic and Reconstructive Surgery 2008; 122(2):527–533Loren Schechter, MDSchechter, LS. On Guard for DVT. Plastic Surgery Products 2007(June)David H. Song, MDSong DH, eds. Plastic Surgery Essentials for Students 7th ed.Arlington Heights, IL: Plastic Surgery Education Foundation; 2007.Raman J, Straus D, Song DH. Rigid plate fixation of the sternum.Ann Thorac Surg 2007; 84(3):1056–8Tseng CY, Lang PO, Cipriani NA, Song DH. Pedicle preservationtechnique for arterial and venous turbocharging of free DIEPand muscle-sparing TRAM flaps. Plast Reconstr Surg 2007;120(4):851–4Aycock J, Fichera A, Colwell JC, Song DH. Parastomal HerniaRepair With Acellular Dermal Matrix. J Wound OstomyContinence Nurs 2007; 34(5):521–523Mikhail AA, Song DH, Zorn KC, Orvieto MA, Taxy JB, Lin SP,Mendiola FP, Shalhav AL, Zagaja GP. Sural Nerve Grafting inRobotic Laparoscopic Radical Prostatectomy: Interim Report.J Endourol 2007Reynolds WS, Gottlieb LJ, Lucioni A, Rapp DE, Song DH,Bales GT. Vesicovaginal Fistula Repair with Rectus AbdominusMyofascial Interposition Flap. Urology 2008Zorn KC, Bernstein AJ, Gofrit ON, Shikanov SA, Mikhail AA,Song DH, Zagaja GP, Shalhav AL. Long-Term Functional andOncological Outcomes of Patients Undergoing Sural NerveInterposition Grafting during Robot-Assisted LaparoscopicRadical Prostatectomy. J Endourol 2008Wu LC, Iteld L, Song DH. Supercharging the transverse rectusabdominis musculocutaneous flap: breast reconstruction forthe overweight and obese population. Ann Plast Surg 2008;60(6):609–13RESEARCHJoel Collier, PhDJung JP, Jones JL, Cronier SA, Collier JH. Modulating themechanical properties of self-assembled peptide hydrogels via nativechemical ligation. Biomaterials 2008; 29:2143–2151J.A. Kopechek, T. M. Abruzzo, B. Wang, S.M. Chrzanowski D.A.B.Smith, P. Kee, S.L. Huang, J.H. Collier, D.D. McPherson, C.K.Holland. Ultrasound-mediated release of hydrophilic and lipophilicagents from echogenic liposomes. Journal of Ultrasound inMedicine 2008; in pressP. Jing, J. S. Rudra, A. B. Herr, and J. H. Collier. Self-assemblingpeptide polymers designed from fibrin coiled coils. Biomacromolecules2008; in pressJ.H. Collier. Modular self-assembling biomaterials for directingcellular processes. Soft Matter 2008; in pressP. Jing, J. P. Jung, and J. H. Collier. Nanostructured MaterialsConstructed from Polypeptides In: Donglu Shi, eds. Nanoscienceand its Applications in Biomedicine. Springer-Verlag; 2008: in pressKarl Matlin, PhDKawedia JD, Jiang M, Kulkarni A, Waechter HE, Matlin KS, PaulettiGM, Menon AG. The PKA pathway contributes to Hg++ inducedalterations in phosphorylation and subcellular distribution of occludinassociated with increased tight junction permeability of salivaryepithelial cell monolayers. J Pharmacol Exp Ther 2008Martin ter Beest, PhDter Beest MB. The use of syntaxin chimeras to study polarizedprotein trafficking in epithelial cells. Methods Mol Biol 2008;440:171–86Mirjam Zegers, PhDZegers M. Roles of p21-activated kinases and associated proteins inepithelial wound healing. Int Rev Cell Mol Biol 2008; 267:253–98Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM,Fan QW, Weiss WA, Zegers MM, Mostov KE. Involvement ofRhoA, ROCK I and myosin II in inverted orientation of epithelialpolarity. EMBO Rep 2008TRANSPLANTATIONAnita Chong, PhDLi Y, Ma L, Shen J, Chong AS. Peripheral deletion of maturealloreactive B cells induced by costimulation blockade. Proc NatlAcad Sci USA 2007; 104:12093–8Ding J, Zhou T, Ma L, Yin D, Shen J, Ding CPY, Tang IY, ByrneGW, Chong AS. Expression of complement regulatory proteinsin accommodated xenografts induced by anti-a-Gal IgG1 in arat-to-mouse model Am. J. Transplantation 2007; (in press)Ding J, Zhou T, Zeng H, Ma L, Yin D, Shen J, and Chong AS.Hyperacute rejection by anti-Gal IgG1, IgG2a and IgG2b isdependent on complement and Fc-gamma receptors (revised andresubmitted to J. Immunol.) 2007Chen L, Wang T, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H,Wang CR, Alegre, ML, Chong AS. Prevention of allograft toleranceby bacterial infection with Listeria monocytogenes J. Immunol2007; under revisionDing JW, Zhou T, Ma L, Yin D, Shen J, Ding CP, Tang IY, ByrneGW, Chong AS. Expression of Complement Regulatory Proteins inAccommodated Xenografts Induced by Anti-alpha-Gal IgG(1) in aRat-to-Mouse Model. Am J Transplant 2007Kirk AD, Bldwin WM, Cascalho MI, Chong AS, Sykes M, WestLJ. American Society of Transplantation symposium on B cells intransplantation: harnessing humoral immunity from rodent modelsto clinical practice. Am. J. Transplant 2007; 7(1464–70)Ding JW, Zhou T, Zeng H, Ma L, Verbeek JS, Yin D, Shen J, ChongAS. Hyperacute Rejection by Anti-Gal IgG1, IgG2a, and IgG2bIs Dependent on Complement and Fc-{gamma} Receptors. JImmunol 2008; 180(1):261–8Lee DD, Grossman E, Chong AS. Cellular therapies for type 1diabetes. Horm Metab Res 2008; 40(2):147–54Li Y, Ma L, Yin D, Shen J, Chong AS. Long-term control of alloreactiveB cell responses by the suppression of T cell help. J Immunol2008; 180(9):6077–84Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H,Wang CR, Alegre ML, Chong AS. Prevention of Allograft Toleranceby Bacterial Infection with Listeria monocytogenes. J Immunol2008; 180(9):5991–9Ding JW, Zhou TT, Zeng HZ, Ma L, Verbeek JS, Yin D, Shen J,and Chong AS. Hyperacute rejection by anti-Gal IgG1, IgG2a andIgG2b is dependent on complement and Fc-gamma receptors.J. Immunol. 2008(180):261–6853ANNUAL REPORT 2008

PUBLICATIONS 2007–200854UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYDing JW, Zhou TT, Ma L, Yin D, Shen J, Ding CYP, Tang IY, ByrneGW and Chong AS. Expression of complement regulatory proteinsin accommodated xenografts induced by anti-?-Gal IgG1 in arat-to-mouse model. Am. J. Transplant. 2008(8):32–40Ma L, Xiang Z, Sherrill TP, Wang L, Blackwell TS, Williams P,Chong A, Chari R, Yin DP. Bioluminescence imaging visualizesactivation of nuclear factor-kappaB in mouse cardiac transplantation.Transplantation 85 2008(85):903–910Xiang Z, Ma LL, Manicassamy S, Ganesh BB, Williams P, ChariR, Chong A, Yin DP. CD4+ T cells are sufficient to elicit allograftrejection and major histocompatibility complex class I molecule isrequired to induce recurrent autoimmune diabetes after pancreastransplantation in mice. Transplantation 2008 (85):1205–11Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signalingin transplantation. Curr Opin Organ Transplant 2008; 13(4):358–65Jinwen Ding, MD, PhDDing JW, Zhou T, Ma L, Yin D, Shen J, Ding CP, Tang IY, ByrneGW, Chong AS. Expression of Complement Regulatory Proteins inAccommodated Xenografts Induced by Anti-alpha-Gal IgG(1) in aRat-to-Mouse Model. Am J Transplant 2007Ding JW, Zhou T, Zeng H, Ma L, Verbeek JS, Yin D, Shen J, ChongAS. Hyperacute Rejection by Anti-Gal IgG1, IgG2a, and IgG2bIs Dependent on Complement and Fc-{gamma} Receptors.J Immunol 2008; 180(1):261–8Marc Garfinkel, MDGarfinkel, Marc R. Review of “Islet Transplantation and Beta CellReplacement Therapy,” (A.M. James Shapiro and James A.M. Shaw,eds.) Doody’s Review Services, Doody Enterprises, Inc., Chicago2008:http://www.doody.comRobert Harland, MDCook RI, Wreathall J, Smith A, Cronin DC, Rivero O, HarlandRC, Raman J, Battles J, Reason J. Probabilistic Risk Assessment ofAccidental ABO-Incompatible Thoracic Organ TransplantationBefore and After 2003. Transplantation 2007; 84(12):1602–1609J. Michael Millis, MDDiamond IR, Fecteau A, Millis JM, Losanoff JE, Ng V, Anand R,Song C. Impact of Graft Type on Outcome in Pediatric LiverTransplantation: A Report From Studies of Pediatric LiverTransplantation (SPLIT). Ann Surg 2007; 246(2):301–310Losanoff JE, Millis JM. Temporary abdominal coverage for adultliver transplantation. Liver Transpl 2007; 13(9):1349–1350Losanoff JE, Millis JM. Giant necrotizing abscess of a liver transplantafter gunshot injury. Transplantation 2007; 84(10):1373–4Cronin DC, Millis JM. Living donor liver transplantation:The ethics and the practice. Hepatology 2007; 47(1):11–13Losanoff JE, Millis JM. Liver hemangioma complicated byobstructive jaundice. Am J Surg 2008Te HS, Anderson AS, Millis JM, Jeevanandam V, Jensen DM.Current state of combined heart-liver transplantation in the UnitedStates. J Heart Lung Transplant 2008; 27(7):753–9Anderson CD, Turmelle YP, Lowell JA, Nadler M, Millis M, AnandR. Martz K, Shepherd RW; SPLIT Research Group. The effect ofRecipient - specific surgical issues on outcomes of liver transplantationin biliary atresia. Am J Transplant 2008; 8(6):1197–204Giuliano Testa, MDLumpaopong A, Mathew AV, John E, Jelnin V, Benedetti E, Testa G,Oberholzer J, Sankary H, Ruiz C. Early coronary calcification inchildren and young adults with end-stage renal disease. TransplantProc 2007; 39(1):37–9wVenu M, Brown RD, Lepe R, Berkes J, Cotler SJ, Benedetti E, TestaG, Venu RP. Laboratory diagnosis and nonoperative management ofbiliary complications in living donor liver transplant patients. J ClinGastroenterol 2007; 41(5):501–6Mohanty SR, Testa G, LaBrecque DR, Mitros FA. Progressivemultifocal leukoencephalopathy with peripheral demyelinatingneuropathy in a liver transplant patient Gastroenterology &Hepatology 2007; 3(1):70-76Losanoff JE, Millis JM, Harland RC, Testa G.. Hepato-splenomesentrictruck Am Coll Surg 2007; 204(3):511Losanoff JE, Holder-Murray JM, Ahmed EB, Cochrane AB, Testa G,Millis JM.. 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PUBLICATIONS 2007–200856UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYEggener SE, Yossepowitch O, Kundu S, Motzer RJ, Russo P. RiskScore and Metastasectomy Independently Impact Prognosis ofPatients With Recurrent Renal Cell Carcinoma. J Urol 2008Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S,Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, CaoX, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-AhmadieH, Eastham JA, Eggener SE, Fine SW. The role of SPINK1 inETS rearrangement-negative prostate cancers. Cancer Cell 2008;13(6):519–28Russo P, Jang TL, Pettus JA, Huang WC, Eggener SE, O’Brien MF,Karellas ME, Karanikolas NT, Kagiwada MA. Survival rates afterresection for localized kidney cancer: 1989 to 2004. Cancer 2008;113(1):84–96Yossepowitch O, Thompson RH, Leibovich BC, Eggener SE,Pettus JA, Kwon ED, Herr HW, Blute ML, Russo P. Positivesurgical margins at partial nephrectomy: predictors and oncologicaloutcomes. J Urol 2008; 179(6):2158–63Eggener SE, Yossepowitch O, Roehl KA, Loeb S, Yu X, CatalonaWJ. Relationship of prostate-specific antigen velocity to histologicfindings in a prostate cancer screening program. Urology 2008;71(6):1016–9Eggener SE, Guillonneau B. Laparoscopic radical prostatectomy:ten years later, time for evidence-based foundation. Eur Urol 2008;54(1):4–7Yossepowitch O, Eggener SE, Serio AM, Carver BS, Bianco FJ,Scardino PT, Eastham JA. Secondary therapy, metastatic progression,and cancer-specific mortality in men with clinically high-riskprostate cancer treated with radical prostatectomy. Eur Urol 2008;53(5):950–9Glenn Gerber, MDShalhav AL, Mikhail AA, Orvieto MA, Gofrit ON, Gerber GS,Zorn KC. Adult stentless laparoscopic pyeloplasty. JSLS 2007;11(1):8–13Gerber GS. Editorial comment. Urology 2007; 70(3):594–5Zorn KC, Orvieto MA, Mikhail AA, Lyon MB, Gerber GS,Steinberg GD, Shalhav AL. Case report: radiofrequency ablationinducedrenal-pelvic obstruction resulting in nephrectomy.J Endourol 2007; 21(9):1059–64Gerber GS and Stockton BR. Trends in endourologic practice.Laparoscopic nephron-sparing surgery. J Endourology 2007;21:458–459Laven BA, Orsini N, Andersson SO, Johansson JE, Gerber GS,Wolk A. Birth Weight, Abdominal Obesity and the Risk of LowerUrinary Tract Symptoms in a Population Based Study of SwedishMen. J Urol 2008; 179:1891–1896Gerber GS, Acharya SS. Management of Ureteropelvic JunctionObstruction. J Endourology 2008; 22:859–861Mohan S. Gundeti, MDGundeti MS, Patel Y, Duffy PG, Cuckow PM, Wilcox DT, MushtaqI. An initial experience of 100 paediatric laparoscopic nephrectomieswith transperitoneal or posterior prone retroperitoneoscopicapproach. Pediatr Surg Int 2007; 23(8):795–9Gundeti MS, Wilcox DT. Laproscopy for Undescended Testis In.eds. Endourology Techniques in Pediatric Urology by P Godbole.Springer; 2007Gundeti MS. Wilms’ Tumor, eds. Pediatric Urology by Gearhart,Moriquand & Rink. 2nd ed. Elsevier; 2008Gundeti MS, Reynolds WS, Duffy PG, Mushtaq I. “The VascularHitch” (Laparoscopic transposition of lower pole Crossing vessels):An alternate treatment of Pediatric ureterovascular ureteropelvicjunction obstruction. Journal of Urology 2008 (November)Gundeti MS, Reynolds WS, Eng MK, Zagaja GP. PediatricRobotic—Assisted Laparoscopic Augmentation Ileocystoplasty andMitranoff Appendicovesicostomy: Complete imtracorporeal-Initialcase report. Urology 2008 (June)Gundeti MS, Acharya SS, Zagaja GP, Shalhav AL, Zorn KC.Wolffian Duct Derivative Anomalies: Technical considerationwhen encountered during Assisted radical prostatectomy EuropeanUrology 2008(June)Carrie Rinker-Schaeffer, PhDRinker-Schaeffer C. MKK6 and MKK7 during prostate cancerprogression: an important role for SAPK signalling in prostaticneoplasia. J Pathol 2007Taylor J, Hickson J, Lotan T, Yamada DS, Rinker-Schaeffer C. Usingmetastasis suppressor proteins to dissect interactions among cancercells and their microenvironment. Cancer Metastasis Rev 2007Robinson VL, Shalhav O, Otto K, Kawai T, Gorospe M, Rinker-Schaeffer CW. Mitogen-Activated Protein Kinase Kinase 4/c-JunNH2-Terminal Kinase Kinase 1 Protein Expression Is Subject toTranslational Regulation in Prostate Cancer Cell Lines. Mol CancerRes 2008; 6(3):501–8Lotan T, Hickson J, Souris J, Huo D, Taylor J, Li T, Otto K, YamadaSD, Macleod K, Rinker-Schaeffer CW. c-Jun NH2-terminalkinase activating kinase 1/mitogen-activated protein kinase kinase4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasisinvolves growth arrest and p21 up-regulation. Cancer Res 2008;68(7):2166–75Hickson J, Diane Yamada S, Berger J, Alverdy J, O’Keefe J, BasslerB, Rinker-Schaeffer C. Societal interactions in ovarian cancermetastasis: a quorum-sensing hypothesis. Clin Exp Metastasis 2008Taylor JL, Szmulewitz RZ, Lotan T, Hickson J, Griend DV, YamadaSD, Macleod K, Rinker-Schaeffer CW. New paradigms for thefunction of JNKK1/MKK4 in controlling growth of disseminatedcancer cells. Cancer Lett 2008Arieh Shalhav, MDZorn KC, Gong EM, Mendiola FP, Mikhail AA, Orvieto MA,Gofrit ON, Steinberg GD, Shalhav AL. Operative outcomes ofupper pole laparoscopic partial nephrectomy: comparison of lowerpole laparoscopic and upper pole open partial nephrectomy.Urology 2007; 70(1):28–34Shalhav AL, Mikhail AA, Orvieto MA, Gofrit ON, Gerber GS,Zorn KC. Adult stentless laparoscopic pyeloplasty. JSLS 2007;11(1):8–13Zorn KC, Gofrit ON, Steinberg GD, Shalhav AL. Evolution ofRobotic Surgery in the Treatment of Localized Prostate Cancer.Curr Treat Options Oncol 2007Gofrit ON, Zorn KC, Taxy JB, Lin S, Zagaja GP, Steinberg GD,Shalhav AL. Predicting the Risk of Patients With Biopsy GleasonScore 6 to Harbor a Higher Grade Cancer. J Urol 2007Gong EM, Zorn KC, Gofrit ON, Lucioni A, Orvieto MA, ZagajaGP, Shalhav AL. Early laparoscopic management of acute postoperativehemorrhage after initial laparoscopic surgery. J Endourol 2007;21(8):872–8Zorn KC, Orvieto MA, Mikhail AA, Lyon MB, Gerber GS, SteinbergGD, Shalhav AL. Case report: radiofrequency ablation-inducedrenal-pelvic obstruction resulting in nephrectomy. J Endourol 2007;21(9):1059–64Msezane LP, Gofrit ON, Lin S, Shalhav AL, Zagaja GP, Zorn KC.Prostate weight: an independent predictor for positive surgicalmargins during robotic-assisted laparoscopic radical prostatectomy.Can J Urol 2007; 14(5):3697–701Gofrit ON, Zorn KC, Steinberg GD, Zagaja GP, Shalhav AL. TheWill Rogers Phenomenon in Urological Oncology. J Urol 2007Mikhail AA, Song DH, Zorn KC, Orvieto MA, Taxy JB, Lin SP,Mendiola FP, Shalhav AL, Zagaja GP. Sural Nerve Grafting inRobotic Laparoscopic Radical Prostatectomy: Interim Report.J Endourol 2007Zorn KC, Gallina A, Hutterer GC, Walz J, Shalhav AL, Zagaja GP,Valiquette L, Gofrit ON, Orvieto MA, Taxy JB, Karakiewicz PI.External validation of a nomogram for prediction of side-specificextracapsular extension at robotic radical prostatectomy. J Endourol2007; 21(11):1345–52Zorn KC, Gofrit ON, Orvieto MA, Mikhail AA, Galocy RM,Shalhav AL, Zagaja GP. Da vinci robot error and failure rates: singleinstitution experience on a single three-arm robot unit of morethan 700 consecutive robot-assisted laparoscopic radical prostatectomies.J Endourol 2007; 21(11):1341–4Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder Neck Contracture after Robot-Assisted LaparoscopicRadical Prostatectomy: Evaluation of Incidence and RiskFactors and Impact on Urinary Function. J Endourol 2007Msezane LP, Zorn KC, Gofrit ON, Schade GR, Shalhav AL. Casereport: conservative management of a large capnothorax followinglaparoscopic renal surgery. J Endourol 2007; 21(12):1445–8Zorn KC, Gofrit ON, Shalhav AL. Use of bone wax duringlaparoscopic renal ablative procedures: optimizing port utilizationand reducing tract-site exposure. JSLS 2007; 11(4):453–5Eng MK, Shalhav AL. Laparoscopic nephroureterectomy: long-termoutcomes. Curr Opin Urol 2008; 18(2):157–62Zorn KC, Gofrit ON, Zagaja GP, Shalhav AL. Use of theEndoholder Device during Robotic-Assisted LaparoscopicRadical Prostatectomy: The “Poor Man’s” Fourth Arm Equivalent.J Endourol 2008; 22(2):385–8Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder neck contracture after robot-assisted laparoscopicradical prostatectomy: evaluation of incidence and risk factorsand impact on urinary function. J Endourol 2008; 22(1):97–104Mendiola FP, Zorn KC, Mikhail AA, Lin S, Orvieto MA, ZagajaGP, Shalhav AL. Urinary and Sexual Function Outcomes amongDifferent Age Groups after Robot-Assisted LaparoscopicProstatectomy. J Endourol 2008; 22(3):519–24Msezane LP, Katz MH, Gofrit ON, Shalhav AL, Zorn KC.Hemostatic agents and instruments in laparoscopic renal surgery.J Endourol 2008; 22(3):403–8Gofrit ON, Mikahail AA, Zorn KC, Zagaja GP, Steinberg GD,Shalhav AL. Surgeons’ perceptions and injuries during and afterurologic laparoscopic surgery. Urology 2008; 71(3):404–7Gong EM, Orvieto MA, Zorn KC, Lucioni A, Steinberg GD,Shalhav AL. Comparison of Laparoscopic and Open PartialNephrectomy in Clinical T(1a) Renal Tumors. J Endourol 2008Zorn KC, Bernstein AJ, Gofrit ON, Shikanov SA, Mikhail AA,Song DH, Zagaja GP, Shalhav AL. Long-Term Functional andOncological Outcomes of Patients Undergoing Sural NerveInterposition Grafting during Robot-Assisted LaparoscopicRadical Prostatectomy. J Endourol 2008Gofrit ON, Stadler WM, Zorn KC, Lin S, Silvestre J, Shalhav AL,Zagaja GP, Steinberg GD. Adjuvant chemotherapy in lymph nodepositive bladder cancer. Urol Oncol 2008Gofrit ON, Zorn KC, Silvestre J, Shalhav AL, Zagaja GP, MsezaneLP, Steinberg GD. The predictive value of multi-targeted fluorescentin-situ hybridization in patients with history of bladder cancer.Urol Oncol 2008; 26(3):246–9Gattone VH, Siqueira TM, Powell CR, Trambauugh CM,Lingeman JE, Shalhav AL. Contribution of Renal Innervationto Hypertension in Rat Autosomal Dominant Polycystic KidneyDisease. Exp Biol Med (Maywood) 2008Zorn KC, Gofrit ON, Steinberg GP, Taxy JB, Zagaja GP, ShalhavAL. Planned Nerve Preservation to Reduce Positive SurgicalMargins during Robot-Assisted Laparoscopic RadicalProstatectomy. J Endourol 2008Shalhav AL. Editorial Comment. J Urol 2008Shikanov SA, Eng MK, Bernstein AJ, Katz M, Zagaja GP, ShalhavAL, Zorn KC. Urinary and Sexual Quality of Life 1 Year FollowingRobotic Assisted Laparoscopic Radical Prostatectomy. J Urol 2008Lucioni A, Orvieto MA, Zorn KC, Lotan T, Gong EM, SteinbergGD, Shalhav AL. Efficacy of the argon beam coagulator alone inobtaining hemostasis after laparoscopic porcine heminephrectomy:a pilot study. Can J Urol 2008; 15(3):4091–6Shalhav AL, Shikanov SA. Does radiofrequency ablation preservelong-term renal function in patients with small renal masses?Nat Clin Pract Urol 200857ANNUAL REPORT 2008

PUBLICATIONS 2007–200858UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYEng MK, Zorn KC, Harland RC, Bernstein AJ, Katz M, ShikanovS, Shalhav AL. Fifteen-Year Follow-up of Transplantation of aCadaveric Polycystic Kidney: A Case Report. Transplant Proc 2008;40(5):1747–50Shikanov SA, Thong A, Gofrit ON, Zagaja GP, Steinberg GD,Shalhav AL, Zorn KC. Robotic Laparoscopic Radical Prostatectomyfor Biopsy Gleason 8 to 10: Prediction of Favorable PathologicOutcome with Preoperative Parameters. J Endourol 2008Eng MK, Katz MH, Bernstein AJ, Shikanov S, Shalhav AL,Zorn KC. Laparoscopic Port-Site Metastasis in Urologic Surgery.J Endourol 2008Gary Steinberg, MDSoloway MS, Lee CT, Steinberg GD, Ghandi AA, Jewett MA.Difficult decisions in urologic oncology: Management of highgradeT1 transitional cell carcinoma of the bladder. Urol Oncol2007; 25(4):338–40Zorn KC, Gong EM, Mendiola FP, Mikhail AA, Orvieto MA,Gofrit ON, Steinberg GD, Shalhav AL. Operative outcomes ofupper pole laparoscopic partial nephrectomy: comparison of lowerpole laparoscopic and upper pole open partial nephrectomy.Urology 2007; 70(1):28–34Steinberg GD. Editorial Comments. J Urol 2007Zorn KC, Gofrit ON, Steinberg GD, Shalhav AL. Evolution ofRobotic Surgery in the Treatment of Localized Prostate Cancer.Curr Treat Options Oncol 2007Mendiola FP, Zorn KC, Gofrit ON, Mikhail AA, Orvieto MA,Msezane LP, Steinberg GD. Cystectomy in the ninth decade:operative results and long-term survival outcomes. Can J Urol2007; 14(4):3628–34Gofrit ON, Zorn KC, Taxy JB, Lin S, Zagaja GP, Steinberg GD,Shalhav AL. Predicting the Risk of Patients With Biopsy GleasonScore 6 to Harbor a Higher Grade Cancer. J Urol 2007Zorn KC, Orvieto MA, Mikhail AA, Lyon MB, Gerber GS,Steinberg GD, Shalhav AL. Case report: radiofrequency ablationinducedrenal-pelvic obstruction resulting in nephrectomy.J Endourol 2007; 21(9):1059–64Gofrit ON, Zorn KC, Steinberg GD, Zagaja GP, Shalhav AL. TheWill Rogers Phenomenon in Urological Oncology. J Urol 2007Mendiola FP, Zorn KC, Gofrit ON, Mikhail AA, Orvieto MA,Msezane LP, and Steinberg GD. Cystectomy in the ninth decade:operative results and long-term survival outcomes The CanadianJ of Urol. 2007; 14(4):3628–34Steinberg GD. Editorial Comment. J Urol 2008Gofrit ON, Mikahail AA, Zorn KC, Zagaja GP, Steinberg GD,Shalhav AL. Surgeons’ perceptions and injuries during and afterurologic laparoscopic surgery. Urology 2008; 71(3):404–7Gong EM, Orvieto MA, Zorn KC, Lucioni A, Steinberg GD,Shalhav AL. Comparison of Laparoscopic and Open PartialNephrectomy in Clinical T(1a) Renal Tumors. J Endourol 2008Gofrit ON, Zorn KC, Silvestre J, Shalhav AL, Zagaja GP, MsezaneLP, Steinberg GD. The predictive value of multi-targeted fluorescentin-situ hybridization in patients with history of bladder cancer.Urol Oncol 2008; 26(3):246–9Gofrit ON, Stadler WM, Zorn KC, Lin S, Silvestre J, Shalhav AL,Zagaja GP, Steinberg GD. Adjuvant chemotherapy in lymph nodepositive bladder cancer. Urol Oncol 2008Steinberg GD. J Urol 2008Steinberg GD. Editorial Comment. J Urol 2008Lucioni A, Orvieto MA, Zorn KC, Lotan T, Gong EM, SteinbergGD, Shalhav AL. Efficacy of the argon beam coagulator alone inobtaining hemostasis after laparoscopic porcine heminephrectomy:a pilot study. Can J Urol 2008; 15(3):4091–6Shikanov SA, Thong A, Gofrit ON, Zagaja GP, Steinberg GD,Shalhav AL, Zorn KC. Robotic Laparoscopic Radical Prostatectomyfor Biopsy Gleason 8 to 10: Prediction of Favorable PathologicOutcome with Preoperative Parameters. J Endourol 2008Katz MH, Steinberg GD. Should fluorescence cystoscopy be usedfor transurethral resection in patients with high-grade T1 bladdercancer? Nat Clin Pract Urol 2008Gregory Zagaja, MDRapp DE, Gong EM, Reynolds WS, Lucioni A, Zagaja GP. Assessmentof the Core Learning Objectives Curriculum for the UrologyClerkship. J Urol 2007Gofrit ON, Zorn KC, Taxy JB, Lin S, Zagaja GP, Steinberg GD,Shalhav AL. Predicting the Risk of Patients With Biopsy GleasonScore 6 to Harbor a Higher Grade Cancer. J Urol 2007Gong EM, Zorn KC, Gofrit ON, Lucioni A, Orvieto MA, ZagajaGP, Shalhav AL. Early laparoscopic management of acute postoperativehemorrhage after initial laparoscopic surgery. J Endourol 2007;21(8):872–8Msezane LP, Gofrit ON, Lin S, Shalhav AL, Zagaja GP, Zorn KC.Prostate weight: an independent predictor for positive surgicalmargins during robotic-assisted laparoscopic radical prostatectomy.Can J Urol 2007; 14(5):3697–701Gofrit ON, Zorn KC, Steinberg GD, Zagaja GP, Shalhav AL. TheWill Rogers Phenomenon in Urological Oncology. J Urol 2007Mikhail AA, Song DH, Zorn KC, Orvieto MA, Taxy JB, Lin SP,Mendiola FP, Shalhav AL, Zagaja GP. Sural Nerve Grafting inRobotic Laparoscopic Radical Prostatectomy: Interim Report. JEndourol 2007Zorn KC, Gallina A, Hutterer GC, Walz J, Shalhav AL, Zagaja GP,Valiquette L, Gofrit ON, Orvieto MA, Taxy JB, Karakiewicz PI.External validation of a nomogram for prediction of side-specificextracapsular extension at robotic radical prostatectomy. J Endourol2007; 21(11):1345–52Zorn KC, Gofrit ON, Orvieto MA, Mikhail AA, Galocy RM,Shalhav AL, Zagaja GP. Da vinci robot error and failure rates: singleinstitution experience on a single three-arm robot unit of morethan 700 consecutive robot-assisted laparoscopic radical prostatectomies.J Endourol 2007; 21(11):1341–4Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder Neck Contracture after Robot-Assisted LaparoscopicRadical Prostatectomy: Evaluation of Incidence and RiskFactors and Impact on Urinary Function. J Endourol 2007Liauw SL, Weichselbaum RR, Zagaja GP, Jani AB. SalvageRadiotherapy After Postprostatectomy Biochemical Failure: DoesPretreatment Radioimmunoscintigraphy Help Select Patients withLocally Confined Disease? Int J Radiat Oncol Biol Phys 2008Zorn KC, Gofrit ON, Zagaja GP, Shalhav AL. Use of theEndoholder Device during Robotic-Assisted Laparoscopic RadicalProstatectomy: The “Poor Man’s” Fourth Arm Equivalent.J Endourol 2008; 22(2):385–8Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder neck contracture after robot-assisted laparoscopicradical prostatectomy: evaluation of incidence and risk factorsand impact on urinary function. J Endourol 2008; 22(1):97–104Mendiola FP, Zorn KC, Mikhail AA, Lin S, Orvieto MA, ZagajaGP, Shalhav AL. Urinary and Sexual Function Outcomes amongDifferent Age Groups after Robot-Assisted LaparoscopicProstatectomy. J Endourol 2008; 22(3):519–24Gofrit ON, Mikahail AA, Zorn KC, Zagaja GP, Steinberg GD,Shalhav AL. Surgeons’ perceptions and injuries during and afterurologic laparoscopic surgery. Urology 2008; 71(3):404–7Zorn KC, Bernstein AJ, Gofrit ON, Shikanov SA, Mikhail AA,Song DH, Zagaja GP, Shalhav AL. Long-Term Functional andOncological Outcomes of Patients Undergoing Sural NerveInterposition Grafting during Robot-Assisted LaparoscopicRadical Prostatectomy. J Endourol 2008Gofrit ON, Zorn KC, Silvestre J, Shalhav AL, Zagaja GP, MsezaneLP, Steinberg GD. The predictive value of multi-targeted fluorescentin-situ hybridization in patients with history of bladder cancer.Urol Oncol 2008; 26(3):246–9Gofrit ON, Stadler WM, Zorn KC, Lin S, Silvestre J, Shalhav AL,Zagaja GP, Steinberg GD. Adjuvant chemotherapy in lymph nodepositive bladder cancer. Urol Oncol 2008Zorn KC, Gofrit ON, Steinberg GP, Taxy JB, Zagaja GP, ShalhavAL. Planned Nerve Preservation to Reduce Positive SurgicalMargins during Robot-Assisted Laparoscopic RadicalProstatectomy. J Endourol 2008Shikanov SA, Eng MK, Bernstein AJ, Katz M, Zagaja GP, ShalhavAL, Zorn KC. Urinary and Sexual Quality of Life 1 Year FollowingRobotic Assisted Laparoscopic Radical Prostatectomy. J Urol 2008Shikanov SA, Thong A, Gofrit ON, Zagaja GP, Steinberg GD,Shalhav AL, Zorn KC. Robotic Laparoscopic Radical Prostatectomyfor Biopsy Gleason 8 to 10: Prediction of Favorable PathologicOutcome with Preoperative Parameters. J Endourol 2008Kevin Zorn, MDZorn KC, Gong EM, Mendiola FP, Mikhail AA, Orvieto MA,Gofrit ON, Steinberg GD, Shalhav AL. Operative outcomes ofupper pole laparoscopic partial nephrectomy: comparison of lowerpole laparoscopic and upper pole open partial nephrectomy.Urology 2007; 70(1):28–34Shalhav AL, Mikhail AA, Orvieto MA, Gofrit ON, Gerber GS,Zorn KC. Adult stentless laparoscopic pyeloplasty. JSLS 2007;11(1):8–13Zorn KC, Starks CL, Gofrit ON, Orvieto MA, Shalhav AL.Embolization of renal-artery pseudoaneurysm after laparoscopicpartial nephrectomy for angiomyolipoma: case report and literaturereview. J Endourol 2007; 21(7):763–8Zorn KC, Gofrit ON, Steinberg GD, Shalhav AL. Evolution ofRobotic Surgery in the Treatment of Localized Prostate Cancer.Curr Treat Options Oncol 2007Mendiola FP, Zorn KC, Gofrit ON, Mikhail AA, Orvieto MA,Msezane LP, Steinberg GD. Cystectomy in the ninth decade:operative results and long-term survival outcomes. Can J Urol2007; 14(4):3628–34Gofrit ON, Zorn KC, Taxy JB, Lin S, Zagaja GP, Steinberg GD,Shalhav AL. Predicting the Risk of Patients With Biopsy GleasonScore 6 to Harbor a Higher Grade Cancer. J Urol 2007Gong EM, Zorn KC, Gofrit ON, Lucioni A, Orvieto MA, ZagajaGP, Shalhav AL. Early laparoscopic management of acute postoperativehemorrhage after initial laparoscopic surgery. J Endourol 2007;21(8):872–8Msezane LP, Gofrit ON, Lin S, Shalhav AL, Zagaja GP, Zorn KC.Prostate weight: an independent predictor for positive surgicalmargins during robotic-assisted laparoscopic radical prostatectomy.Can J Urol 2007; 14(5):3697–701Zorn KC, Orvieto MA, Mikhail AA, Lyon MB, Gerber GS,Steinberg GD, Shalhav AL. Case report: radiofrequency ablationinducedrenal-pelvic obstruction resulting in nephrectomy.J Endourol 2007; 21(9):1059–64Gofrit ON, Zorn KC, Steinberg GD, Zagaja GP, Shalhav AL. TheWill Rogers Phenomenon in Urological Oncology. J Urol 2007Zorn KC, Gofrit ON, Orvieto MA, Mikhail AA, Galocy RM,Shalhav AL, Zagaja GP. Da vinci robot error and failure rates: singleinstitution experience on a single three-arm robot unit of morethan 700 consecutive robot-assisted laparoscopic radical prostatectomies.J Endourol 2007; 21(11):1341–4Mikhail AA, Song DH, Zorn KC, Orvieto MA, Taxy JB, Lin SP,Mendiola FP, Shalhav AL, Zagaja GP. Sural Nerve Grafting inRobotic Laparoscopic Radical Prostatectomy: Interim Report.J Endourol 2007Zorn KC, Gallina A, Hutterer GC, Walz J, Shalhav AL, Zagaja GP,Valiquette L, Gofrit ON, Orvieto MA, Taxy JB, Karakiewicz PI.External validation of a nomogram for prediction of side-specificextracapsular extension at robotic radical prostatectomy. J Endourol2007; 21(11):1345–5259ANNUAL REPORT 2008

PUBLICATIONS 2007–2008Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder Neck Contracture after Robot-Assisted LaparoscopicRadical Prostatectomy: Evaluation of Incidence and RiskFactors and Impact on Urinary Function. J Endourol 2007Msezane LP, Zorn KC, Gofrit ON, Schade GR, Shalhav AL. Casereport: conservative management of a large capnothorax followinglaparoscopic renal surgery. J Endourol 2007; 21(12):1445–8Gofrit ON, Stadler WM, Zorn KC, Lin S, Silvestre J, Shalhav AL,Zagaja GP, Steinberg GD. Adjuvant chemotherapy in lymph nodepositive bladder cancer. Urol Oncol 2008Zorn KC, Gofrit ON, Steinberg GP, Taxy JB, Zagaja GP, ShalhavAL. Planned Nerve Preservation to Reduce Positive SurgicalMargins during Robot-Assisted Laparoscopic Radical Prostatectomy.J Endourol 2008thresholds utilizing high-resolution B-mode ultrasound validatedwith computed tomography angiography (CTA). J Vasc Surg 2008;48(1):104–112Shaalan WE, Wahlgren CM, Desai T, Piano G, Skelly C, BassiounyHS. Reappraisal of velocity criteria for carotid bulb/internalcarotid artery stenosis utilizing high-resolution B-mode ultrasoundvalidated with computed tomography angiography. J Vasc Surg 2008Cava Filters: A Single-Institution Experience. Cardiovasc InterventRadiol 2008; 31(2):308–315Shaalan WE, Wahlgren CM, Desai T, Piano G, Skelly C, BassiounyHS. Reappraisal of velocity criteria for carotid bulb/internalcarotid artery stenosis utilizing high-resolution B-mode ultrasoundvalidated with computed tomography angiography. J Vasc Surg2008; 48(1):104–112Atanda Jr A, Wahlgren CM, Piano G, Sullivan C. Vascular injuryrequiring repair associated with a pediatric femur fracture: A casereport and review of the literature Clin Ortho and Rel Res 2008;under review60UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYZorn KC, Gofrit ON, Shalhav AL. Use of bone wax duringlaparoscopic renal ablative procedures: optimizing port utilizationand reducing tract-site exposure. JSLS 2007; 11(4):453–5Msezane LP, Reynolds WS, Gofrit ON, Shalhav AL, Zagaja GP,Zorn KC. Bladder neck contracture after robot-assisted laparoscopicradical prostatectomy: evaluation of incidence and risk factorsand impact on urinary function. J Endourol 2008; 22(1):97–104Zorn KC, Gofrit ON, Zagaja GP, Shalhav AL. Use of theEndoholder Device during Robotic-Assisted LaparoscopicRadical Prostatectomy: The “Poor Man’s” Fourth Arm Equivalent.J Endourol 2008; 22(2):385–8Gofrit ON, Mikahail AA, Zorn KC, Zagaja GP, Steinberg GD,Shalhav AL. Surgeons’ perceptions and injuries during and afterurologic laparoscopic surgery. Urology 2008; 71(3):404–7Mendiola FP, Zorn KC, Mikhail AA, Lin S, Orvieto MA, ZagajaGP, Shalhav AL. Urinary and Sexual Function Outcomes amongDifferent Age Groups after Robot-Assisted LaparoscopicProstatectomy. J Endourol 2008; 22(3):519–24Msezane LP, Katz MH, Gofrit ON, Shalhav AL, Zorn KC. Hemostaticagents and instruments in laparoscopic renal surgery.J Endourol 2008; 22(3):403–8Gong EM, Orvieto MA, Zorn KC, Lucioni A, Steinberg GD,Shalhav AL. Comparison of Laparoscopic and Open PartialNephrectomy in Clinical T(1a) Renal Tumors. J Endourol 2008Zorn KC. Robotic Radical Prostatectomy: Assurance of Water-Tight Vesicourethral Anastomotic Closure with the Lapra-TyClip. J Endourol 2008Zorn KC, Bernstein AJ, Gofrit ON, Shikanov SA, Mikhail AA,Song DH, Zagaja GP, Shalhav AL. Long-Term Functional andOncological Outcomes of Patients Undergoing Sural NerveInterposition Grafting during Robot-Assisted LaparoscopicRadical Prostatectomy. J Endourol 2008Schade GR, Gofrit ON, Zorn KC. Renal angiomyolipoma withintravascular extension into the inferior vena cava: a case reportand review of the literature. Can J Urol 2008; 15(2):4012–5Gofrit ON, Zorn KC, Silvestre J, Shalhav AL, Zagaja GP, MsezaneLP, Steinberg GD. The predictive value of multi-targeted fluorescentin-situ hybridization in patients with history of bladder cancer.Urol Oncol 2008; 26(3):246–9Gofrit ON, Pode D, Pizov G, Zorn KC, Katz R, Duvdevani M,Shapiro A. The natural history of bladder carcinoma in situ afterinitial response to bacillus Calmette-Gúerin immunotherapy. UrolOncol 2008Shikanov SA, Eng MK, Bernstein AJ, Katz M, Zagaja GP, ShalhavAL, Zorn KC. Urinary and Sexual Quality of Life 1 Year FollowingRobotic Assisted Laparoscopic Radical Prostatectomy. J Urol 2008Lucioni A, Orvieto MA, Zorn KC, Lotan T, Gong EM, SteinbergGD, Shalhav AL. Efficacy of the argon beam coagulator alone inobtaining hemostasis after laparoscopic porcine heminephrectomy:a pilot study. Can J Urol 2008; 15(3):4091–6Shikanov SA, Thong A, Gofrit ON, Zagaja GP, Steinberg GD,Shalhav AL, Zorn KC. Robotic Laparoscopic Radical Prostatectomyfor Biopsy Gleason 8 to 10: Prediction of Favorable PathologicOutcome with Preoperative Parameters. J Endourol 2008Eng MK, Katz MH, Bernstein AJ, Shikanov S, Shalhav AL, ZornKC. Laparoscopic Port-Site Metastasis in Urologic Surgery. JEndourol 2008Eng MK, Zorn KC, Bernstein AJ, Katz M, Shalhav AL. Transplantationof a cadaveric polycystic kidney: An update with 15 yearfollow-up. Transplant Proc 2008; 40(5):1747–1750VASCULAR SURGERY AND ENDOVASCULAR THERAPYHisham Bassiouny, MDLee SW, Smith DS, Loth F, Fischer PF, Bassiouny HS. Numericaland experimental simulation of transitional flow in a blood vesseljunction. International Journal of Heat and Mass Transfer 2007;51:1–22Fischer PF, Loth F, Lee SE, Lee SW, Smith DS, Bassiouny HS.Simulation of high Reynolds number vascular flows. InternationalJournal of Computer Methods in Applied Mechanics andEngineering (CMAME) 2007; 196:3049–3060Wahlgren CM, Piano G, Desai TR, Shaalan W, Bassiouny HS.Transperitoneal versus retroperitoneal suprarenal cross-clampingfor repair of AAA with a hostile infrarenal aortic neck. Annals ofVascular Surgery 2007; 21(6):687–694Lee SW, Smith DS, Loth F, Fischer PF, Bassiouny HS. Importanceof flow division on transition to turbulence within an arteriovenousgraft. J Biomech 2007; 40(5):981–92Loth F, Fischer PF, Bassiouny HS. Blood flow in end-to-sideanastamoses: Annual Review of Fluid Dynamics 2008; 40:367–393Wahlgren CM, Skelly CL, Shalhav A, Bassiouny HS. Hybrid laparoroboticdebranching and endovascular repair of thoracoabdominalaortic aneurysm. Annals of Vascular Surgery 2008; 22:285–289Shaalan WE, Wahlgren CM, Desai T, Piano G, Skelly C, BassiounyHS. Reappraisal of internal carotid artery stenosis velocityBlebea J, Labroupoulos N, Bassiouny HS, Johanning JM. Recommendedreporting standards for the vascular assessment of patients. JVasc Surg 2008; In pressLoor G, Skelly CL, Wahlgren CM, Bassiouny HS, Piano G, ShaalanW, Desai TR. A comparison of infrainguinal bypass and rotationalatherectomy in the treatment of advance arterial occlusive disease.J Vasc Med 2008; under reviewLoor G, Bassiouny HS, Valentin C, Shao MY, Funaki B, Desai TR.Natural history of retroperitonela hematomas: Should size aloneinfluence the decision to evacuate? JACS 2008; under reviewLee SE, Lee SW, Fischer PF, Bassiouny HS, Loth F. Direct numericalsimulation of transitional flow in a stenosed carotid bifurcation.J Biomech 2008Tina Desai, MDWahlgren CM, Piano G, Desai T, Shaalan W, Bassiouny H.Transperitoneal versus Retroperitoneal Suprarenal Cross-Clampingfor Repair of Abdominal Aortic Aneurysm with a Hostile InfrarenalAortic Neck. Ann Vasc Surg 2007; 21(6):687–94Shaalan WE, Wahlgren CM, Desai T, Piano G, Skelly C, BassiounyHS. Reappraisal of velocity criteria for carotid bulb/internalcarotid artery stenosis utilizing high-resolution B-mode ultrasoundvalidated with computed tomography angiography. J Vasc Surg2008; 48(1):104–112Spiguel L, Desai TR. Commentary on “Embolic protection ininfrainguinal interventions.” Perspect Vasc Surg Endovasc Ther 2008;20(1):68–9Kirkwood ML, Wahlgren CM, Desai TR. The Use of ArterialClosure Devices for Incidental Arterial Injury. Vasc EndovascularSurg 2008Loor G, Skelly Cl, Wahlgren CM, Bassiouny HS, Piano G, ShaalanW, Desai TR. A comparison of infrainguinal bypass and rotationalatherectomy in the treatment of advanced arterial occlusive diseaseJ Vasc Med 2008; under reviewLoor G, Bassiouny HS, Valentin C, Shao MY, Funaki B, Desai TR.Natural history of retroperitoneal hematomas: Should size aloneinfluence the decision to evacuate? JACS 2008; under reviewGiancarlo Piano, MDWahlgren CM, Piano G, Desai T, Shaalan W, Bassiouny H.Transperitoneal versus Retroperitoneal Suprarenal Cross-Clampingfor Repair of Abdominal Aortic Aneurysm with a Hostile InfrarenalAortic Neck. Ann Vasc Surg 2007; 21(6):687–94Van Ha TG, Chien AS, Funaki BS, Lorenz J, Piano G, Shen M,Leef J. Use of Retrievable Compared to Permanent Inferior VenaLoor G, Skelly Cl, Wahlgren CM, Bassiouny HS, Piano G, ShaalanW, Desai TR. A comparison of infrainguinal bypass and rotationalatherectomy in the treatment of advanced arterial occlusive diseaseJ Vasc Med 2008; under reviewChristopher Skelly, MDSkelly CL, Chandiwal A, Vosicky JE, Weichselbaum RR, RoizmanB. Attenuated herpes simplex virus 1 blocks arterial apoptosis andintimal hyperplasia induced by balloon angioplasty and reducedblood flow. Proc Natl Acad Sci USA 2007; 104(30):12474–8Wahlgren CM, Prema J, Spiguel LR, Skelly CL. Restenosis aftercarotid angioplasty and stent: a review. Italian J Vasc Endovasc Surg2007; 14:103–114Wahlgren CM, Lohman R, Pearce BJ, Spiguel LR, Dorafshar A,Skelly CL. Metachronous giant brachial artery pseudoaneurysms:a case report and review of the literature. Vasc Endovascular Surg2007; 41(5):467–72Shaalan WE, Wahlgren CM, Desai TR, Piano G, Skelly CL,Bassiouny HS. Reappraisal of internal carotid artery stenosis veloctythresholds utilizing high-resolution B-made ultrasound validatedwith computed tomography angiography (CTA). Journal of VascularSurgery 2008; 48(1):104–112Wahlgren CM, Skelly CL, Shalhav A, Bassiouny HS. Hybrid laparoroboticdebranching and endovascular repair of thoracoabdominalaortic aneurysm. Annals of Vascular Surgery 2008; 22:285–289Spiguel LR, Skelly CL. Nicotinic Effects on Vascular SmoothMuscle Cell Homeostasis. J Surg Res 2008; in pressLoor G, Skelly CL, Wahlgren CM, Bassiouny HS, Piano G, ShaalanW, Desai TR. A comparison of infrainguinal bypass and rotationalatherectomy in the treatment of advanced arterial occlusive disease.J Vasc Med 2008; under review61ANNUAL REPORT 2008

DEVELOPMENTThe University of Chicago Department of Surgery hasreceived generous contributions that help us to sustainLeft: The Dennis and Claire Nardoni Surgical Conference Center features state-of-the-art technology and cross-communicationand grow our clinical, research and educational programs.Supporters of the Department help us transform surgicalcapabilities. Right: (Left to Right) Mitchell C. Posner, MD, Claire Nardoni, Dennis Nardoni, Jeffrey B. Matthews, MD, and CraigDuchossois at the ribbon-cutting ceremony for the Dennis and Claire Nardoni Surgical Conference Center.care through the realization of our aspirations and priorities,62UNIVERSITY OF CHICAGO DEPARTMENT OF SURGERYsuch as development of the latest technologies, tissueengineering, cancer research and treatment, regenerativemedicine and further research into the basic biology ofsurgical disease.We would like to thank our corporations, foundationsand individual donors for their extraordinary generosityin support of our academic programs.In fiscal year 2008, some of the Department’s majordonors include:The Brain Research FoundationThe Brinson FoundationThe Foley Family FoundationThe Michael Rolfe Pancreatic Cancer FoundationJudy and Wayne LewisMr. James P. McHughMr. Earl MeltzerMrs. Rita MeltzerGladys and Arthur PancoeThis unique, innovative facility is a newly designed,interactive, educational meeting and conference centerin the Department of Surgery featuring state-of-thearttechnology and remarkable cross-communicationcapabilities including video conferencing and live feedconnections to the operating rooms.We look forward to another full year of outreachactivities, which will include the University of ChicagoPhemister Surgical Society annual alumni reception,Discovery and Impact programs, trustee hosted dinners,tours, CME courses and lectures. If you’d like moreinformation about one of these events or how you canmake a difference to help educate the next generationof leaders, develop advanced treatments and offer hopeto those in need, contact either:Katy StaglAssociate Director of Development63ANNUAL REPORT 2008Left: Donald Liu, MD, PhD, speaking at his chair ceremonyfor his appointment as the Mary Campau Ryerson Professor.Right: James L. Madara, MD, (left), John Alverdy, MD,(center) and Jeffrey B. Matthews (right) at Dr. Alverdy’s chairceremony for his appointment as the Sara and Harold LincolnThompson Professor.Mr. and Mrs. John B. SnyderOpportunities for giving include patient care programs,designated research projects, fellowships and namedprofessorships. This past year alone, we were able tohonor four of our distinguished faculty with namedprofessorships, including: John C. Alverdy, MD, Sara andHarold Lincoln Thompson Professor; David Frim, MD,PhD, Ralph Cannon Professor of Neurosurgery; DonaldC. Liu, MD, PhD, Mary Campau Ryerson Professor;and Arieh Shalhav, MD, Fritz and Mary Lee DudaFamily Professor.Another key accomplishment was the opening of theDennis and Claire Nardoni Surgical Conference Center.University of Chicago Medical Centerkstagl@mcdmail.uchicago.edu(773) 834-1301http://sparkdiscovery.uchicago.eduJeffrey B. Matthews, MDDallas B. Phemister Professor of SurgeryChairman, Department of SurgeryThe University of Chicago5841 S. Maryland Ave. MC 5029Chicago, IL 60637jmatthews@surgery.bsd.uchicago.edu(773) 702-0881http://surgery.uchicago.edu

DEPARTMENT OF SURGERY773.702.0881Web site: http://surgery.uchicago.eduDesign: Words&Pictures, Inc.

DEPARTMENT OF SURGERY5841 South Maryland Avenue, MC 5029Chicago, IL 60637773.702.0881Web site: http://surgery.uchicago.edu