Book of Abstracts - Australian Centre for Economic Research on ...

3rd Cell Stress Society International Congress on
Stress Responses in Biology and Medicine and
2nd World Conference <strong>of</strong> Stress
month. Three sets <strong>of</strong> the mentioned EMR doses (5 hr/day) induced significant decrease <strong>of</strong> proliferating cell
number within the RMS <strong>of</strong> rats irradiated at P8 regardless postirradiation survival period. On the other hand
the same doses <strong>of</strong> the EMR applied in two sets induced increase <strong>of</strong> proliferating cells numbers only in the
acute postirradiation period. In the aging rats the same doses <strong>of</strong> EMR induced decrease <strong>of</strong> proliferationg cell
number regardless postirradiation survival period.
5J_09_P
(poster section B1, poster board #253, 25 th <strong>of</strong> August)
IMPULSE ACTIVITY OF SUPRAOPTIC CELLS OF HYPOTHALAMUS AFTER LONG-
LASTING INFLUENCE OF LOW-INTENSITY EXTREMELY HIGH FREQUENCY
RADIATION
G. Yu. Grigoryan, S. M. Minassian, S. G. Sahakyan
Yerevan State University, Alek Manoogyan Str. 1, 375025 Yerevan, Armenia
The influence <strong>of</strong> environmental factors was sharply increased in existing ecological condition. In particular,
long-lasting influence <strong>of</strong> electromagnetic radiation <strong>of</strong> different ranges results in a stress-related strained state
<strong>of</strong> the organism. Our investigation was aimed at the revealing <strong>of</strong> effects <strong>of</strong> low-intensity extremely high
frequency radiation on the spontaneous activity <strong>of</strong> the rats’ supraoptic nucleus neurons <strong>of</strong> hypothalamus
within different periods <strong>of</strong> influence (up to 15 days). In acute experiments on nembutal-anesthetized rats, the
extracellular recording and analysis <strong>of</strong> impulse activity <strong>of</strong> supraoptic cells in norm and after exposure were
carried out. The distributions <strong>of</strong> neurons by the degree <strong>of</strong> regularity and dynamics <strong>of</strong> neuronal current flows
as well as the average frequency <strong>of</strong> impulsation and the interspike intervals' coefficient <strong>of</strong> variation were
evaluated. The shifts <strong>of</strong> the impulse activity <strong>of</strong> supraoptic cells, concerning both <strong>of</strong> internal structure and <strong>of</strong>
statistic parameters <strong>of</strong> the impulse streams, under the 15-day exposure were revealed. The presence <strong>of</strong>
statistically significant maximal expressiveness <strong>of</strong> the investigated parameters shifts on the 10th day and the
tendency <strong>of</strong> their similarity with the initial data on the 15th day <strong>of</strong> the electromagnetic factor influence was
find out. We have observed increase <strong>of</strong> neurons’ regularity grade that is correlated with some decrease in
interspike intervals' coefficient <strong>of</strong> variation. The significant reduction <strong>of</strong> quantity <strong>of</strong> neurons with group
activity was revealed as well. Phase character <strong>of</strong> changes <strong>of</strong> supraoptic cells’ average frequency in dynamics <strong>of</strong>
15-day radiation was observed also. It allowed us to assume that the influence <strong>of</strong> electromagnetic radiation
could lead to the modulation <strong>of</strong> neurons excitability.
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