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The Role of the Respiratory Therapist in Organ Donation The ...

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<strong>The</strong> <strong>Role</strong> <strong>of</strong> <strong>the</strong> <strong>Respiratory</strong><br />

<strong>The</strong>rapist <strong>in</strong> <strong>Organ</strong> <strong>Donation</strong><br />

Presented by<br />

Oscar Colon, RN CPTC<br />

In-house Cl<strong>in</strong>ical <strong>Donation</strong> Specialist III<br />

<strong>The</strong> Shar<strong>in</strong>g Network<br />

• Private non-pr<strong>of</strong>it service organization<br />

• Federal designation to provide recovery<br />

services<br />

• State licensed<br />

• Available 24 hours/7 days a week<br />

• Arrange for <strong>the</strong> recovery <strong>of</strong> all organs and<br />

tissues<br />

<strong>Organ</strong> Transplant<br />

Wait<strong>in</strong>g Lists<br />

January 2010<br />

105,000Total Wait<strong>in</strong>g <strong>in</strong> U.S.<br />

3,100 Total Wait<strong>in</strong>g In NJ<br />

1


Hospitals<br />

Conditions <strong>of</strong> Participation<br />

1. Refer all deaths to <strong>the</strong><br />

OPO. Referral must be<br />

“timely” and<br />

“imm<strong>in</strong>ent.”<br />

2. Hospitals must<br />

participate with <strong>the</strong>ir<br />

approved OPO <strong>in</strong><br />

Medical Reviews.<br />

3. Only staff tra<strong>in</strong>ed or<br />

employed by an OPO<br />

may <strong>of</strong>fer families <strong>the</strong><br />

options <strong>of</strong> donation<br />

4. All request for donation<br />

must be a collaborative<br />

effort between OPO and<br />

hospital.<br />

5. Develop cooperative<br />

relationships with eye<br />

and tissue banks.<br />

6. <strong>The</strong> OPO must<br />

determ<strong>in</strong>e donor<br />

suitability.<br />

Current Cl<strong>in</strong>ical Triggers:<br />

When to Refer<br />

Imm<strong>in</strong>ent Death Referrals<br />

Regardless <strong>of</strong> age, diagnosis, cause <strong>of</strong> death, sedation or religious beliefs<br />

call on all vented patients<br />

with<strong>in</strong> 1 hour <strong>of</strong> meet<strong>in</strong>g any <strong>of</strong> <strong>the</strong> follow<strong>in</strong>g cl<strong>in</strong>ical triggers:<br />

• Glasgow coma scale (GCS) 5 or less<br />

• Absence <strong>of</strong> 2 or more <strong>of</strong> <strong>the</strong> follow<strong>in</strong>g reflexes:<br />

Cough Reflex<br />

Gag Reflex<br />

Pupillary response to light Corneal Reflex<br />

Response to Pa<strong>in</strong><br />

Loss <strong>of</strong> Respirations<br />

• Call when contemplat<strong>in</strong>g discussions <strong>of</strong> <strong>the</strong> follow<strong>in</strong>g:<br />

Before withdrawal <strong>of</strong> life support, mak<strong>in</strong>g End <strong>of</strong> Life Decisions -<br />

while organs for transplant are still viable<br />

How <strong>the</strong> staff sees us:<br />

2


Incidence <strong>of</strong> Bra<strong>in</strong> Death<br />

• About 75,000 deaths per year <strong>in</strong> N.J.<br />

• 32,000 – 34,000 <strong>of</strong> those deaths <strong>in</strong> hospitals<br />

• Only 275-325 are bra<strong>in</strong> dead and medically<br />

suitable<br />

• That is less than .01% <strong>of</strong> all deaths<br />

<strong>Organ</strong> <strong>Donation</strong><br />

One organ donor can save up to 8 lives<br />

• Heart<br />

• Lungs<br />

• Liver<br />

• Kidneys<br />

• Pancreas<br />

• Small Intest<strong>in</strong>e<br />

Tissue <strong>Donation</strong><br />

(50 or more potential recipients)<br />

• Bone - orthopedic surgeries such as sp<strong>in</strong>al, knee<br />

replacements, hip revisions and dental procedures.<br />

• S<strong>of</strong>t tissue – for sport <strong>in</strong>juries such as Achilles tendon<br />

replacement<br />

• Corneas – restores sight<br />

• Heart valves – used for heart valve replacement<br />

surgery<br />

• Blood vessels – for bypass surgery<br />

• Sk<strong>in</strong> – used for wound and burn graft<strong>in</strong>g<br />

3


Steps <strong>in</strong> <strong>the</strong> <strong>Donation</strong> Process<br />

• 1. Referral<br />

• 2. Evaluation<br />

• 3. Consent<br />

• 4. Ma<strong>in</strong>tenance<br />

• 5. Recovery<br />

• 6. Follow-up<br />

<strong>The</strong> Referral<br />

• Report all deaths –mandated by COP<br />

• Cardiac deaths – Call with<strong>in</strong> 1 hour after <strong>the</strong><br />

patient expires<br />

• Potential organ donor – Call with<strong>in</strong> 1 hour<br />

when <strong>the</strong> patient meets cl<strong>in</strong>ical triggers at or<br />

<strong>in</strong>itiation <strong>of</strong> bra<strong>in</strong> death protocol, Glasgow<br />

Coma Scale <strong>of</strong> 5 or less<br />

<strong>The</strong> Evaluation<br />

• Response –on sight transplant<br />

coord<strong>in</strong>ator<br />

• Donor suitability-lab data, current<br />

status<br />

• Requirements for declaration <strong>of</strong> death<br />

• Medical and social history thru chart<br />

review<br />

4


<strong>The</strong> Consent<br />

• Family assessment-legal NOK and decision<br />

makers<br />

• Decoupl<strong>in</strong>g <strong>in</strong>formation<br />

• Presentation <strong>of</strong> donation options by<br />

“Effective Requestor”<br />

• Legal consent<br />

• Test<strong>in</strong>g -<strong>in</strong>fectious disease screen<strong>in</strong>g<br />

• Medical exam<strong>in</strong>er<br />

Ma<strong>in</strong>tenance<br />

• Ma<strong>in</strong>ta<strong>in</strong> optimal organ function<br />

• Maximize on number <strong>of</strong> recipients<br />

• Ma<strong>in</strong>ta<strong>in</strong> hemodynamic stability<br />

• Adequate oxygenation<br />

<strong>Organ</strong> Shar<strong>in</strong>g<br />

• All recipients listed with UNOS (United<br />

Network for <strong>Organ</strong> Shar<strong>in</strong>g)<br />

• Match run lists from donor <strong>in</strong>formation<br />

• Each organ has separate list<br />

• OPO mandated to share organs by list<br />

• Local centers get greatest priority<br />

5


<strong>The</strong> Recovery<br />

• Use <strong>of</strong> operat<strong>in</strong>g room at donor hospital<br />

• Surgical recovery and preservation <strong>of</strong><br />

organs<br />

• Tissue recovery after organs recovered<br />

• Reconstruction <strong>of</strong> body<br />

• Body released – to medical exam<strong>in</strong>er or<br />

funeral home<br />

Follow up<br />

• Family - provide follow up letter<br />

• Hospital staff - outcomes and appreciation<br />

• Family aftercare support<br />

• Communication - donor family and<br />

recipient(s)<br />

When are you dead<br />

6


New Jersey Legal Def<strong>in</strong>ition<br />

• “An <strong>in</strong>dividual who has susta<strong>in</strong>ed ei<strong>the</strong>r (1)<br />

IRREVERSIBLE cessation <strong>of</strong> circulatory and<br />

respiratory functions, or (2) IRREVERSIBLE<br />

cessation <strong>of</strong> ALL functions <strong>of</strong> <strong>the</strong> bra<strong>in</strong> <strong>in</strong>clud<strong>in</strong>g<br />

<strong>the</strong> bra<strong>in</strong> stem, is dead.<br />

A determ<strong>in</strong>ation <strong>of</strong> death must be made <strong>in</strong><br />

accordance with accepted medical standards.”<br />

State Regulations for Bra<strong>in</strong> Death<br />

• Board <strong>of</strong> Medical Exam<strong>in</strong>ers took law and<br />

passed regulations<br />

• Assure consistent practice<br />

• Create standard <strong>of</strong> care<br />

• Provided level <strong>of</strong> authority to develop new<br />

standards as time progressed<br />

Bra<strong>in</strong> Death: Board Of ME<br />

Appropriate Observation Period<br />

Age<br />

Cause <strong>of</strong> Injury<br />

Cl<strong>in</strong>ical Exams:<br />

M<strong>in</strong>imum<br />

Period <strong>of</strong><br />

Observation<br />

Confirmatory<br />

Test<br />

Any age Any cause One exam only Yes<br />

< 2 months Any cause 48 hours No<br />

2 to 12<br />

months<br />

Any cause 24 hrs No<br />

> 12 months Any cause 6 hrs No<br />

7


Ascerta<strong>in</strong> Irreversibility<br />

• Known etiology<br />

• Rule out <strong>in</strong>toxication<br />

• Rule out abnormal metabolic states<br />

• Rule out pr<strong>of</strong>ound hypo<strong>the</strong>rmia<br />

• Temporal space between exams<br />

Ascerta<strong>in</strong> Totality<br />

• Unresponsiveness GCS <strong>of</strong> 3<br />

• Absence <strong>of</strong> bra<strong>in</strong> stem reflexes<br />

• Apnea<br />

• Acceptance <strong>of</strong> sp<strong>in</strong>al reflexes<br />

• Cerebral Doppler<br />

Confirmatory Tests<br />

• Nuclear Cerebral Blood Flow Study<br />

• Cerebral Vessel Angiography / MRI<br />

8


<strong>The</strong> Apnea Test<br />

• A method to determ<strong>in</strong>e absolute apnea<br />

• Based on a f<strong>in</strong>d<strong>in</strong>g that apnea cannot be<br />

reliably diagnosed unless it occurs <strong>in</strong> a<br />

sett<strong>in</strong>g <strong>of</strong> adequate hypercarbic stimulation<br />

<strong>of</strong> <strong>the</strong> bra<strong>in</strong>stem.<br />

• A PaCO2 <strong>of</strong> 60 mmHG or more is generally<br />

considered adequate hypercarbic<br />

stimulation <strong>of</strong> <strong>the</strong> respiratory centers.<br />

Perform<strong>in</strong>g <strong>the</strong> Apnea Test<br />

• Obta<strong>in</strong> a basel<strong>in</strong>e ABG<br />

• Make necessary ventilator changes to achieve a<br />

PaCO2 <strong>of</strong> 40 mmHG and a pH


Perform<strong>in</strong>g <strong>the</strong> Apnea Test<br />

• If spontaneous breath<strong>in</strong>g does not occur and<br />

patient is hemodynamically stable; after 10<br />

m<strong>in</strong>utes draw an ABG<br />

• If PaCO2 is greater than 60 mmHG or 20<br />

po<strong>in</strong>ts above basel<strong>in</strong>e PaCO2 and <strong>the</strong>re<br />

have been no spontaneous respirations; <strong>the</strong><br />

test is positive and <strong>the</strong> patient is considered<br />

to be apneic<br />

How can you help<br />

• Notify MD/RN <strong>of</strong> changes <strong>in</strong> patients<br />

ventilatory status<br />

• Inquire if <strong>the</strong> referral has been made to<br />

NJSN – If not call us 1800-541-0075<br />

• Please do not mention <strong>Donation</strong>!!!!<br />

• Be an active part <strong>of</strong> <strong>the</strong> healthcare team;<br />

jo<strong>in</strong> <strong>in</strong> our huddles<br />

• Provide aggressive pulmonary support<br />

Someth<strong>in</strong>g to th<strong>in</strong>k about..<br />

• “What’s good for <strong>the</strong> Lungs is<br />

good for <strong>the</strong> Body”<br />

10


How can you help<br />

• Help overcome atelectasis<br />

• Ma<strong>in</strong>ta<strong>in</strong> HOB at 30 degrees<br />

• Turn patient every 2 hours<br />

• Frequent suction<strong>in</strong>g and good mouth care<br />

• Chest PT every 4 hours<br />

• Hyper <strong>in</strong>flate ETT cuff; which reduces aspiration<br />

and protects <strong>the</strong> lungs<br />

• Bronchodilators every 4 hours<br />

• Pulmonary toilet<br />

• Lung Recruitment<br />

Pulmonary Management Goal<br />

is to<br />

Ensure adequate ventilation<br />

• Pressure - Control Ventilation<br />

• TV 10-15ml/kg<br />

• Peep 5-10cm<br />

• ABG’s every 2-3 hours adjust sett<strong>in</strong>gs accord<strong>in</strong>gly to<br />

ma<strong>in</strong>ta<strong>in</strong> optimal parameters<br />

– pH 7.35 -7.45<br />

– PaCO2 35-45<br />

– PaO2 >100<br />

– HCO3 22-26<br />

– O2 Sat 95-100%<br />

• PIP < 30 cm H2O<br />

Requirements for Lung <strong>of</strong>fers<br />

• O 2 Challenge (pO2 > 300mmHg)<br />

• Arterial Blood Gases<br />

• Sputum Culture<br />

• Chest X-rays<br />

• Bronchoscopy<br />

• Lung measurements<br />

• Pulmonary Consult<br />

11


O2 Challenge<br />

• Place patient on 100% FIO2 with 5cm<br />

PEEP for 30 m<strong>in</strong>utes<br />

• After 30 m<strong>in</strong>utes draw an ABG & switch<br />

FIO2 back to orig<strong>in</strong>al sett<strong>in</strong>g<br />

• Lung Transplant Surgeons are look<strong>in</strong>g for<br />

PaO2 >300<br />

What is DCD<br />

• Formerly called Non-Heart-Beat<strong>in</strong>g-<strong>Donation</strong>, <strong>Donation</strong> After<br />

Cardiac Death has been an end-<strong>of</strong>-life option for patients and<br />

families for than 30 years.<br />

• After <strong>the</strong> decision has been made that <strong>the</strong> patient has no chance <strong>of</strong><br />

survival and <strong>the</strong> family has decided to withdraw life support, <strong>the</strong><br />

Shar<strong>in</strong>g Network is contacted and evaluates <strong>the</strong> patient for<br />

medical suitability. If patient is suitable, <strong>the</strong> family is <strong>of</strong>fered <strong>the</strong><br />

option <strong>of</strong> DCD.<br />

• It is <strong>the</strong> recovery <strong>of</strong> organs from those patients who do not meet<br />

<strong>the</strong> criteria <strong>of</strong> bra<strong>in</strong> death. Usually, <strong>the</strong>se patients have suffered a<br />

severe, irreversible bra<strong>in</strong> <strong>in</strong>jury, but reta<strong>in</strong> some bra<strong>in</strong> stem<br />

activity<br />

DCD is Not a New Process……<br />

• Kidney transplants began <strong>in</strong> <strong>the</strong> 1950s<br />

• Early recoveries were from DCD donors<br />

• Bra<strong>in</strong> death criteria established <strong>in</strong> 1960s<br />

• Recent renewed <strong>in</strong>terest <strong>in</strong> DCD-<strong>the</strong> wait<strong>in</strong>g<br />

list is ever grow<strong>in</strong>g!<br />

12


SCORE:<br />

8-12 High Risk for cont<strong>in</strong>u<strong>in</strong>g to brea<strong>the</strong> after extubation<br />

13-18 Moderate Risk for cont<strong>in</strong>u<strong>in</strong>g to brea<strong>the</strong> after extubation<br />

19-24 Low Risk for cont<strong>in</strong>u<strong>in</strong>g to brea<strong>the</strong> after extubation<br />

DCD TOOL<br />

• Prior to <strong>the</strong> test record <strong>the</strong> BP, Pulse, O2 sat<br />

• Disconnect <strong>the</strong> patient from <strong>the</strong> ventilator<br />

• After 5 m<strong>in</strong>utes and 10 m<strong>in</strong>utes record <strong>the</strong><br />

follow<strong>in</strong>g:<br />

– BP, Pulse, O2 sat, respiratory effort (yes or no),<br />

respiratory rate, Tidal volume, NIF<br />

• If patient becomes unstable (O2 sat 40 3<br />

2 – Tidal Volume<br />

Tidal Volume > 200ml 1<br />

Tidal Volume < 200ml 3<br />

3 – Negative Inspiratory Force (NIF)<br />

NIF > -20cmH2O 1<br />

NIF -1 to -20cmH2O 3<br />

****No Spontaneous Respirations automatic 9<br />

5 - BMI<br />

30 3<br />

6 - Vasopressors<br />

No Vasopressors 1<br />

S<strong>in</strong>gle Vasopressor 2<br />

Multiple Vasopressors 3<br />

7 - Patient Age<br />

0-30 1<br />

31-50 2<br />

51 + 3<br />

8 - Intubation<br />

Endotracheal Tube 3<br />

Tracheostomy 1<br />

9 - Oxygenation After 10 M<strong>in</strong>utes<br />

O2 Sat. > 90% 1<br />

O2 Sat. 80-89% 2<br />

O2 Sat. < 79% 3<br />

10- Leak Test: Present Absent Total Score →<br />

Date <strong>of</strong> Extubation:<br />

Date <strong>of</strong> Expiration:<br />

Time <strong>of</strong> Extubation:<br />

Time <strong>of</strong> Expiration:<br />

Total Time:<br />

Formula for Calculat<strong>in</strong>g BMI<br />

BMI = (_________weight <strong>in</strong> pounds__________) X 703<br />

(Height <strong>in</strong> <strong>in</strong>ches) X (Height <strong>in</strong> <strong>in</strong>ches)<br />

13


<strong>Respiratory</strong> <strong>The</strong>rapist’s <strong>Role</strong> <strong>in</strong><br />

<strong>the</strong> OR<br />

Bra<strong>in</strong> Dead – pulmonary management, help transport <strong>the</strong><br />

patient, preferably on a portable vent<br />

- hand <strong>of</strong>f to anes<strong>the</strong>sia<br />

DCD - help transport <strong>the</strong> patient, preferably on a portable<br />

vent<br />

- assist <strong>the</strong> attend<strong>in</strong>g physician and <strong>the</strong><br />

ICU nurse with extubation <strong>in</strong> <strong>the</strong> O.R. as<br />

per standard ICU procedure (suction,<br />

extubate etc.)<br />

Families<br />

give <strong>the</strong> gift<br />

<strong>of</strong> life...<br />

if only we give<br />

<strong>the</strong>m <strong>the</strong><br />

opportunity.<br />

Thank You !!!<br />

Disclaimer<br />

All lecture materials will be posted for 30 days after <strong>the</strong> date <strong>of</strong><br />

<strong>the</strong> conference. <strong>The</strong> material is <strong>in</strong>tended for educational<br />

purposes only, public distribution or use <strong>of</strong> this material is not<br />

allowed without <strong>the</strong> speaker's permission. For more<br />

<strong>in</strong>formation please contact:<br />

http://shrp.umdnj.edu/programs/rspth/UH_conference.htm<br />

Terrence Shenfield<br />

Program Coord<strong>in</strong>ator<br />

shenfite@umdnj.edu<br />

(973) 972-8825<br />

14

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