Student Accolades Congratulations to our newly funded F30 Awards! Amin Afrazi, Regulation <strong>of</strong> TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis (Mentor: David Hackam, MD, PhD) Agnieszka Kalinowski, Molecular Determinants <strong>of</strong> Lamin A Accumulation in Human Aging and Disease (Mentor: Kris Noel Dahl, PhD) Gerald Nora, Processing <strong>of</strong> Alternative Structures in Telomeric DNA (Mentor: Patricia Opresko, PhD) Daniel Roh, Homeostatic Roles <strong>of</strong> Connexin43 in response to DNA Damage (Mentor: James Funderburgh, PhD) Deepak Soneji, Sensitization <strong>of</strong> Intact Nociceptors Following Contralateral Nerve Injury (Mentor: Richard Koerber, PhD) Jeremy Tilstra, The Role <strong>of</strong> NF-kB Signaling in Aging (Mentor: Paul Robbins, PhD) Congratulations, Doctor! Recently Awarded PhDs Mehret Birru The Associations <strong>of</strong> Ethnicity, Cardiovascular Risk Factors, and Socioeconomic Status with Subclinical Cardiovascular Disease, Advisor: Karen Matthews, PhD (Epidemiology; Pitt) Christopher Crowe Critical Role <strong>of</strong> Interleukin-17 Receptor Signaling in the Immunopathology <strong>of</strong> Influenza Infection, Advisor: Jay Kolls, MD (Immunology; Pitt) Sherrie Divito Recipient Dendritic Cells Dictate Allograft Fate, Advisor: Adrian Morelli, MD, PhD (Immunology; Pitt) Corrine Kliment Extracellular Superoxide Dismutase, Oxidative Stress and Extracellular Matrix Syndecans in Pulmonary and Cardiac Fibrosis, Advisor: Tim Oury, MD, PhD (Cellular and Molecular Pathology; Pitt) Cyrus Raji The Role <strong>of</strong> Hypertensive Vascular Disease in Brain Aging and Neurodegeneration, Advisor: William Klunk, MD, PhD (Cellular & Molecular Pathology; Pitt) Peter Vosler Critical Role <strong>of</strong> Eukaryotic Translation Initiation Factor 4G Degradation in Mediating Ischemia-induced Neuronal Death, Advisor: Jun Chen, MD, PhD (Neuroscience; Pitt) Genevieve Woodard Evaluating Novel Risk Factor Associations for Subclinical Cardiovascular Disease, Advisor: Kim Sutton-Tyrrell, M.P.H., Dr.P.H. (Epidemiology; Pitt) 6 Pezzone, from page 2 for the second year Digestion and Nutrition course, rounds with residents and works with fellows in the clinic, all <strong>of</strong> which allow him many opportunities to teach medical trainees. Dr. Pezzone emphasizes that “an advantage <strong>of</strong> being an MD/PhD is having the ability to work on clinical trials and make clinical observations that can then be studied in animal models <strong>of</strong> disease. It’s great being able to work on both sides <strong>of</strong> the equation.” In addition to the progress made with his work on gastrointestinal pain research, Dr. Pezzone has also received the honor <strong>of</strong> being named one <strong>of</strong> <strong>Pittsburgh</strong> Magazine’s Top Doctors for the past two years. He enjoys being invited to conferences for patient organizations as well as speaking to the public about new therapies and clinical trials that have the potential to help a great many <strong>of</strong> his patients that suffer from pain with no identifiable source. Over the course <strong>of</strong> the 22 years Dr. Pezzone has spent here at the <strong>University</strong> <strong>of</strong> <strong>Pittsburgh</strong>, he has found that what he values most are the connections and collaborations he has established with other faculty. He believes that this would certainly not be the case had he gone elsewhere for residency or for fellowship. Dr. Pezzone’s pearls <strong>of</strong> wisdom for current students in our program, whether they be starting out in their pre-clinical medical school years or are thinking about residency program applications is “to find good mentors and keep working hard. Your persistence will pay <strong>of</strong>f.” by Lolita Nidadavolu, G1 Dr. Pezzone can be contacted at pezzone@pitt.edu.
New <strong>MSTP</strong> Student Publications through October 2009 Agrawal, V., Johnson, S.A., Reing, J., Zhang, L., Tottey, S., Wang, G., Hirschi, K.K., Braunhut, S., Gudas, L.J., Badylak, S.F. (2009). An epimorphic regeneration approach to tissue replacement in adult mammals. Proceedings <strong>of</strong> the National Academy <strong>of</strong> Sciences. Accepted. Agrawal, V., Brown, B.N., Beattie, A.J., Gilbert, T.W., Badylak, S.F. (2009). Evidence <strong>of</strong> Innervation following Extracellular Matrix Scaffold Mediated Remodeling <strong>of</strong> Muscular Tissues. Journal <strong>of</strong> Tissue Engineering and Regenerative Medicine. Accepted, PMID: 19701935. Gilbert, T.W., Agrawal, V., Gilbert, M.R., Povirk, K.M., Badylak, S.F., Rosen, C.A. (2009). Liver Derived Extracellular Matrix as a Biologic Scaffold Material for Acute Vocal Fold Repair. Laryngoscope. 119(9): 1856-63. PMID: 19572393. Redman, P.T., Hartnett, K.A., Aras, M.A., Levitan, E.S. and Aizenman, E. (2009). Regulation <strong>of</strong> apoptotic potassium currents by coordinated zinc-dependent signaling. Journal <strong>of</strong> Physiology. 587:4393-4404. Aras, M.A., Saadi R.A. and E. Aizenman, (2009). Zn2+ regulates Kv2.1 voltagedependent gating and localization following ischemia. European Journal <strong>of</strong> Neuroscience. In press. Urban, N.N. and A.C. Arevian. (2009). Computing with dendrodendritic synapses in the olfactory bulb. Ann NY Acad Sci. 1170:264-9. Bales, J.W., Wagner, A.K., Kline, A.E. and C.E. Dixon. (2009). Persistent Cognitive Dysfunction After Traumatic Brain Injury: A Dopamine Hypothesis. Neuroscience and Biobehavioral Rev. 33(7):981-1003. Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W. and C.E. Dixon. Expression <strong>of</strong> protein phosphatase 2b (calcineurin) subunit a is<strong>of</strong>orms in rat hippocampus following a traumatic brain injury. Journal <strong>of</strong> Neurotrauma. Sep 14, 2009. Epub ahead <strong>of</strong> print. XuFeng, R., Boyer, M.J., Shen, H., Li, Y., Yu, H., Gao, Y., Yang, Q., Wang, Q., and T. Cheng. (2009). ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. PNAS 106(42):17763-8. Cackowski, F.C., Anderson, J.L, Patrene, K., Choksi, R.J., Shapiro, Steven D. and G.D. Roodman. (2009). Osteoclasts are important for bone angiogenesis. Blood. First Edition Online. DOI: 10.1182/Blood-2009-08-237628 Wells, A., Chao, Y. and Q. Wu. (2009). Biology <strong>of</strong> Cancer Metastases to the Liver. Molecular Pathology <strong>of</strong> Liver Diseases. Monga PS, editor. Springer Press. G<strong>of</strong>f, J.P., Shields, D.S., Seki, M., Choi, S., Epperly, M.W., Dixon, T., Wang, H., Bakkenist, C.J., Dertinger, S.D., Torous, D.K., Wittschieben, J., Wood, R.D. and J.S. Greenberger. (2009). Lack <strong>of</strong> DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiation Research. 172:165-74. Momciloviæ, O., Choi, S., Varum, S., Bakkenist, C., Schatten, G. and C. Navara. (2009). Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells. Stem Cells. 27:1822-35. Yan, J., Hokey, D.A., Morrow, M.P., Corbitt, N., Harris, K., Harris, D. and D.B. Weiner. (2009). Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques. Vaccine. 27: 3260-3266. Yan, J., Reichenbach, D.K., Corbitt, N., Hokey, D.A., Ramanathan, M.P., McKinney, K.A., Weiner, D.B. and D. Sewell. (2009) Induction <strong>of</strong> antitumor immunity in vivo following delivery <strong>of</strong> a novel HPV-16 DNA vaccine encoding an E6/ E7 fusion antigen. Vaccine. 27(3):431-40. Divito, S.J., Haught, J.M., English J.C. 3rd, and L.K. Ferris. (2009). An extensive case <strong>of</strong> dermonecrotic arachnidism. J Clin Aesthetic Dermatol. 2(9):40-43. Ogren, J.A., Bragin, A., Wilson, C.L., H<strong>of</strong>tman, G.D., Lin, J.J., Dutton, R.A., Fields, T.A., Toga, A.W., Thompson, P.M., Engel, J. Jr, and R.J. Staba. (2009). Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns. Epilepsia. 50(6):1361-70. [Image on cover] Oh, H.-I., Ye, S.H., Johnson, C.A. Jr, Woolley, J. R., Federspiel, W.J. and W.R. Wagner. Hemocompatibility Assessment <strong>of</strong> Carbonic Anhydrase Modified Hollow Fiber Membranes for Artificial Lungs. Artif Organs. Accepted. Ye, S.H., Johnson, C.A. Jr., Woolley, J.R., Oh, H.-I., Gamble, L.J., Ihsihara, K. and W.R. Wagner. (2009). Surface Modification <strong>of</strong> a Titanium Alloy with a Phospholipid Polymer by a Plasma-Induced Grafting Technique to Improve Surface Thromboresistance. Colloids and Surfaces B: Biointerfaces. 74: 96102. Isse, K., Specht, S., Lunz, J.G. III, Kang, L.I., Mizuguchi, Y., and A.J. Demetris. Estrogen Stimulates Female Biliary Epithelial Cell IL-6 Expression in Mice. Hepatology. In press. Kliment, C.R., Suliman, H.B., Tobolewski, J.M., Reynolds, C.M., Day, B.J., Zhu, X., McTiernan, C.F., McGaffin, K.R., Piantadosi, C.A. and T.D. Oury. (2009). Extracellular Superoxide Dismutase Regulates Cardiac Function and Fibrosis. J Mol Cell Cardiol. 47(5):730-42. PMID: 19695260 Guo, R.J., Funakoshi, S., Lee, H., Kong, J., and J.P. Lynch. (2009). The intestinespecific transcription factor Cdx2 inhibits â-catenin/TCF transcriptional activity by disrupting the â-catenin/TCF protein complex. Carcinogenesis. Epub ahead <strong>of</strong> print. Davidson, H.C., Leibowitz, M.S., Lopez-Albaitero, A. and R.L. Ferris. (2009). Immunotherapy for head and neck cancer. Oral Oncol. May 11, Epub ahead <strong>of</strong> print. Milutinovic, P.S., Zhao, J. and J.M. Sonner, (2009). Tolerance to is<strong>of</strong>lurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 108(1): 176-80. Cantor, R.S., Twyman, K.S., Milutinovic, P.S. and R. Haseneder. (2009). A kinetic model <strong>of</strong> ion channel electrophysiology: bilayer-mediated effects <strong>of</strong> agonists and anesthetics on protein conformational transitions. S<strong>of</strong>t Matter. 5: 3266-3278. Yang, M., Adla, S., Temburni, M.K., Patel, V.P., Lagow, E.L., Brady, O.A., Tian, J., Boulos, M.I. and D.S. Galileo. (2009) Stimulation <strong>of</strong> glioma cell motility by expression, proteolysis, and release <strong>of</strong> the L1 neural cell recognition molecule. Cancer Cell Int. In Press. Roh, D.S., Cook, A.L., Rhee, S.S., Joshi, A., Kowalski, R., Dhaliwal, D.K. and J.L. Funderburgh. (2008). DNA cross-linking, double-strand breaks, and apoptosis in corneal endothelial cells after a single exposure to mitomycin C. Invest Ophthalmol Vis Sci. 49(11):4837-43. Roh, D.S, and J.L. Funderburgh. (2009). A Brief Review: The Impact <strong>of</strong> Mitomycin-C During Photorefractive Keratectomy on the Corneal Endothelium. J <strong>of</strong> Refractive Surgery. Accepted. Sanders J.L., Boudreau, R.M., Cappola, A.R., Arnold, A.M., Robins, J., Cushman, M. and A.B. Newman. Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate (DHEAS) decline in the oldest old: the Cardiovascular Health Study All Stars Study. J Am Geriatr Soc. Accepted. Amesur, N., Wang, D., Chang, W., Weiser, D., Klatzky, R., Shukla, G. and G. Stetten, (2009). Peripherally Inserted Central Catheter Placement by Experienced Interventional Radiologist using the Sonic Flashlight. Journal <strong>of</strong> Vascular and Interventional Radiology. In press. Anderson, B., Silverman, G.K., Loewenstein, G.F., Schulkin, J. and S. Zinberg. (2009). Factors associated with physicians’ reliance on pharmaceutical sales representatives. Academic Medicine. 84:994-1002. Morris H.M., Stopczynski R.E., and D.A. Lewis. NPY mRNA expression in the prefrontal cortex: selective reduction in the superficial white matter <strong>of</strong> subjects with schizoaffective disorder. Schizophrenia Research. In press. Urish, K.L., Vella, J. B., Okada, M., Deasy, B. M.,Tobita, K., Keller, B. B., Cao, B., Piganelli, J. D. and J. Huard. (2009). Antioxidant levels represent a major determinant in the regenerative capacity <strong>of</strong> muscle stem cells. Mol Biol Cell. 20: 509-520. Vella, L.A., Yu, M., Fuhrmann, S.R., El-Amine, M., Epperson, D.E., and O.J. Finn. (2009). Healthy Individuals Have T Cell and Antibody Responses to the Tumor Antigen Cyclin B1 that When Elicited in Mice Protect from Cancer. Proc Natl Acad Sci U S A. 106(33):14010-5. Vella, L.A., Yu, M., Phillips, A.B. and O.J. Finn. (2009). Immunity Against Cyclin B1 Tumor Antigen Delays Development <strong>of</strong> Spontaneous Cyclin B1+ Tumors in p53-/- Mice. Ann N Y Acad Sci. In Press. Gao, Y., Cao, G., Zhang, W., Hu, X., Stetler, R.A. Vosler P.S. and J. Chen. Neuroprotection against hypoxic-ischemic brain injury by inhibiting the apoptotic protease activating factor-1 pathway. Stroke. Accepted. Vosler, P.S., Graham, S.H., Wechsler, L. and J. Chen. (2009). Mitochondrial targets for stroke: Focusing basic science research toward development <strong>of</strong> clinically translatable therapeutics. Stroke. 40(9): 3149-55. Vosler, P.S., Sun, D., Wang, S., Gao, Y., Kitner, D.B., Signore, A.P., Cao, G. and J. Chen. (2009). Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1 and calpain-signaling pathways. Experimental Neurology. 218: 213-220. Garrido, J.L., Wheeler, D.S., Leiva Vega, L., Friedman, P.A. and G. Romero. (2009). Role <strong>of</strong> Phospholipase D in Parathyroid Hormone Type 1 Receptor Signaling and Trafficking. Mol Endocrinol. Epub ahead <strong>of</strong> print. PMID: 19837945. Wen, J., Zhu, X., Liu, B., You, L., Kong, L., Lee, H.I., Han, K.P., Wong, J.L., Rhode, P.R. and H.C. Wong. (2008). Targeting activity <strong>of</strong> a TCR/IL-2 fusion protein against established tumors. Cancer Immunol Immunother. 57: 1781-1794. Chavez, J.L., Wong, J.L. and R.S. Duran. (2008). Core-shell nanoparticles: Characterization and study <strong>of</strong> their use for the encapsulation <strong>of</strong> hydrophobic fluorescent dyes. Langmuir. 24: 2064-2071. 7 7