BIOGRAPHICAL SKETCH Sved, Alan F. Professor of Neuroscience ...
BIOGRAPHICAL SKETCH Sved, Alan F. Professor of Neuroscience ...
BIOGRAPHICAL SKETCH Sved, Alan F. Professor of Neuroscience ...
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NAME<strong>Sved</strong>, <strong>Alan</strong> F.<strong>BIOGRAPHICAL</strong> <strong>SKETCH</strong>Provide the following information for the Senior/key personnel and other significant contributors.Follow this format for each person. DO NOT EXCEED FOUR PAGES.eRA COMMONS USER NAME (credential, e.g., agency login)AFSVEDPOSITION TITLE<strong>Pr<strong>of</strong>essor</strong> <strong>of</strong> <strong>Neuroscience</strong> and PsychiatryChairman, Department <strong>of</strong> <strong>Neuroscience</strong>EDUCATION/TRAINING (Begin with baccalaureate or other initial pr<strong>of</strong>essional education, such as nursing, include postdoctoral training andresidency training if applicable.)DEGREEINSTITUTION AND LOCATIONMM/YYFIELD OF STUDY(if applicable)Syracuse University, Syracuse NY BS 05/1976 Biology and PsychologyMassachusetts Institute <strong>of</strong> Tech, Cambridge MA PhD 08/1980 <strong>Neuroscience</strong>Cornell Medical College, New York NY Postdoctoral 09/1982 <strong>Neuroscience</strong>A. Personal StatementI have more than 25 years <strong>of</strong> experience mentoring and teaching trainees at the undergraduate, graduate,and post-doctoral levels. My laboratory <strong>of</strong>fers research training in areas related to central neural control <strong>of</strong>autonomic function and also the neurobiology <strong>of</strong> nicotine as it relates to nicotine self-administration in rats. Aschair <strong>of</strong> the Department <strong>of</strong> <strong>Neuroscience</strong> and as Co-Director <strong>of</strong> the Center for <strong>Neuroscience</strong> at the University <strong>of</strong>Pittsburgh, I am involved in the oversight <strong>of</strong> doctoral training in neuroscience . I also serve as PI <strong>of</strong> a T32 grantin Basic <strong>Neuroscience</strong>. Within the MD/PHD program, I serve on the Steering Committee and as a CareerAdvisor.Positions and HonorsPrevious Employment and Experience1982-87 Instructor to Associate <strong>Pr<strong>of</strong>essor</strong>, University <strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey, Newark NJ1982-87 Research Physiologist and Chief <strong>of</strong> the Neuroendocrine Research Laboratory, Neurology andResearch Services, Veterans Administration Medical Center, East Orange NJ1984-87 Associate Faculty, Institute <strong>of</strong> Animal Behavior, Rutgers University, Newark NJ1987-94 Associate <strong>Pr<strong>of</strong>essor</strong>, Departments <strong>of</strong> Behavioral <strong>Neuroscience</strong> and Psychiatry, University <strong>of</strong>Pittsburgh, Pittsburgh, PA1994- <strong>Pr<strong>of</strong>essor</strong>, Departments <strong>of</strong> <strong>Neuroscience</strong> and Psychiatry, University <strong>of</strong> Pittsburgh, Pittsburgh PA1999-02 Co-Director, Graduate Training Program, Center for <strong>Neuroscience</strong>, University <strong>of</strong> Pittsburgh2002- Chairman <strong>of</strong> the Department <strong>of</strong> <strong>Neuroscience</strong>, University <strong>of</strong> Pittsburgh2002- Co-director <strong>of</strong> the Center for <strong>Neuroscience</strong>, University <strong>of</strong> PittsburghSelected Other Pr<strong>of</strong>essional Activities1993-98 member, Experimental Cardiovascular Sciences Study Section, National Institutes <strong>of</strong> Health1998- Fellow, American Heart Association2000-09 Steering committee, Neural Control and Autonomic Regulation Section, American PhysiologicalSociety; Chair from 2003-2006.2001-2004 Program Committee, American Physiological Society2001-2005 Cardiovascular Regulation Grant Review Group, American Heart Association2002- member, Editorial Board, Hypertension2004-2007 Associate Editor, American Journal <strong>of</strong> Physiology – Regulatory, Integrative, and Comparative2006-2010 Senior Editor, Brain Research2007-2010 Councilor, Association <strong>of</strong> <strong>Neuroscience</strong> Departments and Programs (ANDP); now Committee <strong>of</strong><strong>Neuroscience</strong> Departments and Programs (C-NDP) <strong>of</strong> Society for <strong>Neuroscience</strong>2008-2009 Chair, Vascular Biology & Blood Pressure Regulation grant review, Region 1, American HeartAssociation2010-2013 Councilor, American Physiological Society
Honors and Awards1984 New Investigator Research Award, National Institutes <strong>of</strong> Health1987 Exceptional Merit Award, University <strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey1987 Established Investigator Award, American Heart Association2000 American Physiological Society: Neural Control and Autonomic Regulation Research Recognition Award2006 Provost’s Award for Mentoring Excellence, University <strong>of</strong> Pittsburgh2014 University <strong>of</strong> Pittsburgh Post-Doctoral Association Advocacy AwardB. Selected Peer-reviewed Publications (Selected from over 200 peer-reviewed publications)Most closely related to the current application:Palmatier MI, Levin ME, Mays KL, Donny EC, Caggiula AR, <strong>Sved</strong> AF. Bupropion and nicotine enhanceresponding for nondrug reinforcers via dissociable pharmacological mechanisms inrats.Psychopharmacology (Berl). 2009 Dec;207(3):381-90. Epub 2009 Sep 17. PMID: 19760281Liu X, Jernigen C, Gharib M, Booth S, Caggiula AR, <strong>Sved</strong> AF. Effects <strong>of</strong> dopamine on drug cue-inducedreinstatement <strong>of</strong> nicotine-seeking behaviour in rats. Behavioral Pharmacology 21 (2) 153-160, 2010.PMID: 20168211Weaver MT, Geier CF, Levin ME, Caggiula AR, <strong>Sved</strong> AF, Donny EC. Adolescent exposure to nicotine resultsin reinforcement enhancement but does not affect adult responding in rats. Drug Alcohol Depend. 2012Apr 6. [Epub ahead <strong>of</strong> print] PubMed PMID: 22483812.Donny EC, Caggiula AR, Sweitzer M, Chaudhri N, Gharib M, <strong>Sved</strong> AF. Self-administered and yoked nicotineproduce robust increases in blood pressure and changes in heart rate with modest effects <strong>of</strong> behavioralcontingency in rats. Pharmacol Biochem Behav. 2011 Sep;99(3):459-67. Epub 2011 Apr 29. PubMedPMID: 21554897Smith TT, Levin ME, Schassburger RL, Buffalari DM, <strong>Sved</strong> AF, Donny EC. Gradual and Immediate NicotineReduction Result in Similar Low-Dose Nicotine Self-administration. Nicotine Tob Res. 2013 Jul 1. [Epubahead <strong>of</strong> print] PMID: 23817582Selected Other PublicationsBourassa EA, Fang X, <strong>Sved</strong> AF, Speth RC. AT1 angiotensin II receptor and novel non-AT1, non-AT2angiotensin II/III binding site in brainstem cardiovascular regulatory centers <strong>of</strong> the spontaneouslyhypertensive rat. Brain Res. 1359:98-106, 2010. Epub 2010 Aug 31. PMID: 20807518Card JP, Kobiler O, McCambridge J, Ebdlahad S, Shan Z, Raizada MK, <strong>Sved</strong> AF, Enquist LW. Microdissection<strong>of</strong> neural networks by conditional reporter expression from a Brainbow herpesvirus. Proc Natl Acad Sce2011 Feb 3Levin ME, Weaver MT, Palmatier MI, Caggiula AR, <strong>Sved</strong> AF, Donny EC. Varenicline dose dependentlyenhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancingeffects <strong>of</strong> nicotine. Nicotine Tob Res. 2012 Mar;14(3):299-305. Epub 2011 Oct 12. PubMed PMID:21994342; PubMed Central PMCID: PMC3281240.Card JP, Kobiler O, Ludmir EB, Desai V, <strong>Sved</strong> AF, Enquist LW. A Dual Infection Pseudorabies VirusConditional Reporter Approach to Identify Projections to Collateralized Neurons in Complex NeuralCircuits, PLoS ONE, PLoS One. 2011;6(6):e21141. Epub 2011 Jun 16.PMID:21698154Agassandian K, Shan Z, Raizada M, <strong>Sved</strong> AF, Card JP. C1 catecholamine neurons form local circuit synapticconnections within the rostroventrolateral medulla <strong>of</strong> rat. <strong>Neuroscience</strong>. 2012 Dec 27;227:247-59. doi:10.1016/j.neuroscience.2012.09.049. Epub 2012 Oct 3.
C. Research SupportOngoing Research Support1 R01 DA10464-09 (Donny, PI) 4/1/97 – 6/30/14 (NCE)Effects <strong>of</strong> Self Administered vs. Noncontingent NicotineThis project examines the role <strong>of</strong> nicotine as an enhancer <strong>of</strong> rewarding environmental stimuli in rats.Role: co-InvestigatorRO1 HL093134 (Card, PI)4/1/09-3/31/14 (NCE)Rostroventrolateral Medulla and Central Integration <strong>of</strong> Cardiovascular Regulation.This project examines the neuroanatomical projections <strong>of</strong> the C1 neuronal group in the rostral ventrolateralmedulla.Role: co-InvestigatorU54 DA031659 (<strong>Sved</strong> PI project 4; Donny PI <strong>of</strong> Center) 10/1/11-9/30/16Evaluating New Nicotine Standards for Cigarettes. Project 4: Interactions between nicotine and othercigarette smoke components in supporting self-administration: a preclinical assessment.This project examines the interactions between nicotine and other cigarette smoke components (minoralkaloids, beta-carbolines, acetylaldehyde) in supporting self-administration in rats.Role: PI <strong>of</strong> Project 4 <strong>of</strong> the Center.RO1-HL-113180 (Cai, PI, <strong>Sved</strong> co-Investigator) 06/01/13-05/31/17Hypothalamic IKK-Beta in Obesity-related Hypertensionthis project hypothesizes that IKK-beta in POMC neurons employs glutamate signaling from these neurons toactivate downstream presympathetic neurons and drive the sympathetic induction <strong>of</strong> OHT. Three SpecificAims are proposed to test this hypothesis: (1) Study the hypertensive role <strong>of</strong> IKK-beta and glutamate in POMCneurons; (2) Study the sympathetic basis <strong>of</strong> OHT involving IKK-beta and glutamate in POMC neurons; (3)Study the POMC neuron-related neural circuitry in relation to OHT.Completed Research SupportNSF 0918867 (<strong>Sved</strong>, PI) 9/1/09-8/30/12“Viral microdissection <strong>of</strong> central circuitry integrating autonomic function.,This project using viral based neuroanatomical tracing to examine the central organization <strong>of</strong> neural circuitsintegrating autonomic function.Role: PI
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