BIOGRAPHICAL SKETCH David J. Hackam, MD, Ph.D. Professor of ...

NAMEDavid J. Hackam, M.D., Ph.D.eRA COMMONS USER NAMEhackamdjBIOGRAPHICAL SKETCHProvide the following information for the key personnel and other significant contributors.Follow this format for each person. DO NOT EXCEED FOUR PAGES.POSITION TITLEProfessor of SurgeryProfessor of Cell Biology & PhysiologyAssociate Dean for Medical Student ResearchEDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)INSTITUTION AND LOCATIONChildren’s Hospital of Pittsburgh of UPMCUniv of Toronto, Department of SurgeryUniv of Toronto, Toronto, CanadaDEGREE(if applicable)YEAR(s)2000-20021995-20001995-1998FIELD OF STUDYPediatric SurgeryGeneral SurgeryCell BiologyPh.D.Univ of Western Ontario, London, Canada M.D. 1988-1992 MedicineUniv of Western Ontario, London, Canada Pre-Med 1986-1988 Applied Math/GeneticsA. Personal StatementI am uniquely qualified to serve as an advisor for the MSTP program at the University of Pittsburgh. I am asurgeon scientist, and have mentored medical students, residents and post-doctoral scholars. My traineeshave matched in the residencies of their choice, and are now heavily involved with academic programselsewhere. My trainees have also been fortunate to win local, national and international awards. I look furtherto additional mentorship duties within our MSTP program, which I believe to be the leader amongst MSTPprograms in other academic medical centers.B. Positions and HonorsPositions and Employment:1992-1996 - General Surgery Residency Program, University of Toronto, Toronto, Ontario, Canada; 1998-2000Post Doctoral Fellowship, Division of Cell Biology, Hospital for Sick Children, Toronto, Canada / Fellowship,Division of Cell Biology, Hospital for Sick Children, Toronto, Canada; 2000-2002 - Fellowship in PediatricSurgery, Children’s Hospital of Pittsburgh and University of Pittsburgh School of Medicine; 2002-2006Assistant Professor of Surgery, Cell Biology and Physiology, Children’s Hospital of Pittsburgh and University ofPittsburgh School of Medicine; 2006 – 2007; Roberta Simmons Assistant Professor of Pediatric Surgery,University of Pittsburgh School of Medicine; 2007 – 2010: Roberta Simmons Associate Professor of PediatricSurgery, University of Pittsburgh School of Medicine; 2011 – Watson Professor of Surgery, University ofPittsburgh; 2011 – Associate Dean for Medical Student Research, University of Pittsburgh School of Medicine.Honors and Awards (selected):1992 Alpha Omega Alpha Honor Medical Society. 1996 Ethicon Society of University Surgeons ResidentResearch Fellowship, 1996 Medical Research Council of Canada Research Fellowship;1996 American Societyof Cell Biology Predoctoral Research Award; 1997 Surgical Infection Society Resident Award-First Prize OralPresentation; 1998 Hospital for Sick Children Research Institute Andrew Sass-Kortsak Research Award; 1998 RoyalCollege of Physicians and Surgeons of Canada: Canadian Research Gold Medal for Specialty Residents in Surgery;1999 William S. Fenwick Research Award, Faculty of Medicine, University of Toronto; 2004-7 OutstandingAchievement Award in Patient Care, Children’s Hospital of Pittsburgh; 2005 Who’s Who in Medical SciencesEducation; 2007 Michael Miller Young Investigator Award, Children’s Hospital of Pittsburgh; 2010 – Membership,American Society of Clinical Investigation; 2011 – Membership, American Surgical Association; 2011-Watson Chair ofSurgery, University of Pittsburgh. 2013 – President-elect, Society of University Surgeons; 2013 – Medical StudentResearch Mentorship award; University of PittsburghC. Selected peer-reviewed publications (in chronological order) from a total of 105.

Additional recent publications of importance to the field (in chronological order)1. Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, BrancaM, Ma C, Ozolek J, Hackam DJ. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4signaling in the intestinal epithelium. Gastroenterology. 2010 Sep;139(3):904-172. Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M,Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Intestinal epithelialToll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.Gastroenterology 2012; 143(3):708-183. Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF,Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Amniotic fluidinhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A.2012;109(28):11330-5D. Research Support.Ongoing Research Support:R01DK083752-05 Hackam (PI) 09/15/08-06/30/17Modulation of TLR4 and TLR9 Signaling in NECThe goal of this study is to determine how the interaction between the cytoplasmic receptor TLR9 regulates thedevelopment of NEC through effects on TLR4 signaling in immune and non-immune cells.R01GM078238-06 Hackam (PI) 01/01/12-11/30/15TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitisThe goal of this study is to evaluate the role of TLR4 signaling in the pathogenesis of necrotizing enterocolitis.Completed Research Support:5P50GM053789 Overall PI - Billiar; Project 2 PI: Hackam 9/15/08 – 8/31/12Regulation of Intestinal Mucosal Injury and Repair after Trauma/Hemorrhagic shock.The goal of the project is to evaluate the factors that regulate intestinal mucosal injury and repair in the settingof major trauma. Project 2 received three years support in the last funding cycle.K08 GM65583 Hackam (PI) 07/01/02-06/30/2006Mechanisms of intestinal restitution in NEC.The goal of this study was to determine the mechanisms that regulate enterocyte migration in vitro and in vivoin the pathogenesis of necrotizing enterocolitis.