BIOGRAPHICAL SKETCH David J. Hackam, MD, Ph.D. Professor of ...

Additional recent publications of importance to the field (in chronological order)1. Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, BrancaM, Ma C, Ozolek J, Hackam DJ. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4signaling in the intestinal epithelium. Gastroenterology. 2010 Sep;139(3):904-172. Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M,Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Intestinal epithelialToll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.Gastroenterology 2012; 143(3):708-183. Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF,Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Amniotic fluidinhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A.2012;109(28):11330-5D. Research Support.Ongoing Research Support:R01DK083752-05 Hackam (PI) 09/15/08-06/30/17Modulation of TLR4 and TLR9 Signaling in NECThe goal of this study is to determine how the interaction between the cytoplasmic receptor TLR9 regulates thedevelopment of NEC through effects on TLR4 signaling in immune and non-immune cells.R01GM078238-06 Hackam (PI) 01/01/12-11/30/15TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitisThe goal of this study is to evaluate the role of TLR4 signaling in the pathogenesis of necrotizing enterocolitis.Completed Research Support:5P50GM053789 Overall PI - Billiar; Project 2 PI: Hackam 9/15/08 – 8/31/12Regulation of Intestinal Mucosal Injury and Repair after Trauma/Hemorrhagic shock.The goal of the project is to evaluate the factors that regulate intestinal mucosal injury and repair in the settingof major trauma. Project 2 received three years support in the last funding cycle.K08 GM65583 Hackam (PI) 07/01/02-06/30/2006Mechanisms of intestinal restitution in NEC.The goal of this study was to determine the mechanisms that regulate enterocyte migration in vitro and in vivoin the pathogenesis of necrotizing enterocolitis.