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Substance Abuse and Nurses - the New Mexico Board of Nursing

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Chronic<br />

• Neurobiology <strong>of</strong> addiction<br />

• Use for pleasurable effect (reward) or positive<br />

reinforcement<br />

• Continued seeking <strong>of</strong> pleasure/reward<br />

• Sensitization or adaptation to reward (tolerance)<br />

• Use to avoid adverse effects (withdrawal) or negative<br />

reinforcement<br />

• Rewarded behavior is reinforcing behavior (operant<br />

conditioning)<br />

• Changes in brain chemistry can be permanent<br />

• Helps explain inability to reduce/control use <strong>and</strong> relapse<br />

after abstinence (Koob & Le Moal, 2008)

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