Protein structure and dynamics
Protein structure and dynamics
Protein structure and dynamics
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<strong>Protein</strong> <strong>dynamics</strong>: proteins are NOT<br />
static<br />
‣ X-ray <strong>structure</strong>s can be<br />
misleading:<br />
‣ appear static<br />
‣ subject to crystal-lattice lattice<br />
artifacts<br />
NMR PDB files often contain<br />
many <strong>structure</strong>s<br />
consistent with data<br />
1AK8.pdb (calcium-bound calmodulin)<br />
1AK8.pdb (calcium bound calmodulin)<br />
Note local fluctuations – e.g., helixfraying
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