Information Brochure (pdf) - Physiology and Neurobiology ...

We will then determine the function of their homologous
genes in mice. Using this comparative approach,
we hope to understand the conserved pathways regulating
oviduct secretory cell formation and physiological
function in humans, to provide the basis for understanding
the origin of ovarian cancer, and to develop
biomarkers for early diagnosis of ovarian cancer.
Selected Publications
Sun, J. and Deng, W. M. (2005). Notch-dependent
downregulation of the homeodomain gene cut is required for
the mitotic cycle/endocycle switch and cell differentiation in
Drosophila follicle cells. Development 132, 4299-308.
Sun, J. and Deng, W. M. (2007). Hindsight mediates the role of
notch in suppressing hedgehog signaling and cell proliferation.
Dev Cell 12, 431-42.
Sun, J. and Spradling, A. C. (2012). NR5A Nuclear Receptor
Hr39 Controls Three-Cell Secretory Unit Formation in
Drosophila Female Reproductive Glands. Curr Biol 22,
862-871.
Sun, J. and Spradling, A. C. (2013). Ovulation in Drosophila is
controlled by secretory cells of the female reproductive tract.
Elife 2, e00415.
Sun, J., Smith, L., Armento, A. and Deng, W. M. (2008).
Regulation of the endocycle/gene amplification switch by Notch
and ecdysone signaling. J Cell Biol 182, 885-96.
Shyu, L. F., Sun, J., Chung, H. M., Huang, Y. C. and Deng, W. M.
(2009). Notch signaling and developmental cell-cycle arrest in
Drosophila polar follicle cells. Mol Biol Cell 20, 5064-73.
Poulton, J. S., Huang, Y. C., Smith, L., Sun, J., Leake, N.,
Schleede, J., Stevens, L. M. and Deng, W. M. (2011). The
microRNA pathway regulates the temporal pattern of Notch
signaling in Drosophila follicle cells. Development 138, 1737-45.