BIOGRAPHICAL SKETCH Ora A. Weisz, Ph.D. Professor of ...

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Potter, B.A., Ihrke, G., Bruns, J.R., Weixel, K.M., and Weisz, O.A. (2004) Specific N-glycans direct apical
delivery of transmembrane, but not soluble or GPI-anchored forms of endolyn in MDCK cells. Mol. Biol. Cell.
15:1407-1416. PMID: 14699065
Potter, B.A., Weixel, K.M., Bruns, J.R., Ihrke, G., and Weisz, O.A. (2006) N-Glycans mediate apical recycling
of the sialomucin endolyn in polarized MDCK cells. Traffic 7:146-154. PMID: 16420523
Guerriero, C.J., Weixel, K.M., Bruns, J.R., and Weisz, O.A. (2006) Phosphatidylinositol 5-kinase stimulates
apical biosynthetic delivery via an Arp2/3-dependent mechanism. J. Biol. Chem. 281:15376-15384. PMID:
16601114
Blumental-Perry, A., Haney, C.J., Weixel, K.M., Watkins, S.C., Weisz, O.A., and Aridor, M. (2006)
Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export. Dev. Cell. 11:671-682.
PMID: 16935843
Cresawn, K.O., Potter, B.A., Oztan, A., Guerriero, C.J., Ihrke, G., Goldenring, J.R., Apodaca, G, and Weisz,
O.A. (2007) Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins.
EMBO J., 26:3737-3748. PMID: 17673908
Miedel, M.T., Rbaibi, Y., Guerriero, C.J., Colletti, G., Weixel, K.M., Weisz, O.A.* and Kiselyov, K.* (2008)
Membrane traffic and turnover in TRP-ML1 deficient cells: A revised model for Mucolipidosis Type IV
pathogenesis. J. Exp. Med. 205:1477-1490. PMID: 18504305 *corresponding authors (Cover article)
Khandelwal, P., Ruiz, W.G., Elena Balestreire-Hawryluk, E. Weisz, O.A., Goldenring, J.R., and Apodaca, G.
(2008) Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc. Natl.
Acad. Sci. USA, 105:15773-15778. PMID: 18843107
D. Research Support:
R01 DK064613 (Weisz) 05/01/09 - 04/30/13 Role: PI
NIH/NIDDK
Regulation of Polarized Traffic by PI-Metabolizing Enzymes
The aims of this proposal are to (1) determine whether apical and basolateral pools of PIP 2 are independently
regulated in renal epithelial cells; (2) examine how changes in PIP 2 levels mediated by agonist stimulation of G
protein coupled receptors affect polarized endocytosis; and (3) determine how murine PI5KIalpha regulates
apical endocytosis.
R01 DK54407 (Weisz) 09/01/98 – 08/31/12 Role: PI
NIH/NIDDK
Regulation of Apical Traffic in Renal Epithelial Cells
The aim of this project is to understand the mechanisms by which apical membrane traffic is regulated. Major
goals are to identify the cytoplasmic components required for apical vesicle release from the TGN and to
examine the mechanism of glycan-dependent apical sorting in polarized epithelial cells.
R01 DK57718 (Johnson) 02/01/02 – 12/31/11 Role: Co-Investigator
NIH/NIDDK
Trafficking and Regulation of the Epithelial Na + Channel
This proposal has three specific aims: 1. To characterize the molecular mechanisms involved in ENaC retrieval
from apical membrane; 2. To characterize the pathways and regulation of ENaC recycling; 3. To characterize
the cellular site and mechanism of non-coordinate regulation.
P30 DK079307 (Kleyman) 09/01/08-07/31/13 Role: Center Assoc. Dir.
NIH/NIDDK
Pittsburgh Center for Kidney Research
The objective of the Center is to reinforce and expand interactions among investigators at the University of
Pittsburgh and colleagues at Mount Sinai School of Medicine, to develop new directions of investigation using
electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renalrelated
research. The Center includes four cores and supports pilot and feasibility projects.
1 R01 DK084184-01 (Pastor-Soler) 09/01/09-08/30/14 Role: Co-Investigator
NIH/NIDDK