10.11.2012 Views

FCP OP MEDICAL BioHealth Trends FCP OP ... - Sal. Oppenheim

FCP OP MEDICAL BioHealth Trends FCP OP ... - Sal. Oppenheim

FCP OP MEDICAL BioHealth Trends FCP OP ... - Sal. Oppenheim

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

<strong>OP</strong>PENHEIM ASSET MANAGEMENT SERVICES S.À R.L.<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong> <strong>BioHealth</strong>-<strong>Trends</strong> <strong>Trends</strong><br />

SMALL AND MID-CAP HEALTHCARE INVESTMENTS – GROWTH THROUGH INNOVATION<br />

Luxembourg Luxembourg, 06/30/2012


Contents<br />

Fund orientation Page 3<br />

Healthcare market Page 6<br />

Investment process Page 15<br />

Growth in different market phases Page 19<br />

Stock picking and portfolio structure Page 22<br />

PPerformance f PPage 31<br />

Summary Page 38<br />

OOutlook tl k PPage 40<br />

Annex: Fund data and note about risks Page 45<br />

06/30/2012| Page 2 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


FUND ORIENTATION<br />

Small and mid-cap healthcare investments<br />

BASIC ORIENTATION<br />

� MMedical di l St Strategy* t * iis one of f th the lleading di independent i d d t healthcare h lth investment i t t consultants lt t iin<br />

Europe.<br />

� The focus of the investment spectrum p is on small and mid-cap p companies. p<br />

� Our target**: Early identification of new growth trends for high returns.<br />

*Medical Strategy GmbH, Gräfelfing near Munich<br />

**This investment target may or may not be achieved and cannot be regarded as any type of assurance or guarantee.<br />

The fund fund’ss investment strategy can be changed at any time within the legal and contractual limits. limits Details of these limits can be found in the sales prospectus prospectus.<br />

06/30/2012| Page 3 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


FUND ORIENTATION<br />

Medical Strategy – consultants specialising in healthcare investments<br />

THE TEAM<br />

Dr Dr. med. med Michael Fischer: Founder of the company, company more than 15 years of experience in the portfolio<br />

management of healthcare investments<br />

Jürgen Harter: Qualified investment expert (ZfU), more than 20 years of experience in the banking sector<br />

Harald Schwarz: Qualified economist, more than 20 years of experience in international pharmaceutical<br />

companies<br />

Stefan Kraft: Qualified economist, analyst<br />

Katrin Winterstein: Back office<br />

Grit Fischer: Technical analysis<br />

THE SCIENTIFIC ADVISORY COUNCIL<br />

Prof. Dr. med. Peter Hohenberger: Head of thoracic surgery department and special surgical oncology<br />

department p at the University y Hospital p of Mannheim<br />

Prof. Dr. med. Manfred Weber: Chief physician of the City of Cologne’s Medical Hospital I<br />

Prof. Dr. med. Thomas Zeller: Chief physician and head of the angiology department of the Bad Krozingen<br />

Cardiac Centre<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

As of: 03/31/2010<br />

06/30/2012| Page 4 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


FUND ORIENTATION<br />

The investment spectrum for healthcare investors<br />

Venture<br />

OVER 1000 FIRMS /<br />

25% OF MARKET CAPITALIZATION<br />

Capital<br />

Ziopharm<br />

ImmunoGen Atricure<br />

Arqule<br />

Incyte<br />

Ligand<br />

Staar<br />

Surgical<br />

Alk Abello<br />

Drug<br />

Discovery/<br />

Technology<br />

Clinical<br />

development<br />

CA. 100 FIRMS / 75 % OF<br />

MARKET CAPITALIZATION<br />

Future-oriented healthcare portfolio Typical healthcare portfolio<br />

USD 100 m<br />

market cap.<br />

Commercial<br />

sales<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich (adapted UBS)<br />

Biomarin<br />

Biogen<br />

IDEC<br />

Celgene Gilead<br />

Amgen<br />

Profitability Several products in the<br />

marketplace<br />

USD 2 bn<br />

market cap.<br />

USD 30 bn<br />

market cap.<br />

<strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong>: investment focus is on small and mid-cap<br />

companies right across the entire healthcare spectrum*<br />

Big Pharma<br />

USD 100 bn<br />

market cap.<br />

As of: 03/31/2012<br />

*The fund fund’ss investment strategy can be changed at any time within the legal and contractual limits limits. Details of these limits can be found in the sales prospectus prospectus.<br />

.<br />

06/30/2012| Page 5 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Sector rotation: Health Care Market outperforming<br />

30%<br />

20%<br />

10%<br />

0%<br />

-10%<br />

-20%<br />

-30%<br />

-40%<br />

REASONS<br />

COMPARISION OF INDEX PERFORMANCE (USD)<br />

Indexed representation: 06/30/2011 = 0%<br />

-50% 50%<br />

06/11 07/11 08/11 09/11 10/11 11/11 12/11 01/12 02/12 03/12 04/12 05/12 06/12<br />

� Health care as defensive investment<br />

� Low PE ratios within the Large Cap-Segment / High dividend yields<br />

� Innovation as emerging investment theme<br />

NASDAQ Biotech<br />

Index<br />

AMEX Pharma<br />

Index<br />

S&P 500 Index<br />

EURO STOXX 50<br />

Index (in USD)<br />

Source: Datastream As of: 06/30/2012<br />

Past Performance is no indicator of future performance and not a guarantee of future success.<br />

06/30/2012| Page 6 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Why invest in the healthcare sector?<br />

Number of Alzheimer A patients (m) (<br />

Medicare costs (in USD bn)<br />

Number of Alzheimer patients in the USA (in m, left scale)<br />

16 1400<br />

14<br />

13,5<br />

1200<br />

12<br />

1000<br />

1000<br />

10<br />

8<br />

800<br />

6<br />

4,5<br />

5,6<br />

600<br />

4<br />

241<br />

400<br />

2<br />

0<br />

Potential savings (in USD bn)<br />

20-50 *<br />

2004 2020 2050<br />

Forecast<br />

Innovative drugs g can ggenerate high g ppotential savings g<br />

200<br />

0<br />

Medicare costs (UUSD<br />

bn) Pootential<br />

savings (UUSD<br />

bn)<br />

*According to the Lewin Group<br />

model. Higher potential<br />

savings are expected if a drug<br />

118 118-401* 401* 500<br />

iis ddeveloped l dthat h can ddelay l<br />

400<br />

300<br />

200<br />

100<br />

0<br />

onset of the disease; the<br />

potential savings are lower if a<br />

drug merely slows down the<br />

progression of the disease.<br />

The greatest saving is<br />

achieved if both are possible.<br />

Source: Alzheimer’s Association As of: 2010<br />

06/30/2012| Page 7 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Increased life expectancy entails rising costs<br />

Kosten Costs im iin<br />

i 2004 Jahr (in 2004 US (in dol US-Dollar) Ulars)<br />

30.000<br />

25.000<br />

20 20.000 000<br />

15.000<br />

10.000<br />

5.000<br />

0<br />

Healthcare Gesundheitskosten costs per person pro Person in US dollars in US-Dollar<br />

0-18 19-44 45-54 55-64 65-74 75-84 85+<br />

Altersgruppen<br />

Age groups<br />

PER CAPITA HEALTHCARE COSTS<br />

� Persons over the age of 65 consume nearly 4<br />

times as much medication as 35- to 44-yearolds<br />

� Health costs rise disproportionately as people<br />

grow older<br />

Source: U.S. Department of Health & Human Services, Centers for Medicare & Medicaid Services (CMS), http://www4.cms.gov/NationalHealthExpendData/downloads/2004-age-tables.pdf, 2004<br />

06/30/2012| Page 8 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Growth through innovation<br />

100<br />

90<br />

80<br />

70<br />

60<br />

50<br />

40<br />

30<br />

20<br />

10<br />

0<br />

DEVEL<strong>OP</strong>MENT OF DRUGS<br />

Start Idea Research Pre-clinical Phase I Phase II Phase III Approval Early market<br />

phase phase<br />

Value of drug<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich As of: March 2010<br />

Companies p achieved ggreatest ggrowth in final clinical pphases and upon p approval pp<br />

06/30/2012| Page 9 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Pipeline: development of medical drugs in the USA<br />

DISEASE PRODUCTS IN THE PIPELINE<br />

CCancer 861<br />

Infections 338<br />

Autoimmune diseases 59<br />

HIV/AIDS 97<br />

Heart 312<br />

Diabetes 183<br />

Total 1850<br />

Source: Pharmaceutical Research and Manufacturers of America (PhRMA) As of: 2010<br />

06/30/2012| Page 10 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Pharma-equities: Since 2000 end of growth era<br />

450<br />

400<br />

350<br />

300<br />

250<br />

200<br />

AMEX-PHARMA-INDEX (USD) EARNINGS GROWTH AND PER<br />

Period: 11/1996 to 06/2012<br />

150<br />

11/96 11/98 11/00 11/02 11/04 11/06 11/08 11/10 11/12<br />

Source: Datastream<br />

PER 2012<br />

expected<br />

PER 2013<br />

expected<br />

Expected sales<br />

growth 2011-2014 2011 2014<br />

Expected earnings<br />

growth g 2011-2014<br />

US<br />

Big- Pharma<br />

EU<br />

Big-Pharma<br />

11,9 12,0<br />

11 11,7 7 10 10,7 7<br />

0,6% 3,9%<br />

2,3% 8,0%<br />

Source: Medical Strategy GmbH, Gräfelfing bei München, yahoo! Finance<br />

(5.8.2011), Citi (29.12.2011)<br />

06/30/2012| Page 11 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Pharmaceutical industry – transforming the business model<br />

40<br />

35<br />

30<br />

25<br />

20<br />

15<br />

10<br />

5<br />

0<br />

10<br />

18<br />

EXPECTED PATENT EXPIRIES IN THE PHARMACEUTICAL INDUSTRY<br />

iin USD bbn � Situation: Declining sales as a result of expired<br />

37<br />

patents, therapy substitution and a lack of research<br />

efficiency<br />

29<br />

23<br />

20<br />

17<br />

16<br />

14 14 14<br />

2005 2006 2007 2008 2009 2010 2011e 2012e 2013e 2014e 2015e 2016e<br />

Source: Medical Strategy GmbH, IMS, FDA, Bernstein Research As of: 2011<br />

13<br />

� TTransformation: f ti<br />

› Mega-mergers (Pfizer/Wyeth)<br />

› Transformation into bio-pharmaceutical companies<br />

(Roche/Genentech)<br />

› Diversification by adding speciality pharma<br />

(Novartis/Alcon) and medtech (Abbott/Advanced<br />

Medical Optics)<br />

› Expansion in emerging markets<br />

Patent expiries p have a negative g impact p on future development p<br />

06/30/2012| Page 12 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Big-Biotech-Equities: Valuation under pressure<br />

140<br />

120<br />

100<br />

80<br />

60<br />

40<br />

20<br />

0<br />

Pi Price/Earings-Ratio<br />

/E i R ti<br />

NASDAQ Biotech S&P 500 Index<br />

PER-COMPRESSION 2004-2009<br />

THE REASONS<br />

� Decreasing growth rates<br />

� Approaching patent expiration; defined<br />

approval path for bio-generics<br />

� Additional factors such as health care reform,<br />

price pressure (EU), and decreasing research<br />

productivity<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich As of: June 2012<br />

Source for PE Time series data: Datastream<br />

06/30/2012| Page 13 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


HEALTHCARE MARKET<br />

Biotech: Large Caps largely depleted<br />

MARKET CAPITALISATION BIOTECH-SECTOR IN 2001 AND TAKE-OVERS<br />

Sonstige Other<br />

42%<br />

AMGN<br />

23%<br />

DNA 10%<br />

GENZ 4%<br />

IMNX 5%<br />

ABI 2%<br />

CHIR 3%<br />

MLNM<br />

IDHP 3%<br />

2% BGEN 3%<br />

MEDI 3%<br />

Source: Credit Suisse First Boston As of: 26.11.2001<br />

YYear Ti Ticker k TTarget-Company t C BBuyer<br />

2010 GENZ Genzyme Sanofi<br />

2009 DNA Genentech Roche<br />

2008 MLNM Millennium Takeda<br />

2008 ABI Applied Biosciences Invitrogen<br />

2007 MEDI Mediummune AstraZeneca<br />

2006 CHIR Chiron Novartis<br />

2003 IDHP Idec Biogen<br />

2002 IMNX Immunex Amgen<br />

� Number of US-Large Caps were largely depleted by take-overs over the last couple of years<br />

� Funds within the peer group loose their investment candidates and enter unknown territory<br />

06/30/2012| Page 14 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


INVESTMENT PROCESS<br />

Basis for a successful strategy within the health care industry<br />

THE RIGHT COMPANY STOCK PICKING<br />

AT RIGHT PRICE VALUATION MODEL<br />

AT RIGHT TIME TIMING<br />

06/30/2012| Page 15 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


INVESTMENT PROCESS<br />

Our investment criteria<br />

� Degree of innovation:<br />

Has the company the potential to establish new standards within its field?<br />

� Stage of development:<br />

Has the product been rolled out sufficiently to the market, so that the opportunities/risks-relation<br />

can be assessed concretely?<br />

� Management and financing:<br />

Has management g sufficient experience p and is the company p y financed for at least 2 yyears?<br />

� Valuation:<br />

Does the current stock price offer an above average growth potential compared to the fair value<br />

price i th the stock t k iis expected t d tto reach h over ttwo tto th three years? ?<br />

Avoid drawdown of overvalued firms e.g. Dendreon<br />

Th The ffund’s d’ iinvestment t t strategy t t can be b changed h d at t any ti time within ithi th the llegal l and d contractual t t l li limits. it DDetails t il of f th these li limits it can bbe ffound diin th the sales l prospectus.<br />

t<br />

06/30/2012| Page 16 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


INVESTMENT PROCESS<br />

Example case: ImmunoGen (Biotech)<br />

Price in USD<br />

16<br />

14<br />

12<br />

10<br />

8<br />

30.06.20111<br />

31.07.20111<br />

31.08.20111<br />

30.09.20111<br />

31.10.20111<br />

30.11.20111<br />

31.12.20111<br />

31.01.20122<br />

29.02.20122<br />

31.03.20122<br />

30.04.20122<br />

IMMUNOGEN<br />

31.05.20122<br />

30.06.20122<br />

� One of the leading companies for antibodytoxin-conjugates<br />

� Trastuzumab-DM Trastuzumab DM 1(partner Roche) as<br />

potential Herceptin-replacement – planned for<br />

filing 2012<br />

� 8f 8 further th products d t (partly ( tl li licenced d tto partner t<br />

firms) in phase I and II of clinical trial<br />

� Average g buy y pprice<br />

7.17 USD<br />

Average market cap in USD: 1019,6 Million<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich As of: 06/2012<br />

Past Performance is no indicator of future performance and not a guarantee of future success. The fund’s investment strategy can be<br />

changed at any time within the legal and contractual limits. Details of these limits can be found in the sales prospectus.<br />

06/30/2012| Page 17 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


INVESTMENT PROCESS<br />

The Investment process: Systematic investment decisions<br />

Company<br />

contacts<br />

Annual reports<br />

RESEARCH OF FUND ADVISOR<br />

Investment<br />

conferences<br />

Scientific<br />

conventions,<br />

publications<br />

Expert<br />

opinion*<br />

Medical Strategy‘s<br />

internal data base<br />

(stage of development, patents, competitors, financial parameters)<br />

Proprietary<br />

valuation model<br />

Buy- / Sell recommendation<br />

EXTERNAL RESEARCH<br />

Specialized Broker<br />

*expert opinion:<br />

Prof. Dr. Peter Hohenberger, surgical hospital<br />

Mannheim<br />

Prof. Dr. Manfred Weber<br />

chief physic of medical hospital<br />

Med. Klinik I – Kliniken der Stadt Köln<br />

Prof. Dr. Thomas Zeller, chief physician of<br />

angiology of the cardiological center Bad<br />

Krozingen<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich As of: 12/2010<br />

06/30/2012| Page 18 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


GROWTH IN DIFFERENT MARKET PHASES<br />

Considerable outperformance* as compared to key indices since issue<br />

135<br />

120<br />

105<br />

90<br />

75<br />

60<br />

45<br />

30<br />

PERFORMANCE SINCE INCEPTION<br />

Indexed representation: 10/30/2000 =EUR100 = EUR 100<br />

15 10/00 10/01 10/02 10/03 10/04 10/05 10/06 10/07 10/08 10/09 10/10 10/11 10/12<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong> <strong>Trends</strong> Share<br />

class EUR, EUR outperformance<br />

o tperformance<br />

(in percentage points) versus:<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong><br />

<strong>BioHealth</strong>-<strong>Trends</strong><br />

EUR<br />

NASDAQ Biotech- Biotech<br />

Index (in EUR)<br />

MSCI World Index (in<br />

EUR)<br />

S&P 500 Index (in<br />

EUR)<br />

AAmex Pharma-Index<br />

Ph I d<br />

(in EUR)<br />

MSCI World Index (in EUR) 64,0% NASDAQ Biotech Index (EUR) 54,5%<br />

AMEX Pharma Index (EUR) 74,0% S&P 500 Index (EUR) 63,6%<br />

Source: Datastream (Price indices in EUR / The previous day’s closing rates were used in each case to calculate the index performance and to convert the exchange rates.<br />

Because the fund is mainly invested in North America, this takes the time difference into account.) , <strong>Oppenheim</strong> Asset Management Services S.à r.l. (fund performance<br />

calculated according to Bundesverband Investment und Asset Management e.V. (BVI) / Initial charges (for investment and reinvestment) as well as individual costs such as the<br />

custodian t di ffee were not ti included. l d d PPerformance f would ldtturn out tllower ifth if these charges h and dcosts t were iincluded. l d d )<br />

*Past Performance is no indicator of future performance and not a guarantee of future success. As of 06/30/2012<br />

06/30/2012| Page 19 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


GROWTH IN DIFFERENT MARKET PHASES<br />

Considerable outperformance* as compared to key indices over 3 years<br />

220<br />

200<br />

PERFORMANCE OVER 3 YEARS<br />

Indexed representation: 06/30/2009 =EUR100 = EUR 100<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong><br />

<strong>BioHealth</strong>-<strong>Trends</strong><br />

EUR<br />

180 NASDAQ Bi Biotech t h<br />

Index (EUR)<br />

160<br />

140<br />

120<br />

100<br />

80<br />

06/09 06/10 06/11 06/12<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong> <strong>Trends</strong><br />

Share class EUR, outperformance<br />

(in percentage points) versus:<br />

S&P 500 Index<br />

(EUR)<br />

MSCI World (EUR)<br />

Amex Pharma Index<br />

(EUR)<br />

NASDAQ Biotech Index (EUR) -44,7 S&P 500 Index (EUR) -9,0<br />

AMEX Pharma Index (EUR) 6,8 MSCI World (EUR) 13,3<br />

Source: Datastream (Price indices in EUR / The previous day’s closing rates were used in each case to calculate the index performance and to convert the exchange rates.<br />

Because the fund is mainly invested in North America, this takes the time difference into account.) , <strong>Oppenheim</strong> Asset Management Services S.à r.l. (fund performance<br />

calculated according to Bundesverband Investment und Asset Management e.V. (BVI) / Initial charges (for investment and reinvestment) as well as individual costs such as the<br />

custodian t di ffee were not ti included. l d d PPerformance f would ldtturn out tllower ifth if these charges h and dcosts t were iincluded. l d d )<br />

*Past Performance is no indicator of future performance and not a guarantee of future success. As of 06/30/2012<br />

06/30/2012| Page 20 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


GROWTH IN DIFFERENT MARKET PHASES<br />

Considerable outperformance* as compared to key indices since issue<br />

80 %<br />

70 %<br />

60 %<br />

50 %<br />

40 %<br />

30 %<br />

20 %<br />

10 %<br />

0 %<br />

64 64,0% 0%<br />

MSCI World Index (in<br />

EUR)<br />

OUTPERFORMANCE SINCE ISSUE (EUR)<br />

Period: 12/30/2000 to 06/30/2012<br />

74,0%<br />

AMEX Pharma Index<br />

(EUR)<br />

54,5%<br />

NASDAQ Biotech Index<br />

(EUR)<br />

63 63,6% 6%<br />

S&P 500 Index (EUR)<br />

Source: Datastream (Price indices in EUR / The previous day’s closing rates were used in each case to calculate the index performance and to convert the exchange rates.<br />

Because the fund is mainly invested in North America, this takes the time difference into account.) , <strong>Oppenheim</strong> Asset Management Services S.à r.l. (fund performance<br />

calculated according to Bundesverband Investment und Asset Management e.V. (BVI) / Initial charges (for investment and reinvestment) as well as individual costs such as the<br />

custodian t di ffee were not ti included. l d d PPerformance f would ldtturn out tllower ifth if these charges h and dcosts t were iincluded. l d d )<br />

*Past Performance is no indicator of future performance and not a guarantee of future success. As of 06/30/2012<br />

06/30/2012| Page 21 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

Factors influencing performance: market capitalisation vs. stockpicking<br />

PERFORMANCE IN EUR (%)<br />

Median performance by<br />

size classes<br />

less than USD 200 m<br />

USD 200-499 m<br />

USD 500-999 m<br />

USD 1000-1999 m<br />

USD 2000 m & over<br />

11.000 000 - 44.999 999 Mio Mio. USD<br />

≥ 5000 Mio. USD<br />

Source: BioCentury<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong><br />

<strong>BioHealth</strong>-<strong>Trends</strong><br />

EUR<br />

100<br />

60<br />

20<br />

-20 20<br />

-60<br />

-100 100<br />

Reprinted by permission of BioCentury Publications, Inc.<br />

PERFORMANCE AND MARKET CAPITALISATION<br />

-31,6<br />

-26,3<br />

-39,4<br />

-45,0<br />

-65,7<br />

-21,0<br />

67,0<br />

34,6<br />

38,1<br />

15,6<br />

0,8<br />

11,6<br />

20,9 17,4<br />

13,8 13,2<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

Source for fund performance: <strong>Oppenheim</strong> Asset Management Services S.à r.l., performance calculated according to BVI method<br />

Growth in the past is no indication of future performance and no guarantee of success in the future.<br />

-7,1 ,<br />

-3,8<br />

10,1<br />

-3,4<br />

-10 -10,2 2<br />

-16,3<br />

-30,5<br />

-29,7<br />

15,4<br />

0,3<br />

17,0<br />

15,3<br />

2008 2009 2010 2011 2012 YTD<br />

18,3<br />

17,7<br />

As of: 06/30/2012<br />

06/30/2012| Page 22 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

Added value through access to interesting finance possibilities (selected<br />

PIPE deals), ), Private financing g rounds in which the fund took part p<br />

DATE COMPANY TERMS PRICE AS AT 29.06.12<br />

11.10.2010 Cerus 2,85 USD, 50% warrant coverage 3.32 USD<br />

2011-01-31 Celsion Corp<br />

Preferred shares + 100% warrant coverage<br />

(conversion price 2.4045 USD)<br />

3.07 USD<br />

2011 2011-01-04 01 04 AVIBi AVI Biopharma h 150USD 1.50 USD 063USD 0.63 USD<br />

2011-05-18 Celldex Therapeutics 3.15 USD 5.18 USD<br />

2011 2011-06-16 06 16 Tekmira Pharmaceuticals 22.85 85 USD USD, 50% warrant coverage 211USD 2.11 USD<br />

2012-02-08 Mannkind 2.40 USD, 60% warrant coverage 2.29 USD<br />

2012-02-10 2012 02 10 Vernalis Subscription rights at 00.20 20 GBP 023GBP 0.23 GBP<br />

2012-03-15 Intellipharmaceutics 2.75 USD 3.22 USD<br />

10.04.2012 Titan Pharna<br />

16.04.2012 Allon Therapeutics<br />

Source: Medical Strategy GmbH GmbH, Gräfelfing near Munich<br />

*equally devided into series A and B warrants, which have different maturities<br />

0.85 USD<br />

200% warrant coverage* coverage<br />

0.25 CAD<br />

50% warrant coverage<br />

0.70 USD<br />

0.24 CAD<br />

06/30/2012| Page 23 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

Corporate takeovers (2011/2012)<br />

STOCKS SELECTED FOR THE PORTFOLIO OF <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong><br />

Over taken From Sector<br />

Price in mil mil. Premium<br />

USD<br />

in %<br />

<strong>Sal</strong>es-Multiple<br />

Cypress Ramius EmPharma 255 160% 7.5-times<br />

Genzyme Sanofi Biotech 20 20.100 100 50% 45times 4.5-times<br />

Prostrakan Kyowa Hakko EmPharma 470 21% 3-times<br />

Celera Quest Biotech 671 28% 5.2-times<br />

Chemgenex Cephalon Biotech 231 59% na<br />

Orthovita Stryker Medtech 305 41% 3.2- times<br />

Adolor Cubist EmPharm 190-415 121-355%* 4.4-times**<br />

Micromet Amgen Biotech 1160 33% na<br />

Oridion Covidien Medtech 300 72% 4.3-times<br />

Human Genome<br />

Sciences<br />

Biotech GSK 2600 81%*** 14-times<br />

Ardea EmPharma AstraZeneca 1260 54% NA<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich As of: April 2012<br />

*Cash 4.25 USD, plus up to 4.50 USD in case predefined milestones are reached / ** Based on Cash-Payment<br />

06/30/2012| Page 24 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Sources of Outperformance<br />

The Outperformance is mainly dependent upon company specific events:<br />

IImportant t t events t are<br />

� Progress in trial<br />

�� Product approval<br />

� Reimbursement acceptance<br />

� Gain of market share<br />

� Reach of profitability<br />

� Partnered products<br />

� Company take-over<br />

� Initial Broker Coverage<br />

Risk adjusted weighting of candidates which offer the best opportunities<br />

VVery high hi h performance f contribution t ib ti of f single i l portfolio tf li names<br />

06/30/2012| Page 25 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

Portfolio structure by market capitalisation<br />

40<br />

35<br />

30<br />

25<br />

20<br />

15<br />

10<br />

5<br />

0<br />

23,7<br />

FOCUS ON SMALL AND MEDIUM-SIZED COMPANIES<br />

33,4<br />

Sh Share of f fund f d assets t (%)<br />

19,1<br />

< USD 200 m USD 200 - 500 m USD 500 - 1500 m USD 1500 - 5000 m > USD 5000 m CCash h<br />

Number 38 26 14 7 9<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

The fund’s investment strategy can be changed at any time within the legal and contractual limits limits. Details of these<br />

limits can be found in the sales prospectus.<br />

9,4<br />

13,4<br />

1,0<br />

As of: 06/30/2012<br />

06/30/2012| Page 26 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Risk control<br />

� Concentration on companies with products in advanced stages of development or early market<br />

phases<br />

� Continually monitor the opportunities-risks-profile of investments and adjust the portfolio<br />

weighting accordingly<br />

� Bread diversification (ca. 70-90 titles) and companies with different business models<br />

� Use of derivatives in light of critical events, which might lead to heavy price movements such as<br />

results from studies/trials and product approvals<br />

Th The ffund’s d’ iinvestment t t strategy t t can be b changed h d at t any ti time within ithi th the llegal l and d contractual t t l li limits. it DDetails t il of f th these li limits it can bbe ffound diin th the sales l prospectus.<br />

t<br />

06/30/2012| Page 27 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Comparison of Volatility<br />

VOLATILITY CAME OUT AT THE LOWER END COMPARED TO PEER FUNDS<br />

FUNDS FONDS 1 1J 1 year Jahr ear h 3 3J 3 years Jahre ears h 5 5J 5 Jahre years ears h<br />

Dexia Equities L Biotechnology D 25,70% 21,70% 27,90%<br />

Pictet-Biotech-P 30,40% 23,10% 25,90%<br />

Allianz Rcm Biotechnologie - A - Eur 21,60% 18,60% 22,10%<br />

Franklin Biotechnology Discovery Fund A (Acc) 24,80% 19,60% 22,20%<br />

Nordea 1 Biotech Fund Bp-Usd 25 25,50% 50% 20 20,30% 30% 22 22,90% 90%<br />

UBS (Lux) Equity Fund - Biotech B 28,10% 22,70% 25,90%<br />

BNP Paribas L1 Equity Biotechnology World C 22,00% 20,00% 25,00%<br />

DWS Biotech Typ O 25,00% 21,30% 25,30%<br />

Lacuna - Biotech 22,90% 19,10% 21,40%<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> 22,50% , 17,30% , 22,30% ,<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> H 23,50% 17,70% 22,10%<br />

Source: Datastream, , share price p volatilityy in fund currencyy As of. 06/30/2012<br />

Growth in the past is no indication of future performance and no guarantee of success in the future.<br />

06/30/2012| Page 28 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

The five leading investments<br />

COMPANY<br />

SHARE OF FUND<br />

ASSETS (%)<br />

MARKET CAP.<br />

(USD m)<br />

LIGAND PHARMA SHS 6,1 334 Biotechnology<br />

IMMUNOGEN SHS 5,8 1294 Biotechnology<br />

FURIEX PHARMA SHS 3,8 208<br />

BASILEA PHARMA N-<br />

AKT<br />

SECTOR COMMENT<br />

Emerging<br />

Pharma<br />

2,8 455 Biotechnology<br />

Broad product pipeline<br />

Royalties on 4 products with market presence (alter alia Promacta / GSK for treatment of<br />

thrombopenia)<br />

One of the leading companies for antibody-toxin-conjugates<br />

Trastuzumab-DM 1(partner Roche) as potential Herceptin-replacement – planned for filing 2012<br />

8 further products (partly verpartnert) in phase I and II of clinical trial<br />

Emerging Pharma company with several development programs<br />

With Nesina and Priligy already two products in the market (through partners)<br />

High sales expectation through royalty income from diabetes drug Nesina with blockbuster<br />

potential<br />

Swiss Biotech company with focus on dermatology and antibiotics<br />

With Toctino Basilea already has the first product for treatment of severe chronical hand eczema<br />

on the market<br />

In the United States Toctino is in late stage of clinical trial<br />

Moreover ant-infective envisaged as partner product<br />

· Global bio-pharmaceutical company, focused on CNS and<br />

UCB AKT 2,8 9271 Biotechnology immunology, growth particularly with biotech products like Cimzia<br />

· Broad product pipeline<br />

Focus on potential future climbers and special situations<br />

Source: Medical Strategy GmbH GmbH, Gräfelfing near Munich / Source for market capitalisation: Datastream<br />

As of: 06/30/2012<br />

The fund’s investment strategy can be changed at any time within the legal and contractual limits. Details of these limits can be found in the sales prospectus.<br />

06/30/2012| Page 29 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


STOCKPICKING AND PORTFOLIO STRUCTURE<br />

Portfolio structure by product status<br />

Companies with<br />

products on the<br />

market a e<br />

39,0 %<br />

Companies with<br />

products on the<br />

market and<br />

profitable<br />

26,0 %<br />

PRODUCT STATUS INDUSTRIES<br />

Share of fund assets<br />

Cash<br />

1,0 %<br />

Products in early<br />

clinical phase<br />

10,0 %<br />

Products in phase<br />

III and in approval<br />

process<br />

24,0 %<br />

Share of fund assets (%)<br />

Biotechnology 49,1<br />

Emerging Pharma 34,0<br />

Emerging Medtech 14,7<br />

Healthcare Services 1,2<br />

Cash 1,0<br />

Total 100,0<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

As of: 06/30/2012<br />

The fund’s investment strategy can be changed at any time within the legal and contractual limits. Details of these limits can be found in the sales prospectus.<br />

Focus on companies close to the market<br />

06/30/2012| Page 30 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Multiple awards<br />

SAUREN FUND RESEARCH<br />

Source: Sauren Fonds-Research AG<br />

Valid: 2011-2012<br />

SAUREN<br />

FUND MANAGER RATING 2011<br />

Fund Award 2012, €URO / €URO am Sonntag<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR<br />

in the equity funds (biotechnology) category<br />

2nd place over 3 years<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR H<br />

in the equity funds (biotechnology) category<br />

3rd place over 3 years<br />

Source: €uro, issue 02/2012 Validity: 2012<br />

06/30/2012| Page 31 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Standard & Poor’s Fund Management Rating<br />

LONG-TERM RATING RATING<br />

<strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong><br />

since June 2010<br />

Copyright © 2010. Standard and Poor’s, a division of The McGraw-Hill Companies,<br />

Li Limited. it d RReproduction d ti or di distribution t ib ti off S&P FFundd MManagementt RRatings ti andd S&P’ S&P’s<br />

trademarks, trade names, service marks or logos in any form is prohibited except<br />

with the prior written permission of S&P. S&P its affiliates and sources do not<br />

guarantee the accuracy, completeness or availability of any information and are not<br />

responsible for any errors or omissions or for the results obtained from the use of<br />

such information. S&P, ITS AFFILIATES AND SOURCES GIVE NO EXPRESS OR<br />

IMPLIED WARRANTIES WARRANTIES, INCLUDING INCLUDING, BUT NOT LIMITED TO TO, ANY<br />

WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR<br />

PURPOSE OR USE. In no event shall S&P, its affiliates or sources be liable for any<br />

indirect, special or consequential damages in connection with S&P Fund<br />

Management Ratings.<br />

Source: Standard & Poor’s Valid until reassessed by S&P<br />

<strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong><br />

2011/2012<br />

An S&P Fund Management Rating represents an opinion only and should not be<br />

relied li d on when h making ki an iinvestment t t ddecision i i as th the ffundd rating ti iis ffor iinformation f ti<br />

purposes only and not tailored to a specific investor. Copyright (c) 2010 Standard &<br />

Poor's, a division of The McGraw-Hill Companies, Inc.<br />

S&P Fund Management Ratings are regarded as a mark of quality for investment<br />

funds.<br />

Th They are bbased d on personall iinterviews i with ih the h ffundd manager andd offer ff an<br />

independent evaluation of consistency in performance and of the quality of the fund<br />

management<br />

Source: Standard & Poor’s Validity: 08/2011 – 08/2012<br />

06/30/2012| Page 32 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Performance: <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR<br />

1300 1.300<br />

1.200<br />

1.100<br />

1.000<br />

900<br />

800<br />

700<br />

600<br />

500<br />

MODEL CALCULATION (5 YEARS) INVESTMENT OF EUR 1000<br />

400<br />

06/07 06/08 06/09 06/10 06/11 06/12<br />

PERFORMANCE OVER 12 MONTH PERIODS<br />

06/07-06/08 06/08-06/09 06/09-06/10 06/10-06/11 06/11-06/12<br />

-31,98% 26,67% 21,85% 10,85% 13,36%<br />

Performance including all internal costs as<br />

well as the charge for the initial investment.<br />

Individual costs such as custodian fee were<br />

not included. Performance would turn out<br />

lower if these charges and costs were<br />

included.<br />

Initial charges (for investment and<br />

reinvestment) as well as individual costs<br />

such as the custodian fee were not included.<br />

Performance would turn out lower if these<br />

charges and costs were included.<br />

Source: <strong>Oppenheim</strong> Asset Management Services S.à r.l. As of: 06/30/2012<br />

Fund Performance calculated according to Bundesverband Investment und Asset Management e.V. (BVI)<br />

Past Performance is no indicator of future performance and not a guarantee of future success.<br />

06/30/2012| Page 33 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Performance: <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR H<br />

1300 1.300<br />

1.200<br />

1.100<br />

1.000<br />

900<br />

800<br />

700<br />

600<br />

500<br />

MODEL CALCULATION (5 YEARS) INVESTMENT OF EUR 1000<br />

400<br />

06/07 06/08 06/09 06/10 06/11 06/12<br />

PERFORMANCE OVER 12 MONTH PERIODS<br />

06/07-06/08 06/08-06/09 06/09-06/10 06/10-06/11 06/11-06/12<br />

-23,44% 15,77% 10,85% 22,90% 2,92%<br />

Performance including all internal costs as<br />

well as the charge for the initial<br />

investment.<br />

Individual costs such as custodian fee<br />

were not included. Performance would<br />

turn out lower if these charges and costs<br />

were included.<br />

Initial charges (for investment and<br />

reinvestment) as well as individual costs<br />

such as the custodian fee were not included included.<br />

Performance would turn out lower if these<br />

charges and costs were included.<br />

Source: <strong>Oppenheim</strong> Asset Management Services S.à r.l. As of: 06/30/2012<br />

Fund Performance calculated according to Bundesverband Investment und Asset Management e.V. (BVI)<br />

Past Performance is no indicator of future performance and not a guarantee of future success.<br />

06/30/2012| Page 34 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Share class EUR H far-reaching hedging* against foreign currency risks<br />

130<br />

COMPARISON OF SHARE CLASSES<br />

IIndexed d d representation: t ti 04 04.10.2005 10 2005 = EUR 100<br />

120<br />

<strong>FCP</strong> <strong>OP</strong><br />

<strong>MEDICAL</strong><br />

<strong>BioHealth</strong>-<br />

110 <strong>Trends</strong> EUR H<br />

100<br />

90<br />

80<br />

70<br />

60<br />

50<br />

10/05 10/06 10/07 10/08 10/09 10/10 10/11 10/12<br />

<strong>FCP</strong> <strong>OP</strong><br />

<strong>MEDICAL</strong><br />

<strong>BioHealth</strong>-<br />

<strong>Trends</strong> EUR<br />

* This investment target may<br />

or may not be achieved and<br />

cannot be regarded as any<br />

type of assurance or<br />

guarantee.<br />

Source: <strong>Oppenheim</strong> Asset<br />

Management Services S.à r.l.<br />

(fund: performance calculated<br />

according to BVI method)<br />

Initial charges (for investment<br />

and reinvestment) as well as<br />

individual costs such as the<br />

custodian fee were not<br />

included. Performance would<br />

turn out lower if these charges<br />

and costs were included.<br />

Growth in the past is no<br />

indication of future<br />

performance and no guarantee<br />

of success in the future.<br />

As of: 06/30/2012<br />

Investments in a currency-hedged share class have been possible since October<br />

2005<br />

06/30/2012| Page 35 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

Leading position in performance comparison with other biotech funds<br />

140<br />

120<br />

100<br />

80<br />

60<br />

40<br />

PEER FUND COMPARISON<br />

Indexed representation: 30 30.10.2000 10 2000 = EUR 100<br />

20<br />

10/00 10/01 10/02 10/03 10/04 10/05 10/06 10/07 10/08 10/09 10/10 10/11 10/12<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> BioHe@lth-<strong>Trends</strong> Share Anteilklasse class EUR EUR ESPA Stock Biotec T Dexia Eqs L Biotechnology C Acc<br />

PF (LUX) Biotech P Cap SEB Concept BioTech B Allianz RCM Biotechnologie A EUR<br />

Franklin Biotechnology Disc A Acc $ ING (L) Invest Biotechnology P USD Acc Nordea-1 Biotech BP<br />

CS EF (Lux) Global Biotech Aberdeen B UBS (LUX) EF Biotech B USD P DWS Biotech-Aktien Typ O<br />

BNPP L1 Equity World Biotech Acc Lacuna - APO BioTech Oyster Oncology USD<br />

Since its issue on<br />

30.10.2000, the <strong>FCP</strong><br />

Medical <strong>BioHealth</strong>-<br />

<strong>Trends</strong> has<br />

significantly<br />

outperformed funds<br />

in the reference<br />

group group.<br />

Peer group funds<br />

focus primarily on<br />

stocks with higher<br />

capitalisation.<br />

Source for <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> data: <strong>Oppenheim</strong> Asset Management Services S.à r.l. , performance calculated according to BVI method /<br />

Source for peer funds: Datastream / Initial charges (for investment and reinvestment) as well as individual costs such as the custodian fee were not included.<br />

Performance would turn out lower if these charges and costs were included included. Growth in the past is no indication of future performance and no guarantee of<br />

success in the future. As of: 06/30/2012<br />

06/30/2012| Page 36 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


PERFORMANCE<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Peer group comparison<br />

FUND CATEGORY: EQUITIES BIOTECHNOLOGY<br />

ISIN S Ranking over nach 10 10 year Jahren period 10 Jahre years Rang rank 5 years Jahre Rang rank 3 3 years Jahre Rang rank 1 1 year Jahr Rang rank<br />

Sektordurchschnitt/Anzahl<br />

Sector average/number<br />

52,9 14 35,3 15 81,1 16 19,4 16<br />

LU0108459040 Dexia Eqs L Biotechnology C Acc 108,6 1 71,0 1 146,0 1 22,1 8<br />

AT0000746755 ESPA Stock Biotec T 85,3 2 44,9 6 94,5 4 34,1 2<br />

LU0118405827 SEB Concept BioTech D 84,5 3 44,7 7 103,2 3 28,5 4<br />

LU0115986761 RH&F Global Life Sciences Fund 65,9 4 68,2 2 128,3 2 10,0 13<br />

LU0130190969 CS SICAV (Lux) Equity Biotechnology B 65,3 5 40,7 9 84,1 8 23,9 7<br />

LU0090689299 Pictet-Biotech-P USD 63,1 6 14,6 13 46,5 15 14,9 11<br />

LU0109394709 Franklin Biotechnology Disc A Acc $ 61 61,5 5 7 48 48,1 1 5 94 94,0 0 5 28 28,9 9 3<br />

LU0119891520 <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR 58,5 8 21,7 11 63,3 12 4,4 15<br />

LU0348461467 DekaLux-BioTech CF 44,1 9 27,4 10 76,0 9 27,1 5<br />

LU0069152568 UBS (Lux) EF Biotech (USD) P-acc 36,2 10 54,4 3 91,9 6 19,2 9<br />

LU0125232032 UniSector: GenTech A 30,4 11 3,6 14 31,6 16 8,3 14<br />

DE0008481862 Allianz Biotechnologie A EUR 28,0 12 42,8 8 71,3 10 26,7 6<br />

DE0009769976 DWS Biotech-Aktien Typ O 21,7 13 50,0 4 91,0 7 36,1 1<br />

LU0095994793 Lacuna-Biotech -12,9 14 -16,7 15 67,5 11 12,7 12<br />

LU0228344361 <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR H 14,7 12 50,4 14 -4,1 16<br />

LU0415392322 BB Biotech B USD 57,7 13 18,5 10<br />

Source: Morningstar (Performance calculated according to BVI method), Initial charges (for investment and reinvestment) as well as individual costs such as the custodian fee were not included.<br />

Performance would turn out lower if these charges and costs were included. Growth in the past is no indication of future performance and no guarantee of success in the future. As of: 31/05/2012<br />

06/30/2012| Page 37 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


SUMMARY<br />

Biotech funds: overview of the top five<br />

DWS Biotech Typ O JB EF Biotech-USD / A<br />

Allianz RCM<br />

Biotechnologie A EUR<br />

DekaLux-BioTech CF<br />

Regeneron Pharma Pharma. 90% 9,0 % Amgen 90% 9,0 % Biogen Idec Inc 89% 8,9 % Regeneron Pharma Pharma. 75% 7,5 %<br />

Alexion Pharma 8,0 % Vertex Pharm. 7,4 % Amgen 7,3 % Alexion Pharma 7,5 %<br />

Gilead Sciences 6,7 % Biogen Idec Inc 7,2 % Celgene 5,7 % Gilead Sciences 5,8 %<br />

Vertex Pharm. 5,7 % Celgene 6,8 % Onyx Pharmaceuticals 5,3 % Celgene 5,5 %<br />

Biogen Idec Inc 5,0 % Regeneron Pharma. 5,6 % Medivation 5,2% Vertex Pharm. 5,0 %<br />

Total Summe of top Top 55 34,4 % Total Summe of top Top 55 36,1 % Total Summe of top Top 55 32,3 % Total Summe of top Top 5 5 31,3 %<br />

Pictet Funds (LUX) (LUX)-Biotech-P Biotech P Cap Cap- UBS (Lux) Equity Fund - Biotech<br />

iSharesNasdaq<br />

<strong>FCP</strong><strong>OP</strong><strong>MEDICAL</strong><strong>BioHealth</strong>-<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong><br />

EUR<br />

(USD) P-acc<br />

Biotechnology Index<br />

<strong>Trends</strong> EUR<br />

Vertex Pharm. 6,8 % Biogen Idec Inc 8,4 % Alexion Pharma 8,2 % Ligand Pharma 6,1 %<br />

Incyte 6,0 % Gilead Sciences 7,6 % Amgen 7,3 % Immunogen 5,8 %<br />

Biogen Idec Inc 5,7 % Amgen 6,7 % Regeneron Pharma. 6,4 % Furiex Pharma 3,8 %<br />

Onyx Pharmaceuticals 5,7 % Vertex Pharm. 5,1 % Gilead Sciences 5,5 % Basilea Pharma N-Akt 2,8 %<br />

Gilead Sciences 5,6 % Celgene 4,7 % Biogen Idec Inc 5,5 % UCB 2,8 %<br />

TTotal SSumme t l of f top tTTop 5 5 298% 29,8 % SSumme TTotal t l of f TTop top t 5 5 324% 32,4 % TTotal SSumme t l of f top tTTop 5 5 33 33,0 0 % TTotal SSumme t l of f top tTTop 5<br />

5 212% 21,2 %<br />

Source: information provided by the respective management company As of: 05/31/2012<br />

As of 06/30/2012: <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> EUR, Allianz RCM Biotechnologie A EUR, iSharesNasdaq Biotechnology Index<br />

06/30/2012| Page 38 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


SUMMARY<br />

Current arguments in favour of the <strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong><br />

� Persuasive long-term data (outperformance of relevant indices)*<br />

� The portfolio p is ppositioned with a forward-looking g focus: ggrowth, innovation and stability y are the<br />

investment criteria<br />

� The rating level of the companies in the fund portfolio can still (as of 30.09.2011) be classified<br />

as favourable<br />

� The sub-fund <strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong> is available in an unhedged and a hedged<br />

share class<br />

� The sub-fund <strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong> is available in two institutional share classes<br />

� Undifferentiated correction creates opportunities, which can be used through rebalancing<br />

The <strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong> offers potential growth above the market<br />

average**<br />

* Growth in the past is no indication of future performance and no guarantee of success in the future.<br />

** This investment target may or may not be achieved and cannot be regarded as any type of assurance or guarantee guarantee.<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

06/30/2012| Page 39 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


OUTLOOK<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Outlook (I)<br />

2,60 tn<br />

USD<br />

GROWTH OF THE WORLD HEALTHCARE MARKET<br />

Worldwide <strong>Sal</strong>es in 2010<br />

Worldwide <strong>Sal</strong>es in 2020<br />

5,8 tn USD 9,6 tn USD<br />

2,40 tn<br />

USD<br />

390t 3,90 tn<br />

USD<br />

0,80 tn<br />

USD<br />

Th The emerging i markets k t will ill mainly i l<br />

contribute to the global healthcare growth<br />

270tn 2,70 tn<br />

USD<br />

USA Europe/OECD Emerging markets<br />

Source: Morgan Stanley 2010, 2010 Berenberg 2010 2010, (based on data of the IMF IMF, WHO and own calculations)<br />

calculations),<br />

calculation by Medical Strategy GmbH 2011<br />

06/30/2012| Page 40 <strong>Oppenheim</strong> Asset Management Services S.à r.l.<br />

3,00 tn<br />

USD


OUTLOOK<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong>: Outlook (II)<br />

� Transformation process within the large-cap segment makes innovative small- and mid-caps<br />

currently appear as a specially interesting investment segment<br />

� Focus on the mid- and small-cap area offers above average growth potential – number of U.S.<br />

large-cap Biotech firms reduced to four after Genzyme-take-over.<br />

� Small/mid-caps stay numerous and are still sought-after as take-over candidates<br />

� The winner will be the firm/product with high potential for innovation (Pricing Power)<br />

Source: Medical Strategy GmbH, GmbH Gräfelfing near Munich<br />

The fund’s investment strategy can be changed at any time within the legal and contractual limits. Details of these limits can be found in the sales prospectus.<br />

06/30/2012| Page 41 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


OUTLOOK<br />

Current crisis: effects on Health Care Sector<br />

� The fund invests predominantly in product developer (drugs, medical technology) – the health<br />

care service sector only serves as portfolio addition: current weight 1.7%<br />

� Investments are focused in innovative product developers – only mildly affected by possible<br />

austerity measures – possible rebate constraints in the U.S. and Europe will rather affect<br />

established companies<br />

� The <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> invests in the Pipeline, that is to say predominantly<br />

in prospective sales<br />

� Companies with new disease influencing or curing drugs have pricing power<br />

<strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<strong>Trends</strong> only limited affected by budget reductions<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

06/30/2012| Page 42 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


OUTLOOK<br />

Basis for outperformance of Health Care Sector<br />

� New product cycle starts<br />

› Revolutionary treatment concepts for many fields in therapy<br />

� Peak of patent expiration in 2012 highlights pipelines<br />

› Sector will regain growth characteristics (FDA more efficient in 2011)<br />

� Transformation of drug industry<br />

› Big Pharma reduces R&D and focuses on severe chronic diseases (inter alia through M&A)<br />

� Cost benefit analysis for new therapies<br />

› NICE (VBP), IQWiG, IPAB – boosts new, more sophisticated special drugs (inter alia Orphan)<br />

� Global growth of health care spending (% GDP)<br />

› Emerging Markets, Demographics (>65 years), Universal Coverage<br />

<strong>Trends</strong> bring forward young, emerging companies with innovative products<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

06/30/2012| Page 43 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


OUTLOOK<br />

Current crisis: effects on <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong><br />

� Debt crisis in Europe, U.S. and Japan<br />

� Heightened g uncertainty y of economic development p – defensive sectors like health care favored<br />

� Already approved as well as new more restrictive austerity budgets for EU countries<br />

� U.S. - compromise for raising the debt ceiling: reductions sum up to 4 tn USD - Medicare<br />

(pensioner health insurance) and Medicaid (health insurance for people in need) may be<br />

affected by cut-backs of up to 300 bn USD over a 10 year time period<br />

�� Approximately 80% of Medicare/Medicaid expenses are dispensed with the regional service<br />

sector<br />

� The proportion of Medicare compensated drugs relative to global sales of 800 bn. USD = 7%<br />

Service Sector is more affected by budget reduction<br />

Source: Medical Strategy GmbH, Gräfelfing near Munich<br />

06/30/2012| Page 44 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


ANNEX: FUND DATA AND NOTE ABOUT RISKS<br />

Overview of fund data<br />

FUND DATA<br />

Management company:<br />

Legal form:<br />

External consultant:<br />

Depositary bank:<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong><br />

Sub-fund: <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong><br />

The fund was issued on 30 October 2000<br />

under the name Fonds Commun de<br />

Placement <strong>MEDICAL</strong> Medical <strong>BioHealth</strong>-<br />

<strong>Trends</strong> as a sub-fund of the umbrella fund<br />

Fonds Commun de Placement <strong>MEDICAL</strong> in<br />

accordance with the law of the Grand Duchy<br />

of Luxembourg according to Part II of the law<br />

relating to organisms for joint investments of<br />

30 March 1988. The fund changed its name to<br />

<strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> with<br />

effect from 16 August 2004.<br />

The sub-fund <strong>FCP</strong> <strong>OP</strong> Medical <strong>BioHealth</strong>-<br />

<strong>Trends</strong> is available in two institutional share<br />

classes.<br />

1Theindicatedfeemaybeadjustedupwardas well as downward at any time within the limits<br />

contained in the prospectus. 06/2012<br />

<strong>Oppenheim</strong> Asset Management Services S.à r.l., Luxembourg<br />

Fonds Commun de Placement <strong>MEDICAL</strong> in<br />

Fonds Commun de Placement according to law of the Grand Duchy of Luxembourg<br />

Medical Strategy GmbH, Gräfelfing district Munich<br />

<strong>Sal</strong>. <strong>Oppenheim</strong> jr. & Cie. S.C.A., Luxembourg<br />

SHARE CLASS EUR EUR H I I H<br />

Security identification<br />

number<br />

941135 / LU0119891520 A0F69B / LU0228344361 A0MNRQ / LU0294851513 A0MQG5 / LU0295354772<br />

Fund currency: EUR EUR EUR EUR<br />

2The performance fee is only paid when and if<br />

the Specific Net Asset Value per Unit reaches,<br />

Use of profits: distributed distributed distributed distributed<br />

at half year end, a new high, compared to the<br />

high at the previous half year end (the “High<br />

Fiscal year end: 31 December 31 December 31 December 31 December<br />

Water Mark”) and only on the new excess<br />

appreciation over the said high at the end of<br />

the previous half year for the Specific Net<br />

Date share first issued: 30 October 2000 4 October 2005 25 May 2007 8 May 2007<br />

Asset Value per Unit. The Net Asset Value per<br />

Unit is adjusted by any distributions that may<br />

Issue surcharge arise.<br />

1 Issue surcharge %: effektive: 55.0 0 / maxmal: 55.0 0 effektive: 5.0 5 0 / maximal: 5.0 5 0 effektive:50/maximal:50 effektive: 5.0 / maximal: 5.0 effektive:50/maximal:50<br />

effektive: 5.0 / maximal: 5.0<br />

Depositary bank fee<br />

3Total Expense Ratio (TER) is calculated<br />

according to SFA method and contains all<br />

costs (with exception of transaction costs and<br />

performance fee)<br />

Portfolio Turnover Rate (PTR) for reporting<br />

period January 1, 2011 to Dezember 31,<br />

2011 l l t d di t SFA th d<br />

1 p.a. %: effektive: 0.15 / maximal: 0.15 effektive: 0.15 / maximal: 0.15 effektive: 0.15 / maximal: 0.15 effektive: 0.15 / maximal: 0.15<br />

Management fee 1 p.a. %: effektive: 1.7 / maximal: 1.9 effektive: 1.7 / maximal: 1.9 effektive: 1.2 / maximal: 1.9 effektive: 1.2 / maximal: 1.9<br />

2<br />

Performance fee rule<br />

15 % of outperformance referring to NAV per share and half<br />

year.<br />

10 % of outperformance referring to NAV per share and half<br />

year.<br />

2011 calculated according to SFA method:<br />

0,85.<br />

The fund is an opportunity-oriented investment<br />

for investors with a long-term investment<br />

horizon. The particular investment policy of<br />

the fund entails a more pronounced<br />

opportunities-risks profile. This means that<br />

higher fluctuation in the share prices<br />

2 :<br />

Total expense ratio 3 year.<br />

Outperformance is deemed to be the semi-annual performance<br />

in excess of 2,5 %<br />

year.<br />

Outperformance is deemed to be the semi-annual performance<br />

in excess of 2,5 %<br />

%<br />

(excluding performance<br />

fee), financial year:<br />

2.11 / 31. December 2011 2.13 / 31. December 2011 1.52 / 31. December 2011 1.59 / 31. December 2011<br />

PPerformance f fee f %, %<br />

financial year:<br />

0.00 / 31. December 2011 0.37 / 31. December 2011 0.00 / 31. December 2011 0.28 / 31. December 2011<br />

higher fluctuation in the share<br />

(increased volatility) is possible.<br />

prices<br />

06/30/2012| Page 45 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


ANNEX: FUND DATA AND NOTE ABOUT RISKS<br />

A few words about risks<br />

Investment funds are subject to the risk of falling share prices because fluctuations in the value of the assets contained in the fund are reflected in the share<br />

price.<br />

The fund invests in shares and is thus subject j to the volatilityy and the risk of possible p share price p losses on the stock markets. Stocks are picked p from within<br />

the healthcare sector. The evaluation of companies in the healthcare industry may be based on less reliable assumptions because product development and<br />

approval depend on the results of comprehensive series of tests. This lack of certainty can result in an increased share price volatility. Because there may be<br />

little information available about the status of the development and the approval process, investing in such stocks may be highly speculative.<br />

Stocks are picked worldwide. Investments of this type open up additional potential earnings yet also entail an exchange rate risk and are thus subject to the<br />

effects of social, political and economic changes in these countries.<br />

The particular investment policy of the <strong>FCP</strong> <strong>OP</strong> <strong>MEDICAL</strong> <strong>BioHealth</strong>-<strong>Trends</strong> entails a more pronounced opportunities-risks profile. This means that higher<br />

fluctuation in the share prices (increased volatility) is possible.<br />

The fund is an opportunity-oriented investment for investors with a long-term investment horizon.<br />

The fund’s investment strategy can be changed at any time within the legal and contractual limits. Details of these limits can be found in the sales prospectus.<br />

Growth in the past is no indication of future performance and no guarantee of success in the future. The indices illustrated are solely for the purposes of<br />

general market information.<br />

Detailed information and risk descriptions can be found in the sales prospectuses that can be obtained free of charge from the <strong>Oppenheim</strong> Fonds Trust<br />

GmbH, Unter Sachsenhausen 4, 50667 Cologne or online at www.oppenheim-fonds.de.<br />

06/30/2012| Page 46 <strong>Oppenheim</strong> Asset Management Services S.à r.l.


Disclaimer<br />

Management company:<br />

<strong>Oppenheim</strong> Asset Management<br />

SServices S.à S r.l.<br />

4, rue Jean Monnet<br />

L-2180 Luxembourg<br />

www.oppenheim-fonds.lu<br />

Paying Agent in Germany:<br />

<strong>Sal</strong>. <strong>Oppenheim</strong> jr. & Cie. AG & Co.<br />

KGaA<br />

Unter Sachsenhausen 4<br />

50667 Cologne<br />

Germany<br />

and its branches<br />

Paying Agent and Distribution in Austria:<br />

Deutsche Bank Österreich AG<br />

Vienna Main Office<br />

Palais Equitable<br />

Stock im Eisen-Platz 3<br />

AA-1010 1010 Vi Vienna<br />

© Copyright<br />

This publication is copyright-protected. All rights appertaining thereto, even in case of only partial use, shall remain<br />

reserved, particularly with regard to the following: translation, reprinting, recital, use of images and graphics,<br />

broadcasting broadcasting, duplication via microfiche or other means means, and storage in data processing equipment equipment. Any duplication<br />

of this publication or portions thereof, even in isolated cases, shall be subject to the limitations set forth under the<br />

law. Any breaches may carry civil and criminal penalties.<br />

Exclusion of liability<br />

Although this presentation was prepared with reasonable care care, it can not be ruled out out, that it is incomplete or<br />

includes mistakes. The editor, its managing directors, executive employees or staff members therefore do not take<br />

the liability for the accuracy, completeness and actuality of the information. This applies as well to the data<br />

contained in this document and provided by third parties even though only data is used which was considered<br />

reliable. A possible incorrectness or incompleteness of information does not constitute a direct or secondary liability<br />

in case of claims.<br />

If statements t t t are contained t i d iin thi this publication bli ti concerning i market k t conditions diti th they representt your own view i on th the<br />

portrayed situation. Hereby we neither make generally valid statements nor give recommendations or investment<br />

advice. Moreover the remarks are based on our judgment of the current legal and tax conditions. Statements<br />

contained in this publication may be changed at any time without prior notice.<br />

The publication may not be understood as sale offer or as request to submit an offer to purchase investment<br />

securities. In particular it is not a prospectus in the legal sense, but a promotional description, which in meant for<br />

individual information. Reading this publication is no substitute for individual consultancy.<br />

Details contained in this publication do not represent an investment consulting service, but simply give a short<br />

summarizing abstract of the basic characteristics of the fund.<br />

The complete specifications for the fund, detailed notice on investments objectives, fees and risks as well as legal<br />

and tax notice are contained in the prospectus.<br />

The prospectus is the solely obligatory basis for the purchase of fund shares. Please read the prospectus carefully<br />

and seek advice from you legal and/or tax advisor before investing.<br />

You get the prospectus on request at the following address: <strong>Oppenheim</strong> Fonds Trust GmbH, Unter Sachsenhausen<br />

4, 50667 Cologne or on the internet at www.oppenheim-fonds.de.<br />

06/30/2012| Page 47 <strong>Oppenheim</strong> Asset Management Services S.à r.l.

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!