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Contents - Middle East Journal of Family Medicine

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ORIGINAL CONTRIBUTION AND<br />

CLINICAL INVESTIGATION<br />

The results <strong>of</strong> this study indicate that the mean scores for<br />

group A (mean=1.5500) was considerably lower than B<br />

(mean=3.7500) & C (mean=2.6000). The mean values for<br />

group C further showed a reduction in the colony numbers<br />

than B. On statistical analysis a significant difference was<br />

found between groups C & B (p value = 0.0004).<br />

DISCUSSION AND CONLCUSION<br />

The oral cavity is a reservoir for commensal and pathogenic<br />

micro-organisms. A complete state <strong>of</strong> asepsis is hardly<br />

prevalent in the oral cavity. This however does not imply<br />

that there is an active infection at all times, but certainly<br />

depicts the constant presence <strong>of</strong> micro-organisms which<br />

may result in their frequent transmission to the different<br />

communicating regions <strong>of</strong> the oral cavity such as the<br />

oropharnyx, lungs, nasal cavity, eustachian canal, sinuses<br />

etc. This may not pose a significant threat in a state <strong>of</strong><br />

normalcy, but, in the presence <strong>of</strong> an existing infection<br />

the normal oral micro flora itself may potentially super<br />

add to an existing infection. Conversely, an existing focal<br />

sepsis in the oral cavity may act as a continual supply<br />

<strong>of</strong> pathogens and pus resulting in a chronic insidious<br />

recurrent oropharyngeal infection <strong>of</strong> some sort which is<br />

usually not responsive to antibiotic therapy. Such cases<br />

usually resolve with the elimination <strong>of</strong> the source <strong>of</strong><br />

infection but also can be significantly controlled to a great<br />

extent at the onset itself with a direct local reduction in the<br />

pathogenic numbers through the use <strong>of</strong> local antiseptics<br />

such as chlorhexidine. 15<br />

The primary application <strong>of</strong> CHX is predominantly<br />

restricted to field <strong>of</strong> dentistry, that too, as a post procedural<br />

therapeutic rinse. 9 The focus must however shift, as the<br />

study clearly evidences its potential antiseptic actions. It<br />

will indeed be certainly beneficial if the prescription <strong>of</strong><br />

CHX mouth-rinse is added as an adjunct to conventional<br />

therapy. 16<br />

The outcome <strong>of</strong> this simple clinical trial clearly illustrates<br />

the substantial reduction in the bacterial numbers <strong>of</strong> the<br />

cultures obtained from samples with and without <strong>of</strong> the<br />

use <strong>of</strong> CHX mouth rinse. It only progresses to highlight<br />

further the compelling need to maintain oral asepsis.<br />

Therefore, from the obtained results the authors conclude<br />

– that a significant decrease in the bacterial count is present<br />

with the use <strong>of</strong> CHX. Therefore the clinical relevance <strong>of</strong><br />

the study can substantiate the following measures:<br />

• That it is imperative to use CHX mouth rinse as a<br />

recommended ‘pre-procedural’ standard protocol<br />

for all dental related procedures and prior to any<br />

procedures performed in the oral and oropharyngeal<br />

region.<br />

• And further propose that it may be routinely prescribed<br />

by other practitioners in various other specialties<br />

<strong>of</strong> medicine routinely as a mouth rinse to augment<br />

their conventional therapeutic methods for treating<br />

oropharyngeal and other related infections, so as<br />

to definitely ensure an infection free and possibly a<br />

sterile oral and oropharyngeal environment.<br />

REFERENCES<br />

1. Coulter WA, Russell C. Effect <strong>of</strong> chlorhexidine on plaque<br />

development in an artificial mouth. Microbios 1976;16:21-8.<br />

2. Van der Weijden GA, Timmerman MF, Novotny AG, Rosema<br />

NA, Verkerk AA. Three different rinsing times and inhibition<br />

<strong>of</strong> plaque accumulation with chlorhexidine. J Clin Periodontol<br />

2005;32:89-92.<br />

3. Santos S, Herrera D, Lopez E, O’Connor A, Gonzalez I,<br />

Sanz M. A randomized clinical trial on the short-term clinical<br />

and microbiological effects <strong>of</strong> the adjunctive use <strong>of</strong> a 0.05%<br />

chlorhexidine mouth rinse for patients in supportive periodontal<br />

care. J Clin Periodontol 2004;31:45-51.<br />

4. Barasch A, Safford MM, Dapkute-Marcus I, Fine DH. Efficacy<br />

<strong>of</strong> chlorhexidine gluconate rinse for treatment and prevention<br />

<strong>of</strong> oral candidiasis in HIV-infected children: a pilot study. Oral<br />

Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:204-7.<br />

5. Caso A, Hung LK, Beirne OR. Prevention <strong>of</strong> alveolar osteitis<br />

with chlorhexidine: a meta-analytic review. Oral Surg Oral Med<br />

Oral Pathol Oral Radiol Endod 2005;99:155-9.<br />

6. Dodd MJ, Larson PJ, Dibble SL, et al. Randomized clinical trial<br />

<strong>of</strong> chlorhexidine versus placebo for prevention <strong>of</strong> oral mucositis<br />

in patients receiving chemotherapy. Oncol Nurs Forum<br />

1996;23:921-7.<br />

7. Zamany A, Safavi K, Spangberg LS. The effect <strong>of</strong> chlorhexidine<br />

as an endodontic disinfectant. Oral Surg Oral Med Oral Pathol<br />

Oral Radiol Endod 2003;96:578-81.<br />

8. Pitten FA, Kiefer T, Buth C, Doelken G, Kramer A. Do cancer<br />

patients with chemotherapy-induced leukopenia benefit from an<br />

antiseptic chlorhexidine-based oral rinse A double-blind, blockrandomized,<br />

controlled study. J Hosp Infect 2003;53:283-91.<br />

9. Van Strydonck DA, Timmerman MF, van der Velden U, van der<br />

Weijden GA. Plaque inhibition <strong>of</strong> two commercially available<br />

chlorhexidine mouthrinses. J Clin Periodontol 2005;32:305-9.<br />

10. Sreenivasan PK, Gittins E. The effects <strong>of</strong> a chlorhexidine<br />

mouthrinse on culturable microorganisms <strong>of</strong> the tongue and<br />

saliva. Microbiol Res 2004;159:365-70.<br />

11. Cheesebrough M. Medical Laboratory manual for tropical<br />

countries, Vol. II - Microbiology: ELBS, 1991.<br />

12. Greenwood D, Slack RCB, Peutherer JF. A Guide to Microbial<br />

Infections : Pathogenesis, Immunity, Laboratory Diagnosis &<br />

Control. 16 ed: Churchill Livingstone, 2003.<br />

13. Barer MR, Harwood CR. Bacterial viability and cultability,<br />

1999.<br />

14. Greenwood D. Medical Microbiology - Chapter 7. 16 ed:<br />

Churchill Livingstone, 2003.<br />

15. Buckner RY, Kayrouz GA, Briner W. Reduction <strong>of</strong> oral microbes<br />

by a single chlorhexidine rinse. Compendium 1994;15:512, 514,<br />

516 passim; quiz 520.<br />

16. Hennessy B, Joyce A. A survey <strong>of</strong> preprocedural antiseptic<br />

mouth rinse use in Army dental clinics. Mil Med 2004;169:600-<br />

3.<br />

13<br />

MEJFM - Volume 3 Issue 5 - November 2005

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