Veterinary Allergy Products and Services - Greer

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ALLERGENIC EXTRACT – FLEA ANTIGEN DIRECTIONS FOR USE FLEA ANTIGEN DESCRIPTION: Flea antigen is an aqueous extract of the whole bodies of Ctenocephalides spp. with phenol added as a preservative. ACTIONS: The exact mechanism by which flea antigen elicits an allergic response is still under investigation. It has been demonstrated however, that successful hyposensitization treatment decreases specific IgE antibody levels, theoretically by increasing the level of blocking IgG antibodies. These blocking IgG antibodies are believed to complex with the circulating antigen before it can reach the IgE present on the skin and trigger the allergic response. INDICATIONS 1. DIAGNOSTIC: Flea antigen is a valuable aid in the diagnosis of flea bite allergy. Compatible clinical signs and documented exposure to fleas are also necessary to establish the diagnosis. 2. THERAPEUTIC: Flea antigen extract is indicated as an aid in alleviating the symptoms associated with flea bite allergy. A program of controlling the flea population by breaking the life cycle and minimizing flea infestation on the animal should be initiated before or concurrent with hyposensitization treatment. Concomittant antibiotic therapy and an appropriate bathing program should be given where significant secondary bacterial infection is evident. Short-term corticosteroid therapy may be used as an adjunct in the early stages of therapy. CONTRAINDICATIONS 1. DIAGNOSTIC: Corticosteroids will inhibit the histamine mediated immediate skin test. Any patient that has undergone continual corticosteroid treatment should discontinue this treatment for a period of one week for every month of said treatment before this patient is skin tested. However, animals with severe skin problems should be treated with antibiotics, soothing baths and possibly short term oral cortisone until their skin conditions will not interfere with skin testing. 2. THERAPEUTIC: Flea antigen is indicated for hyposensitization only when flea bite hypersensitivity has been unequivocally demonstrated both clinically and by intradermal skin testing. PRECAUTIONS: Have in stock the following: 1. A hydrocortisone (such as Solu-Cortef ® ) or a prednisolone (such as Solu-Delta-Cortef ® ). 2. An antihistamine such as diphenhydramine hydrochloride (Benadryl ® ). 3. Epinephrine diluted 1:1,000. Keep patient under observation for a period of at least 30 minutes after administration. Note: Animals prone to severe reactions should be given diphenhydramine hydrochloride (Benadryl ® ) 30 minutes prior to treatment dose administration.
1 REACTIONS: Adverse reactions are very rarely seen and usually consist of an exacerbation of clinical signs if too large a dose is given. However, in the event of an overdose or alternatively, exquisite sensitivity of the animal, the patient may exhibit restlessness, panting, generalized hives, vomiting, circulatory collapse, and diarrhea (See Overdose section below for treatment). There are also several normal reactions that may occur and the owner should be advised of these prior to administration of the allergen. Temporary pain and discomfort may be experienced at the time of injection, with some stiffness and soreness occurring later. A small area of ulceration may occur where intradermal administration is employed. OVERDOSAGE: If symptoms of overdosage occur (See Reactions section above) treatment employing (a), (b) or (c) below or a combination thereof can be effective in combating an adverse reaction. (a) Intravenous injection of hydrocortisone (i.e. Solu-Cortef ® ) in a dosage of 10-15 mg/lb, or alternatively, a prednisolone (i.e. Solu-Delta-Cortef ® ) in a dosage of 5 mg/lb. (b) Intramuscular or subcutaneous injection of epinephrine in a dosage of 0.5-1.0 ml at 1:1,000. (c) Intravenous injection of an antihistamine such as diphenhydramine hydrochloride (Benadryl ® ) in a dosage of 0.5-1.0 mg/lb. Note: In a crisis situation epinephrine may be administered intravenously. Use 0.5 to 1.0 ml of a 1:1,000 dilution. SKIN TESTING: DOSAGE AND ROUTE OF ADMINISTRATION 1. Materials Needed: a. Sterile 1 ml tuberculin type syringes with 25 or 26 gauge needles, 3/8 to ½ inch in length. b. Flea antigen at 1:1,000 w/v (final concentration). c. Diluent control (negative control). d. 1:100,000 w/v histamine phosphate (positive control). 2. Suggested Procedure: a. Prepare the test area by clipping and cleansing testing site (lateral thorax or inguinal area). b. Five minutes prior to the test, the site may be cleaned with alcohol which is allowed to dry by evaporation. c. Using a separate syringe for each solution, load the 1 ml tuberculin syringe with 0.1 ml of control solution or flea extract. d. Ensure that all air bubbles have been expelled from the loaded syringe, because injection of air bubbles may force dermal cells apart and create false reactions. e. The injection sites should be at least 2.5 cm from each other and the injections should be atraumatic. f. After gently stretching the skin around the test site, the needle is inserted into the skin at an angle of approximately ten (10) degrees with the bevel upwards. g. Stop inserting the needle when the entire bevel is buried in the skin (ideally the bevel should be visible through the superficial layers of the skin). h. Inject 0.05 ml of the control solution or flea extract and gently remove the needle to prevent traumatic hemorrhage.
Page 1 and 2: Veterinary Allergy Products and Ser
Page 3 and 4: Ordering Information To set up a ne
Page 5 and 6: • — Item is offered in one or m
Page 7 and 8: — Item is offered in one or more
Page 17 and 18: Sterile Diluents Diluents come in a
Page 19 and 20: Sterile Empty Vials Manufactured by
Page 21 and 22: Syringes and Syringe Trays Item # D
Page 23 and 24: Item # Size Qty/Case Jiffy Mailing
Page 25 and 26: GREER ® Pharmacy GREER ® Pharmacy
Page 28: GREER Veterinary PO Box 800 639 Nuw
Page 36 and 37: 2 i. Retain the remaining 0.05 ml o

Veterinary Allergy Products and Services - Greer

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