Veterinary Allergy Products and Services - Greer

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2 i. Retain the remaining 0.05 ml of control solution or flea extract in case the wheal is unsatisfactory due to movement of the patient or poor injection technique. j. The skin test should be completed as soon as possible to allow simultaneous comparison of the flea antigen wheal against the controls. 3. Interpretation: a. Immediate (IgE mediated) reactivity will cause a wheal within 15 minutes. b. A wheal that is five (5) or more millimeters greater than the negative control denotes a positive reaction. However, a strong positive is likely to be close to the histamine injection in size, and will be a minimum of one (1) centimeter in diameter. c. If patient is negative at 15 minutes reexamine after 24 hours to check for delayed reactions. d. See Overdose procedure if adverse reactions occur. HYPOSENSITIZATION: DOSAGE AND ROUTE OF ADMINISTRATION: Discussion: The optimum dosage and route of administration of flea antigen has not been clearly established and currently many dosage schedules are in use. Subcutaneous or intradermal injections have been administered with success, 6 7 but it has been noted that if at least part of each injection is intradermal the response seems improved. 1 A suggested treatment schedule is offered below, however; in the final analysis the dosage and length of treatment will depend upon the sensitivity and responsiveness of the patient. Treatment: The suggested hyposensitization dose is 0.1-0.5 ml of the Flea Antigen at a 1:100 w/v per 25 lbs. of body weight. Treatments should be initiated with a 0.1 ml/25 lbs. dose and gradually increased to a maintenance dose of 0.5 ml/25 lbs. The treatment should continue for a 6 to 24 week period. The injection is administered intradermally at a number of sites with a 1.0 ml sterile tuberculin syringe, using a 25 or 26 gauge needle 3/8 to ½ inch in length. Intradermal injections should not exceed 0.2 ml per site or adverse reactions may occur. SUGGESTED DOSAGE SCHEDULE Week Volume of 1:100 w/v Flea Antigen per 25 lbs. of Body Weight 1 0.1 ml 2 0.2 ml 3 0.3 ml 4 0.4 ml 5 0.5 ml 6 0.5 ml Bi-weekly to 24 weeks if necessary etc. Boosters can be given if symptoms reoccur or as a prophylactic measure before flea season. The booster dose should not exceed the last dose given. HOW SUPPLIED: Flea antigen is supplied in sterile 10 ml vials at a concentration of 1:100 w/v (aqueous only).
3 References: 1 Austin, V. H.; Atopic Skin Disease. Modern Veterinary Practice. May, pp. 355-361. 1976. 2 Chamberlain, K. W.; Biological Management of the Allergic Patient. Veterinary Clinics of North America. 4, pp. 65-78. 1974. 3 Halliwell, R. E. W.; Flea Bite Dermatitis. The Compendium on Continuing Education of the Small Animal Practitioner. 1(5), pp. 367-371. 1979. 4 Kirk, R. W. and Bistner, S. I.; Handbook of Veterinary Procedures and Emergency Treatment. W. B. Saunders Co., Philadelphia, pp. 16-17. 1969. 5 Michaeli, D. and Goldfarb, S.; Clinical Studies on the Hyposensitization of Dogs and Cats to Flea Bites. Australian Veterinary Journal. 44, pp. 161-165. 1968. 6 Nesbitt, G. H. and Schmitz, J. A.; Flea Bite Allergenic Dermatitis: A Review and Survey of 330 Cases. Journal of American Veterinary Medical Association (JAVMA). 173 (3), pp. 282-288. 1978. 7 Saunders, E. B.; Hyposensitization for Flea Bite Hypersensitivity. Veterinary Medicine/Small Animal Clinician (VM/SAC). May, pp. 879-881. 1977. 8 August, J. R.; The Intradermal Test as a Diagnostic Aid for Canine Atopic Disease. Journal of the American Animal Hospital Association (JAAHA). 18, pp. 164-171. 1982. GREER LABORATORIES, INC. Post Office Box 800 Lenoir, North Carolina 28645 USA U.S.D.A. Veterinary License No. 294 4-85 2.5M
Page 1 and 2: Veterinary Allergy Products and Ser
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Page 5 and 6: • — Item is offered in one or m
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Page 17 and 18: Sterile Diluents Diluents come in a
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Page 21 and 22: Syringes and Syringe Trays Item # D
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Veterinary Allergy Products and Services - Greer

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