Yearbook 2012 - Galderma
Yearbook 2012 - Galderma
Yearbook 2012 - Galderma
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committed<br />
we are<br />
yearbook 2 0 1 2
<strong>Galderma</strong><br />
<strong>2012</strong><br />
CONTINUE THE EXPERIENCE ONLINE<br />
Get access to the enriched online edition of the yearbook at yearbook.galderma.com,<br />
or by scanning the QR codes present in every chapter.<br />
GALDERMA CORPORATE SERVICES - Tour Europlaza - 20, Avenue André Prothin - 92927 La Défense Cedex – France. www.galderma.com. This document has been prepared by the Corporate<br />
& Digital Communications Department.<br />
Executive director: Humberto C. Antunes - Executive editor: Sébastien Cros - Senior editor: Nadège des Closets - Design and production:<br />
. June 2013. Photos: Kim<br />
Freeman, Tom Hussey Photography, LLC, Gavin Jowitt/Capa Pictures, Michel Labelle, Yannick Labrousse, Yann Leborgne, Mats Lundqvist, Nathalie Oundjian-Guréghian, Corbis, Plainpicture,<br />
iStock, BSIP, Phanie, Getty Images, Thinkstock, <strong>Galderma</strong>, R.R. - Epiduo, Oracea, Clobex, Differin, Rozex/MetroGel, Silkis/Vectical, Benzac, Tri-Luma, Loceryl, Cetaphil, Metvix, Azzalure,<br />
Restylane and Emervel are registered trademarks of <strong>Galderma</strong>. Dysport is a trademark of Ipsen.
CONTENTS<br />
INTERVIEW WITH HUMBERTO C. ANTUNES<br />
EXECUTIVE COMMITTEE<br />
<strong>2012</strong> KEY FACTS<br />
<strong>2012</strong> KEY FIGURES<br />
PAGE 06<br />
PAGE 08<br />
PAGE 10<br />
PAGE 12<br />
We are committed to delivering<br />
PAGES 14 TO 21<br />
PAGES 22 TO 31<br />
innovative medical solutions to meet<br />
PAGES 32 TO 39<br />
the dermatological needs of people<br />
throughout their lifetime while<br />
PAGES 40 TO 45<br />
serving healthcare professionals<br />
around the world.<br />
PAGES 46 TO 53<br />
04<br />
05
Doing the<br />
right thing<br />
every day<br />
What is the driving force behind<br />
<strong>Galderma</strong>’s ambition statement<br />
We want to provide the best medical solutions in dermatology.<br />
That is what <strong>Galderma</strong> stands for. But how<br />
we do business is just as important as the products and<br />
services we offer. <strong>Galderma</strong> has evolved from a mainly<br />
prescription medication company to one that also offers<br />
Aesthetic & Corrective solutions and Self-medication<br />
drugs. Our Prescription business has thrived in ways<br />
that were unimaginable before. As we developed these<br />
businesses, we realized that each had a specific model.<br />
We also examined how people - patients, healthcare<br />
professionals, stakeholders and regulators - interacted<br />
with the company. Now, we see the future differently.<br />
How does this statement<br />
reflect changes in the company<br />
and its environment<br />
We are at a turning point, due to demographic evolution,<br />
the distribution of wealth in new markets and increased<br />
social mobility. Access to better, more innovative products<br />
is improving. Communications have changed, so<br />
have regulations. Our new ambition statement stems<br />
from our fundamental objective to provide innovative<br />
medical solutions for people with skin, hair and nail needs.<br />
Our model is based on research and development and<br />
evidence-based treatments. It is a medical business, and<br />
we are focusing on solutions, not just drugs. We meet<br />
patients’ needs through the convergence of science and<br />
technology: chemistry, physics, devices, and even light.<br />
As we are providing solutions for people with medical<br />
needs in dermatology, we are working more closely with<br />
healthcare professionals, who are in the best position to<br />
diagnose a problem and prescribe the right solution.<br />
Are you broadening your audience<br />
Providing the right solutions is not simply about inventing<br />
them. We have to make them accessible. The<br />
world has become very complex. Developing a breakthrough<br />
drug does not necessarily mean it will become<br />
accessible. It requires regulatory approval and listing<br />
in patients’ formularies. Insurance companies need<br />
to recognize its value and agree to pay for it. Pharmacies,<br />
hospitals or clinics need to carry it. We must work<br />
with all these partners to ensure the availability of our<br />
products and treatments. Patients are becoming more<br />
demanding too: they want solutions immediately - and<br />
they deserve to get them!<br />
The world’s one million dermatology-related healthcare<br />
providers have a huge impact. We will talk to them.<br />
Hundreds of thousands of pharmacists carry our products.<br />
We are registering products in more places and<br />
reaching new cities in countries where we have sometimes<br />
been for a long time. We are launching products,<br />
of course, but the biggest change is our role as a catalyst.<br />
It will energize us to go the extra mile and ensure that<br />
anybody who needs to, can have access to <strong>Galderma</strong>’s<br />
medical solutions.<br />
Why was the company reorganized<br />
into three Global Business Units<br />
We restructured into business units that work together,<br />
transversally. Why Because the solutions people need<br />
do not just come from standalone Prescriptions, Selfmedication<br />
or Aesthetic & Corrective treatments, but<br />
from a combination of all of these. We offer solutions<br />
through a transversal, holistic approach to treatment.<br />
A skin cancer patient, for example, needs a selfmedication<br />
solution that helps prevent sun damage, he/<br />
she also needs prescription drugs to treat the lesions<br />
and procedures that will correct or restore part of the<br />
damage. Today, <strong>Galderma</strong> offers all three of these solutions.<br />
We have the same approach for milder afflictions.<br />
<strong>Galderma</strong>'s strategy is to be a<br />
'lifetime' brand: what is behind this<br />
approach<br />
Healthy skin is a very precious asset throughout our<br />
entire life, and people are becoming increasingly<br />
aware of this. The world's population is ageing, not just<br />
in Europe but also in countries like Brazil or China.<br />
As we live longer, we aspire to a better quality of life.<br />
<strong>Galderma</strong>’s approach is very positive and optimistic:<br />
supporting people take care of their skin and appearance<br />
helps them to live a longer, happier life.<br />
We are focusing<br />
on solutions,<br />
not just drugs.<br />
<strong>Galderma</strong>’s culture is founded on<br />
ethical values: how does that influence<br />
your business<br />
Dermatology is fascinating. It is medical, so it has an<br />
impact on the body. However in aesthetic dermatology,<br />
you can also change lives by having an impact on the<br />
soul and spirit. At <strong>Galderma</strong>, we have a mission, a vision<br />
and an ambition. We wish to serve people throughout<br />
the whole of their lifetime, so the way in which we<br />
do that is extremely important. The sustainability of<br />
our business and our mission depends on doing things<br />
right, every day. Respecting the rules, of course, but<br />
also answering needs and building on the responsible<br />
principles we share. In the digital age, it is important to<br />
train all our teams to communicate effectively with physicians<br />
and patients, to know the rules and regulations.<br />
It is about interaction with the outside world but also<br />
how we proceed internally, how <strong>Galderma</strong> respects the<br />
environment and diversity. We are committed.<br />
HUMBERTO C. ANTUNES<br />
PRESIDENT & CEO<br />
06<br />
07
Executive<br />
Committee<br />
JANUSZ CZERNIELEWSKI<br />
VICE-PRESIDENT<br />
MEDICAL AFFAIRS<br />
ALAIN JACOT<br />
VICE-PRESIDENT<br />
SCIENTIFIC DIVISION<br />
LYDIE FRÈRE<br />
GENERAL COUNSEL<br />
ALBERT DRAAIJER<br />
VICE-PRESIDENT BUSINESS<br />
DEVELOPMENT & MARKETS,<br />
VICE-PRESIDENT<br />
SELF-MEDICATION GLOBAL<br />
BUSINESS UNIT,<br />
VICE-PRESIDENT A&C<br />
GLOBAL BUSINESS UNIT<br />
ALAIN KIRSCH<br />
VICE-PRESIDENT HUMAN<br />
RESOURCES<br />
CÉCILE DUSSART<br />
VICE-PRESIDENT<br />
MANUFACTURING<br />
& TECHNICAL OPERATIONS<br />
HUMBERTO C. ANTUNES<br />
PRESIDENT & CHIEF<br />
EXECUTIVE OFFICER<br />
CHRISTIAN MATTON<br />
VICE-PRESIDENT<br />
CORPORATE GENERAL<br />
COUNSEL<br />
VIVIANE MONGES<br />
VICE-PRESIDENT FINANCE<br />
& ADMINISTRATION & CFO<br />
FRANÇOIS FOURNIER<br />
VICE-PRESIDENT<br />
NORTH AMERICA<br />
& PRESIDENT USA,<br />
VICE-PRESIDENT<br />
PRESCRIPTION GLOBAL<br />
BUSINESS UNIT<br />
08<br />
09
Key facts<br />
<strong>2012</strong><br />
A NEW ORGANIZATION, A NEW AMBITION STATEMENT,<br />
NUMEROUS PRODUCT LAUNCHES AND THE<br />
CONTINUED INTERNATIONAL EXPANSION:<br />
<strong>2012</strong> IMPROVED GALDERMA'S LEADERSHIP<br />
IN THE FIELD OF DERMATOLOGY.<br />
"AMBITION<br />
STATEMENT"<br />
In June <strong>2012</strong>, <strong>Galderma</strong> confirmed<br />
its commitment to delivering medical<br />
solutions to patients, consumers<br />
and healthcare professionals, with a new<br />
ambition statement.<br />
No.<br />
1<br />
EPIDUO<br />
has been the<br />
No. 1 prescribed<br />
branded<br />
topical agent<br />
used in the acne<br />
therapeutic<br />
field in<br />
the World<br />
since 2011 (1) .<br />
New office in Shanghai<br />
At the end of <strong>2012</strong>, <strong>Galderma</strong> China (2) inaugurated<br />
its new office facilities in Shanghai, which have become<br />
the headquarters for the Greater China region.<br />
92%<br />
participation rate for<br />
the first global employee<br />
survey, showing how<br />
willing <strong>Galderma</strong> people<br />
are to contribute to<br />
the company’s evolution.<br />
3<br />
Global Business Units<br />
<strong>Galderma</strong> is implementing<br />
a new organization to<br />
better serve its 3 markets:<br />
Prescription, Self-medication<br />
and Aesthetic & Corrective.<br />
Rosacea<br />
campaign<br />
The “U.S. Face-to-Face with Rosacea”<br />
campaign features Cynthia Nixon,<br />
actress in Sex and the City, who was<br />
herself diagnosed with rosacea. The<br />
campaign aims at changing the way<br />
people view rosacea, to help improve<br />
patients’ quality of life.<br />
www.rosaceafacts.com<br />
New territories<br />
for Dysport<br />
Ipsen and <strong>Galderma</strong> increased their<br />
collaboration for Dysport, one of<br />
the leaders in the aesthetic muscle relaxant<br />
market. Both companies renewed their<br />
partnership in Brazil and Argentina, and<br />
extended it to Australia and South Korea.<br />
Restylane<br />
Skinboosters<br />
After launching a campaign combining<br />
outdoor, print, digital and PR<br />
communications with an in-clinic<br />
campaign in Sweden and Mexico.<br />
Restylane Skinboosters sales rose by<br />
more than 60% in the two test countries<br />
during the project period.<br />
Launch of<br />
Cetaphil<br />
Dermacontrol<br />
a cosmetic range designed for use in<br />
patients treated for acne. The Cetaphil<br />
range has offered patients cleansing and<br />
moisturizing skincare solutions for over<br />
60 years. Today, it includes 16 products.<br />
1,500<br />
attendees at the two<br />
<strong>Galderma</strong> symposia for<br />
acne and rosacea during the<br />
European Academy<br />
of Dermatology and<br />
Venereology (EADV) in Prague.<br />
12<br />
DECEMBER<br />
<strong>Galderma</strong><br />
and Spirig<br />
(1) Source: IMS Health - Monthly Midas database,<br />
all countries selected - Topical anti acne market - Nov. <strong>2012</strong> MAT,<br />
retail Rx Market - at sales manufacturerlocal currency dollar value.<br />
(2) Under the Q-Med legal entity.<br />
entered into a definitive agreement under<br />
which <strong>Galderma</strong> will acquire Spirig, the<br />
leader in dermatology in Switzerland.<br />
300 patients<br />
have been enrolled in the phase II<br />
clinical study of NVC-422<br />
for Impetigo. This formulation,<br />
developed by a <strong>Galderma</strong> and<br />
NovaBay R&D partnership, could<br />
replace traditional antibiotics<br />
in the treatment of Impetigo.<br />
10<br />
11
Key figures<br />
<strong>2012</strong><br />
FIVE YEARS OF GROWTH HAVE TURNED<br />
GALDERMA INTO A COMPANY OPERATING<br />
WORLDWIDE, WITH A BALANCED<br />
PORTFOLIO OF MEDICAL SOLUTIONS<br />
AND BRANDS IN DERMATOLOGY.<br />
SALES BY FRANCHISE<br />
in million Euros<br />
Acne 356.1<br />
Therapeutic Skincare Line 290.6<br />
Rosacea 287.3<br />
Aesthetic & Corrective 268.6<br />
Psoriasis 117.4<br />
Onychomycosis 103.7<br />
Skin Cancer 23.2<br />
Pigmentary Disorders 5.1<br />
Other Products 138.9<br />
GENDER DISTRIBUTION<br />
53 % 47 %<br />
The company has wholly-owned affiliates in 31 countries<br />
with a worldwide network of exclusive distributors and employs<br />
more than 4,200 people around the world.<br />
SALES BY GEOGRAPHIC AREA<br />
SALES BY BUSINESS LINES<br />
<strong>Galderma</strong>'s overall growth rate in <strong>2012</strong><br />
versus 2011 went up 5.9% like-for-like<br />
and 12.9% based on reported figures.<br />
<strong>Galderma</strong> made the most of<br />
<strong>2012</strong> by redefining its ambition<br />
statement, striking the right balance<br />
in its growth drivers and continuing<br />
its international expansion.<br />
20 %<br />
27 %<br />
53 %<br />
AESTHETIC &<br />
CORRECTIVE<br />
SELF-MEDICATION<br />
PRESCRIPTION<br />
<strong>2012</strong> sales<br />
€1.59 Billion<br />
GROWTH OVER FIVE YEARS<br />
in million Euros - Sales more than doubled in five years.<br />
1,600<br />
1,400<br />
1,200<br />
1,000<br />
800<br />
600<br />
400<br />
735<br />
2007<br />
854<br />
978<br />
1,203<br />
1,410<br />
1,591<br />
2008 2009 2010 2011 <strong>2012</strong><br />
Source: Company data at the end of December <strong>2012</strong> - At published rates.<br />
North America 49%<br />
8 19% 57 12<br />
<strong>Galderma</strong> conducts research<br />
in 8 key therapeutic areas.<br />
Latin America 12%<br />
of sales are invested to<br />
discover and develop<br />
new products and access<br />
innovative technologies.<br />
EMEA 24%<br />
new patents registered in <strong>2012</strong>.<br />
6,500 patent applications and<br />
patents have been filed by<br />
<strong>Galderma</strong> since its creation.<br />
Asia Pacific 15%<br />
new chemical entities in<br />
development and 7 products<br />
tested in Phase II and Phase III<br />
clinical studies.<br />
12<br />
13
FOCUSED<br />
FRANÇOIS FOURNIER<br />
VICE-PRESIDENT<br />
OF THE PRESCRIPTION<br />
GLOBAL BUSINESS UNIT<br />
ALBERT DRAAIJER AND FRANÇOIS<br />
FOURNIER DISCUSS HOW<br />
GALDERMA IS GEARING UP TO<br />
FACE NEW OPPORTUNITIES.<br />
What is the aim of the new organization<br />
François Fournier: We have exciting opportunities<br />
ahead of us. Our new organization in Global Business<br />
Units empowers us to achieve our ambitions in the<br />
Prescription, Self-medication and Aesthetic &<br />
Corrective businesses simultaneously. It will enable<br />
us to embrace market diversity, from a changing<br />
landscape in the U.S., to new needs in Europe and<br />
opportunities in the fastest growing economies.<br />
Albert Draaijer: We are experiencing a global spread<br />
of interest for dermatology with increasing demand<br />
for new products and solutions. Latin America and<br />
Asia are growing fast. The new organization is going<br />
to allow us to leverage and accelerate the development<br />
of each of our three businesses.<br />
How does this change translate<br />
<strong>Galderma</strong>’s ambitions<br />
AD: We have put the triple business model in place. As<br />
a result, almost every country has a Prescription team,<br />
a Self-medication team and an Aesthetic & Corrective<br />
team. With the help of the functions represented in the<br />
GBUs, we have been very successful in opening new<br />
fields of dermatology in various countries.<br />
FF: We are rolling out our extended portfolio<br />
geographically, with more global products for greater<br />
impact and alignment. We work closely with the<br />
markets so that we can adjust to local specificities.<br />
We are<br />
committed...<br />
How do you see the future<br />
FF: People will remain at the heart of our actions.<br />
Dermatology is a specialty with a strong human<br />
component. We think about patients first, providing<br />
them with effective and safe solutions. We will<br />
strengthen our partnerships with dermatology<br />
organizations and our long-established relationships<br />
with healthcare professionals. With a lifetime portfolio,<br />
three businesses, global reach and reinforced<br />
competitiveness, our future is bright.<br />
AD: <strong>Galderma</strong> was a very young company 10 years<br />
ago. We were well established in the US, with a<br />
smaller presence in other parts of the world. Today,<br />
we have a sound geographic balance, with a presence<br />
in more than 70 countries. We are poised for growth<br />
because we are rolling out to the whole world and<br />
strengthening our leadership in dermatology.<br />
ALBERT DRAAIJER<br />
VICE-PRESIDENT OF THE<br />
SELF-MEDICATION AND AESTHETIC<br />
& CORRECTIVE GLOBAL BUSINESS UNITS<br />
06<br />
15
FOCUSED<br />
Achieving true potential<br />
Building a stronger position in the<br />
Aesthetic & Corrective and Selfmedication<br />
markets, while sustaining<br />
the high growth level in the core<br />
Prescription business are key. A new<br />
organization leveraging company<br />
resources and skills has therefore<br />
been set up.<br />
Answering dermatological<br />
needs throughout the world<br />
<strong>Galderma</strong> has experienced remarkable<br />
growth in recent years. In a short<br />
time span, the company has changed<br />
from an essentially dermatological<br />
prescription-based business into<br />
a worldwide leader with three global<br />
businesses in more than 70 countries:<br />
Prescription, Self-medication and<br />
Aesthetic & Corrective.<br />
Taken together, these businesses offer<br />
the most comprehensive range of skin<br />
health solutions available to patients<br />
and consumers worldwide. While activities<br />
share the same values, they<br />
function in different ways. Models<br />
and access to markets vary; customers<br />
may be patients, consumers, healthcare<br />
professionals, or all three; distribution<br />
channels and prescribers change depending<br />
on the country, and product<br />
launches and life cycle management<br />
differ. They all nevertheless have a<br />
common goal: to answer dermatological<br />
needs with the same level of engagement<br />
and innovation, of service<br />
and product quality.<br />
Reaching that goal requires specialized<br />
skills and a strong vision of the future<br />
of dermatology. Today, <strong>Galderma</strong>'s<br />
commitment is to move from being<br />
a market leader to becoming a global<br />
company that shapes the dermatology<br />
market. Anticipating needs, reducing<br />
time to market and partnering closely<br />
with healthcare professionals and listening<br />
to patients and consumers are<br />
the vital steps to fulfilling this vision.<br />
Moving from a market leader<br />
to becoming a global company that shapes<br />
the dermatology market.<br />
A three-fold strategy<br />
In June <strong>2012</strong>, <strong>Galderma</strong> announced its<br />
decision to create three Global Business<br />
Units (GBU); one for each of its<br />
cornerstone activities. Working with all<br />
the teams at regional and country levels,<br />
this new organization will offer a stronger<br />
strategic focus, consolidate skills and<br />
resources, and boost innovation and<br />
execution capabilities across different<br />
geographic regions. It represents a new<br />
way to conduct business, to better serve<br />
customers and patients.<br />
The first mission of the three Global<br />
Business Units is to sharpen the strategy.<br />
Making sure that the right products<br />
in the right portfolios are available on<br />
time; ensuring that high-potential solutions<br />
are being developed; and organizing,<br />
prioritizing and developing product<br />
ranges. As a result, the company is<br />
focused, investing and working on key<br />
markets where growth potential can be<br />
maximized.<br />
On a global level, product launches<br />
will accelerate. A new treatment for rosacea<br />
is expected to be rolled out over<br />
the globe after grant of market authorizations.<br />
This international launch is<br />
prepared by the Prescription Global<br />
Business Unit in very close cooperation<br />
with local markets.<br />
Excellence<br />
in aesthetics<br />
Located in Uppsala,<br />
Sweden, <strong>Galderma</strong>’s<br />
Global Center of Excellence<br />
concentrates the<br />
discovery, development,<br />
manufacturing, medical<br />
and regulatory affairs as<br />
well as strategic brand and<br />
channel management of<br />
the Aesthetic & Corrective<br />
(A&C) Global Business Unit.<br />
The state of the art R&D<br />
team drives the innovation<br />
on hyaluronic acid-based<br />
gels and in particular uses<br />
the patented NASHA<br />
technology to develop<br />
stabilized, non-animal<br />
hyaluronic acid-based<br />
products and also<br />
anticipate for the products<br />
of the future. The annual<br />
production capacity of<br />
10 million units spans a<br />
comprehensive portfolio of<br />
medical solutions. This is in<br />
total more than 400 people<br />
committed to the A&C<br />
business operating for<br />
<strong>Galderma</strong> in Uppsala.<br />
4 ,230<br />
EMPLOYEES WORLDWIDE.<br />
MORE THAN<br />
300 PEOPLE JOINED<br />
GALDERMA IN <strong>2012</strong>.<br />
3<br />
GLOBAL BUSINESS UNITS<br />
WERE CREATED IN <strong>2012</strong>, ONE<br />
FOR EACH OF GALDERMA’S<br />
CORNERSTONE ACTIVITIES.<br />
+12.9%<br />
THE COMPANY’S OVERALL<br />
GROWTH RATE IN<br />
<strong>2012</strong> VERSUS 2011 (BASED ON<br />
REPORTED FIGURES).<br />
1.59<br />
BILLION EUROS:<br />
GALDERMA’S <strong>2012</strong> SALES.<br />
6.9%<br />
GALDERMA’S SHARE<br />
OF THE GLOBAL<br />
DERMATOLOGY MARKET.<br />
Source: IMS data - D+J1A+J2A<br />
(dermatology only), MAT<br />
December <strong>2012</strong> – 39 countries<br />
16<br />
17
FOCUSED<br />
Coordination between all functions<br />
makes it possible to plan this important<br />
operation seamlessly. It also shows a new<br />
way of functioning within the company:<br />
faster execution, more efficiency and offering<br />
better visibility to all involved.<br />
Transversal expertise<br />
The new organization impacts operations<br />
at all levels. Delivering demanddriven<br />
dermatological medical solutions,<br />
the company is offering its three<br />
categories of products and services on<br />
all markets. At country level, affiliates are<br />
now dealing with three families of solutions,<br />
Prescription, Self-medication and<br />
Aesthetic & Corrective. Each category<br />
remains unique and different, requiring<br />
a high level of specialized knowledge<br />
and dedicated resources. The pivotal<br />
role of the local teams is strengthened<br />
by the transversal expertise provided by<br />
the specialized Global Business Units,<br />
so that together they deliver the best<br />
solutions and services to healthcare<br />
professionals and patients. Expertise in<br />
the Aesthetic field, for example, does not<br />
rest in the simple sale of a product. It is<br />
more specifically about providing the<br />
proper service to a physician and ensuring<br />
the best patient experience. It might<br />
well involve helping a doctor develop<br />
his practice in a field with which he is<br />
not necessarily familiar. In this respect,<br />
providing physicians with services such<br />
as training sessions is essential. Similarly,<br />
the role of the Global Business Unit goes<br />
beyond developing and manufacturing<br />
new products. It also helps to earmark<br />
resources and build comprehensive programs<br />
to better deliver the Aesthetic &<br />
Corrective experience.<br />
Leveraging opportunities<br />
Another challenge of the new organization<br />
is leveraging existing opportunities<br />
throughout the company. Sharing<br />
services, production facilities and R&D<br />
across all three segments is essential.<br />
Integrating operations by monitoring<br />
results, providing guidelines and best<br />
practices is a common need. New synergies<br />
are identified between the different<br />
categories of products. Self-medication<br />
products, for instance, are derived from<br />
Prescription solutions or developed independently.<br />
Specific Self-medication<br />
marketing know-how and packaging<br />
are optimized for other categories of<br />
solutions, on consumer-driven markets<br />
where brand perception is crucial.<br />
Focusing on simplicity<br />
<strong>Galderma</strong>’s commitment is to develop<br />
business by keeping in touch and answering<br />
market needs. The human factor<br />
is ever present. The challenge of working<br />
across divisions and Global Business<br />
Units is first and foremost a question of<br />
helping people work together efficiently.<br />
For that reason, the company aims for<br />
simplicity. An entrepreneurial spirit is a<br />
precious asset for any fast-growing company,<br />
and <strong>Galderma</strong> strives to nurture<br />
that mindset. Its new organization aims<br />
at helping employees reach their goals<br />
and fulfill their ambitions. The foundation<br />
may be based on strategy, products<br />
and timely execution, but ultimately it is<br />
about sharing the same passion for and<br />
commitment to dermatology.<br />
The challenge of working<br />
across divisions and Global<br />
Business Units is first<br />
and foremost a question<br />
of helping people work<br />
together efficiently.<br />
<strong>Galderma</strong> UK: new models and partnerships<br />
<strong>Galderma</strong>’s broadening<br />
focus and three business<br />
models strategy have<br />
received strong feedback<br />
from affiliates and some<br />
markets have been<br />
prompt to implement<br />
these changes. The<br />
UK context has been<br />
particularly challenging<br />
as dermatology has been<br />
gradually pushed outside<br />
of the treatment scope<br />
of the National Health<br />
Service. As a result, fewer<br />
patients are referred to a<br />
dermatologist; GPs and<br />
nurses are encouraged to<br />
prescribe and treat. The<br />
government even created<br />
a Pharmacy “P” category,<br />
which allows the patient<br />
to obtain a prescription<br />
product from the<br />
pharmacist, bypassing a<br />
physician’s consultation<br />
fee. “Over the next five<br />
years, Self-medication<br />
products are expected<br />
to rival our Prescription<br />
business,” observes Larry<br />
Potgieter, General<br />
Manager <strong>Galderma</strong> UK<br />
& Ireland. “We plan<br />
to increase the Selfmedication<br />
team to<br />
support the doubling of<br />
this business every three<br />
years, and expand on<br />
our capabilities in the<br />
Aesthetic & Corrective<br />
business.” Developing<br />
promotion campaigns<br />
and building business<br />
partnerships are key for<br />
the Self-medication skin,<br />
hair and nail categories.<br />
In <strong>2012</strong>, <strong>Galderma</strong> UK<br />
implemented a media<br />
campaign for Curanail,<br />
resulting in 26% sales<br />
growth year-on-year and<br />
consolidating its<br />
leadership position in a<br />
highly competitive space.<br />
Another development is<br />
<strong>Galderma</strong> UK’s strategic<br />
alliance with Boots, leader<br />
in UK pharmacy retail. The<br />
partnership is structured<br />
to include Prescription to<br />
OTC switches as well as<br />
developing a ‘Serious<br />
Skincare Section’ in their<br />
pharmacies. As a result,<br />
<strong>Galderma</strong> UK reported<br />
a strong year, with a sales<br />
record of over €62 million<br />
in addition to winning<br />
numerous awards. These<br />
achievements reflect the<br />
priority of moving even<br />
closer to consumers while<br />
ensuring sales force<br />
excellence.<br />
Monitoring patient safety<br />
Vigilance Department collects, monitors and<br />
assesses adverse events reported in relation<br />
with use of <strong>Galderma</strong> products. <strong>Galderma</strong>’s<br />
close relationship with prescribers<br />
and authorities is key in facilitating the<br />
reporting of reactions to products. Often,<br />
healthcare professionals will mention the<br />
problems they encountered to <strong>Galderma</strong>’s<br />
sales representatives, who forward the<br />
information to a local safety officer, a local<br />
function in charge of product safety.<br />
All reports are processed in the company’s<br />
global database and assessed in terms of<br />
seriousness, listedness and causality. In<br />
<strong>2012</strong>, the company put in place a new global<br />
pharmacovigilance system, accessible<br />
for the main affiliates. Acting proactively,<br />
the same system will ultimately be used<br />
for product vigilance in the Aesthetic &<br />
Corrective field as well, in order to handle<br />
all vigilance issues regardless of the type<br />
of medicinal products (ie. drugs, medical<br />
devices or cosmetic) or any combination<br />
of these. <strong>Galderma</strong> is also actively adapting<br />
its processes to meet the new European<br />
legislation, with a shared emphasis on<br />
quality and compliance. Patient safety<br />
is ever the priority.<br />
+15.9% 53%<br />
GROWTH IN THE<br />
SELF-MEDICATION<br />
SEGMENT IN <strong>2012</strong>.<br />
4.73<br />
DAYS OF TRAINING<br />
BY EMPLOYEE IN <strong>2012</strong>.<br />
OF WOMEN<br />
A BALANCED GENDER<br />
DISTRIBUTION.<br />
18<br />
19
FOCUSED<br />
Engaged employees,<br />
empowered teams<br />
Alain Kirsch, Vice-President Human<br />
Resources, tells us about the first<br />
global employee survey conducted<br />
at <strong>Galderma</strong>.<br />
Why carry out a global<br />
employee survey<br />
Alain Kirsch: In <strong>2012</strong>, we felt the moment<br />
was right, given the recent change<br />
and growth we had experienced.<br />
It was the right time to take the pulse of<br />
our employees, to find out how they felt<br />
in the company and what areas we could<br />
improve.<br />
What did the survey show<br />
AK: A very large amount of data! There<br />
is plenty to learn in the comments our<br />
employees shared with us as part of the<br />
survey. Overall, the results show higher<br />
positive scores than our sector, the pharmaceutical<br />
industry sector, and reflect<br />
the high level of engagement. <strong>Galderma</strong><br />
is seen as a good employer.<br />
What actions will ensue<br />
AK: We will continue sharing our vision,<br />
strategies and ambitions. A bigger<br />
investment in training will be made,<br />
particularly in locations where learning<br />
activities were lacking. Several initiatives<br />
at global and local level are planned to<br />
improve people’s opportunities for developing<br />
employee evolution. Regarding<br />
organization effectiveness, delegation<br />
and empowerment, changes have<br />
been made, improving governance and<br />
project management prioritization processes.<br />
In response to the survey, many<br />
other initiatives will be launched in 2013.<br />
SURVEY: A VERY HIGH<br />
PARTICIPATION<br />
The global employee<br />
survey was conducted<br />
over three weeks in June<br />
and July <strong>2012</strong>, through<br />
an online questionnaire<br />
made available by Towers<br />
Watson, an HR consulting<br />
firm. Employee participation<br />
was very high: 92% filled<br />
in the form and one person<br />
in two volunteered<br />
additional comments, a<br />
remarkable qualitative<br />
contribution. The main<br />
finding of the survey is a<br />
very strong engagement of<br />
all employees, from senior<br />
managers to support staff.<br />
72.4%<br />
AVERAGE FAVORABLE<br />
SCORE ACROSS ALL<br />
CATEGORIES, RANGING<br />
BY ITEM FROM 60% TO<br />
90%, VERSUS 70% IN THE<br />
PHARMACEUTICAL NORM,<br />
(RANGING FROM 57% TO 87%).<br />
90% FAVORABLE<br />
FEEDBACK ON “GOALS AND<br />
OBJECTIVES”, THE HIGHEST<br />
SCORE OF THE SURVEY,<br />
AND EVEN HIGHER THAN<br />
THE HIGH PERFORMANCE<br />
COMPANIES.<br />
61% FAVORABLE<br />
FEEDBACK ON “TRAINING”,<br />
THE LOWEST SCORE OF<br />
THE SURVEY.<br />
Empowering teams for optimal performance<br />
How does Australia’s<br />
performance reflect<br />
the level of employee<br />
commitment<br />
Given the changes and<br />
extraordinary growth<br />
(+35.1%) we were<br />
experiencing as a business,<br />
<strong>2012</strong> was a critical period<br />
for managing compliance,<br />
commitment and<br />
communication.<br />
Our team was dedicated to<br />
achieving objectives that<br />
were clearly communicated<br />
and agreed upon.<br />
What initiatives were<br />
taken to further engage<br />
employees<br />
Staff received strong<br />
encouragement to<br />
reach beyond targeted<br />
objectives and find<br />
creative solutions within a<br />
framework. Management<br />
techniques were reviewed<br />
and employees helped to<br />
develop their knowledge<br />
and skills. All managers<br />
answered a 360° survey<br />
to identify best practices<br />
and areas of potential<br />
improvement for reaching<br />
superior employee<br />
engagement. Employees,<br />
in turn, were encouraged<br />
to be accountable for their<br />
results and empowered<br />
to “do business with<br />
customers”. Delegation and<br />
decision-making processes<br />
were optimized. Formal<br />
reports and customer<br />
reviews enabled staff to<br />
monitor and track results.<br />
What about improving<br />
team empowerment<br />
Effective knowledge<br />
sharing stimulates true<br />
employee empowerment.<br />
We actively promoted<br />
transparency, ensuring<br />
that expected outcomes<br />
were communicated,<br />
information was consistent<br />
and campaigns aligned.<br />
Business updates circulated<br />
via email, newsletters<br />
and presentations at<br />
sales meetings and staff<br />
communication sessions.<br />
How did individual<br />
training contribute<br />
We encouraged individuals<br />
to be accountable for<br />
their own learning and<br />
development, and provided<br />
access to an online selfdevelopment<br />
assessment<br />
tool. Employees received<br />
reports and strategic<br />
pointers to work on<br />
improvement areas. As a<br />
result, Australian employees<br />
are empowered to drive<br />
their own development,<br />
steer themselves and own<br />
their tasks.<br />
“Effective knowledge sharing<br />
stimulates true employee<br />
empowerment.”<br />
LISA GEORGE,<br />
HR MANAGER GALDERMA AUSTRALIA<br />
ETHICALLY ENGAGED<br />
Values, ethics and compliance<br />
are part of <strong>Galderma</strong>’s culture.<br />
The values set the framework for<br />
daily operations and are viewed as<br />
assets for the organization. High performance<br />
and high integrity are objectives<br />
that, far from clashing, work<br />
very well together. At <strong>Galderma</strong>,<br />
training and open dialogue related to<br />
ethics, compliance and legal topics<br />
are constants. Quality Assurance and<br />
compliance teams work hard to understand<br />
the business and always<br />
keep the company’s strategies and<br />
objectives in mind.<br />
Throughout the world, government<br />
and public scrutiny of the pharmaceutical<br />
industry is growing, notably<br />
regarding interactions with healthcare<br />
professionals. Relations between<br />
<strong>Galderma</strong> and healthcare professionals<br />
are transparent and<br />
focused on medical and scientific<br />
exchanges on diseases and their<br />
treatments.<br />
More generally, <strong>Galderma</strong> strives to<br />
meet the high standards of ethical<br />
practices in all its operations. The<br />
company’s Code of Ethics is more a<br />
statement of values and conduct<br />
than a set of rules. It addresses principles<br />
on interactions with healthcare<br />
professionals but also focuses<br />
on the patient and more generally<br />
people, caring for individuals and<br />
their balance, diversity and responsibility.<br />
The company requires employees<br />
to always act according to<br />
the Company values and Code of<br />
Ethics, with a strong reminder that<br />
the well-being of patients comes first<br />
and foremost. At <strong>Galderma</strong>, ethical<br />
behavior has no finish lines, we always<br />
strive to be better.<br />
20<br />
21
INNOVATIVE<br />
NICOLE LAUDIGNON AND<br />
THIERRY BILBAULT TALK ABOUT<br />
WHAT GOES INTO CULTIVATING<br />
INNOVATION THROUGH TEAMWORK,<br />
FROM EARLY R&D TO FULL-SCALE<br />
MANUFACTURING.<br />
How do you work together<br />
Nicole Laudignon: The Full Development<br />
Department develops products from their inception to<br />
their submission to Regulatory Authorities. Work with<br />
Manufacturing & Technical Operations (M&TO)<br />
begins at the very early stages of development, optimizing<br />
the progress from drug discovery to product<br />
development and full scale commercialization. Production<br />
knowledge and experience has to be transferred<br />
to M&TO as seamlessly as possible.<br />
Thierry Bilbault: Because we engage with R&D teams<br />
at the early development stage of a new chemical entity,<br />
we know which projects move into the scope of the Full<br />
Development team and when. Main deliverables and<br />
their timelines are determined together and monthly<br />
follow-up meetings on specific projects are held.<br />
How do you deliver an innovative medical solution<br />
NL: Our job is to design and develop innovative formulations,<br />
not only for new chemical entities but also<br />
throughout our products' life cycle management.<br />
TB: Beyond launching a product for the first time, innovation<br />
is how fast it can be rolled out to the rest of<br />
the world. Managing product life cycle is innovative:<br />
whether maintaining an existing solution on a market or<br />
finding new markets for it. Packaging must also be innovative,<br />
as we constantly strive to find the best way for<br />
patients to use a product with new features and benefits.<br />
...to delivering<br />
innovative<br />
medical<br />
solutions...<br />
NICOLE LAUDIGNON<br />
DIRECTOR OF FULL DEVELOPMENT<br />
(R&D)<br />
Tell us about a successful innovation…<br />
NL: Pliaglis Cream is a topical local anesthetic. It is applied<br />
as a cream and then dries to form a flexible membrane<br />
that can be peeled from the skin. The formulation<br />
of the product, composed of the two molecules, lidocaine<br />
and tetracaine, has been challenging: the “mixture”<br />
forms a homogeneous oil but needs to be integrated in a<br />
high water content to hydrate the skin. A solution for an<br />
optimized formulation was created by our development<br />
teams and successfully transferred to M&TO.<br />
TB: Working in tandem with the Full development<br />
team, in <strong>2012</strong> we launched, within 12 months after<br />
its transfer from Full Development to Manufacturing,<br />
Cetaphil Dermacontrol, a range of two cosmetic<br />
products designed for use in patients treated for acne<br />
including Cetaphil Dermacontrol Oil Control Foam<br />
Wash, a unique foaming formula packaged in an innovative<br />
packaging. Delivering a commercial product<br />
in fast track mode was a key deliverable and illustration<br />
of the speed-to-market process.<br />
THIERRY BILBAULT<br />
TECHNICAL DIRECTOR<br />
(M&TO)<br />
23
INNOVATIVE<br />
A unique capability<br />
in dermatological R & D<br />
Research & Development centers are<br />
spread across different continents to<br />
focus on local needs, discover new<br />
molecules and launch products able<br />
to help patients all through their lives.<br />
Innovation is built<br />
into <strong>Galderma</strong>’s DNA<br />
Today <strong>Galderma</strong> stands among the few<br />
companies capable of inventing, developing<br />
and bringing to market dermatological<br />
solutions that are truly innovative.<br />
The extent of its strong commitment to<br />
R&D and access to innovative technologies<br />
is reflected in an annual investment<br />
equivalent to 19% of the company’s<br />
sales. Beyond figures, creativity is also a<br />
mindset in all the company’s activities.<br />
The teams at <strong>Galderma</strong>’s major research<br />
facilities actively pursue creativity on a<br />
grand scale, through discovering and<br />
testing new molecules and compounds,<br />
adapting new packaging to new uses,<br />
and sourcing new functions and partnerships<br />
for existing products in cooperation<br />
with the world’s leading biotechnology<br />
companies and dermatological<br />
research units.<br />
Shaping the future<br />
At <strong>Galderma</strong>, innovation implies a global<br />
approach. It starts by observing and<br />
anticipating the global dermatological<br />
needs of patients, which are often very<br />
different in nature.<br />
Then, solutions are developed to answer<br />
these needs very specifically. Solutions<br />
are technology-based, in the broadest<br />
sense of the term, from molecules and<br />
new chemical entities (NCE) to various<br />
means of administration (oral, topical or<br />
injectable) and the regulatory status attributed<br />
to the solution, such as Prescription<br />
drugs, Self-medication products or<br />
Aesthetic & Corrective medical devices.<br />
Combining patient needs with innovation<br />
is what allows <strong>Galderma</strong> to contribute<br />
to shaping the future of dermatology.<br />
<strong>Galderma</strong> is the leader in filing patents<br />
within the field of dermatology.<br />
Patent champion<br />
If patent applications are an accurate<br />
measure of innovation, the results are<br />
consistent. For several years, <strong>Galderma</strong><br />
has been the leader in filing patents<br />
within the field of dermatology, with<br />
over 50 applications registered each<br />
year. In all, the company has filed more<br />
than 6,500 patent applications and<br />
patents worldwide since its founding.<br />
Innovation patents cover new molecules,<br />
galenic formulas, dermatology<br />
indications, manufacturing processes,<br />
packaging and many other categories.<br />
Throughout the years, <strong>Galderma</strong> has<br />
continually supported core research<br />
activities. For Prescription drugs, these<br />
range from early discovery phases to<br />
regulatory submissions and span several<br />
main therapeutic areas like acne,<br />
rosacea, steroid-responsive dermatoses,<br />
pigmentary disorders and nonmelanoma<br />
skin cancer. At each stage<br />
and across every field, innovation is<br />
a constant, even for well-established<br />
products. For example, Epiduo, the<br />
most prescribed branded topical agent<br />
used in the acne therapeutic field in<br />
the world (1) , has just been approved for<br />
populations aged 9 to 11 in the United<br />
States: a powerful innovation, based<br />
on the evidence of an effective and<br />
A global R&D<br />
presence<br />
<strong>Galderma</strong> has research<br />
and development facilities<br />
in France, Sweden, the<br />
United States and Japan.<br />
The Sophia Antipolis site in<br />
France is the world’s largest<br />
R&D center specialized<br />
in dermatology and has<br />
a staff of about 500. The<br />
center hosts <strong>Galderma</strong>'s<br />
in-house research,<br />
pre-clinical and core<br />
development activities.<br />
In Uppsala (Sweden),<br />
the Global Aesthetic<br />
Center of Excellence is<br />
dedicated to Aesthetic &<br />
Corrective treatments. Its<br />
80 researchers have built<br />
extensive expertise in the<br />
field of hyaluronic acid.<br />
The Princeton center<br />
(New Jersey, USA) is<br />
focused on clinical<br />
development projects,<br />
aiming at the registration<br />
of products in the US and<br />
Canada. Clinical studies<br />
also support regulatory<br />
submissions around<br />
the world. In Tokyo, the<br />
R&D team is dedicated<br />
to the development<br />
and registration of new<br />
products for Japan.<br />
Some of <strong>Galderma</strong>’s<br />
extensive clinical<br />
studies involve over<br />
1,000 patients in 30 to 60<br />
different locations.<br />
600<br />
MORE THAN<br />
600 EMPLOYEES IN THE<br />
SCIENTIFIC DIVISION.<br />
19%<br />
OF GALDERMA’S<br />
SALES ARE DEDICATED<br />
TO R&D AND ACCESS<br />
TO INNOVATIVE<br />
TECHNOLOGIES.<br />
57<br />
NEW PATENTS WERE<br />
REGISTERED IN <strong>2012</strong>.<br />
6,500<br />
PATENT APPLICATIONS<br />
AND PATENTS HAVE BEEN<br />
FILED BY GALDERMA SINCE<br />
ITS CREATION.<br />
12<br />
NEW CHEMICAL ENTITIES<br />
ARE IN DEVELOPMENT AND<br />
7 PRODUCTS ARE CURRENTLY<br />
BEING TESTED IN PHASE II AND<br />
PHASE III CLINICAL STUDIES.<br />
24<br />
25
INNOVATIVE<br />
safety-driven solution. Major new<br />
Prescription products are slated for<br />
launch over the next three years.<br />
New areas of research<br />
Self-medication offers a world of possibilities<br />
for innovation. Research is required<br />
to switch a Prescription product<br />
into a Self-medicated solution and file a<br />
successful submission to regulatory authorities.<br />
Loceryl nail lacquer is a good<br />
example of a category switch, allowing<br />
patients to self-treat. In the short term,<br />
a number of new Self-medication formulations<br />
and brands are expected to<br />
address the needs of patients satisfactorily.<br />
Improving patient compliance also<br />
means developing innovative products<br />
that are easy to use.<br />
The Aesthetic & Corrective segment is<br />
also a core research area, with a dedicated<br />
Center of Excellence in Uppsala,<br />
Sweden, where research and development<br />
of hyaluronic acid gel-based treatments<br />
is carried out. A key area of development<br />
is how to optimize product use<br />
and achieve excellent results with two or<br />
three times less product injections, for<br />
instance. Another key focus is clinical<br />
research: consumers, physicians and authorities<br />
alike are expressing an ongoing<br />
need for evidence-based, safe products.<br />
Ongoing development<br />
R&D resourcing is constantly being<br />
driven forward. New people are regularly<br />
recruited to strengthen teams and<br />
expand expertise. Establishing new collaborations<br />
with the best partners possible,<br />
be they small biotechnology companies<br />
or large pharmaceutical groups,<br />
is also a key source of creativity. A partnership<br />
with a major biopharmaceutical<br />
leader, the innovation-driven AstraZeneca,<br />
is currently exploring compounds<br />
developed for other indications, which<br />
could prove very useful in dermatology.<br />
Licensing agreements with other industry<br />
partners also provide synergistic<br />
frameworks that give the company an<br />
innovative edge within strategic areas of<br />
research, such as rare skin diseases.<br />
In the critical field of skin cancer, where<br />
many medical needs are still left unanswered,<br />
<strong>Galderma</strong> further expanded its<br />
collaborations this year with two leading<br />
dermatologists and authorities on<br />
skin cancers, and their teams: Professor<br />
Martine Bagot, of the Saint-Louis<br />
Hospital in Paris, France, and Professor<br />
Madeleine Duvic, Deputy Chairman<br />
of the Department of Dermatology at<br />
The University of Texas, MD Anderson<br />
Cancer Center in Houston, Texas, USA.<br />
Major innovations in the pipeline<br />
<strong>Galderma</strong>’s large network of experts<br />
also contributes to research, notably<br />
through carrying out clinical studies.<br />
Some studies are very extensive, involving<br />
1,000 patients or more and<br />
span 30 to 60 different locations at a<br />
given time around the globe. Currently,<br />
twelve new chemical entities are<br />
in development and seven products<br />
are tested in Phase II and Phase III<br />
clinical studies.<br />
In terms of research volume, diversity<br />
and skills, <strong>Galderma</strong> is well-positioned<br />
to come up with great new solutions.<br />
It is even possible that the company is<br />
reaching a major turning point. Over<br />
the last decade, it has been highly successful<br />
in finding new molecules and its<br />
knowledge base has expanded considerably.<br />
A substantial number of major<br />
innovations are now in the pipeline.<br />
Over the next five years, the company’s<br />
portfolio of marketed products will<br />
be deeply renewed across categories.<br />
Finding innovative solutions for people<br />
around the world will continue to be<br />
the strongest contribution <strong>Galderma</strong><br />
can make to the future of dermatology.<br />
(1) Source: IMS Health - Monthly Midas database,<br />
all countries selected - Topical anti acne market -<br />
Nov.<strong>2012</strong> MAT, retail Rx Market - at sales manufacturer<br />
local currency dollar value<br />
A partnership against antibiotic resistant impetigo<br />
<strong>Galderma</strong> has established<br />
a long-term Research<br />
and Development<br />
partnership with<br />
California-based biotech<br />
company NovaBay,<br />
to develop an effective<br />
treatment against<br />
impetigo and conduct its<br />
phase II clinical studies.<br />
Impetigo is a highly<br />
infectious bacterial<br />
skin disease that affects<br />
mostly children which,<br />
when left untreated,<br />
can lead to complications<br />
such as pneumonia<br />
or arthritis. Antibiotic<br />
treatments for the<br />
disease are increasingly<br />
obsolete, as the<br />
bacteria responsible for<br />
impetigo's transmission,<br />
Staphylococcus aureus<br />
and Streptococcus<br />
pyogenes, develop<br />
resistance to the agents<br />
used to overcome them.<br />
The non antibiotic, antiinfective,<br />
proprietary<br />
NVC-422 topical<br />
formulation (also known<br />
as Aganocide treatment),<br />
developed by the<br />
<strong>Galderma</strong> and NovaBay<br />
partnership, could replace<br />
traditional antibiotics<br />
in the treatment of<br />
impetigo. The topical<br />
NVC-422 preclinical and<br />
clinical safety has been<br />
established by <strong>Galderma</strong>,<br />
with the successful<br />
completion of studies<br />
involving more than<br />
300 healthy volunteers<br />
at 24 clinical sites in<br />
four countries, as well<br />
as the feasibility of<br />
manufacturing scale-up<br />
and long-term shelf life.<br />
In early 2013, the<br />
expansion of the phase IIb<br />
clinical trial for NVC-422<br />
will take place in South<br />
Africa. The incidence<br />
of the disease is known<br />
to be particularly high<br />
in tropical countries,<br />
including sub-Saharan<br />
Africa. "The treatment of<br />
impetigo is a significant<br />
unmet need in South<br />
Africa, and the expansion<br />
of this international study<br />
into that market is an<br />
important step for our<br />
partner <strong>Galderma</strong>," said<br />
Dr. Ron Najafi, Chairman<br />
and Chief Executive<br />
Officer of NovaBay.<br />
25,000<br />
SQ.METER<br />
THE SOPHIA ANTIPOLIS<br />
R&D CENTER IS GALDERMA’S<br />
LARGEST FACILITY.<br />
1,700<br />
SCIENTIFIC<br />
PUBLICATIONS IN <strong>2012</strong>.<br />
9-11<br />
EPIDUO HAS JUST BEEN APPROVED<br />
AS AN ADDITIONAL INDICATION<br />
FOR POPULATIONS AGED 9 TO 11<br />
IN THE UNITED STATES.<br />
11,000<br />
MORE THAN 11,000 MOLECULES<br />
TESTED BY END OF <strong>2012</strong>.<br />
1,750<br />
PHARMACEUTICAL<br />
REGISTRATIONS<br />
IN ALL GALDERMA'S<br />
AREAS OF EXPERTISE<br />
26<br />
27
INNOVATIVE<br />
Reactive and quality-driven<br />
manufacturing<br />
Internalizing production<br />
is a top priority for<br />
<strong>Galderma</strong>’s Manufacturing<br />
and Technical Operations.<br />
Because they are market-driven<br />
and flexible, <strong>Galderma</strong>’s Manufacturing<br />
and Technical Operations<br />
(the M&TO Division) provide an<br />
uninterrupted supply of the highest<br />
quality of Prescription, Self-medication<br />
and Aesthetic & Corrective<br />
products to affiliates and distributors<br />
around a fast changing world.<br />
Internalizing production<br />
At <strong>Galderma</strong>, manufacturing relies on<br />
four principles: safety, quality, service<br />
and cost efficiency. It is reviewed on an<br />
ongoing basis to provide the best level<br />
of performance while keeping unit<br />
costs in check. Market developments<br />
are also tracked closely, and processes<br />
are reorganized and adapted wherever<br />
growth potential is found.<br />
In <strong>2012</strong>, 75% of <strong>Galderma</strong> products<br />
were produced internally, compared to<br />
15% in 2000. When demand for new<br />
solutions reaches critical mass and<br />
forecasts point to sustainable demand,<br />
the M&TO Division evaluates<br />
the opportunity to internalize<br />
production, further improving<br />
product supply, quality, safety<br />
and reducing costs. This ongoing<br />
effort at <strong>Galderma</strong> should reach<br />
an in-house production target of<br />
80% by 2020; the current production<br />
exceeds 120 million units per year.<br />
Leveraging <strong>Galderma</strong>'s<br />
know-how<br />
The production facility in Alby-sur-<br />
Chéran (France) was opened in 1994<br />
and expanded to include the Industrial<br />
Development team in 1998. This<br />
site counts 270 employees, produces<br />
more than 40 million units per year and<br />
serves over 70 countries.<br />
The Industrial Development department<br />
spearheads development of clinical<br />
batches for trial worldwide, hones<br />
manufacturing processes for new<br />
products, acquisitions and transfers.<br />
In short, it is in charge of leveraging<br />
<strong>Galderma</strong>’s technical know-how, leading<br />
to improved global production<br />
performance.<br />
The Uppsala (Sweden) production<br />
site, formerly Q-Med, is part of the<br />
Center of Excellence for Aesthetic<br />
& Corrective solutions. As such, it is<br />
fully dedicated to the manufacturing<br />
of products in the aesthetics category,<br />
notably hyaluronic acid-based injectables.<br />
Uppsala counts 175 employees,<br />
and has an annual capacity of 10 million<br />
units, a production rate that allows<br />
the company to meet growing demands<br />
in the Aesthetic & Corrective dermatology<br />
market.<br />
Serving regional demand<br />
Since the year 2000, the manufacturing<br />
site at Baie d’Urfé (Canada) produces<br />
Prescription products for the US market<br />
and Self-medication products for all<br />
markets, in both liquid and semi-liquid<br />
formulas. Annual production here is<br />
65 million units, with a headcount of<br />
270 employees.<br />
Life cycle management brings more to products<br />
Patient needs differ<br />
from one region or<br />
country to another.<br />
<strong>Galderma</strong> life cycle<br />
management addresses<br />
these specificities while<br />
helping to keep products<br />
on a certain market or<br />
find new markets for<br />
existing ones. A classic<br />
example is switching a<br />
Prescription product<br />
into a Self-medication<br />
solution. In China, for<br />
instance, Government<br />
policy and consumer<br />
habits favor over-thecounter<br />
medication, and<br />
the rollout of accessible,<br />
effective consumerdriven<br />
brands suits local<br />
market conditions.<br />
In certain markets,<br />
products can also be<br />
updated to bring new<br />
benefits to patients.<br />
Introducing a new pump<br />
application system,<br />
for example, has been<br />
shown to improve patient<br />
compliance. Once a<br />
patient need is identified,<br />
a comprehensive<br />
presentation of technical<br />
options makes it possible<br />
to evaluate and test<br />
concepts or prototypes<br />
with patients and<br />
customers.<br />
The company’s Industrial<br />
Development team and<br />
associated packaging<br />
development teams<br />
oversee the execution<br />
of packaging-based<br />
initiatives that make<br />
a real difference to<br />
consumers and patients.<br />
The first challenge is to<br />
collect input from all<br />
relevant stakeholders<br />
including markets, global<br />
marketing, Research &<br />
Development, industrial<br />
sites and functions,<br />
then identify innovative<br />
and global packaging<br />
solutions that will meet<br />
required criteria:<br />
patient acceptability,<br />
technical aspects, cost,<br />
speed to market, etc.<br />
In <strong>2012</strong>, examples of new<br />
life cycle management<br />
product launches in<br />
<strong>2012</strong> included the US<br />
launches of Epiduo pump<br />
(under development<br />
for global roll-out),<br />
Differin 0.3%, Metrogel<br />
pumps and Clobex Spray<br />
Improved Nozzle.<br />
75 %<br />
OF GALDERMA PRODUCTS<br />
ARE SOURCED INTERNALLY.<br />
152<br />
MILLION UNITS<br />
PRODUCED IN <strong>2012</strong>.<br />
800<br />
EMPLOYEES IN THE MANUFACTURING<br />
& TECHNICAL OPERATIONS DIVISION.<br />
+40%<br />
PRODUCTION CAPACITY<br />
AFTER PLANT EXTENSIONS IN FRANCE<br />
AND CANADA IN 2011.<br />
28<br />
29
INNOVATIVE<br />
Since 2004, a production site in Hortolândia<br />
(Brazil) has served the Latin<br />
American market; it also manufactures<br />
some solutions for the global market<br />
(excluding the U.S.). The site, which<br />
has a staff of 50, has a production of 6<br />
million units in liquid and paste form<br />
per year. However, Hortolândia’s capacity<br />
is quickly expanding in order<br />
to better serve a fast-growing regional<br />
market and anticipate new needs.<br />
Shaping a new industrial<br />
landscape<br />
The Alby, Baie d’Urfé and Hortolândia<br />
sites are ISO 14001 (environment)<br />
and OHSAS 18001 (safety) certified.<br />
All sites are regularly audited by health<br />
authorities such as the FDA (United<br />
States), ANVISA (Brazil), ANSM<br />
(France) or the KFDA (South Korea).<br />
The acquisition of Spirig, announced<br />
at the end of <strong>2012</strong>, offers <strong>Galderma</strong><br />
an opportunity to shape a new industrial<br />
landscape and forge a new path<br />
to the manufacturing of solids, one of<br />
the Swiss company’s areas of expertise.<br />
Spirig’s Egerkingen headquarters will<br />
become a Center of Excellence with a<br />
strong manufacturing arm.<br />
<strong>Galderma</strong>’s remaining production is<br />
outsourced to some 40 subcontractors,<br />
which comply with same set of specifications<br />
and requirements exercised<br />
by the company in its own plants. Each<br />
supplier is fully committed to applying<br />
the <strong>Galderma</strong> Code of Ethics, as part<br />
of the company’s general purchasing<br />
terms. A dedicated team of the M&TO<br />
Division works closely with subcontractors,<br />
who are audited according to the<br />
same key performance indicators observed<br />
in <strong>Galderma</strong>’s units. Nevertheless,<br />
internalizing production remains a<br />
top priority. The high standards of quality<br />
and productivity within the company<br />
make it possible to leverage 20% of<br />
costs when a product is manufactured<br />
in-house.<br />
Manufacturing at <strong>Galderma</strong> is in a<br />
constant state of flux: thanks to new or<br />
increased capacity, geographical expansion<br />
and market opportunities, production<br />
organization is striving for a leaner,<br />
more reactive and flexible outfit.<br />
Optimized supply chain<br />
“Flexibility” is the key<br />
word for <strong>Galderma</strong>’s<br />
future supply chain across<br />
the organization. One<br />
of the company’s main<br />
challenges for the future is<br />
serving consumer-driven<br />
market needs, as in the<br />
case of Self-medication<br />
solutions. This fast<br />
moving market is less<br />
predictable and more<br />
volatile than traditional<br />
product categories such<br />
as Prescription. To act<br />
quickly and efficiently<br />
on these segments, the<br />
company must involve<br />
all its main functions in<br />
product launches and<br />
structure a responsive<br />
supply chain. Specifically,<br />
the new organization will<br />
improve time to market<br />
for all products. A lean<br />
and transversal process<br />
is now in motion, based<br />
on a three-year roadmap<br />
and key performance<br />
indicators, involving both<br />
global business units and<br />
teams at market level.<br />
A pillar of future logistics<br />
is a new regional<br />
organization. Regional<br />
Sales and Operational<br />
Planning, for instance,<br />
will improve industrial<br />
resource management<br />
and support better<br />
sales forecast. Planning<br />
functions are combined,<br />
with a regional supply<br />
chain management for<br />
enhanced efficiency. The<br />
benefits expected from<br />
this new organization<br />
are decreasing air freight<br />
and reducing product<br />
obsolescence, inventory<br />
and subcontracting.<br />
An improved businessdriven<br />
process will bring<br />
significant savings to the<br />
company while serving<br />
market needs more<br />
efficiently.<br />
A 10-YEAR<br />
INDUSTRIAL PLAN<br />
DRIVEN<br />
BY GROWTH<br />
Over the next ten years, the<br />
company will focus on growth<br />
markets and increase its manufacturing<br />
capacity according to market<br />
potential. Bringing production<br />
closer to the demand is a logical<br />
move. Being able to manufacture<br />
in a more reactive and flexible<br />
way will meet market needs better.<br />
This priority is backed by a new<br />
transversal approach to manufacturing,<br />
in which dedicated teams<br />
track markets and strive to fully<br />
understand needs. This knowledge<br />
is then translated into a proactive<br />
production strategy. Since it was<br />
first implemented in North America,<br />
the growth-driven production<br />
principle has rolled out to Brazil,<br />
where <strong>Galderma</strong>’s Hortôlandia<br />
plant will expand to better serve<br />
this high-growth market and other<br />
Latin American countries. China,<br />
India and South East Asia are also<br />
priorities.<br />
4<br />
The<br />
MANUFACTURING SITES:<br />
FRANCE (ALBY-SUR-CHÉRAN)<br />
SWEDEN (UPPSALA), CANADA<br />
(BAIE D’URFÉ), AND BRAZIL<br />
(HORTOLÂNDIA).<br />
announcement<br />
of Spirig acquisition<br />
will bring additional<br />
manufacturing and<br />
R&D capabilities in<br />
Egerkingen.<br />
40<br />
SUBCONTRACTORS, COMPLYING WITH SAME SET<br />
OF SPECIFICATIONS AND REQUIREMENTS EXERCISED<br />
BY THE COMPANY IN ITS OWN PLANTS.<br />
At <strong>Galderma</strong>, manufacturing<br />
relies on four principles:<br />
safety, quality, service and<br />
cost efficiency.<br />
30<br />
31
WENDY ADAMS AND MARC<br />
WANNHOFF TALK ABOUT HOW<br />
GALDERMA GROWS AND<br />
EVOLVES THROUGH A CLOSE<br />
RELATIONSHIP WITH PATIENTS.<br />
helps address cost containment. Also, the Aesthetics<br />
& Corrective category is growing as the population<br />
lives longer.<br />
Mark Wannhoff: In Germany also, the interest in<br />
aesthetic solutions is growing. As the population ages,<br />
people want to look as good as they feel inside.<br />
SPECIALISTS<br />
...to meeting the<br />
dermatological<br />
needs of people<br />
throughout<br />
their lifetime...<br />
WENDY ADAMS<br />
GENERAL MANAGER<br />
GALDERMA CANADA<br />
What new needs are patients expressing today<br />
Wendy Adams: In Canada, ethnic diversity is prevalent<br />
and changing quickly. Patients want products<br />
that care for their specific needs and easier access to<br />
dermatologists. Fewer new medications are getting reimbursed,<br />
so increasing the Self-medication portfolio<br />
How are you responding to those needs<br />
MW: We don’t only offer selective treatments in dermatology;<br />
we provide a full approach. In Germany, almost<br />
100 sales reps have daily contact with customers,<br />
nearly 1,000 exchanges per day. That’s the basis for everything,<br />
and it cascades within our organization. We<br />
demonstrate our commitment to dermatology through<br />
funding various awards for scientific research in dermatology,<br />
for example, and market activities such as<br />
in-pharmacy patient information days and awareness<br />
campaigns, like the ‘Skin Health Days’ events held<br />
about 15 times per year.<br />
WA: We’ve been fortunate in putting products on the<br />
market for Prescription and Self-medication and we’re<br />
considering Pliaglis within our Aesthetic & Corrective<br />
business. We’re simplifying our solutions, which also<br />
helps with compliance. Patient education is a focus: we<br />
reach out to teens in their lingo and our Cetaphil club<br />
has over 30,000 online members.<br />
What future developments are you excited<br />
about now<br />
WA: We’ve begun installing computer terminals in dermatology<br />
and family physicians’ clinics to help educate<br />
patients. Dermatology is so visual: <strong>Galderma</strong> is leading<br />
the way with this initiative.<br />
MW: Interaction is key: getting feedback from patients<br />
about what they need and what has helped them deal<br />
with their issues in daily life is deeply gratifying.<br />
MARK WANNHOFF<br />
GENERAL MANAGER<br />
GALDERMA GERMANY<br />
33
SPECIALISTS<br />
A new dermatology landscape<br />
The field of dermatology is changing<br />
fast: the emergence of new markets,<br />
the maturing of established ones<br />
and the importance of the digital<br />
age demand targeted, customtailored<br />
and evidence-based solutions<br />
for patients, healthcare<br />
professionals and authorities alike.<br />
A tectonic shift is underway in the dermatology<br />
landscape. New populations<br />
of consumers are growing exponentially.<br />
People in traditional markets are<br />
changing how and where they consume;<br />
response to health reforms and a<br />
desire to age gracefully are also at play.<br />
Consequently dermatology is receiving<br />
a lot of attention and <strong>Galderma</strong> is<br />
spearheading the change. Its roll-out of<br />
innovative medical solutions in the Prescription,<br />
Self-medication or Aesthetic<br />
& Corrective segments has significantly<br />
increased, serving patients all around<br />
the world. For example, the creation of<br />
a Global Aesthetic Center of Excellence,<br />
in Uppsala (Sweden), underscores the<br />
company’s holistic commitment to better<br />
serving an expanding market.<br />
As new needs appear, <strong>Galderma</strong> is working<br />
closely with healthcare professionals,<br />
focusing on services, solutions and better<br />
serving patients. Building new product<br />
segments, focusing on demands, investment<br />
and reactivity, <strong>Galderma</strong> is organized<br />
to deliver a synergistic portfolio<br />
across its three businesses. By adapting<br />
offers to customers and practitioners<br />
within various markets, by remaining<br />
close to patient feelings and aspirations,<br />
the company has improved the dermatological<br />
experience for all.<br />
Responding to new market needs<br />
The population explosion in emerging<br />
countries has opened an important<br />
new area for dermatology: by 2030,<br />
80% of the global middle class will live<br />
there. The rise of younger, Internet<br />
<strong>Galderma</strong> is adapting its offers to customers<br />
and practitioners within various markets.<br />
and media-savvy consumers in places<br />
such as Asia, Eastern Europe, India and<br />
Brazil shows the importance in getting<br />
the right product to the right consumer,<br />
swiftly. Building trust is key. Thanks<br />
to demographics’, growing spending<br />
power and increasingly well-informed<br />
interest in proper skincare, <strong>Galderma</strong><br />
has responded to strong needs across its<br />
three businesses within new markets.<br />
In the Prescription business, for example,<br />
treatments for acne and rosacea<br />
serve significant demand across regions,<br />
with Epiduo as a leading drug bringing<br />
efficacy and safety in the treatment of<br />
mild, moderate and severe acne. Recent<br />
launches such as Oracea, or the increasing<br />
interest in Rozex, even strengthen the<br />
comprehensive drug portfolio. In 2014,<br />
<strong>Galderma</strong> will reinforce this momentum<br />
with the roll-out of a new treatment of<br />
erythema associated with rosacea.<br />
Promoting synergies<br />
between markets<br />
While facilitating global roll-outs, the<br />
company is also capitalizing on lessons<br />
learned in new markets, leveraging<br />
them to better serve previously established<br />
ones. The strong support of<br />
specific innovative initiatives facilitates<br />
synergies among disparate markets,<br />
Cetaphil: an<br />
expanding asset<br />
Cetaphil products have<br />
offered patients effective<br />
and adapted cleansing and<br />
moisturizing skincare<br />
solutions for over sixty<br />
years. The range has<br />
evolved over the years to<br />
address more specific<br />
needs and today includes<br />
16 products. The Disease-<br />
Specific Product (DSP)<br />
range has been developed<br />
to meet the requirements<br />
of physicians for a specially<br />
adapted therapeutic<br />
skincare range, such as<br />
Cetaphil Restoraderm for<br />
people suffering from<br />
atopic dermatitis, the<br />
number 1 skin condition<br />
encountered by<br />
dermatologists. The recent<br />
launch of Cetaphil<br />
Dermacontrol provides a<br />
therapeutic skincare range<br />
for patients treated for<br />
acne, in particular, a face<br />
wash and facial moisturizer<br />
SPF 30 which make the<br />
daily treatment regime<br />
easier to follow. The DSP<br />
portfolio registers the<br />
highest sales growth of<br />
the brand: +37% in <strong>2012</strong>.<br />
95%<br />
OF 1.4 BILLION NEW INHABITANTS<br />
IN THE WORLD OVER THE NEXT<br />
TWENTY YEARS ARE EXPECTED<br />
TO BE BORN IN ASIA AND AFRICA. (1)<br />
1<br />
BILLION PEOPLE<br />
IN 2030 WILL BE AGED<br />
OVER 65 YEARS BY 2030,<br />
VERSUS 8% TODAY (1) .<br />
(1) Source: U.N. Population<br />
Prospects, The 2010 Revision.<br />
+5.8%<br />
THE PROJECTED ANNUAL INCREASE OF GLOBAL<br />
HEALTH SPENDING UP TO 2020, OUTSTRIPPING<br />
PROJECTED GLOBAL ECONOMIC GROWTH.<br />
Source: Bain (2011), The Great Eight – Trillion Dollar<br />
Growth Trends to 2020.<br />
3.2<br />
BILLION PEOPLE WILL BELONG<br />
TO THE GLOBAL MIDDLE CLASS BY 2020,<br />
VERSUS 1.8 BILLION IN 2010.<br />
Source: OEDC Development Centre, The<br />
Emerging Middle Class.<br />
34<br />
35
SPECIALISTS<br />
with products from all portfolios earmarked<br />
to receive extra resources and<br />
focus. One of these products was the highpotential<br />
Restylane Skinboosters treatment.<br />
Two countries in different stages<br />
of development were chosen to source<br />
best practices: Mexico, a high potential<br />
market, and Sweden, with a solid customer<br />
base. After launching a campaign<br />
combining outdoor, print, digital and PR<br />
communications with an in-clinic campaign,<br />
Restylane Skinboosters established<br />
itself as the major aesthetic treatment in<br />
each market.<br />
Camp Wonder: a special<br />
summer for children with<br />
skin diseases<br />
Promoting international exchanges<br />
Today, healthcare reform dominates headlines<br />
in mature markets. Governments in<br />
Europe and around the world continue to<br />
cut costs by de-reimbursing certain categories<br />
of prescription treatments. Products<br />
become generic or over-the-counter<br />
and patients and consumers are increasingly<br />
forced to pay out of their pocket.<br />
A new market for reliable and value priced<br />
self-medicated dermatological solutions is<br />
emerging, in which <strong>Galderma</strong> is bringing<br />
innovative and high-quality offers.<br />
The ageing of the European population<br />
has created new needs. People remain active<br />
both inside and outside of the professional<br />
arena. Consumers want to look as<br />
good as they feel and an increasing number<br />
of quality injectors and techniques<br />
drive strong growth in the Aesthetic &<br />
Corrective category. Patient demand for<br />
more strictly regulated product approval<br />
and marketing of facial fillers favor evidence-based<br />
companies, such as <strong>Galderma</strong>.<br />
Building strong partnerships with authorities<br />
to ensure appropriate consumer<br />
safety is a necessity.<br />
To this end, <strong>Galderma</strong> is reinforcing its<br />
engagement in clinical studies worldwide,<br />
forging partnerships with academic institutions<br />
and organizations, supporting<br />
Young patients with chronic and lifethreatening<br />
skin diseases as well as their<br />
families are subjected to an unusual set of<br />
constraints. In the U.S., <strong>Galderma</strong> partners<br />
through the brand Cetaphil with the nonprofit<br />
Children Skin’s Disease Foundation,<br />
the founder of Camp Wonder. Camp<br />
Wonder is a free of charge summer camp<br />
in California, where 100 children aged<br />
7 to 16 can get a week away from stares and<br />
bullies and instead experience the childhood<br />
joys of summer camp. Acceptance and<br />
empowerment are the foundation of Camp<br />
Wonder’s philosophy. Counselors are<br />
often former campers, facilities are fully<br />
educational programs like Euroderm<br />
Excellence (see page 43). Promoting better<br />
knowledge of dermatology, diseases<br />
and treatments, the company has devoted<br />
considerable energy and investment<br />
to supporting global and local congresses<br />
in the field. It vows to promote exchange<br />
and attain a deeper understanding of what<br />
physicians and patients are looking for<br />
now and in the future.<br />
Connecting with people<br />
Today, <strong>Galderma</strong> is an industry leader<br />
in anticipating patient needs, researching<br />
and developing new ideas. Experience<br />
demonstrates that, no matter what<br />
the medical field or platform may be,<br />
investing time in cultivating relationships<br />
and exchanging information will always<br />
be an organization’s greatest strength.<br />
In times of change, the best way to prepare<br />
for the future is to connect with<br />
people. All of them.<br />
handicapped accessible and activities are<br />
tailored for every camper’s needs. A large<br />
on-site medical staff of volunteer physicians,<br />
nurses, medical students and other<br />
healthcare professionals offer children a safe<br />
and happy experience. As a proud supporter<br />
of Camp Wonder, <strong>Galderma</strong> provides a<br />
generous grant and employee volunteers<br />
during the camp and throughout the year.<br />
Learn more on: http://www.csdf.org<br />
Lena’s aesthetic treatment<br />
“I decided to have some<br />
aesthetic treatment when<br />
I discovered that the older<br />
I got, the more I was<br />
fighting a losing battle<br />
against gravity. Everything<br />
started going downwards!<br />
It is a fact of life, but<br />
nonetheless a sad one.<br />
So when I realized you can<br />
do something about it<br />
without a major procedure,<br />
I set up a time for a<br />
consultation with a clinic.<br />
I wanted to do something<br />
about my tired-looking<br />
eyes. Also, the wrinkles<br />
around my mouth made<br />
me look annoyed and<br />
irritated, which is really<br />
something I am not! I was<br />
surprised at how little time<br />
it took to do the treatment,<br />
I had thought it would be<br />
much more complicated,<br />
but it only took half an hour<br />
and wasn't dramatic at all.<br />
I got a small bruise from the<br />
injection, but could easily<br />
cover it with a concealer<br />
and no-one could see<br />
anything the day after.<br />
While I was at the clinic,<br />
I learned about the<br />
skinboosters and<br />
became curious about<br />
them, because my<br />
skin was a bit dry.<br />
I booked a series of<br />
treatments, as you have<br />
to repeat them for<br />
maximum effect.<br />
I am amazed when I look<br />
at the results today.<br />
“It has really been a lift for me<br />
mentally as well. I think the<br />
connection between looking good<br />
and feeling good is really strong.”<br />
LENA AUGUSTSSON ,<br />
STOCKHOLM, SWEDEN<br />
I feel a lot fresher now,<br />
I think the treatments have<br />
made me look at least<br />
6–7 years younger.<br />
It has really been a lift<br />
for me mentally as well<br />
because I think that<br />
the connection between<br />
looking good and feeling<br />
good is really strong.<br />
The funny thing is that<br />
although a lot of people<br />
have told me I look much<br />
more alert now, no one has<br />
suspected anything or<br />
asked if I have had a<br />
procedure done. Which<br />
is quite amazing, because<br />
I can easily tell the<br />
difference from looking<br />
at photos of myself before<br />
and after the treatment.”<br />
IMPROVING MEDICATION<br />
AGAINST ROSACEA<br />
Leader on the rosacea market,<br />
<strong>Galderma</strong> is about to bring to<br />
market a new solution for redness,<br />
subject to approval by<br />
health authorities. Rosacea is a<br />
common, chronic inflammatory skin<br />
disease. Fair-skinned individuals and<br />
women tend to be more prone to the<br />
disease. Both genetic and environmental<br />
factors may be involved in<br />
the pathogenesis, but research has<br />
yet to reveal its exact causes. Sufferers'<br />
most frequent complaint is about<br />
intense redness of the facial skin, often<br />
accompanied by flushing, visible<br />
blood vessels and pimples. Rosacea<br />
can cause emotional distress including<br />
embarrassment, anxiety and low<br />
self-esteem. This is a major reason<br />
why the proper treatment of rosacea<br />
through the improvement of the<br />
physical signs and symptoms of the<br />
disease can contribute to patients’<br />
psychosocial well-being. While there<br />
is still no cure for rosacea, <strong>Galderma</strong><br />
has long been the leader in providing<br />
sufferers with effective and safe treatments<br />
like Rozex/Metro and Oracea.<br />
On condition of its approval by<br />
health authorities, <strong>Galderma</strong> should<br />
offer a new innovative treatment for<br />
the erythema of rosacea. In clinical<br />
studies, once daily application of the<br />
gel was well-tolerated, offering fast<br />
and durable relief from redness. It<br />
would be the first approved medication<br />
specifically developed to directly<br />
target the erythema of rosacea. As<br />
part of <strong>Galderma</strong>’s holistic approach<br />
to providing innovative dermatological<br />
solutions, besides prescription<br />
drugs, patients need to be counseled<br />
about potential trigger factors for rosacea<br />
and on the use of gentle, nonirritating<br />
skin care products.<br />
36<br />
37
SPECIALISTS<br />
<strong>Galderma</strong>’s key<br />
therapeutic areas<br />
ACNE<br />
ROSACEA<br />
PIGMENTARY<br />
DISORDERS<br />
ONYCHO-<br />
MYCOSIS<br />
PSORIASIS<br />
SKIN<br />
SENESCENCE<br />
SKIN CANCER<br />
RARE SKIN<br />
DISEASES<br />
Acne is a chronic<br />
inflammatory skin disease of<br />
the pilosebaceous gland, linked<br />
to changes in hormone levels,<br />
the condition can last several<br />
years. Acne occurs when the<br />
follicular canals of the gland<br />
become blocked with excess<br />
sebum (a fatty secretion)<br />
and dead cells and presents<br />
as inflamed pustules and<br />
painful red pimples, most<br />
commonly on the face, but<br />
also on the back and chest.<br />
Rosacea is a chronic<br />
inflammatory skin condition<br />
characterized by facial redness,<br />
which is by firstly intermittent<br />
but then becomes permanent.<br />
The disorder, which affects the<br />
T-zone (nose, cheeks, forehead<br />
and chin), can produce other<br />
symptoms such as broken<br />
blood vessels and, occasionally,<br />
papules and pustules which can<br />
look like acne. Rosacea mostly<br />
affects people between the<br />
ages of 30 and 60 and tends<br />
to occur more frequently<br />
among fair-skinned individuals<br />
with light-colored eyes.<br />
Two to five percent of North<br />
Europeans and Americans<br />
suffer from this disorder.<br />
Pigmentary disorders are<br />
characterized by an increase<br />
or decrease in skin pigment.<br />
Melasma (commonly<br />
known as the pregnancy<br />
mask) is the most frequent<br />
disorder, affecting 50 to 70%<br />
of pregnant women. This<br />
hyperpigmentation disorder<br />
can occur following exposure<br />
to the sun or hormonal changes.<br />
Vitiligo is a pigmentary<br />
disorder that affects 0.5 to 2%<br />
of the global population. It is<br />
characterized by white patches<br />
on the skin, usually on the face,<br />
hands, feet and frictional areas.<br />
Onychomycosis (or nail<br />
mycosis) is an increasingly<br />
common disorder, affecting<br />
around 10% of the world<br />
population. One in two people<br />
over the age of 70 suffers<br />
from it. Onychomycosis is<br />
caused by a microscopic fungus<br />
and tends to be more common<br />
in the toe nails. It is a highly<br />
contagious disorder that can<br />
destroy the nail if not treated.<br />
Psoriasis is a chronic,<br />
inflammatory skin disorder<br />
characterized by red, scaly<br />
and sometimes itchy patches.<br />
It affects around 2 to 3 % of<br />
the world population.<br />
It is a lifelong condition with<br />
relapses and remissions that<br />
are both emotionally and<br />
physically stressful. Psoriasis<br />
often develops on the scalp<br />
and nails, and can involve<br />
swelling and pain in the joints<br />
(psoriatic arthritis). There is<br />
currently no cure, but existing<br />
treatments help sufferers<br />
manage their symptoms.<br />
Skin aging is caused by the<br />
passage of time, but also by<br />
exposure to the sun and UV<br />
rays (photoaging). Its effects<br />
can be treated with drugs and<br />
medical procedures such as<br />
injections or laser therapies.<br />
Actinic keratoses are<br />
precancerous lesions frequently<br />
found in fair-skinned patients,<br />
especially with chronic sun<br />
exposure. The lesions appear<br />
as rough, scaly patches on<br />
sun-exposed areas of the body.<br />
If left untreated, they can<br />
develop into a fast-evolving<br />
form of skin cancer called<br />
squamous cell carcinoma.<br />
Basal cell carcinoma is the most<br />
common skin cancer among<br />
fair-skinned people. It affects<br />
mainly sun-exposed areas of the<br />
skin. It is not life-threatening,<br />
but the carcinomas enlarge,<br />
become locally invasive and<br />
can ulcerate. Melanoma is a skin<br />
cancer developing from cells<br />
producing melanin in the skin,<br />
known as melanocytes.<br />
It is the most life-threatening<br />
skin cancer, and often<br />
presents as an asymmetric<br />
pigmented lesion with irregular<br />
borders. Any change in its<br />
color, size or shape requires<br />
immediate consultation with<br />
a dermatologist.<br />
<strong>Galderma</strong> is currently exploring<br />
the treatment of few rare skin<br />
diseases. Congenital ichthyosis<br />
often occurs in a severe form<br />
in the first years of life. Later on<br />
it causes thick, dry, white scales<br />
to appear on the skin which can<br />
be debilitating in their more<br />
severe forms. Palmoplantar<br />
keratodermas are characterized<br />
by an abnormal thickening of<br />
the skin on the palms and soles.<br />
Cutaneous T-cell lymphomas<br />
result from uncontrolled<br />
proliferation of T lymphocytes.<br />
Clinically, it is evidenced by<br />
red scaly patches which are<br />
sometimes pruritic and can<br />
evolve into cutaneous, lymph<br />
nodes or visceral tumors. Gorlin<br />
syndrome is an inherited disease<br />
mainly affecting the skin and<br />
causing basal cell carcinomas<br />
to appear early in life.<br />
38<br />
39
PARTNERS<br />
PARTNERING WITH HEALTHCARE<br />
PROFESSIONALS TO DELIVER VALUE<br />
IS A PRIORITY FOR BENOIT CHARDON<br />
AND BRIAN JOHNSON.<br />
How do you best serve healthcare professionals<br />
in your markets<br />
Benoit Chardon: The Aesthetic & Corrective business<br />
is driven by physicians. Beyond supplying innovative,<br />
high-quality and safe products, we help them<br />
build their practices. Our Alliance Service Program<br />
includes advanced medical education, patient management,<br />
business consulting, merchandising and soon an<br />
e-learning platform.<br />
Brian Johnson: We meet practitioners every day and<br />
understand their medical and business needs. Explaining<br />
how new treatments serve their practice helps<br />
them. Patients’ needs change and clarify: it is easier<br />
to exchange with physicians when we have the right<br />
solution for them. We also support continuous medical<br />
education programs for dermatologists.<br />
Adherence and Performance) program for Epiduo<br />
helps teenagers and young adults follow their treatment<br />
and interact with the brand. We participate in<br />
disease awareness programs like “Face-to-face” for<br />
rosacea, and support events like those organized by the<br />
National Psoriasis Foundation.<br />
BC: In South Korea and China, we launched a successful<br />
Restylane celebrity campaign on TV, building<br />
market and brand equity. In EMEA & Latin America, a<br />
disruptive “before & after” campaign in waiting rooms<br />
associated for the first time premium quality photos<br />
with real-life people testimonials. Direct to consumer<br />
communication is considered by healthcare professionals<br />
as one of the best business drivers.<br />
BRIAN JOHNSON<br />
VICE-PRESIDENT<br />
PRESCRIPTION MARKETING<br />
GALDERMA USA<br />
What has changed in your service<br />
to healthcare providers<br />
BC: With new research on consumer behavior towards<br />
aesthetic procedures, physicians understand better<br />
their new role in serving consumers. They realize that<br />
“patients” are expecting a premium service rather than<br />
a treatment for illness.<br />
BJ: We help practitioners provide value in new situations,<br />
by providing the widest range of innovative<br />
products and services. For example, Tri-Luma, the<br />
only FDA-approved treatment for melasma, can now<br />
be either dispensed by the physician in his office or<br />
prescribed to the patient.<br />
...while serving<br />
healthcare<br />
professionals...<br />
How do you talk directly to patients<br />
BJ: We help patients understand their disease and<br />
improve their experience. The TAP (Treatment,<br />
BENOÎT CHARDON<br />
HEAD OF FACIAL AESTHETICS<br />
41
PARTNERS<br />
A professional commitment<br />
With the Internet and new forms of<br />
media, the dependence of patients<br />
on a healthcare professional’s advice<br />
has changed. Like elsewhere,<br />
proactive self-education and<br />
shared responsibility are strong<br />
trends in dermatology.<br />
Partnering with professionals<br />
<strong>Galderma</strong> shares with healthcare professionals<br />
the mission of finding the<br />
right solutions for the changing needs<br />
of patients. A key part of that goal is<br />
developing partnerships with these<br />
professionals, to help them understand<br />
and better explain treatment benefits to<br />
patients who are more aware of their<br />
condition than before. Dermatologists<br />
are the most highly qualified medical<br />
professionals to deal with skin conditions,<br />
but there are many other healthcare<br />
providers who help patients find<br />
the right treatments for their needs.<br />
Among them, general practitioners,<br />
pediatricians, plastic surgeons, oncologists<br />
and gynecologists are increasingly<br />
treating skin conditions. Nurses are in<br />
constant contact with patients. Pharmacists<br />
play a key role in ensuring that<br />
the right products and solutions reach<br />
the patient, particularly in the case of<br />
Self-medication.<br />
<strong>Galderma</strong> engages with all of these<br />
professionals in a transparent and<br />
open way. Clinical studies provide<br />
a very practical point of contact<br />
with healthcare professionals. They<br />
offer physicians a firsthand view<br />
on <strong>Galderma</strong> treatments and their<br />
effectiveness. The company’s diligence<br />
on pharmacovigilance is another<br />
valuable contact point.<br />
Helping future practitioners<br />
Programs sponsored by the company<br />
are essential to the relationship with<br />
professionals. With the guidance<br />
of the Medical Affairs department,<br />
Helping healthcare professionals understand<br />
and better explain treatment benefits to patients.<br />
<strong>Galderma</strong> is supporting a number of<br />
initiatives to provide valuable services<br />
helping physicians in their daily<br />
practice of dermatology. Furthermore,<br />
the company is also committed to<br />
supporting a high level of education for<br />
dermatology residents. The residents’<br />
program (see box on the right side),<br />
which the company supports through<br />
the European Dermatology Forum, is<br />
a seminar that puts future practitioners<br />
in touch with leading authorities in<br />
dermatology. Another initiative, which<br />
<strong>Galderma</strong> supports in the United States,<br />
helps student residents prepare for their<br />
final board examination in dermatology.<br />
Improving professional experience<br />
In the Aesthetic & Corrective field,<br />
training physicians in procedures is<br />
central and provides ample resources<br />
for better understanding of their<br />
needs. Some are medical, such as<br />
demonstrating how physicians should<br />
use new product injection techniques<br />
for better results and an enhanced<br />
patient experience. But change is<br />
also afoot in the way physicians run<br />
their aesthetic practice. These courses<br />
provided by <strong>Galderma</strong>, part of the<br />
Alliance Service Program, help<br />
professionals improve their practice<br />
management and patient service.<br />
A new generation<br />
of European<br />
Dermatologists<br />
The European Dermatology<br />
Forum (EDF) organizes<br />
Euroderm Excellence, an<br />
annual training program<br />
for European Residents in<br />
dermatology. <strong>Galderma</strong> is<br />
the exclusive sponsor of this<br />
program that provides<br />
strong academic value for<br />
students, bringing qualitative<br />
and practical knowledge<br />
to them. The course gathers<br />
the best dermatology<br />
residents from European<br />
countries. This 4-day<br />
training program in practical<br />
clinical dermatology deals<br />
with all aspects of research<br />
and practical skills. Since<br />
the beginning, over 1,400<br />
students and 100 of the most<br />
famous teachers have<br />
joined this international<br />
training course. It is a great<br />
opportunity for all<br />
participants to develop<br />
their professional network<br />
and further their skills and<br />
education. This event is<br />
shared across universities<br />
all over Europe, and the 10 th<br />
anniversary will be<br />
celebrated in 2013.<br />
45 %<br />
OF DERMATOLOGY DRUGS<br />
IN NORTH AMERICA ARE PRESCRIBED<br />
BY DERMATOLOGISTS, 33%<br />
BY GENERAL PRACTITIONERS<br />
AND 19% BY PEDIATRICIANS.<br />
Source: Wolters Kluwer.<br />
19%<br />
IN JAPAN, ACNE-RELATED<br />
PATIENT CONSULTATION RATES<br />
JUMPED FROM 14% TO 19%,<br />
FOLLOWING AN ACNE AWARENESS<br />
PROGRAM SPONSORED BY<br />
GALDERMA.<br />
30,000<br />
PEOPLE IN CANADA<br />
ARE MEMBERS OF THE<br />
CETAPHIL SKINCARE CLUB.<br />
The purpose of <strong>Galderma</strong>'s<br />
Harmony Program is to teaching<br />
aesthetic physicians to achieve<br />
good, balanced results with<br />
2 to 3 injections, versus up to 10.<br />
1,000<br />
THE AVERAGE NUMBER OF<br />
DAILY CONTACTS BETWEEN<br />
HEALTHCARE PROFESSIONALS<br />
AND GALDERMA’S<br />
SALES FORCE IN GERMANY.<br />
42<br />
43
PARTNERS<br />
Likewise, <strong>Galderma</strong>’s Harmony program<br />
offers a complete holistic diagnostic<br />
approach so that physicians can<br />
listen to patients better and understand<br />
what they expect from an aesthetic<br />
consultation.<br />
Providing reliable<br />
information<br />
Communicating with patients is part<br />
of <strong>Galderma</strong>’s commitment. This includes<br />
educating them, helping them<br />
consult a doctor and understanding<br />
their disease and its treatment. With<br />
the Internet, patients are exposed to a<br />
huge amount of information, not all of<br />
it accurate or complete. The company<br />
works with medical institutions and patient<br />
advocacy groups all over the world<br />
to provide patients with the most appropriate<br />
and reliable information.<br />
Treatment compliance is a big issue.<br />
Reaching out online<br />
To encourage new means of exchange<br />
and interactions amongst dermatologists<br />
and healthcare professionals, <strong>Galderma</strong><br />
supports online educational platforms and<br />
services. Among them, Dermquest.com<br />
is a website dedicated to practicing and<br />
future dermatologists. It features one of the<br />
Ensuring that the patient follows prescriptions<br />
precisely, in the right quantity<br />
and frequency, is essential. Often,<br />
the answer lies in product innovation.<br />
Offering Epiduo in a pump format has<br />
improved acne treatment compliance<br />
for teenagers. A mobile application allows<br />
Epiduo patients to track progress<br />
and share with their practitioners. The<br />
growing importance of Self-medication<br />
has prompted <strong>Galderma</strong> to step up its<br />
efforts in patient education. Initiatives<br />
such as online Cetaphil clubs have<br />
built large communities. Sometimes,<br />
people do not know that there is a<br />
medical solution for what ails them.<br />
In Germany, “Skin Health Days” are an<br />
important disease awareness campaign<br />
about rosacea, which informs those<br />
suffering from that condition on how<br />
it can be treated. Feedback has been<br />
overwhelming.<br />
largest image bank with more than 23,000<br />
photos available, expert opinions, case<br />
notes and resources relevant to the practice<br />
of dermatology. A panel of respected<br />
international dermatologists sits on the<br />
editorial board and helps continuously<br />
improving the platform in order to meet the<br />
needs of its members. Derm101.com offers<br />
access to the most current research about<br />
Building confidence<br />
Helping people acquire a better awareness<br />
of skin conditions and treatments<br />
contributes to building a virtual circle<br />
between patients and healthcare professionals.<br />
Ultimately, positive patient experiences<br />
delivered via the right solution<br />
prescribed or recommended by wellinformed<br />
healthcare professionals are<br />
what count most at <strong>Galderma</strong>. Good<br />
experiences and testimonials serve as<br />
reminders that people are at the heart<br />
of everything the company does.<br />
diagnosis and treatment of skin diseases,<br />
and the platform is also tailored to meet the<br />
specific needs of pediatricians and family<br />
physicians practicing dermatology. The<br />
new mobile applications in both English<br />
and Spanish make this platform even more<br />
accessible and helpful in the daily practice.<br />
More than 50,000 physicians in the world<br />
are already members.<br />
Caring for the Littlest Patients<br />
Dr. Manju Elizabeth George<br />
is pediatric dermatologist<br />
in Palm Beach Gardens,<br />
Florida. She is boardcertified<br />
in adult and<br />
pediatric dermatology.<br />
What new dermatological<br />
needs are you now seeing<br />
in your practice<br />
In my practice I am now<br />
encountering younger<br />
children (ages 8-10) and<br />
adolescents with acne.<br />
Also, there are many infants<br />
and children with atopic<br />
dermatitis (eczema),<br />
whose parents are highly<br />
knowledgeable: they<br />
prefer organic and natural<br />
products, they know<br />
about parabens and are<br />
environmentally aware.<br />
Is it difficult for patients<br />
to follow treatment<br />
protocol<br />
Yes, at times it can<br />
be difficult because<br />
medications and treatment<br />
protocol can be<br />
complicated. I often<br />
provide handouts and write<br />
out instructions clearly,<br />
numbered in order.<br />
Very often, I show parents<br />
how to apply a medication.<br />
I always ask them to call<br />
the office if they have<br />
any questions and<br />
tell them, "Things should<br />
be getting better, not<br />
worse so please call me.”<br />
How do you work<br />
to improve<br />
patient outcomes<br />
I often tell patients,<br />
"I can give you all the<br />
products you want but if<br />
you don't use them it<br />
doesn't matter". If patients<br />
like the product, they will<br />
use it. Patient satisfaction<br />
and tolerability are key.<br />
How do you work<br />
with <strong>Galderma</strong><br />
I work with <strong>Galderma</strong> in<br />
developing acne education<br />
in the pediatric world,<br />
for providers who may be<br />
seeing acne first line<br />
in their office. I really enjoy<br />
talking to the community<br />
about something<br />
we can all prevent.<br />
What does interaction<br />
with <strong>Galderma</strong> bring you<br />
as a physician<br />
<strong>Galderma</strong> is providing me<br />
with all the resources I need<br />
as a practitioner: studies<br />
and handouts help me<br />
understand a particular<br />
product. I also learn from<br />
other pediatric<br />
dermatologists and<br />
pediatricians and this<br />
interaction really makes me<br />
a better physician. We all<br />
learn from each other.<br />
pediatricdermpb.com<br />
"I really enjoy talking to the<br />
community about something we<br />
can all prevent."<br />
DR. MANJU ELIZABETH GEORGE,<br />
PEDIATRIC DERMATOLOGIST<br />
CLOSE TO<br />
PHARMACISTS<br />
<strong>Galderma</strong> takes special pride<br />
in working closely with pharmacists.<br />
As one-stop providers<br />
for many solutions and products,<br />
pharmacies not only distribute Prescription<br />
products, naturally, but<br />
also the fast-growing category of<br />
Self-medication solutions, which<br />
pharmacists recommend to patients<br />
and consumers. In Brazil, for example,<br />
<strong>Galderma</strong> has developed a close<br />
partnership with pharmacies, offering<br />
a variety of services in about<br />
3,000 pharmacies. With over 425<br />
events in <strong>2012</strong>, impacting almost<br />
7,500 pharmacists and their assistants<br />
in the different categories and<br />
brands of <strong>Galderma</strong> products, the<br />
company has shown its long-term<br />
commitment to this relationship.<br />
Special Cetaphil and Dermotivin<br />
corners were set up and pharmacists<br />
received training sessions for<br />
Loceryl. Many new or emerging<br />
markets, such as Brazil or China,<br />
rely increasingly on Self-medication<br />
brands; <strong>Galderma</strong> is helping pharmacists<br />
better serve their customers<br />
while delivering high-quality training<br />
and materials.<br />
44<br />
45
INTERNATIONAL<br />
TODD ZAVODNICK<br />
SENIOR REGIONAL<br />
DIRECTOR LATIN AMERICA<br />
THREE EXECUTIVES DISCUSS HOW<br />
GLOBAL STRATEGY WAS ALIGNED<br />
WITH LOCAL BUSINESS MODELS TO<br />
BOOST GROWTH IN <strong>2012</strong>.<br />
How did you overcome market challenges <br />
Lee Heeson: In light of a challenging economy and loss<br />
of exclusivity, generating demand through our promoted<br />
brands across the 3 businesses was key. By focusing<br />
on cornerstone brands in Self-medication – Loceryl,<br />
Cetaphil and Benzac – and through talent acquisition<br />
and development, we successfully started the journey<br />
to create the dermatology category in pharmacies. The<br />
total value proposition of our world-class facial injectables<br />
portfolio, injector training and practice development<br />
support enabled us to drive market share gain in<br />
the A&C market. Finally, leadership development was<br />
a major focus with particular emphasis on strategic vision<br />
and agility.<br />
What is driving growth in your areas <br />
Todd Zavodnick: Latin America is a region where<br />
our main focus is to drive brand development and also<br />
shape and expand the overall market with initiatives<br />
across the three businesses. We expect strong double<br />
digit growth from all three business units within the<br />
current 10-year plan horizon. A key focus for us in Latin<br />
America is the expansion of the Aesthetic & Corrective<br />
marketplace, as today only 39% of physicians and<br />
surgeons are participating in non-invasive Aesthetic<br />
& Corrective procedures. We are executing numerous<br />
training initiatives to help grow the market in quantity,<br />
but at the same time ensuring they are quality injectors,<br />
achieving successful, repeatable outcomes over time.<br />
The commitment to our people and their development<br />
is of the utmost importance to achieve our objectives<br />
for today and tomorrow.<br />
What have been the strong points in your region <br />
Kamal Abbasi: Firstly the ‘can do’ attitude prevailing<br />
across the APAC region. The Asian economic boom and<br />
demographic shift, along with the increase of disposable<br />
income, and higher expectation on quality are benefiting<br />
our existing brands and is key for the future portfolio.<br />
It is expected that China will soon be the second<br />
biggest pharmaceutical market in the world. Restylane<br />
is successful and growing fast, with an Aesthetic &<br />
Corrective business in China showing strong potential.<br />
We also sold 5 million units of Cetaphil in China –the<br />
second highest performance in units after the U.S.<br />
Australia, our most successful affiliate to date, has<br />
become a benchmark for us in our 3 business strategy<br />
execution. In Korea, Cetaphil, recommended by<br />
dermatologists, took advantage of a business model<br />
including innovative online presence.<br />
...around<br />
the world.<br />
LEE HEESON<br />
SENIOR REGIONAL DIRECTOR<br />
EUROPE, MIDDLE-EAST, AFRICA<br />
KAMAL ABBASI<br />
SENIOR REGIONAL<br />
DIRECTOR ASIA-PACIFIC<br />
47
INTERNATIONAL<br />
Positioned<br />
for worldwide growth<br />
Following a year of growth in <strong>2012</strong>,<br />
<strong>Galderma</strong> is preparing for another<br />
year of promising results driven<br />
by innovation. It is also a time of<br />
geographic expansion, with<br />
products available in more than 70<br />
countries and improved coverage<br />
in areas where the company was<br />
already present.<br />
A complete spectrum<br />
of solutions<br />
<strong>Galderma</strong>’s global strategy relies on the<br />
simple principle of bringing innovative<br />
Prescription, Self-medication and<br />
Aesthetic & Corrective solutions to patients<br />
and customers in every market<br />
where there is a need. <strong>Galderma</strong> aims to<br />
strengthen its presence with patients<br />
and healthcare professionals by means<br />
of a vast portfolio of innovative medical<br />
solutions for everyone, at every age.<br />
This strategy then determines the company’s<br />
structure, notably as seen in the<br />
creation of new global business units.<br />
Strong brands are <strong>Galderma</strong>’s key asset.<br />
Four of them are ranked in the Top 20<br />
in the dermatology Prescription segment<br />
(1) . Epiduo is the most prescribed<br />
branded topical acne agent in the<br />
world (2) . Oracea, the first systemic treatment<br />
for rosacea, has met with huge<br />
success of sales in countries where it has<br />
been introduced. Loceryl, originally a<br />
Prescription brand, illustrates the potential<br />
of re-categorizing products as<br />
Self-medication: in Germany, sales of<br />
Loceryl have risen sharply since this<br />
treatment for fungal nail infections was<br />
made available over-the-counter in<br />
pharmacies. In the Aesthetic & Correctiveaera,<br />
<strong>Galderma</strong> can rely on a complete<br />
spectrum of solutions for medical<br />
practitioners, with its hyaluronic acidbased<br />
dermal fillers (Restylane and<br />
Emervel), a botulinum toxin type A<br />
(Azzalure), and complementary products<br />
such as Pliaglis and Metvix.<br />
<strong>Galderma</strong> is strongly focusing on new markets,<br />
particularly Asia and Latin America.<br />
Continued expansion<br />
In <strong>2012</strong>, the Company recorded overall<br />
sales growth of 12.9% based on reported<br />
figures, with particularly good results<br />
in Germany, China and Australia.<br />
Mature markets generally consolidated<br />
their performance in <strong>2012</strong>. In North<br />
America, the dermatology market<br />
transformed in <strong>2012</strong>: reshaping of the<br />
competitive landscape, healthcare<br />
changes and generics exposure for<br />
branded drugs. In this challenging environment,<br />
<strong>Galderma</strong> continued its expansion<br />
during a year marked by five<br />
product launches and three registrations<br />
in both the United States and<br />
Canada, where <strong>Galderma</strong> is a leader in<br />
the Prescription market with strong<br />
growing brands. As recessionary<br />
Europe tightens its public medical coverage,<br />
Germany leveraged commercial<br />
efforts and advertising campaigns.<br />
Focusing on emerging markets<br />
There is a clear demarcation between<br />
mature countries and the bustling<br />
emergent markets, which are a strong<br />
focus for <strong>Galderma</strong>. Asia and Latin<br />
America are still in growth mode as<br />
markets take shape. Opportunities<br />
abound, both through the launch of<br />
products already available elsewhere<br />
China:<br />
a clear priority<br />
The company’s objectives in<br />
China are clear: to reinforce a<br />
leading Aesthetic &<br />
Corrective business while<br />
accelerating the Selfmedication<br />
and Prescription<br />
categories through<br />
developing local organizational<br />
and production<br />
capacities. A&C and Selfmedication<br />
are strong growth<br />
drivers. In A&C, Restylane has<br />
drawn more customers<br />
through increased brand<br />
equity and geographical<br />
coverage. Cetaphil continued<br />
to grow fast via increased<br />
distribution to drugstores<br />
and chain pharmacies. The<br />
Self-medication market holds<br />
great promise for switch<br />
products based on<br />
Prescription formulas, such<br />
as Loceryl Nail Lacquer. The<br />
Prescription portfolio is being<br />
actively developed and will<br />
add significant growth<br />
opportunities moving<br />
forward. In <strong>2012</strong>, <strong>Galderma</strong><br />
doubled its sales in this<br />
strategic market.<br />
No. 1<br />
US DERMATOLOGISTS RECOGNIZED<br />
GALDERMA AS NO. 1 DERMATOLOGICAL<br />
COMPANY FOR SEVEN CONSECUTIVE YEARS.<br />
Source: SDI Company Image Survey.<br />
Results in Dermatology, 2011.<br />
No. 2<br />
BRAZIL WAS GALDERMA’S<br />
SECOND LARGEST MARKET<br />
AFTER THE US IN <strong>2012</strong>.<br />
Source: Company data, at the end<br />
of <strong>2012</strong>, at comparable rates.<br />
8%<br />
THE COMPANY’S<br />
GLOBAL HEADCOUNT<br />
INCREASE IN <strong>2012</strong>.<br />
58<br />
MILLION EUROS <strong>2012</strong> GALDERMA<br />
SALES IN GREATER CHINA (1) .<br />
17%<br />
GALDERMA GREW OVER 17%<br />
IN GERMANY DESPITE CHALLENGING<br />
MARKET CONDITIONS (1) .<br />
(1) Source: Company data, at the end<br />
of <strong>2012</strong>, at comparable rates.<br />
48<br />
49
INTERNATIONAL<br />
and through investing in new regions,<br />
such as South East Asia. Among the leading<br />
market-building opportunities are<br />
Singapore, the Philippines and Indonesia,<br />
(one of the most highly populated<br />
countries in the world), followed by Malaysia<br />
and Thailand.<br />
Powerful opportunities<br />
In Asia, and perhaps around the world,<br />
China presents the highest potential for<br />
growth. With three-digit sales growth in<br />
<strong>2012</strong>, China is set to become the<br />
world’s second-biggest market for<br />
pharmaceuticals in the next five years.<br />
<strong>Galderma</strong> has been operating there for<br />
several years, and <strong>2012</strong> marked the beginning<br />
of its expansion in this area,<br />
with the inauguration of an affiliate,<br />
and sales doubled in <strong>2012</strong>. Australia<br />
also performed very well, with a strategy<br />
based on the three businesses and<br />
Dysport, Cetaphil and Epiduo as key<br />
growth drivers. In Latin America, the<br />
rise of the middle class eager to spend<br />
on medical and consumer products to<br />
improve wellness has mirrored <strong>Galderma</strong>’s<br />
capacity for training physicians on<br />
treatment solutions. Both new markets<br />
and brands are expanding rapidly. Brazil<br />
represents the largest potential, reporting<br />
60% of the region’s total revenue<br />
and high opportunity across<br />
categories but many other markets,<br />
such as Mexico, are showing a strong<br />
increase in patient-driven needs.<br />
Responsible growth<br />
Because the company now serves nearly<br />
7% of the world’s dermatology market<br />
(1) and is investing in high potential<br />
markets, it is poised for further growth.<br />
The organic growth strategy is complemented<br />
by its external growth strategy.<br />
For example, in December, the brand<br />
announced the acquisition of the Swiss<br />
laboratory Spirig, the dermatology<br />
market leader in Switzerland. In <strong>2012</strong>,<br />
for the first time in the history of<br />
<strong>Galderma</strong>, more than half of sales were<br />
generated outside the United States: the<br />
company has truly become international.<br />
<strong>Galderma</strong> is more conscious than<br />
ever of its increased responsibilities towards<br />
patients and stakeholders, and of<br />
the importance of driving a business<br />
with compliance and respect.<br />
(1) Source: IMS data - D+J1A+J2A (dermatology<br />
only), MAT December <strong>2012</strong> – 39 countries.<br />
(2) Source: IMS Health - Monthly Midas database,<br />
all countries selected - Topical anti acne market -<br />
Nov.<strong>2012</strong> MAT, retail Rx Market - at sales manufacturer<br />
local currency dollar value.<br />
x2 over 120%<br />
THE COMPANY’S GROWTH IN CHINA IN <strong>2012</strong>.<br />
THE NUMBER OF EMPLOYEES<br />
IN THE ASIA PACIFIC REGION<br />
MORE THAN DOUBLED IN <strong>2012</strong>.<br />
CHINA IS SET TO BECOME THE WORLD’S 2ND<br />
PHARMACEUTICALS MARKET IN THE NEXT 5 YEARS.<br />
Source: Company data, at the end of <strong>2012</strong>, at comparable rates.<br />
Transformation and<br />
reinforcement in the US<br />
With about 600 employees,<br />
<strong>Galderma</strong>’s number one market<br />
continues to expand, generating sales<br />
of around $1 billion. The company<br />
made news in the US in <strong>2012</strong> with four<br />
product launches (Epiduo, Metrogel,<br />
Differin 0.3% pumps and Cetaphil<br />
Dermacontrol for acne-prone skin),<br />
two registrations and ten FDA<br />
consultations while championing<br />
compliance and safety. A leader in the<br />
US Prescription market, <strong>Galderma</strong>’s<br />
brand growth and performance has<br />
surpassed demand with Clobex Spray,<br />
Epiduo and Oracea. The Selfmedication<br />
category was also<br />
reinforced thanks to the continued<br />
strength of flagship brand Cetaphil<br />
– one product is sold every second -<br />
and the successful launch of Cetaphil<br />
Dermacontrol among the dermatology<br />
and pediatric community.<br />
The supplement approved by<br />
the FDA for Pliaglis, a topical<br />
anesthetic as well as the comeback<br />
of Tri-Luma, treating pigmentary<br />
disorders marked new steps<br />
reinforcing <strong>Galderma</strong>’s presence<br />
in the Aesthetic & Corrective area.<br />
<strong>Galderma</strong>’s dedicated Managed Care<br />
team promotes quality healthcare for<br />
dermatology patients by partnering<br />
with managed care organizations,<br />
insurers and third-party payers.<br />
The company actively supports<br />
dermatologic and pediatric<br />
organizations via direct, unrestricted<br />
grants and donations amounting to<br />
$20 million in the last five years. Last<br />
but not least, US-based dermatologists<br />
have recognized <strong>Galderma</strong> as the No.1<br />
dermatological company for seven<br />
consecutive years (3) .<br />
(3) SDI Company Image Survey — Results<br />
in Dermatology, 2011.<br />
Brazil:<br />
Three-category leader<br />
Brazil is a standout example of how<br />
<strong>Galderma</strong> shapes local markets<br />
by responding to local needs with<br />
a complete portfolio and three<br />
businesses at play. In the Prescription<br />
market, Epiduo consolidated its<br />
leadership as the first topical acne<br />
treatment. The third “Acne Day”<br />
in São Paulo was a success, with<br />
700 physicians attending. Clobex,<br />
Avicis and Loceryl significantly gained<br />
market share. The Self-medication<br />
products lead in four of the six market<br />
segments where they are present,<br />
taking the leadership for the first time<br />
in the moisturizer market with 22.4%<br />
market share, thanks to the support of<br />
a dedicated sales team covering 3,000<br />
pharmacies. Aquaclin was launched as<br />
the first OTC brand for acne treatment.<br />
As part of <strong>Galderma</strong>’s scientific<br />
studies support, the first Brazilian<br />
epidemiological study in<br />
onychomycosis “ONO” was<br />
presented. In Aesthetic & Corrective,<br />
Dysport is the leading brand on<br />
the botulinum toxin dermatology<br />
market, with 54% of market share.<br />
Restylane reached record sales<br />
of 100,000 units. The symposium<br />
addressing the global approach<br />
of facial anatomy and treatment<br />
with Dysport and Restylane drew<br />
3,500 participants during the National<br />
Brazilian Congress. The Alliance<br />
service platform in the aesthetic<br />
area was launched adding significant<br />
value to the brands with<br />
a cluster management model.<br />
These results were possible due to<br />
a complete professional relationship<br />
program. Among many other<br />
initiatives, the ‘Fellowship Program’<br />
reached 600 fellows, supporting<br />
various scientific projects and<br />
initiatives.<br />
Sources: IMS, CUP, SAFE System, Research<br />
- A&C Census.<br />
50<br />
51
INTERNATIONAL<br />
<strong>Galderma</strong> worldwide<br />
PARIS<br />
FRANCE<br />
CORPORATE SERVICES<br />
UPPSALA<br />
SWEDEN<br />
R&D AND PRODUCTION<br />
ASIA-PACIFIC<br />
AUSTRALIA<br />
CHINA<br />
HONG KONG<br />
INDIA<br />
JAPAN<br />
PHILIPPINES<br />
SOUTH KOREA<br />
SINGAPORE<br />
TAIWAN<br />
FORT WORTH<br />
TEXAS, USA<br />
NORTH AMERICA<br />
HEADQUARTERS<br />
GALDERMA IS<br />
EXPANDING ITS<br />
INTERNATIONAL<br />
PRESENCE, COVERING<br />
MORE THAN 70<br />
COUNTRIES TODAY.<br />
BAIE D'URFÉ<br />
CANADA<br />
PRODUCTION<br />
PRINCETON<br />
NEW JERSEY, USA<br />
R&D<br />
SOPHIA ANTIPOLIS<br />
FRANCE<br />
R&D<br />
ALBY-SUR-CHÉRAN<br />
FRANCE<br />
PRODUCTION<br />
LAUSANNE<br />
SWITZERLAND<br />
GLOBAL HEADQUARTERS<br />
TOKYO<br />
JAPAN<br />
R&D<br />
EUROPE - MIDDLE EAST<br />
AFRICA<br />
BELGIUM<br />
FRANCE<br />
GERMANY<br />
GREECE<br />
ITALY<br />
POLAND<br />
PORTUGAL<br />
RUSSIA<br />
SOUTH AFRICA<br />
SPAIN<br />
SWEDEN<br />
SWITZERLAND<br />
THE NETHERLANDS<br />
UNITED KINGDOM<br />
LATIN AMERICA<br />
ARGENTINA<br />
BRAZIL<br />
CHILE<br />
COLOMBIA<br />
MEXICO<br />
VENEZUELA<br />
NORTH AMERICA<br />
CANADA<br />
UNITED STATES OF AMERICA<br />
With 31 affiliates and exclusive representatives<br />
throughout the world,<br />
<strong>Galderma</strong> is developing markets<br />
in high potential regions while<br />
answering global needs in its three<br />
businesses: Prescription, Self-medication<br />
and Aesthetic & Corrective<br />
medical solutions.<br />
FIND ALL GALDERMA OFFICES<br />
AROUND THE WORLD<br />
ON WWW.GALDERMA.COM<br />
HORTOLÂNDIA<br />
BRAZIL<br />
PRODUCTION<br />
52<br />
53
Key brands<br />
<strong>Galderma</strong> locations<br />
VISIT ALL THE AFFILIATES WEBSITES ON WWW.GALDERMA.COM<br />
HEADQUARTERS<br />
SWITZERLAND<br />
GALDERMA SA<br />
Avenue Gratta-Paille 2<br />
1018 LAUSANNE<br />
Tel.: 41 21 642 78 00<br />
CORPORATE SERVICES<br />
FRANCE<br />
GALDERMA<br />
INTERNATIONAL S.A.S.<br />
Tour Europlaza La Défense 4<br />
20 avenue André Prothin<br />
92927 La Défense Cedex<br />
Tel.: 33 1 58 86 45 45<br />
SWITZERLAND<br />
GALDERMA SA<br />
Avenue Gratta-Paille 2<br />
1018 LAUSANNE<br />
Tel.: 41 21 642 78 00<br />
R&D<br />
FRANCE<br />
GALDERMA R&D S.N.C.<br />
Les Templiers<br />
2400, route des Colles<br />
06410 Biot<br />
Tel.: 33 4 93 95 70 70<br />
JAPAN<br />
GALDERMA KK (Japan)<br />
9th Floor, Sumitomo Fudosan<br />
Iidabashi No.3 Building<br />
13-1 Nishi-Gokencho<br />
Shinjuku-ku<br />
Tokyo 162-0812<br />
Tel.: 81 3 5229 6900<br />
SWEDEN<br />
Q-MED AB<br />
Seminariegatan 21<br />
Visitors: Fyrisvallsgatan 7<br />
752 28 Uppsala<br />
Tel.: 46 18 474 90 00<br />
UNITED STATES<br />
GALDERMA R&D LLC<br />
5 Cedar Brook Drive - Suite 1<br />
Cranbury, NJ 08512<br />
Tel.: 1 609 409 77 01<br />
PRODUCTION SITES<br />
BRAZIL<br />
GALDERMA BRASIL Ltda.<br />
Rodovia SP 101<br />
Campinas-Monte Mor, Km 9<br />
Condominio Techtown<br />
CEP 13186-904<br />
Hortolândia-SP<br />
Tel.: 55 19 3045 6900<br />
CANADA<br />
GALDERMA PRODUCTION<br />
CANADA INC<br />
19400 Trans-Canada Hwy<br />
Baie d'Urfé, Québec H9X 3S4<br />
TEL.: 1 514 457 33 66<br />
FRANCE<br />
LABORATOIRES<br />
GALDERMA S.A.S.<br />
Zone Industrielle - Touvière<br />
74540 Alby sur Chéran<br />
Tel.: 33 1 58 86 45 45<br />
SWEDEN<br />
Q-MED AB<br />
Seminariegatan 21<br />
Visitors: Fyrisvallsgatan 7<br />
752 28 Uppsala<br />
Tel.: 46 18 474 90 00<br />
AFFILIATES<br />
ARGENTINA<br />
GALDERMA ARGENTINA S.A.<br />
Juramento 1775 8° Piso<br />
(C1428DNA)<br />
Ciudad de Buenos Aires<br />
Tel.: 54 11 4124 0454<br />
AUSTRALIA / NEW ZEALAND<br />
GALDERMA AUSTRALIA<br />
(PTY) LTD.<br />
Suite 4, 13B Narabang Way<br />
Belrose NSW 2085<br />
Tel.: 61 2 9479 0600<br />
BELGIUM<br />
GALDERMA BELGILUX BN<br />
p/a Multiburo<br />
Keivitplein 20C/12<br />
2018 Antwerpen<br />
Tel.: 32 3 897 19 00<br />
BRAZIL<br />
GALDERMA BRASIL LTDA.<br />
R. Surubim, 373 - 4th floor<br />
Cid. Monções - São Paulo /<br />
SP 04571-050<br />
Tel.: 55 11 3524 6300<br />
CANADA<br />
GALDERMA CANADA INC.<br />
105 Commerce Valley Drive<br />
West - Suite 300<br />
Thornhill, Ontario L3T 7W3<br />
Tel.: 1 905 762 2500<br />
CHILE<br />
LABORATORIOS GALDERMA<br />
CHILE LTDA.<br />
Mc Iver N 440 -<br />
Office N 701<br />
Santiago Centro<br />
Tel.: 56 2480 7500<br />
CHINA<br />
GALDERMA INTERNATIONAL<br />
3708 Lippo Plaza<br />
No. 222 Middle Huaihai Rd.<br />
Shanghai 200021 - P.R.China<br />
Tel.: 86 21 2315 9666<br />
COLOMBIA<br />
GALDERMA COLOMBIA S.A.<br />
Carrera 14 N93 B-32<br />
Oficina 504 - Bogota, DC<br />
Tel.: 57 1622 7560 ext 201<br />
FRANCE<br />
GALDERMA<br />
INTERNATIONAL SAS<br />
Tour Europlaza - La Défense 4<br />
20, Avenue André Prothin<br />
92927 La Défense Cedex<br />
Tel.: 33 1 5 8 86 45 45<br />
GERMANY<br />
GALDERMA LABORATORIUM<br />
GMBH<br />
Georg-Glock-Strasse 8<br />
40474 Düsseldorf<br />
Tel.: 49 211 58 601 00<br />
GREECE<br />
GALDERMA HELLAS TRADE<br />
OF PHARMACEUTICAL<br />
PRODUCTS S.A.<br />
Pendelis Avenue 37A<br />
15235 Vrilissia Attica<br />
Tel.: 30 210 81 04 190<br />
HONG KONG<br />
GALDERMA HONG KONG LTD.<br />
Suite 3501-02, 35/F,<br />
Cambridge House, Taikoo<br />
Place, 979 King's Road<br />
Island East, Hong Kong<br />
Tel.: 852 28240333<br />
INDIA<br />
GALDERMA INDIA PVT. LTD.<br />
23, Steelmade Industrial Estate,<br />
2nd Floor - Marol Village,<br />
Andheri (E) - Mumbai 400 059<br />
Tel.: 91 22 6726 1818<br />
ITALY<br />
GALDERMA ITALIA S.p.A.<br />
Centro Direzionale Colleoni<br />
Palazzo Taurus - Ingresso 1<br />
20864 Agrate Brianza (MB)<br />
Tel.: 39 039 63 46 91<br />
JAPAN<br />
GALDERMA KK (Japan)<br />
9th Floor, Sumitomo Fudosan<br />
Iidabashi No.3 Building<br />
13-1 Nishi-Gokencho<br />
Shinjyuku-ku<br />
Tokyo 162-0812<br />
Tel.: 81 3 5229 6900<br />
MEXICO<br />
GALDERMA MEXICO S.A.<br />
de CV Mariano Escobedo<br />
N°. 476 - Piso 10, Torre Polanco<br />
Col. Anzures<br />
Delegación Miguel Hidalgo<br />
11590 México, D.F.<br />
Tel.: 52 55 9126 2000<br />
PHILIPPINES<br />
GALDERMA<br />
PHILIPPINES INC.<br />
Unit 3001 Atlanta Centre<br />
31 Annapolis Street<br />
Greenhills, San Juan<br />
Metro Manila 1502<br />
Tel.: 63 2 470 8000<br />
POLAND<br />
GALDERMA POLSKA Sp.z.o.o.<br />
ul. Laczyny 4<br />
02-820 Warsaw<br />
Tel.: 48 22 331 21 80<br />
PORTUGAL<br />
GALDERMA INTERNATIONAL<br />
Sucursal em Portugal<br />
R. Dr. Antonio Loureiro<br />
- Borges, n7 - 6 Andar -<br />
Arquiparque - Miraflores<br />
1495 - 131 Alges<br />
Tel.: 351 21 315 19 40/41<br />
RUSSIA<br />
GALDERMA LLC.<br />
Leningradskiy prospect 31A,<br />
building 1 - Business Center<br />
Monarkh Tower - 21st floor<br />
125284, Moscow<br />
Tel.: 7 495 540 5017<br />
SINGAPORE<br />
GALDERMA SINGAPORE<br />
PVT. LTD.<br />
1 Kim Seng Promenade<br />
#14-10, Great World City West<br />
Tower - Singapore 237994<br />
Tel.: 65 6838 9360<br />
SOUTH AFRICA<br />
GALDERMA LABORATORIES<br />
SOUTH AFRICA (PTY) LTD.<br />
Wedgefield Office Park<br />
17 Muswell Road South<br />
Bryanston - Phase 2, Block<br />
D, 1st Floor - P.O. Box 71150 -<br />
Bryanston 2021<br />
Tel.: 27 11 706 23 39<br />
SOUTH KOREA<br />
GALDERMA KOREA Ltd.<br />
6F, 7F Bando Building<br />
26 Gromurae-Ro 10-Gil<br />
Seocho-Gu, Seoul, 137-802<br />
Tel.: 82 2 6717 2000<br />
SPAIN<br />
LABORATORIOS<br />
GALDERMA S.A.<br />
C/ Agustín de Foxá, 29 - 4 Pl.<br />
28036 Madrid<br />
Tel.: 34 902 02 7595<br />
SWEDEN<br />
GALDERMA NORDIC AB<br />
Seminariegatan 21<br />
752 28 Uppsala<br />
Tel.: 46 18 444 0330<br />
SWITZERLAND<br />
GALDERMA S.A.<br />
Postfach 492 - 6330 Cham<br />
Tel.: 41 41 7803828<br />
TAIWAN<br />
GALDERMA HK LTD<br />
Taiwan Branch<br />
4-6, 9F, N° 17, Sec. 1<br />
Chengde Rd., Datong Dist.<br />
Taipei City 103<br />
Tel.: 886 22 555 8850<br />
THE NETHERLANDS<br />
GALDERMA BENELUX BV<br />
Postbus 2892 -<br />
3000 CW Rotterdam<br />
Visitors: Weena 723 C7.082<br />
Rotterdam<br />
Tel.: 31 183 69 19 19<br />
UNITED KINGDOM<br />
GALDERMA (UK) LTD.<br />
Meridien House, 1st Floor<br />
69 - 71 Clarendon Road<br />
Watford, Hertfordshire<br />
WD17 1DS<br />
Tel.: 44 1923 208 950<br />
UNITED STATES<br />
GALDERMA<br />
LABORATORIES L.P.<br />
14501 North Freeway<br />
Fort Worth, TX 76177<br />
Tel.: 1 817 961 5000<br />
VENEZUELA<br />
LABORATORIOS GALDERMA<br />
VENEZUELA S.A.<br />
Urbanizacion Sorocaima<br />
Calle Altagracia<br />
Edificio Procter & Gamble,<br />
Nivel Plaza, Mezzanina Sector<br />
La Trinidad - ZP 1080,<br />
Caracas - Edo. Miranda<br />
Tel.: 58 212 820 83 80<br />
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