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Yearbook 2012 - Galderma

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committed<br />

we are<br />

yearbook 2 0 1 2


<strong>Galderma</strong><br />

<strong>2012</strong><br />

CONTINUE THE EXPERIENCE ONLINE<br />

Get access to the enriched online edition of the yearbook at yearbook.galderma.com,<br />

or by scanning the QR codes present in every chapter.<br />

GALDERMA CORPORATE SERVICES - Tour Europlaza - 20, Avenue André Prothin - 92927 La Défense Cedex – France. www.galderma.com. This document has been prepared by the Corporate<br />

& Digital Communications Department.<br />

Executive director: Humberto C. Antunes - Executive editor: Sébastien Cros - Senior editor: Nadège des Closets - Design and production:<br />

. June 2013. Photos: Kim<br />

Freeman, Tom Hussey Photography, LLC, Gavin Jowitt/Capa Pictures, Michel Labelle, Yannick Labrousse, Yann Leborgne, Mats Lundqvist, Nathalie Oundjian-Guréghian, Corbis, Plainpicture,<br />

iStock, BSIP, Phanie, Getty Images, Thinkstock, <strong>Galderma</strong>, R.R. - Epiduo, Oracea, Clobex, Differin, Rozex/MetroGel, Silkis/Vectical, Benzac, Tri-Luma, Loceryl, Cetaphil, Metvix, Azzalure,<br />

Restylane and Emervel are registered trademarks of <strong>Galderma</strong>. Dysport is a trademark of Ipsen.


CONTENTS<br />

INTERVIEW WITH HUMBERTO C. ANTUNES<br />

EXECUTIVE COMMITTEE<br />

<strong>2012</strong> KEY FACTS<br />

<strong>2012</strong> KEY FIGURES<br />

PAGE 06<br />

PAGE 08<br />

PAGE 10<br />

PAGE 12<br />

We are committed to delivering<br />

PAGES 14 TO 21<br />

PAGES 22 TO 31<br />

innovative medical solutions to meet<br />

PAGES 32 TO 39<br />

the dermatological needs of people<br />

throughout their lifetime while<br />

PAGES 40 TO 45<br />

serving healthcare professionals<br />

around the world.<br />

PAGES 46 TO 53<br />

04<br />

05


Doing the<br />

right thing<br />

every day<br />

What is the driving force behind<br />

<strong>Galderma</strong>’s ambition statement<br />

We want to provide the best medical solutions in dermatology.<br />

That is what <strong>Galderma</strong> stands for. But how<br />

we do business is just as important as the products and<br />

services we offer. <strong>Galderma</strong> has evolved from a mainly<br />

prescription medication company to one that also offers<br />

Aesthetic & Corrective solutions and Self-medication<br />

drugs. Our Prescription business has thrived in ways<br />

that were unimaginable before. As we developed these<br />

businesses, we realized that each had a specific model.<br />

We also examined how people - patients, healthcare<br />

professionals, stakeholders and regulators - interacted<br />

with the company. Now, we see the future differently.<br />

How does this statement<br />

reflect changes in the company<br />

and its environment<br />

We are at a turning point, due to demographic evolution,<br />

the distribution of wealth in new markets and increased<br />

social mobility. Access to better, more innovative products<br />

is improving. Communications have changed, so<br />

have regulations. Our new ambition statement stems<br />

from our fundamental objective to provide innovative<br />

medical solutions for people with skin, hair and nail needs.<br />

Our model is based on research and development and<br />

evidence-based treatments. It is a medical business, and<br />

we are focusing on solutions, not just drugs. We meet<br />

patients’ needs through the convergence of science and<br />

technology: chemistry, physics, devices, and even light.<br />

As we are providing solutions for people with medical<br />

needs in dermatology, we are working more closely with<br />

healthcare professionals, who are in the best position to<br />

diagnose a problem and prescribe the right solution.<br />

Are you broadening your audience<br />

Providing the right solutions is not simply about inventing<br />

them. We have to make them accessible. The<br />

world has become very complex. Developing a breakthrough<br />

drug does not necessarily mean it will become<br />

accessible. It requires regulatory approval and listing<br />

in patients’ formularies. Insurance companies need<br />

to recognize its value and agree to pay for it. Pharmacies,<br />

hospitals or clinics need to carry it. We must work<br />

with all these partners to ensure the availability of our<br />

products and treatments. Patients are becoming more<br />

demanding too: they want solutions immediately - and<br />

they deserve to get them!<br />

The world’s one million dermatology-related healthcare<br />

providers have a huge impact. We will talk to them.<br />

Hundreds of thousands of pharmacists carry our products.<br />

We are registering products in more places and<br />

reaching new cities in countries where we have sometimes<br />

been for a long time. We are launching products,<br />

of course, but the biggest change is our role as a catalyst.<br />

It will energize us to go the extra mile and ensure that<br />

anybody who needs to, can have access to <strong>Galderma</strong>’s<br />

medical solutions.<br />

Why was the company reorganized<br />

into three Global Business Units<br />

We restructured into business units that work together,<br />

transversally. Why Because the solutions people need<br />

do not just come from standalone Prescriptions, Selfmedication<br />

or Aesthetic & Corrective treatments, but<br />

from a combination of all of these. We offer solutions<br />

through a transversal, holistic approach to treatment.<br />

A skin cancer patient, for example, needs a selfmedication<br />

solution that helps prevent sun damage, he/<br />

she also needs prescription drugs to treat the lesions<br />

and procedures that will correct or restore part of the<br />

damage. Today, <strong>Galderma</strong> offers all three of these solutions.<br />

We have the same approach for milder afflictions.<br />

<strong>Galderma</strong>'s strategy is to be a<br />

'lifetime' brand: what is behind this<br />

approach<br />

Healthy skin is a very precious asset throughout our<br />

entire life, and people are becoming increasingly<br />

aware of this. The world's population is ageing, not just<br />

in Europe but also in countries like Brazil or China.<br />

As we live longer, we aspire to a better quality of life.<br />

<strong>Galderma</strong>’s approach is very positive and optimistic:<br />

supporting people take care of their skin and appearance<br />

helps them to live a longer, happier life.<br />

We are focusing<br />

on solutions,<br />

not just drugs.<br />

<strong>Galderma</strong>’s culture is founded on<br />

ethical values: how does that influence<br />

your business<br />

Dermatology is fascinating. It is medical, so it has an<br />

impact on the body. However in aesthetic dermatology,<br />

you can also change lives by having an impact on the<br />

soul and spirit. At <strong>Galderma</strong>, we have a mission, a vision<br />

and an ambition. We wish to serve people throughout<br />

the whole of their lifetime, so the way in which we<br />

do that is extremely important. The sustainability of<br />

our business and our mission depends on doing things<br />

right, every day. Respecting the rules, of course, but<br />

also answering needs and building on the responsible<br />

principles we share. In the digital age, it is important to<br />

train all our teams to communicate effectively with physicians<br />

and patients, to know the rules and regulations.<br />

It is about interaction with the outside world but also<br />

how we proceed internally, how <strong>Galderma</strong> respects the<br />

environment and diversity. We are committed.<br />

HUMBERTO C. ANTUNES<br />

PRESIDENT & CEO<br />

06<br />

07


Executive<br />

Committee<br />

JANUSZ CZERNIELEWSKI<br />

VICE-PRESIDENT<br />

MEDICAL AFFAIRS<br />

ALAIN JACOT<br />

VICE-PRESIDENT<br />

SCIENTIFIC DIVISION<br />

LYDIE FRÈRE<br />

GENERAL COUNSEL<br />

ALBERT DRAAIJER<br />

VICE-PRESIDENT BUSINESS<br />

DEVELOPMENT & MARKETS,<br />

VICE-PRESIDENT<br />

SELF-MEDICATION GLOBAL<br />

BUSINESS UNIT,<br />

VICE-PRESIDENT A&C<br />

GLOBAL BUSINESS UNIT<br />

ALAIN KIRSCH<br />

VICE-PRESIDENT HUMAN<br />

RESOURCES<br />

CÉCILE DUSSART<br />

VICE-PRESIDENT<br />

MANUFACTURING<br />

& TECHNICAL OPERATIONS<br />

HUMBERTO C. ANTUNES<br />

PRESIDENT & CHIEF<br />

EXECUTIVE OFFICER<br />

CHRISTIAN MATTON<br />

VICE-PRESIDENT<br />

CORPORATE GENERAL<br />

COUNSEL<br />

VIVIANE MONGES<br />

VICE-PRESIDENT FINANCE<br />

& ADMINISTRATION & CFO<br />

FRANÇOIS FOURNIER<br />

VICE-PRESIDENT<br />

NORTH AMERICA<br />

& PRESIDENT USA,<br />

VICE-PRESIDENT<br />

PRESCRIPTION GLOBAL<br />

BUSINESS UNIT<br />

08<br />

09


Key facts<br />

<strong>2012</strong><br />

A NEW ORGANIZATION, A NEW AMBITION STATEMENT,<br />

NUMEROUS PRODUCT LAUNCHES AND THE<br />

CONTINUED INTERNATIONAL EXPANSION:<br />

<strong>2012</strong> IMPROVED GALDERMA'S LEADERSHIP<br />

IN THE FIELD OF DERMATOLOGY.<br />

"AMBITION<br />

STATEMENT"<br />

In June <strong>2012</strong>, <strong>Galderma</strong> confirmed<br />

its commitment to delivering medical<br />

solutions to patients, consumers<br />

and healthcare professionals, with a new<br />

ambition statement.<br />

No.<br />

1<br />

EPIDUO<br />

has been the<br />

No. 1 prescribed<br />

branded<br />

topical agent<br />

used in the acne<br />

therapeutic<br />

field in<br />

the World<br />

since 2011 (1) .<br />

New office in Shanghai<br />

At the end of <strong>2012</strong>, <strong>Galderma</strong> China (2) inaugurated<br />

its new office facilities in Shanghai, which have become<br />

the headquarters for the Greater China region.<br />

92%<br />

participation rate for<br />

the first global employee<br />

survey, showing how<br />

willing <strong>Galderma</strong> people<br />

are to contribute to<br />

the company’s evolution.<br />

3<br />

Global Business Units<br />

<strong>Galderma</strong> is implementing<br />

a new organization to<br />

better serve its 3 markets:<br />

Prescription, Self-medication<br />

and Aesthetic & Corrective.<br />

Rosacea<br />

campaign<br />

The “U.S. Face-to-Face with Rosacea”<br />

campaign features Cynthia Nixon,<br />

actress in Sex and the City, who was<br />

herself diagnosed with rosacea. The<br />

campaign aims at changing the way<br />

people view rosacea, to help improve<br />

patients’ quality of life.<br />

www.rosaceafacts.com<br />

New territories<br />

for Dysport<br />

Ipsen and <strong>Galderma</strong> increased their<br />

collaboration for Dysport, one of<br />

the leaders in the aesthetic muscle relaxant<br />

market. Both companies renewed their<br />

partnership in Brazil and Argentina, and<br />

extended it to Australia and South Korea.<br />

Restylane<br />

Skinboosters<br />

After launching a campaign combining<br />

outdoor, print, digital and PR<br />

communications with an in-clinic<br />

campaign in Sweden and Mexico.<br />

Restylane Skinboosters sales rose by<br />

more than 60% in the two test countries<br />

during the project period.<br />

Launch of<br />

Cetaphil<br />

Dermacontrol<br />

a cosmetic range designed for use in<br />

patients treated for acne. The Cetaphil<br />

range has offered patients cleansing and<br />

moisturizing skincare solutions for over<br />

60 years. Today, it includes 16 products.<br />

1,500<br />

attendees at the two<br />

<strong>Galderma</strong> symposia for<br />

acne and rosacea during the<br />

European Academy<br />

of Dermatology and<br />

Venereology (EADV) in Prague.<br />

12<br />

DECEMBER<br />

<strong>Galderma</strong><br />

and Spirig<br />

(1) Source: IMS Health - Monthly Midas database,<br />

all countries selected - Topical anti acne market - Nov. <strong>2012</strong> MAT,<br />

retail Rx Market - at sales manufacturerlocal currency dollar value.<br />

(2) Under the Q-Med legal entity.<br />

entered into a definitive agreement under<br />

which <strong>Galderma</strong> will acquire Spirig, the<br />

leader in dermatology in Switzerland.<br />

300 patients<br />

have been enrolled in the phase II<br />

clinical study of NVC-422<br />

for Impetigo. This formulation,<br />

developed by a <strong>Galderma</strong> and<br />

NovaBay R&D partnership, could<br />

replace traditional antibiotics<br />

in the treatment of Impetigo.<br />

10<br />

11


Key figures<br />

<strong>2012</strong><br />

FIVE YEARS OF GROWTH HAVE TURNED<br />

GALDERMA INTO A COMPANY OPERATING<br />

WORLDWIDE, WITH A BALANCED<br />

PORTFOLIO OF MEDICAL SOLUTIONS<br />

AND BRANDS IN DERMATOLOGY.<br />

SALES BY FRANCHISE<br />

in million Euros<br />

Acne 356.1<br />

Therapeutic Skincare Line 290.6<br />

Rosacea 287.3<br />

Aesthetic & Corrective 268.6<br />

Psoriasis 117.4<br />

Onychomycosis 103.7<br />

Skin Cancer 23.2<br />

Pigmentary Disorders 5.1<br />

Other Products 138.9<br />

GENDER DISTRIBUTION<br />

53 % 47 %<br />

The company has wholly-owned affiliates in 31 countries<br />

with a worldwide network of exclusive distributors and employs<br />

more than 4,200 people around the world.<br />

SALES BY GEOGRAPHIC AREA<br />

SALES BY BUSINESS LINES<br />

<strong>Galderma</strong>'s overall growth rate in <strong>2012</strong><br />

versus 2011 went up 5.9% like-for-like<br />

and 12.9% based on reported figures.<br />

<strong>Galderma</strong> made the most of<br />

<strong>2012</strong> by redefining its ambition<br />

statement, striking the right balance<br />

in its growth drivers and continuing<br />

its international expansion.<br />

20 %<br />

27 %<br />

53 %<br />

AESTHETIC &<br />

CORRECTIVE<br />

SELF-MEDICATION<br />

PRESCRIPTION<br />

<strong>2012</strong> sales<br />

€1.59 Billion<br />

GROWTH OVER FIVE YEARS<br />

in million Euros - Sales more than doubled in five years.<br />

1,600<br />

1,400<br />

1,200<br />

1,000<br />

800<br />

600<br />

400<br />

735<br />

2007<br />

854<br />

978<br />

1,203<br />

1,410<br />

1,591<br />

2008 2009 2010 2011 <strong>2012</strong><br />

Source: Company data at the end of December <strong>2012</strong> - At published rates.<br />

North America 49%<br />

8 19% 57 12<br />

<strong>Galderma</strong> conducts research<br />

in 8 key therapeutic areas.<br />

Latin America 12%<br />

of sales are invested to<br />

discover and develop<br />

new products and access<br />

innovative technologies.<br />

EMEA 24%<br />

new patents registered in <strong>2012</strong>.<br />

6,500 patent applications and<br />

patents have been filed by<br />

<strong>Galderma</strong> since its creation.<br />

Asia Pacific 15%<br />

new chemical entities in<br />

development and 7 products<br />

tested in Phase II and Phase III<br />

clinical studies.<br />

12<br />

13


FOCUSED<br />

FRANÇOIS FOURNIER<br />

VICE-PRESIDENT<br />

OF THE PRESCRIPTION<br />

GLOBAL BUSINESS UNIT<br />

ALBERT DRAAIJER AND FRANÇOIS<br />

FOURNIER DISCUSS HOW<br />

GALDERMA IS GEARING UP TO<br />

FACE NEW OPPORTUNITIES.<br />

What is the aim of the new organization<br />

François Fournier: We have exciting opportunities<br />

ahead of us. Our new organization in Global Business<br />

Units empowers us to achieve our ambitions in the<br />

Prescription, Self-medication and Aesthetic &<br />

Corrective businesses simultaneously. It will enable<br />

us to embrace market diversity, from a changing<br />

landscape in the U.S., to new needs in Europe and<br />

opportunities in the fastest growing economies.<br />

Albert Draaijer: We are experiencing a global spread<br />

of interest for dermatology with increasing demand<br />

for new products and solutions. Latin America and<br />

Asia are growing fast. The new organization is going<br />

to allow us to leverage and accelerate the development<br />

of each of our three businesses.<br />

How does this change translate<br />

<strong>Galderma</strong>’s ambitions<br />

AD: We have put the triple business model in place. As<br />

a result, almost every country has a Prescription team,<br />

a Self-medication team and an Aesthetic & Corrective<br />

team. With the help of the functions represented in the<br />

GBUs, we have been very successful in opening new<br />

fields of dermatology in various countries.<br />

FF: We are rolling out our extended portfolio<br />

geographically, with more global products for greater<br />

impact and alignment. We work closely with the<br />

markets so that we can adjust to local specificities.<br />

We are<br />

committed...<br />

How do you see the future<br />

FF: People will remain at the heart of our actions.<br />

Dermatology is a specialty with a strong human<br />

component. We think about patients first, providing<br />

them with effective and safe solutions. We will<br />

strengthen our partnerships with dermatology<br />

organizations and our long-established relationships<br />

with healthcare professionals. With a lifetime portfolio,<br />

three businesses, global reach and reinforced<br />

competitiveness, our future is bright.<br />

AD: <strong>Galderma</strong> was a very young company 10 years<br />

ago. We were well established in the US, with a<br />

smaller presence in other parts of the world. Today,<br />

we have a sound geographic balance, with a presence<br />

in more than 70 countries. We are poised for growth<br />

because we are rolling out to the whole world and<br />

strengthening our leadership in dermatology.<br />

ALBERT DRAAIJER<br />

VICE-PRESIDENT OF THE<br />

SELF-MEDICATION AND AESTHETIC<br />

& CORRECTIVE GLOBAL BUSINESS UNITS<br />

06<br />

15


FOCUSED<br />

Achieving true potential<br />

Building a stronger position in the<br />

Aesthetic & Corrective and Selfmedication<br />

markets, while sustaining<br />

the high growth level in the core<br />

Prescription business are key. A new<br />

organization leveraging company<br />

resources and skills has therefore<br />

been set up.<br />

Answering dermatological<br />

needs throughout the world<br />

<strong>Galderma</strong> has experienced remarkable<br />

growth in recent years. In a short<br />

time span, the company has changed<br />

from an essentially dermatological<br />

prescription-based business into<br />

a worldwide leader with three global<br />

businesses in more than 70 countries:<br />

Prescription, Self-medication and<br />

Aesthetic & Corrective.<br />

Taken together, these businesses offer<br />

the most comprehensive range of skin<br />

health solutions available to patients<br />

and consumers worldwide. While activities<br />

share the same values, they<br />

function in different ways. Models<br />

and access to markets vary; customers<br />

may be patients, consumers, healthcare<br />

professionals, or all three; distribution<br />

channels and prescribers change depending<br />

on the country, and product<br />

launches and life cycle management<br />

differ. They all nevertheless have a<br />

common goal: to answer dermatological<br />

needs with the same level of engagement<br />

and innovation, of service<br />

and product quality.<br />

Reaching that goal requires specialized<br />

skills and a strong vision of the future<br />

of dermatology. Today, <strong>Galderma</strong>'s<br />

commitment is to move from being<br />

a market leader to becoming a global<br />

company that shapes the dermatology<br />

market. Anticipating needs, reducing<br />

time to market and partnering closely<br />

with healthcare professionals and listening<br />

to patients and consumers are<br />

the vital steps to fulfilling this vision.<br />

Moving from a market leader<br />

to becoming a global company that shapes<br />

the dermatology market.<br />

A three-fold strategy<br />

In June <strong>2012</strong>, <strong>Galderma</strong> announced its<br />

decision to create three Global Business<br />

Units (GBU); one for each of its<br />

cornerstone activities. Working with all<br />

the teams at regional and country levels,<br />

this new organization will offer a stronger<br />

strategic focus, consolidate skills and<br />

resources, and boost innovation and<br />

execution capabilities across different<br />

geographic regions. It represents a new<br />

way to conduct business, to better serve<br />

customers and patients.<br />

The first mission of the three Global<br />

Business Units is to sharpen the strategy.<br />

Making sure that the right products<br />

in the right portfolios are available on<br />

time; ensuring that high-potential solutions<br />

are being developed; and organizing,<br />

prioritizing and developing product<br />

ranges. As a result, the company is<br />

focused, investing and working on key<br />

markets where growth potential can be<br />

maximized.<br />

On a global level, product launches<br />

will accelerate. A new treatment for rosacea<br />

is expected to be rolled out over<br />

the globe after grant of market authorizations.<br />

This international launch is<br />

prepared by the Prescription Global<br />

Business Unit in very close cooperation<br />

with local markets.<br />

Excellence<br />

in aesthetics<br />

Located in Uppsala,<br />

Sweden, <strong>Galderma</strong>’s<br />

Global Center of Excellence<br />

concentrates the<br />

discovery, development,<br />

manufacturing, medical<br />

and regulatory affairs as<br />

well as strategic brand and<br />

channel management of<br />

the Aesthetic & Corrective<br />

(A&C) Global Business Unit.<br />

The state of the art R&D<br />

team drives the innovation<br />

on hyaluronic acid-based<br />

gels and in particular uses<br />

the patented NASHA<br />

technology to develop<br />

stabilized, non-animal<br />

hyaluronic acid-based<br />

products and also<br />

anticipate for the products<br />

of the future. The annual<br />

production capacity of<br />

10 million units spans a<br />

comprehensive portfolio of<br />

medical solutions. This is in<br />

total more than 400 people<br />

committed to the A&C<br />

business operating for<br />

<strong>Galderma</strong> in Uppsala.<br />

4 ,230<br />

EMPLOYEES WORLDWIDE.<br />

MORE THAN<br />

300 PEOPLE JOINED<br />

GALDERMA IN <strong>2012</strong>.<br />

3<br />

GLOBAL BUSINESS UNITS<br />

WERE CREATED IN <strong>2012</strong>, ONE<br />

FOR EACH OF GALDERMA’S<br />

CORNERSTONE ACTIVITIES.<br />

+12.9%<br />

THE COMPANY’S OVERALL<br />

GROWTH RATE IN<br />

<strong>2012</strong> VERSUS 2011 (BASED ON<br />

REPORTED FIGURES).<br />

1.59<br />

BILLION EUROS:<br />

GALDERMA’S <strong>2012</strong> SALES.<br />

6.9%<br />

GALDERMA’S SHARE<br />

OF THE GLOBAL<br />

DERMATOLOGY MARKET.<br />

Source: IMS data - D+J1A+J2A<br />

(dermatology only), MAT<br />

December <strong>2012</strong> – 39 countries<br />

16<br />

17


FOCUSED<br />

Coordination between all functions<br />

makes it possible to plan this important<br />

operation seamlessly. It also shows a new<br />

way of functioning within the company:<br />

faster execution, more efficiency and offering<br />

better visibility to all involved.<br />

Transversal expertise<br />

The new organization impacts operations<br />

at all levels. Delivering demanddriven<br />

dermatological medical solutions,<br />

the company is offering its three<br />

categories of products and services on<br />

all markets. At country level, affiliates are<br />

now dealing with three families of solutions,<br />

Prescription, Self-medication and<br />

Aesthetic & Corrective. Each category<br />

remains unique and different, requiring<br />

a high level of specialized knowledge<br />

and dedicated resources. The pivotal<br />

role of the local teams is strengthened<br />

by the transversal expertise provided by<br />

the specialized Global Business Units,<br />

so that together they deliver the best<br />

solutions and services to healthcare<br />

professionals and patients. Expertise in<br />

the Aesthetic field, for example, does not<br />

rest in the simple sale of a product. It is<br />

more specifically about providing the<br />

proper service to a physician and ensuring<br />

the best patient experience. It might<br />

well involve helping a doctor develop<br />

his practice in a field with which he is<br />

not necessarily familiar. In this respect,<br />

providing physicians with services such<br />

as training sessions is essential. Similarly,<br />

the role of the Global Business Unit goes<br />

beyond developing and manufacturing<br />

new products. It also helps to earmark<br />

resources and build comprehensive programs<br />

to better deliver the Aesthetic &<br />

Corrective experience.<br />

Leveraging opportunities<br />

Another challenge of the new organization<br />

is leveraging existing opportunities<br />

throughout the company. Sharing<br />

services, production facilities and R&D<br />

across all three segments is essential.<br />

Integrating operations by monitoring<br />

results, providing guidelines and best<br />

practices is a common need. New synergies<br />

are identified between the different<br />

categories of products. Self-medication<br />

products, for instance, are derived from<br />

Prescription solutions or developed independently.<br />

Specific Self-medication<br />

marketing know-how and packaging<br />

are optimized for other categories of<br />

solutions, on consumer-driven markets<br />

where brand perception is crucial.<br />

Focusing on simplicity<br />

<strong>Galderma</strong>’s commitment is to develop<br />

business by keeping in touch and answering<br />

market needs. The human factor<br />

is ever present. The challenge of working<br />

across divisions and Global Business<br />

Units is first and foremost a question of<br />

helping people work together efficiently.<br />

For that reason, the company aims for<br />

simplicity. An entrepreneurial spirit is a<br />

precious asset for any fast-growing company,<br />

and <strong>Galderma</strong> strives to nurture<br />

that mindset. Its new organization aims<br />

at helping employees reach their goals<br />

and fulfill their ambitions. The foundation<br />

may be based on strategy, products<br />

and timely execution, but ultimately it is<br />

about sharing the same passion for and<br />

commitment to dermatology.<br />

The challenge of working<br />

across divisions and Global<br />

Business Units is first<br />

and foremost a question<br />

of helping people work<br />

together efficiently.<br />

<strong>Galderma</strong> UK: new models and partnerships<br />

<strong>Galderma</strong>’s broadening<br />

focus and three business<br />

models strategy have<br />

received strong feedback<br />

from affiliates and some<br />

markets have been<br />

prompt to implement<br />

these changes. The<br />

UK context has been<br />

particularly challenging<br />

as dermatology has been<br />

gradually pushed outside<br />

of the treatment scope<br />

of the National Health<br />

Service. As a result, fewer<br />

patients are referred to a<br />

dermatologist; GPs and<br />

nurses are encouraged to<br />

prescribe and treat. The<br />

government even created<br />

a Pharmacy “P” category,<br />

which allows the patient<br />

to obtain a prescription<br />

product from the<br />

pharmacist, bypassing a<br />

physician’s consultation<br />

fee. “Over the next five<br />

years, Self-medication<br />

products are expected<br />

to rival our Prescription<br />

business,” observes Larry<br />

Potgieter, General<br />

Manager <strong>Galderma</strong> UK<br />

& Ireland. “We plan<br />

to increase the Selfmedication<br />

team to<br />

support the doubling of<br />

this business every three<br />

years, and expand on<br />

our capabilities in the<br />

Aesthetic & Corrective<br />

business.” Developing<br />

promotion campaigns<br />

and building business<br />

partnerships are key for<br />

the Self-medication skin,<br />

hair and nail categories.<br />

In <strong>2012</strong>, <strong>Galderma</strong> UK<br />

implemented a media<br />

campaign for Curanail,<br />

resulting in 26% sales<br />

growth year-on-year and<br />

consolidating its<br />

leadership position in a<br />

highly competitive space.<br />

Another development is<br />

<strong>Galderma</strong> UK’s strategic<br />

alliance with Boots, leader<br />

in UK pharmacy retail. The<br />

partnership is structured<br />

to include Prescription to<br />

OTC switches as well as<br />

developing a ‘Serious<br />

Skincare Section’ in their<br />

pharmacies. As a result,<br />

<strong>Galderma</strong> UK reported<br />

a strong year, with a sales<br />

record of over €62 million<br />

in addition to winning<br />

numerous awards. These<br />

achievements reflect the<br />

priority of moving even<br />

closer to consumers while<br />

ensuring sales force<br />

excellence.<br />

Monitoring patient safety<br />

Vigilance Department collects, monitors and<br />

assesses adverse events reported in relation<br />

with use of <strong>Galderma</strong> products. <strong>Galderma</strong>’s<br />

close relationship with prescribers<br />

and authorities is key in facilitating the<br />

reporting of reactions to products. Often,<br />

healthcare professionals will mention the<br />

problems they encountered to <strong>Galderma</strong>’s<br />

sales representatives, who forward the<br />

information to a local safety officer, a local<br />

function in charge of product safety.<br />

All reports are processed in the company’s<br />

global database and assessed in terms of<br />

seriousness, listedness and causality. In<br />

<strong>2012</strong>, the company put in place a new global<br />

pharmacovigilance system, accessible<br />

for the main affiliates. Acting proactively,<br />

the same system will ultimately be used<br />

for product vigilance in the Aesthetic &<br />

Corrective field as well, in order to handle<br />

all vigilance issues regardless of the type<br />

of medicinal products (ie. drugs, medical<br />

devices or cosmetic) or any combination<br />

of these. <strong>Galderma</strong> is also actively adapting<br />

its processes to meet the new European<br />

legislation, with a shared emphasis on<br />

quality and compliance. Patient safety<br />

is ever the priority.<br />

+15.9% 53%<br />

GROWTH IN THE<br />

SELF-MEDICATION<br />

SEGMENT IN <strong>2012</strong>.<br />

4.73<br />

DAYS OF TRAINING<br />

BY EMPLOYEE IN <strong>2012</strong>.<br />

OF WOMEN<br />

A BALANCED GENDER<br />

DISTRIBUTION.<br />

18<br />

19


FOCUSED<br />

Engaged employees,<br />

empowered teams<br />

Alain Kirsch, Vice-President Human<br />

Resources, tells us about the first<br />

global employee survey conducted<br />

at <strong>Galderma</strong>.<br />

Why carry out a global<br />

employee survey<br />

Alain Kirsch: In <strong>2012</strong>, we felt the moment<br />

was right, given the recent change<br />

and growth we had experienced.<br />

It was the right time to take the pulse of<br />

our employees, to find out how they felt<br />

in the company and what areas we could<br />

improve.<br />

What did the survey show<br />

AK: A very large amount of data! There<br />

is plenty to learn in the comments our<br />

employees shared with us as part of the<br />

survey. Overall, the results show higher<br />

positive scores than our sector, the pharmaceutical<br />

industry sector, and reflect<br />

the high level of engagement. <strong>Galderma</strong><br />

is seen as a good employer.<br />

What actions will ensue<br />

AK: We will continue sharing our vision,<br />

strategies and ambitions. A bigger<br />

investment in training will be made,<br />

particularly in locations where learning<br />

activities were lacking. Several initiatives<br />

at global and local level are planned to<br />

improve people’s opportunities for developing<br />

employee evolution. Regarding<br />

organization effectiveness, delegation<br />

and empowerment, changes have<br />

been made, improving governance and<br />

project management prioritization processes.<br />

In response to the survey, many<br />

other initiatives will be launched in 2013.<br />

SURVEY: A VERY HIGH<br />

PARTICIPATION<br />

The global employee<br />

survey was conducted<br />

over three weeks in June<br />

and July <strong>2012</strong>, through<br />

an online questionnaire<br />

made available by Towers<br />

Watson, an HR consulting<br />

firm. Employee participation<br />

was very high: 92% filled<br />

in the form and one person<br />

in two volunteered<br />

additional comments, a<br />

remarkable qualitative<br />

contribution. The main<br />

finding of the survey is a<br />

very strong engagement of<br />

all employees, from senior<br />

managers to support staff.<br />

72.4%<br />

AVERAGE FAVORABLE<br />

SCORE ACROSS ALL<br />

CATEGORIES, RANGING<br />

BY ITEM FROM 60% TO<br />

90%, VERSUS 70% IN THE<br />

PHARMACEUTICAL NORM,<br />

(RANGING FROM 57% TO 87%).<br />

90% FAVORABLE<br />

FEEDBACK ON “GOALS AND<br />

OBJECTIVES”, THE HIGHEST<br />

SCORE OF THE SURVEY,<br />

AND EVEN HIGHER THAN<br />

THE HIGH PERFORMANCE<br />

COMPANIES.<br />

61% FAVORABLE<br />

FEEDBACK ON “TRAINING”,<br />

THE LOWEST SCORE OF<br />

THE SURVEY.<br />

Empowering teams for optimal performance<br />

How does Australia’s<br />

performance reflect<br />

the level of employee<br />

commitment<br />

Given the changes and<br />

extraordinary growth<br />

(+35.1%) we were<br />

experiencing as a business,<br />

<strong>2012</strong> was a critical period<br />

for managing compliance,<br />

commitment and<br />

communication.<br />

Our team was dedicated to<br />

achieving objectives that<br />

were clearly communicated<br />

and agreed upon.<br />

What initiatives were<br />

taken to further engage<br />

employees<br />

Staff received strong<br />

encouragement to<br />

reach beyond targeted<br />

objectives and find<br />

creative solutions within a<br />

framework. Management<br />

techniques were reviewed<br />

and employees helped to<br />

develop their knowledge<br />

and skills. All managers<br />

answered a 360° survey<br />

to identify best practices<br />

and areas of potential<br />

improvement for reaching<br />

superior employee<br />

engagement. Employees,<br />

in turn, were encouraged<br />

to be accountable for their<br />

results and empowered<br />

to “do business with<br />

customers”. Delegation and<br />

decision-making processes<br />

were optimized. Formal<br />

reports and customer<br />

reviews enabled staff to<br />

monitor and track results.<br />

What about improving<br />

team empowerment<br />

Effective knowledge<br />

sharing stimulates true<br />

employee empowerment.<br />

We actively promoted<br />

transparency, ensuring<br />

that expected outcomes<br />

were communicated,<br />

information was consistent<br />

and campaigns aligned.<br />

Business updates circulated<br />

via email, newsletters<br />

and presentations at<br />

sales meetings and staff<br />

communication sessions.<br />

How did individual<br />

training contribute<br />

We encouraged individuals<br />

to be accountable for<br />

their own learning and<br />

development, and provided<br />

access to an online selfdevelopment<br />

assessment<br />

tool. Employees received<br />

reports and strategic<br />

pointers to work on<br />

improvement areas. As a<br />

result, Australian employees<br />

are empowered to drive<br />

their own development,<br />

steer themselves and own<br />

their tasks.<br />

“Effective knowledge sharing<br />

stimulates true employee<br />

empowerment.”<br />

LISA GEORGE,<br />

HR MANAGER GALDERMA AUSTRALIA<br />

ETHICALLY ENGAGED<br />

Values, ethics and compliance<br />

are part of <strong>Galderma</strong>’s culture.<br />

The values set the framework for<br />

daily operations and are viewed as<br />

assets for the organization. High performance<br />

and high integrity are objectives<br />

that, far from clashing, work<br />

very well together. At <strong>Galderma</strong>,<br />

training and open dialogue related to<br />

ethics, compliance and legal topics<br />

are constants. Quality Assurance and<br />

compliance teams work hard to understand<br />

the business and always<br />

keep the company’s strategies and<br />

objectives in mind.<br />

Throughout the world, government<br />

and public scrutiny of the pharmaceutical<br />

industry is growing, notably<br />

regarding interactions with healthcare<br />

professionals. Relations between<br />

<strong>Galderma</strong> and healthcare professionals<br />

are transparent and<br />

focused on medical and scientific<br />

exchanges on diseases and their<br />

treatments.<br />

More generally, <strong>Galderma</strong> strives to<br />

meet the high standards of ethical<br />

practices in all its operations. The<br />

company’s Code of Ethics is more a<br />

statement of values and conduct<br />

than a set of rules. It addresses principles<br />

on interactions with healthcare<br />

professionals but also focuses<br />

on the patient and more generally<br />

people, caring for individuals and<br />

their balance, diversity and responsibility.<br />

The company requires employees<br />

to always act according to<br />

the Company values and Code of<br />

Ethics, with a strong reminder that<br />

the well-being of patients comes first<br />

and foremost. At <strong>Galderma</strong>, ethical<br />

behavior has no finish lines, we always<br />

strive to be better.<br />

20<br />

21


INNOVATIVE<br />

NICOLE LAUDIGNON AND<br />

THIERRY BILBAULT TALK ABOUT<br />

WHAT GOES INTO CULTIVATING<br />

INNOVATION THROUGH TEAMWORK,<br />

FROM EARLY R&D TO FULL-SCALE<br />

MANUFACTURING.<br />

How do you work together<br />

Nicole Laudignon: The Full Development<br />

Department develops products from their inception to<br />

their submission to Regulatory Authorities. Work with<br />

Manufacturing & Technical Operations (M&TO)<br />

begins at the very early stages of development, optimizing<br />

the progress from drug discovery to product<br />

development and full scale commercialization. Production<br />

knowledge and experience has to be transferred<br />

to M&TO as seamlessly as possible.<br />

Thierry Bilbault: Because we engage with R&D teams<br />

at the early development stage of a new chemical entity,<br />

we know which projects move into the scope of the Full<br />

Development team and when. Main deliverables and<br />

their timelines are determined together and monthly<br />

follow-up meetings on specific projects are held.<br />

How do you deliver an innovative medical solution<br />

NL: Our job is to design and develop innovative formulations,<br />

not only for new chemical entities but also<br />

throughout our products' life cycle management.<br />

TB: Beyond launching a product for the first time, innovation<br />

is how fast it can be rolled out to the rest of<br />

the world. Managing product life cycle is innovative:<br />

whether maintaining an existing solution on a market or<br />

finding new markets for it. Packaging must also be innovative,<br />

as we constantly strive to find the best way for<br />

patients to use a product with new features and benefits.<br />

...to delivering<br />

innovative<br />

medical<br />

solutions...<br />

NICOLE LAUDIGNON<br />

DIRECTOR OF FULL DEVELOPMENT<br />

(R&D)<br />

Tell us about a successful innovation…<br />

NL: Pliaglis Cream is a topical local anesthetic. It is applied<br />

as a cream and then dries to form a flexible membrane<br />

that can be peeled from the skin. The formulation<br />

of the product, composed of the two molecules, lidocaine<br />

and tetracaine, has been challenging: the “mixture”<br />

forms a homogeneous oil but needs to be integrated in a<br />

high water content to hydrate the skin. A solution for an<br />

optimized formulation was created by our development<br />

teams and successfully transferred to M&TO.<br />

TB: Working in tandem with the Full development<br />

team, in <strong>2012</strong> we launched, within 12 months after<br />

its transfer from Full Development to Manufacturing,<br />

Cetaphil Dermacontrol, a range of two cosmetic<br />

products designed for use in patients treated for acne<br />

including Cetaphil Dermacontrol Oil Control Foam<br />

Wash, a unique foaming formula packaged in an innovative<br />

packaging. Delivering a commercial product<br />

in fast track mode was a key deliverable and illustration<br />

of the speed-to-market process.<br />

THIERRY BILBAULT<br />

TECHNICAL DIRECTOR<br />

(M&TO)<br />

23


INNOVATIVE<br />

A unique capability<br />

in dermatological R & D<br />

Research & Development centers are<br />

spread across different continents to<br />

focus on local needs, discover new<br />

molecules and launch products able<br />

to help patients all through their lives.<br />

Innovation is built<br />

into <strong>Galderma</strong>’s DNA<br />

Today <strong>Galderma</strong> stands among the few<br />

companies capable of inventing, developing<br />

and bringing to market dermatological<br />

solutions that are truly innovative.<br />

The extent of its strong commitment to<br />

R&D and access to innovative technologies<br />

is reflected in an annual investment<br />

equivalent to 19% of the company’s<br />

sales. Beyond figures, creativity is also a<br />

mindset in all the company’s activities.<br />

The teams at <strong>Galderma</strong>’s major research<br />

facilities actively pursue creativity on a<br />

grand scale, through discovering and<br />

testing new molecules and compounds,<br />

adapting new packaging to new uses,<br />

and sourcing new functions and partnerships<br />

for existing products in cooperation<br />

with the world’s leading biotechnology<br />

companies and dermatological<br />

research units.<br />

Shaping the future<br />

At <strong>Galderma</strong>, innovation implies a global<br />

approach. It starts by observing and<br />

anticipating the global dermatological<br />

needs of patients, which are often very<br />

different in nature.<br />

Then, solutions are developed to answer<br />

these needs very specifically. Solutions<br />

are technology-based, in the broadest<br />

sense of the term, from molecules and<br />

new chemical entities (NCE) to various<br />

means of administration (oral, topical or<br />

injectable) and the regulatory status attributed<br />

to the solution, such as Prescription<br />

drugs, Self-medication products or<br />

Aesthetic & Corrective medical devices.<br />

Combining patient needs with innovation<br />

is what allows <strong>Galderma</strong> to contribute<br />

to shaping the future of dermatology.<br />

<strong>Galderma</strong> is the leader in filing patents<br />

within the field of dermatology.<br />

Patent champion<br />

If patent applications are an accurate<br />

measure of innovation, the results are<br />

consistent. For several years, <strong>Galderma</strong><br />

has been the leader in filing patents<br />

within the field of dermatology, with<br />

over 50 applications registered each<br />

year. In all, the company has filed more<br />

than 6,500 patent applications and<br />

patents worldwide since its founding.<br />

Innovation patents cover new molecules,<br />

galenic formulas, dermatology<br />

indications, manufacturing processes,<br />

packaging and many other categories.<br />

Throughout the years, <strong>Galderma</strong> has<br />

continually supported core research<br />

activities. For Prescription drugs, these<br />

range from early discovery phases to<br />

regulatory submissions and span several<br />

main therapeutic areas like acne,<br />

rosacea, steroid-responsive dermatoses,<br />

pigmentary disorders and nonmelanoma<br />

skin cancer. At each stage<br />

and across every field, innovation is<br />

a constant, even for well-established<br />

products. For example, Epiduo, the<br />

most prescribed branded topical agent<br />

used in the acne therapeutic field in<br />

the world (1) , has just been approved for<br />

populations aged 9 to 11 in the United<br />

States: a powerful innovation, based<br />

on the evidence of an effective and<br />

A global R&D<br />

presence<br />

<strong>Galderma</strong> has research<br />

and development facilities<br />

in France, Sweden, the<br />

United States and Japan.<br />

The Sophia Antipolis site in<br />

France is the world’s largest<br />

R&D center specialized<br />

in dermatology and has<br />

a staff of about 500. The<br />

center hosts <strong>Galderma</strong>'s<br />

in-house research,<br />

pre-clinical and core<br />

development activities.<br />

In Uppsala (Sweden),<br />

the Global Aesthetic<br />

Center of Excellence is<br />

dedicated to Aesthetic &<br />

Corrective treatments. Its<br />

80 researchers have built<br />

extensive expertise in the<br />

field of hyaluronic acid.<br />

The Princeton center<br />

(New Jersey, USA) is<br />

focused on clinical<br />

development projects,<br />

aiming at the registration<br />

of products in the US and<br />

Canada. Clinical studies<br />

also support regulatory<br />

submissions around<br />

the world. In Tokyo, the<br />

R&D team is dedicated<br />

to the development<br />

and registration of new<br />

products for Japan.<br />

Some of <strong>Galderma</strong>’s<br />

extensive clinical<br />

studies involve over<br />

1,000 patients in 30 to 60<br />

different locations.<br />

600<br />

MORE THAN<br />

600 EMPLOYEES IN THE<br />

SCIENTIFIC DIVISION.<br />

19%<br />

OF GALDERMA’S<br />

SALES ARE DEDICATED<br />

TO R&D AND ACCESS<br />

TO INNOVATIVE<br />

TECHNOLOGIES.<br />

57<br />

NEW PATENTS WERE<br />

REGISTERED IN <strong>2012</strong>.<br />

6,500<br />

PATENT APPLICATIONS<br />

AND PATENTS HAVE BEEN<br />

FILED BY GALDERMA SINCE<br />

ITS CREATION.<br />

12<br />

NEW CHEMICAL ENTITIES<br />

ARE IN DEVELOPMENT AND<br />

7 PRODUCTS ARE CURRENTLY<br />

BEING TESTED IN PHASE II AND<br />

PHASE III CLINICAL STUDIES.<br />

24<br />

25


INNOVATIVE<br />

safety-driven solution. Major new<br />

Prescription products are slated for<br />

launch over the next three years.<br />

New areas of research<br />

Self-medication offers a world of possibilities<br />

for innovation. Research is required<br />

to switch a Prescription product<br />

into a Self-medicated solution and file a<br />

successful submission to regulatory authorities.<br />

Loceryl nail lacquer is a good<br />

example of a category switch, allowing<br />

patients to self-treat. In the short term,<br />

a number of new Self-medication formulations<br />

and brands are expected to<br />

address the needs of patients satisfactorily.<br />

Improving patient compliance also<br />

means developing innovative products<br />

that are easy to use.<br />

The Aesthetic & Corrective segment is<br />

also a core research area, with a dedicated<br />

Center of Excellence in Uppsala,<br />

Sweden, where research and development<br />

of hyaluronic acid gel-based treatments<br />

is carried out. A key area of development<br />

is how to optimize product use<br />

and achieve excellent results with two or<br />

three times less product injections, for<br />

instance. Another key focus is clinical<br />

research: consumers, physicians and authorities<br />

alike are expressing an ongoing<br />

need for evidence-based, safe products.<br />

Ongoing development<br />

R&D resourcing is constantly being<br />

driven forward. New people are regularly<br />

recruited to strengthen teams and<br />

expand expertise. Establishing new collaborations<br />

with the best partners possible,<br />

be they small biotechnology companies<br />

or large pharmaceutical groups,<br />

is also a key source of creativity. A partnership<br />

with a major biopharmaceutical<br />

leader, the innovation-driven AstraZeneca,<br />

is currently exploring compounds<br />

developed for other indications, which<br />

could prove very useful in dermatology.<br />

Licensing agreements with other industry<br />

partners also provide synergistic<br />

frameworks that give the company an<br />

innovative edge within strategic areas of<br />

research, such as rare skin diseases.<br />

In the critical field of skin cancer, where<br />

many medical needs are still left unanswered,<br />

<strong>Galderma</strong> further expanded its<br />

collaborations this year with two leading<br />

dermatologists and authorities on<br />

skin cancers, and their teams: Professor<br />

Martine Bagot, of the Saint-Louis<br />

Hospital in Paris, France, and Professor<br />

Madeleine Duvic, Deputy Chairman<br />

of the Department of Dermatology at<br />

The University of Texas, MD Anderson<br />

Cancer Center in Houston, Texas, USA.<br />

Major innovations in the pipeline<br />

<strong>Galderma</strong>’s large network of experts<br />

also contributes to research, notably<br />

through carrying out clinical studies.<br />

Some studies are very extensive, involving<br />

1,000 patients or more and<br />

span 30 to 60 different locations at a<br />

given time around the globe. Currently,<br />

twelve new chemical entities are<br />

in development and seven products<br />

are tested in Phase II and Phase III<br />

clinical studies.<br />

In terms of research volume, diversity<br />

and skills, <strong>Galderma</strong> is well-positioned<br />

to come up with great new solutions.<br />

It is even possible that the company is<br />

reaching a major turning point. Over<br />

the last decade, it has been highly successful<br />

in finding new molecules and its<br />

knowledge base has expanded considerably.<br />

A substantial number of major<br />

innovations are now in the pipeline.<br />

Over the next five years, the company’s<br />

portfolio of marketed products will<br />

be deeply renewed across categories.<br />

Finding innovative solutions for people<br />

around the world will continue to be<br />

the strongest contribution <strong>Galderma</strong><br />

can make to the future of dermatology.<br />

(1) Source: IMS Health - Monthly Midas database,<br />

all countries selected - Topical anti acne market -<br />

Nov.<strong>2012</strong> MAT, retail Rx Market - at sales manufacturer<br />

local currency dollar value<br />

A partnership against antibiotic resistant impetigo<br />

<strong>Galderma</strong> has established<br />

a long-term Research<br />

and Development<br />

partnership with<br />

California-based biotech<br />

company NovaBay,<br />

to develop an effective<br />

treatment against<br />

impetigo and conduct its<br />

phase II clinical studies.<br />

Impetigo is a highly<br />

infectious bacterial<br />

skin disease that affects<br />

mostly children which,<br />

when left untreated,<br />

can lead to complications<br />

such as pneumonia<br />

or arthritis. Antibiotic<br />

treatments for the<br />

disease are increasingly<br />

obsolete, as the<br />

bacteria responsible for<br />

impetigo's transmission,<br />

Staphylococcus aureus<br />

and Streptococcus<br />

pyogenes, develop<br />

resistance to the agents<br />

used to overcome them.<br />

The non antibiotic, antiinfective,<br />

proprietary<br />

NVC-422 topical<br />

formulation (also known<br />

as Aganocide treatment),<br />

developed by the<br />

<strong>Galderma</strong> and NovaBay<br />

partnership, could replace<br />

traditional antibiotics<br />

in the treatment of<br />

impetigo. The topical<br />

NVC-422 preclinical and<br />

clinical safety has been<br />

established by <strong>Galderma</strong>,<br />

with the successful<br />

completion of studies<br />

involving more than<br />

300 healthy volunteers<br />

at 24 clinical sites in<br />

four countries, as well<br />

as the feasibility of<br />

manufacturing scale-up<br />

and long-term shelf life.<br />

In early 2013, the<br />

expansion of the phase IIb<br />

clinical trial for NVC-422<br />

will take place in South<br />

Africa. The incidence<br />

of the disease is known<br />

to be particularly high<br />

in tropical countries,<br />

including sub-Saharan<br />

Africa. "The treatment of<br />

impetigo is a significant<br />

unmet need in South<br />

Africa, and the expansion<br />

of this international study<br />

into that market is an<br />

important step for our<br />

partner <strong>Galderma</strong>," said<br />

Dr. Ron Najafi, Chairman<br />

and Chief Executive<br />

Officer of NovaBay.<br />

25,000<br />

SQ.METER<br />

THE SOPHIA ANTIPOLIS<br />

R&D CENTER IS GALDERMA’S<br />

LARGEST FACILITY.<br />

1,700<br />

SCIENTIFIC<br />

PUBLICATIONS IN <strong>2012</strong>.<br />

9-11<br />

EPIDUO HAS JUST BEEN APPROVED<br />

AS AN ADDITIONAL INDICATION<br />

FOR POPULATIONS AGED 9 TO 11<br />

IN THE UNITED STATES.<br />

11,000<br />

MORE THAN 11,000 MOLECULES<br />

TESTED BY END OF <strong>2012</strong>.<br />

1,750<br />

PHARMACEUTICAL<br />

REGISTRATIONS<br />

IN ALL GALDERMA'S<br />

AREAS OF EXPERTISE<br />

26<br />

27


INNOVATIVE<br />

Reactive and quality-driven<br />

manufacturing<br />

Internalizing production<br />

is a top priority for<br />

<strong>Galderma</strong>’s Manufacturing<br />

and Technical Operations.<br />

Because they are market-driven<br />

and flexible, <strong>Galderma</strong>’s Manufacturing<br />

and Technical Operations<br />

(the M&TO Division) provide an<br />

uninterrupted supply of the highest<br />

quality of Prescription, Self-medication<br />

and Aesthetic & Corrective<br />

products to affiliates and distributors<br />

around a fast changing world.<br />

Internalizing production<br />

At <strong>Galderma</strong>, manufacturing relies on<br />

four principles: safety, quality, service<br />

and cost efficiency. It is reviewed on an<br />

ongoing basis to provide the best level<br />

of performance while keeping unit<br />

costs in check. Market developments<br />

are also tracked closely, and processes<br />

are reorganized and adapted wherever<br />

growth potential is found.<br />

In <strong>2012</strong>, 75% of <strong>Galderma</strong> products<br />

were produced internally, compared to<br />

15% in 2000. When demand for new<br />

solutions reaches critical mass and<br />

forecasts point to sustainable demand,<br />

the M&TO Division evaluates<br />

the opportunity to internalize<br />

production, further improving<br />

product supply, quality, safety<br />

and reducing costs. This ongoing<br />

effort at <strong>Galderma</strong> should reach<br />

an in-house production target of<br />

80% by 2020; the current production<br />

exceeds 120 million units per year.<br />

Leveraging <strong>Galderma</strong>'s<br />

know-how<br />

The production facility in Alby-sur-<br />

Chéran (France) was opened in 1994<br />

and expanded to include the Industrial<br />

Development team in 1998. This<br />

site counts 270 employees, produces<br />

more than 40 million units per year and<br />

serves over 70 countries.<br />

The Industrial Development department<br />

spearheads development of clinical<br />

batches for trial worldwide, hones<br />

manufacturing processes for new<br />

products, acquisitions and transfers.<br />

In short, it is in charge of leveraging<br />

<strong>Galderma</strong>’s technical know-how, leading<br />

to improved global production<br />

performance.<br />

The Uppsala (Sweden) production<br />

site, formerly Q-Med, is part of the<br />

Center of Excellence for Aesthetic<br />

& Corrective solutions. As such, it is<br />

fully dedicated to the manufacturing<br />

of products in the aesthetics category,<br />

notably hyaluronic acid-based injectables.<br />

Uppsala counts 175 employees,<br />

and has an annual capacity of 10 million<br />

units, a production rate that allows<br />

the company to meet growing demands<br />

in the Aesthetic & Corrective dermatology<br />

market.<br />

Serving regional demand<br />

Since the year 2000, the manufacturing<br />

site at Baie d’Urfé (Canada) produces<br />

Prescription products for the US market<br />

and Self-medication products for all<br />

markets, in both liquid and semi-liquid<br />

formulas. Annual production here is<br />

65 million units, with a headcount of<br />

270 employees.<br />

Life cycle management brings more to products<br />

Patient needs differ<br />

from one region or<br />

country to another.<br />

<strong>Galderma</strong> life cycle<br />

management addresses<br />

these specificities while<br />

helping to keep products<br />

on a certain market or<br />

find new markets for<br />

existing ones. A classic<br />

example is switching a<br />

Prescription product<br />

into a Self-medication<br />

solution. In China, for<br />

instance, Government<br />

policy and consumer<br />

habits favor over-thecounter<br />

medication, and<br />

the rollout of accessible,<br />

effective consumerdriven<br />

brands suits local<br />

market conditions.<br />

In certain markets,<br />

products can also be<br />

updated to bring new<br />

benefits to patients.<br />

Introducing a new pump<br />

application system,<br />

for example, has been<br />

shown to improve patient<br />

compliance. Once a<br />

patient need is identified,<br />

a comprehensive<br />

presentation of technical<br />

options makes it possible<br />

to evaluate and test<br />

concepts or prototypes<br />

with patients and<br />

customers.<br />

The company’s Industrial<br />

Development team and<br />

associated packaging<br />

development teams<br />

oversee the execution<br />

of packaging-based<br />

initiatives that make<br />

a real difference to<br />

consumers and patients.<br />

The first challenge is to<br />

collect input from all<br />

relevant stakeholders<br />

including markets, global<br />

marketing, Research &<br />

Development, industrial<br />

sites and functions,<br />

then identify innovative<br />

and global packaging<br />

solutions that will meet<br />

required criteria:<br />

patient acceptability,<br />

technical aspects, cost,<br />

speed to market, etc.<br />

In <strong>2012</strong>, examples of new<br />

life cycle management<br />

product launches in<br />

<strong>2012</strong> included the US<br />

launches of Epiduo pump<br />

(under development<br />

for global roll-out),<br />

Differin 0.3%, Metrogel<br />

pumps and Clobex Spray<br />

Improved Nozzle.<br />

75 %<br />

OF GALDERMA PRODUCTS<br />

ARE SOURCED INTERNALLY.<br />

152<br />

MILLION UNITS<br />

PRODUCED IN <strong>2012</strong>.<br />

800<br />

EMPLOYEES IN THE MANUFACTURING<br />

& TECHNICAL OPERATIONS DIVISION.<br />

+40%<br />

PRODUCTION CAPACITY<br />

AFTER PLANT EXTENSIONS IN FRANCE<br />

AND CANADA IN 2011.<br />

28<br />

29


INNOVATIVE<br />

Since 2004, a production site in Hortolândia<br />

(Brazil) has served the Latin<br />

American market; it also manufactures<br />

some solutions for the global market<br />

(excluding the U.S.). The site, which<br />

has a staff of 50, has a production of 6<br />

million units in liquid and paste form<br />

per year. However, Hortolândia’s capacity<br />

is quickly expanding in order<br />

to better serve a fast-growing regional<br />

market and anticipate new needs.<br />

Shaping a new industrial<br />

landscape<br />

The Alby, Baie d’Urfé and Hortolândia<br />

sites are ISO 14001 (environment)<br />

and OHSAS 18001 (safety) certified.<br />

All sites are regularly audited by health<br />

authorities such as the FDA (United<br />

States), ANVISA (Brazil), ANSM<br />

(France) or the KFDA (South Korea).<br />

The acquisition of Spirig, announced<br />

at the end of <strong>2012</strong>, offers <strong>Galderma</strong><br />

an opportunity to shape a new industrial<br />

landscape and forge a new path<br />

to the manufacturing of solids, one of<br />

the Swiss company’s areas of expertise.<br />

Spirig’s Egerkingen headquarters will<br />

become a Center of Excellence with a<br />

strong manufacturing arm.<br />

<strong>Galderma</strong>’s remaining production is<br />

outsourced to some 40 subcontractors,<br />

which comply with same set of specifications<br />

and requirements exercised<br />

by the company in its own plants. Each<br />

supplier is fully committed to applying<br />

the <strong>Galderma</strong> Code of Ethics, as part<br />

of the company’s general purchasing<br />

terms. A dedicated team of the M&TO<br />

Division works closely with subcontractors,<br />

who are audited according to the<br />

same key performance indicators observed<br />

in <strong>Galderma</strong>’s units. Nevertheless,<br />

internalizing production remains a<br />

top priority. The high standards of quality<br />

and productivity within the company<br />

make it possible to leverage 20% of<br />

costs when a product is manufactured<br />

in-house.<br />

Manufacturing at <strong>Galderma</strong> is in a<br />

constant state of flux: thanks to new or<br />

increased capacity, geographical expansion<br />

and market opportunities, production<br />

organization is striving for a leaner,<br />

more reactive and flexible outfit.<br />

Optimized supply chain<br />

“Flexibility” is the key<br />

word for <strong>Galderma</strong>’s<br />

future supply chain across<br />

the organization. One<br />

of the company’s main<br />

challenges for the future is<br />

serving consumer-driven<br />

market needs, as in the<br />

case of Self-medication<br />

solutions. This fast<br />

moving market is less<br />

predictable and more<br />

volatile than traditional<br />

product categories such<br />

as Prescription. To act<br />

quickly and efficiently<br />

on these segments, the<br />

company must involve<br />

all its main functions in<br />

product launches and<br />

structure a responsive<br />

supply chain. Specifically,<br />

the new organization will<br />

improve time to market<br />

for all products. A lean<br />

and transversal process<br />

is now in motion, based<br />

on a three-year roadmap<br />

and key performance<br />

indicators, involving both<br />

global business units and<br />

teams at market level.<br />

A pillar of future logistics<br />

is a new regional<br />

organization. Regional<br />

Sales and Operational<br />

Planning, for instance,<br />

will improve industrial<br />

resource management<br />

and support better<br />

sales forecast. Planning<br />

functions are combined,<br />

with a regional supply<br />

chain management for<br />

enhanced efficiency. The<br />

benefits expected from<br />

this new organization<br />

are decreasing air freight<br />

and reducing product<br />

obsolescence, inventory<br />

and subcontracting.<br />

An improved businessdriven<br />

process will bring<br />

significant savings to the<br />

company while serving<br />

market needs more<br />

efficiently.<br />

A 10-YEAR<br />

INDUSTRIAL PLAN<br />

DRIVEN<br />

BY GROWTH<br />

Over the next ten years, the<br />

company will focus on growth<br />

markets and increase its manufacturing<br />

capacity according to market<br />

potential. Bringing production<br />

closer to the demand is a logical<br />

move. Being able to manufacture<br />

in a more reactive and flexible<br />

way will meet market needs better.<br />

This priority is backed by a new<br />

transversal approach to manufacturing,<br />

in which dedicated teams<br />

track markets and strive to fully<br />

understand needs. This knowledge<br />

is then translated into a proactive<br />

production strategy. Since it was<br />

first implemented in North America,<br />

the growth-driven production<br />

principle has rolled out to Brazil,<br />

where <strong>Galderma</strong>’s Hortôlandia<br />

plant will expand to better serve<br />

this high-growth market and other<br />

Latin American countries. China,<br />

India and South East Asia are also<br />

priorities.<br />

4<br />

The<br />

MANUFACTURING SITES:<br />

FRANCE (ALBY-SUR-CHÉRAN)<br />

SWEDEN (UPPSALA), CANADA<br />

(BAIE D’URFÉ), AND BRAZIL<br />

(HORTOLÂNDIA).<br />

announcement<br />

of Spirig acquisition<br />

will bring additional<br />

manufacturing and<br />

R&D capabilities in<br />

Egerkingen.<br />

40<br />

SUBCONTRACTORS, COMPLYING WITH SAME SET<br />

OF SPECIFICATIONS AND REQUIREMENTS EXERCISED<br />

BY THE COMPANY IN ITS OWN PLANTS.<br />

At <strong>Galderma</strong>, manufacturing<br />

relies on four principles:<br />

safety, quality, service and<br />

cost efficiency.<br />

30<br />

31


WENDY ADAMS AND MARC<br />

WANNHOFF TALK ABOUT HOW<br />

GALDERMA GROWS AND<br />

EVOLVES THROUGH A CLOSE<br />

RELATIONSHIP WITH PATIENTS.<br />

helps address cost containment. Also, the Aesthetics<br />

& Corrective category is growing as the population<br />

lives longer.<br />

Mark Wannhoff: In Germany also, the interest in<br />

aesthetic solutions is growing. As the population ages,<br />

people want to look as good as they feel inside.<br />

SPECIALISTS<br />

...to meeting the<br />

dermatological<br />

needs of people<br />

throughout<br />

their lifetime...<br />

WENDY ADAMS<br />

GENERAL MANAGER<br />

GALDERMA CANADA<br />

What new needs are patients expressing today<br />

Wendy Adams: In Canada, ethnic diversity is prevalent<br />

and changing quickly. Patients want products<br />

that care for their specific needs and easier access to<br />

dermatologists. Fewer new medications are getting reimbursed,<br />

so increasing the Self-medication portfolio<br />

How are you responding to those needs<br />

MW: We don’t only offer selective treatments in dermatology;<br />

we provide a full approach. In Germany, almost<br />

100 sales reps have daily contact with customers,<br />

nearly 1,000 exchanges per day. That’s the basis for everything,<br />

and it cascades within our organization. We<br />

demonstrate our commitment to dermatology through<br />

funding various awards for scientific research in dermatology,<br />

for example, and market activities such as<br />

in-pharmacy patient information days and awareness<br />

campaigns, like the ‘Skin Health Days’ events held<br />

about 15 times per year.<br />

WA: We’ve been fortunate in putting products on the<br />

market for Prescription and Self-medication and we’re<br />

considering Pliaglis within our Aesthetic & Corrective<br />

business. We’re simplifying our solutions, which also<br />

helps with compliance. Patient education is a focus: we<br />

reach out to teens in their lingo and our Cetaphil club<br />

has over 30,000 online members.<br />

What future developments are you excited<br />

about now<br />

WA: We’ve begun installing computer terminals in dermatology<br />

and family physicians’ clinics to help educate<br />

patients. Dermatology is so visual: <strong>Galderma</strong> is leading<br />

the way with this initiative.<br />

MW: Interaction is key: getting feedback from patients<br />

about what they need and what has helped them deal<br />

with their issues in daily life is deeply gratifying.<br />

MARK WANNHOFF<br />

GENERAL MANAGER<br />

GALDERMA GERMANY<br />

33


SPECIALISTS<br />

A new dermatology landscape<br />

The field of dermatology is changing<br />

fast: the emergence of new markets,<br />

the maturing of established ones<br />

and the importance of the digital<br />

age demand targeted, customtailored<br />

and evidence-based solutions<br />

for patients, healthcare<br />

professionals and authorities alike.<br />

A tectonic shift is underway in the dermatology<br />

landscape. New populations<br />

of consumers are growing exponentially.<br />

People in traditional markets are<br />

changing how and where they consume;<br />

response to health reforms and a<br />

desire to age gracefully are also at play.<br />

Consequently dermatology is receiving<br />

a lot of attention and <strong>Galderma</strong> is<br />

spearheading the change. Its roll-out of<br />

innovative medical solutions in the Prescription,<br />

Self-medication or Aesthetic<br />

& Corrective segments has significantly<br />

increased, serving patients all around<br />

the world. For example, the creation of<br />

a Global Aesthetic Center of Excellence,<br />

in Uppsala (Sweden), underscores the<br />

company’s holistic commitment to better<br />

serving an expanding market.<br />

As new needs appear, <strong>Galderma</strong> is working<br />

closely with healthcare professionals,<br />

focusing on services, solutions and better<br />

serving patients. Building new product<br />

segments, focusing on demands, investment<br />

and reactivity, <strong>Galderma</strong> is organized<br />

to deliver a synergistic portfolio<br />

across its three businesses. By adapting<br />

offers to customers and practitioners<br />

within various markets, by remaining<br />

close to patient feelings and aspirations,<br />

the company has improved the dermatological<br />

experience for all.<br />

Responding to new market needs<br />

The population explosion in emerging<br />

countries has opened an important<br />

new area for dermatology: by 2030,<br />

80% of the global middle class will live<br />

there. The rise of younger, Internet<br />

<strong>Galderma</strong> is adapting its offers to customers<br />

and practitioners within various markets.<br />

and media-savvy consumers in places<br />

such as Asia, Eastern Europe, India and<br />

Brazil shows the importance in getting<br />

the right product to the right consumer,<br />

swiftly. Building trust is key. Thanks<br />

to demographics’, growing spending<br />

power and increasingly well-informed<br />

interest in proper skincare, <strong>Galderma</strong><br />

has responded to strong needs across its<br />

three businesses within new markets.<br />

In the Prescription business, for example,<br />

treatments for acne and rosacea<br />

serve significant demand across regions,<br />

with Epiduo as a leading drug bringing<br />

efficacy and safety in the treatment of<br />

mild, moderate and severe acne. Recent<br />

launches such as Oracea, or the increasing<br />

interest in Rozex, even strengthen the<br />

comprehensive drug portfolio. In 2014,<br />

<strong>Galderma</strong> will reinforce this momentum<br />

with the roll-out of a new treatment of<br />

erythema associated with rosacea.<br />

Promoting synergies<br />

between markets<br />

While facilitating global roll-outs, the<br />

company is also capitalizing on lessons<br />

learned in new markets, leveraging<br />

them to better serve previously established<br />

ones. The strong support of<br />

specific innovative initiatives facilitates<br />

synergies among disparate markets,<br />

Cetaphil: an<br />

expanding asset<br />

Cetaphil products have<br />

offered patients effective<br />

and adapted cleansing and<br />

moisturizing skincare<br />

solutions for over sixty<br />

years. The range has<br />

evolved over the years to<br />

address more specific<br />

needs and today includes<br />

16 products. The Disease-<br />

Specific Product (DSP)<br />

range has been developed<br />

to meet the requirements<br />

of physicians for a specially<br />

adapted therapeutic<br />

skincare range, such as<br />

Cetaphil Restoraderm for<br />

people suffering from<br />

atopic dermatitis, the<br />

number 1 skin condition<br />

encountered by<br />

dermatologists. The recent<br />

launch of Cetaphil<br />

Dermacontrol provides a<br />

therapeutic skincare range<br />

for patients treated for<br />

acne, in particular, a face<br />

wash and facial moisturizer<br />

SPF 30 which make the<br />

daily treatment regime<br />

easier to follow. The DSP<br />

portfolio registers the<br />

highest sales growth of<br />

the brand: +37% in <strong>2012</strong>.<br />

95%<br />

OF 1.4 BILLION NEW INHABITANTS<br />

IN THE WORLD OVER THE NEXT<br />

TWENTY YEARS ARE EXPECTED<br />

TO BE BORN IN ASIA AND AFRICA. (1)<br />

1<br />

BILLION PEOPLE<br />

IN 2030 WILL BE AGED<br />

OVER 65 YEARS BY 2030,<br />

VERSUS 8% TODAY (1) .<br />

(1) Source: U.N. Population<br />

Prospects, The 2010 Revision.<br />

+5.8%<br />

THE PROJECTED ANNUAL INCREASE OF GLOBAL<br />

HEALTH SPENDING UP TO 2020, OUTSTRIPPING<br />

PROJECTED GLOBAL ECONOMIC GROWTH.<br />

Source: Bain (2011), The Great Eight – Trillion Dollar<br />

Growth Trends to 2020.<br />

3.2<br />

BILLION PEOPLE WILL BELONG<br />

TO THE GLOBAL MIDDLE CLASS BY 2020,<br />

VERSUS 1.8 BILLION IN 2010.<br />

Source: OEDC Development Centre, The<br />

Emerging Middle Class.<br />

34<br />

35


SPECIALISTS<br />

with products from all portfolios earmarked<br />

to receive extra resources and<br />

focus. One of these products was the highpotential<br />

Restylane Skinboosters treatment.<br />

Two countries in different stages<br />

of development were chosen to source<br />

best practices: Mexico, a high potential<br />

market, and Sweden, with a solid customer<br />

base. After launching a campaign<br />

combining outdoor, print, digital and PR<br />

communications with an in-clinic campaign,<br />

Restylane Skinboosters established<br />

itself as the major aesthetic treatment in<br />

each market.<br />

Camp Wonder: a special<br />

summer for children with<br />

skin diseases<br />

Promoting international exchanges<br />

Today, healthcare reform dominates headlines<br />

in mature markets. Governments in<br />

Europe and around the world continue to<br />

cut costs by de-reimbursing certain categories<br />

of prescription treatments. Products<br />

become generic or over-the-counter<br />

and patients and consumers are increasingly<br />

forced to pay out of their pocket.<br />

A new market for reliable and value priced<br />

self-medicated dermatological solutions is<br />

emerging, in which <strong>Galderma</strong> is bringing<br />

innovative and high-quality offers.<br />

The ageing of the European population<br />

has created new needs. People remain active<br />

both inside and outside of the professional<br />

arena. Consumers want to look as<br />

good as they feel and an increasing number<br />

of quality injectors and techniques<br />

drive strong growth in the Aesthetic &<br />

Corrective category. Patient demand for<br />

more strictly regulated product approval<br />

and marketing of facial fillers favor evidence-based<br />

companies, such as <strong>Galderma</strong>.<br />

Building strong partnerships with authorities<br />

to ensure appropriate consumer<br />

safety is a necessity.<br />

To this end, <strong>Galderma</strong> is reinforcing its<br />

engagement in clinical studies worldwide,<br />

forging partnerships with academic institutions<br />

and organizations, supporting<br />

Young patients with chronic and lifethreatening<br />

skin diseases as well as their<br />

families are subjected to an unusual set of<br />

constraints. In the U.S., <strong>Galderma</strong> partners<br />

through the brand Cetaphil with the nonprofit<br />

Children Skin’s Disease Foundation,<br />

the founder of Camp Wonder. Camp<br />

Wonder is a free of charge summer camp<br />

in California, where 100 children aged<br />

7 to 16 can get a week away from stares and<br />

bullies and instead experience the childhood<br />

joys of summer camp. Acceptance and<br />

empowerment are the foundation of Camp<br />

Wonder’s philosophy. Counselors are<br />

often former campers, facilities are fully<br />

educational programs like Euroderm<br />

Excellence (see page 43). Promoting better<br />

knowledge of dermatology, diseases<br />

and treatments, the company has devoted<br />

considerable energy and investment<br />

to supporting global and local congresses<br />

in the field. It vows to promote exchange<br />

and attain a deeper understanding of what<br />

physicians and patients are looking for<br />

now and in the future.<br />

Connecting with people<br />

Today, <strong>Galderma</strong> is an industry leader<br />

in anticipating patient needs, researching<br />

and developing new ideas. Experience<br />

demonstrates that, no matter what<br />

the medical field or platform may be,<br />

investing time in cultivating relationships<br />

and exchanging information will always<br />

be an organization’s greatest strength.<br />

In times of change, the best way to prepare<br />

for the future is to connect with<br />

people. All of them.<br />

handicapped accessible and activities are<br />

tailored for every camper’s needs. A large<br />

on-site medical staff of volunteer physicians,<br />

nurses, medical students and other<br />

healthcare professionals offer children a safe<br />

and happy experience. As a proud supporter<br />

of Camp Wonder, <strong>Galderma</strong> provides a<br />

generous grant and employee volunteers<br />

during the camp and throughout the year.<br />

Learn more on: http://www.csdf.org<br />

Lena’s aesthetic treatment<br />

“I decided to have some<br />

aesthetic treatment when<br />

I discovered that the older<br />

I got, the more I was<br />

fighting a losing battle<br />

against gravity. Everything<br />

started going downwards!<br />

It is a fact of life, but<br />

nonetheless a sad one.<br />

So when I realized you can<br />

do something about it<br />

without a major procedure,<br />

I set up a time for a<br />

consultation with a clinic.<br />

I wanted to do something<br />

about my tired-looking<br />

eyes. Also, the wrinkles<br />

around my mouth made<br />

me look annoyed and<br />

irritated, which is really<br />

something I am not! I was<br />

surprised at how little time<br />

it took to do the treatment,<br />

I had thought it would be<br />

much more complicated,<br />

but it only took half an hour<br />

and wasn't dramatic at all.<br />

I got a small bruise from the<br />

injection, but could easily<br />

cover it with a concealer<br />

and no-one could see<br />

anything the day after.<br />

While I was at the clinic,<br />

I learned about the<br />

skinboosters and<br />

became curious about<br />

them, because my<br />

skin was a bit dry.<br />

I booked a series of<br />

treatments, as you have<br />

to repeat them for<br />

maximum effect.<br />

I am amazed when I look<br />

at the results today.<br />

“It has really been a lift for me<br />

mentally as well. I think the<br />

connection between looking good<br />

and feeling good is really strong.”<br />

LENA AUGUSTSSON ,<br />

STOCKHOLM, SWEDEN<br />

I feel a lot fresher now,<br />

I think the treatments have<br />

made me look at least<br />

6–7 years younger.<br />

It has really been a lift<br />

for me mentally as well<br />

because I think that<br />

the connection between<br />

looking good and feeling<br />

good is really strong.<br />

The funny thing is that<br />

although a lot of people<br />

have told me I look much<br />

more alert now, no one has<br />

suspected anything or<br />

asked if I have had a<br />

procedure done. Which<br />

is quite amazing, because<br />

I can easily tell the<br />

difference from looking<br />

at photos of myself before<br />

and after the treatment.”<br />

IMPROVING MEDICATION<br />

AGAINST ROSACEA<br />

Leader on the rosacea market,<br />

<strong>Galderma</strong> is about to bring to<br />

market a new solution for redness,<br />

subject to approval by<br />

health authorities. Rosacea is a<br />

common, chronic inflammatory skin<br />

disease. Fair-skinned individuals and<br />

women tend to be more prone to the<br />

disease. Both genetic and environmental<br />

factors may be involved in<br />

the pathogenesis, but research has<br />

yet to reveal its exact causes. Sufferers'<br />

most frequent complaint is about<br />

intense redness of the facial skin, often<br />

accompanied by flushing, visible<br />

blood vessels and pimples. Rosacea<br />

can cause emotional distress including<br />

embarrassment, anxiety and low<br />

self-esteem. This is a major reason<br />

why the proper treatment of rosacea<br />

through the improvement of the<br />

physical signs and symptoms of the<br />

disease can contribute to patients’<br />

psychosocial well-being. While there<br />

is still no cure for rosacea, <strong>Galderma</strong><br />

has long been the leader in providing<br />

sufferers with effective and safe treatments<br />

like Rozex/Metro and Oracea.<br />

On condition of its approval by<br />

health authorities, <strong>Galderma</strong> should<br />

offer a new innovative treatment for<br />

the erythema of rosacea. In clinical<br />

studies, once daily application of the<br />

gel was well-tolerated, offering fast<br />

and durable relief from redness. It<br />

would be the first approved medication<br />

specifically developed to directly<br />

target the erythema of rosacea. As<br />

part of <strong>Galderma</strong>’s holistic approach<br />

to providing innovative dermatological<br />

solutions, besides prescription<br />

drugs, patients need to be counseled<br />

about potential trigger factors for rosacea<br />

and on the use of gentle, nonirritating<br />

skin care products.<br />

36<br />

37


SPECIALISTS<br />

<strong>Galderma</strong>’s key<br />

therapeutic areas<br />

ACNE<br />

ROSACEA<br />

PIGMENTARY<br />

DISORDERS<br />

ONYCHO-<br />

MYCOSIS<br />

PSORIASIS<br />

SKIN<br />

SENESCENCE<br />

SKIN CANCER<br />

RARE SKIN<br />

DISEASES<br />

Acne is a chronic<br />

inflammatory skin disease of<br />

the pilosebaceous gland, linked<br />

to changes in hormone levels,<br />

the condition can last several<br />

years. Acne occurs when the<br />

follicular canals of the gland<br />

become blocked with excess<br />

sebum (a fatty secretion)<br />

and dead cells and presents<br />

as inflamed pustules and<br />

painful red pimples, most<br />

commonly on the face, but<br />

also on the back and chest.<br />

Rosacea is a chronic<br />

inflammatory skin condition<br />

characterized by facial redness,<br />

which is by firstly intermittent<br />

but then becomes permanent.<br />

The disorder, which affects the<br />

T-zone (nose, cheeks, forehead<br />

and chin), can produce other<br />

symptoms such as broken<br />

blood vessels and, occasionally,<br />

papules and pustules which can<br />

look like acne. Rosacea mostly<br />

affects people between the<br />

ages of 30 and 60 and tends<br />

to occur more frequently<br />

among fair-skinned individuals<br />

with light-colored eyes.<br />

Two to five percent of North<br />

Europeans and Americans<br />

suffer from this disorder.<br />

Pigmentary disorders are<br />

characterized by an increase<br />

or decrease in skin pigment.<br />

Melasma (commonly<br />

known as the pregnancy<br />

mask) is the most frequent<br />

disorder, affecting 50 to 70%<br />

of pregnant women. This<br />

hyperpigmentation disorder<br />

can occur following exposure<br />

to the sun or hormonal changes.<br />

Vitiligo is a pigmentary<br />

disorder that affects 0.5 to 2%<br />

of the global population. It is<br />

characterized by white patches<br />

on the skin, usually on the face,<br />

hands, feet and frictional areas.<br />

Onychomycosis (or nail<br />

mycosis) is an increasingly<br />

common disorder, affecting<br />

around 10% of the world<br />

population. One in two people<br />

over the age of 70 suffers<br />

from it. Onychomycosis is<br />

caused by a microscopic fungus<br />

and tends to be more common<br />

in the toe nails. It is a highly<br />

contagious disorder that can<br />

destroy the nail if not treated.<br />

Psoriasis is a chronic,<br />

inflammatory skin disorder<br />

characterized by red, scaly<br />

and sometimes itchy patches.<br />

It affects around 2 to 3 % of<br />

the world population.<br />

It is a lifelong condition with<br />

relapses and remissions that<br />

are both emotionally and<br />

physically stressful. Psoriasis<br />

often develops on the scalp<br />

and nails, and can involve<br />

swelling and pain in the joints<br />

(psoriatic arthritis). There is<br />

currently no cure, but existing<br />

treatments help sufferers<br />

manage their symptoms.<br />

Skin aging is caused by the<br />

passage of time, but also by<br />

exposure to the sun and UV<br />

rays (photoaging). Its effects<br />

can be treated with drugs and<br />

medical procedures such as<br />

injections or laser therapies.<br />

Actinic keratoses are<br />

precancerous lesions frequently<br />

found in fair-skinned patients,<br />

especially with chronic sun<br />

exposure. The lesions appear<br />

as rough, scaly patches on<br />

sun-exposed areas of the body.<br />

If left untreated, they can<br />

develop into a fast-evolving<br />

form of skin cancer called<br />

squamous cell carcinoma.<br />

Basal cell carcinoma is the most<br />

common skin cancer among<br />

fair-skinned people. It affects<br />

mainly sun-exposed areas of the<br />

skin. It is not life-threatening,<br />

but the carcinomas enlarge,<br />

become locally invasive and<br />

can ulcerate. Melanoma is a skin<br />

cancer developing from cells<br />

producing melanin in the skin,<br />

known as melanocytes.<br />

It is the most life-threatening<br />

skin cancer, and often<br />

presents as an asymmetric<br />

pigmented lesion with irregular<br />

borders. Any change in its<br />

color, size or shape requires<br />

immediate consultation with<br />

a dermatologist.<br />

<strong>Galderma</strong> is currently exploring<br />

the treatment of few rare skin<br />

diseases. Congenital ichthyosis<br />

often occurs in a severe form<br />

in the first years of life. Later on<br />

it causes thick, dry, white scales<br />

to appear on the skin which can<br />

be debilitating in their more<br />

severe forms. Palmoplantar<br />

keratodermas are characterized<br />

by an abnormal thickening of<br />

the skin on the palms and soles.<br />

Cutaneous T-cell lymphomas<br />

result from uncontrolled<br />

proliferation of T lymphocytes.<br />

Clinically, it is evidenced by<br />

red scaly patches which are<br />

sometimes pruritic and can<br />

evolve into cutaneous, lymph<br />

nodes or visceral tumors. Gorlin<br />

syndrome is an inherited disease<br />

mainly affecting the skin and<br />

causing basal cell carcinomas<br />

to appear early in life.<br />

38<br />

39


PARTNERS<br />

PARTNERING WITH HEALTHCARE<br />

PROFESSIONALS TO DELIVER VALUE<br />

IS A PRIORITY FOR BENOIT CHARDON<br />

AND BRIAN JOHNSON.<br />

How do you best serve healthcare professionals<br />

in your markets<br />

Benoit Chardon: The Aesthetic & Corrective business<br />

is driven by physicians. Beyond supplying innovative,<br />

high-quality and safe products, we help them<br />

build their practices. Our Alliance Service Program<br />

includes advanced medical education, patient management,<br />

business consulting, merchandising and soon an<br />

e-learning platform.<br />

Brian Johnson: We meet practitioners every day and<br />

understand their medical and business needs. Explaining<br />

how new treatments serve their practice helps<br />

them. Patients’ needs change and clarify: it is easier<br />

to exchange with physicians when we have the right<br />

solution for them. We also support continuous medical<br />

education programs for dermatologists.<br />

Adherence and Performance) program for Epiduo<br />

helps teenagers and young adults follow their treatment<br />

and interact with the brand. We participate in<br />

disease awareness programs like “Face-to-face” for<br />

rosacea, and support events like those organized by the<br />

National Psoriasis Foundation.<br />

BC: In South Korea and China, we launched a successful<br />

Restylane celebrity campaign on TV, building<br />

market and brand equity. In EMEA & Latin America, a<br />

disruptive “before & after” campaign in waiting rooms<br />

associated for the first time premium quality photos<br />

with real-life people testimonials. Direct to consumer<br />

communication is considered by healthcare professionals<br />

as one of the best business drivers.<br />

BRIAN JOHNSON<br />

VICE-PRESIDENT<br />

PRESCRIPTION MARKETING<br />

GALDERMA USA<br />

What has changed in your service<br />

to healthcare providers<br />

BC: With new research on consumer behavior towards<br />

aesthetic procedures, physicians understand better<br />

their new role in serving consumers. They realize that<br />

“patients” are expecting a premium service rather than<br />

a treatment for illness.<br />

BJ: We help practitioners provide value in new situations,<br />

by providing the widest range of innovative<br />

products and services. For example, Tri-Luma, the<br />

only FDA-approved treatment for melasma, can now<br />

be either dispensed by the physician in his office or<br />

prescribed to the patient.<br />

...while serving<br />

healthcare<br />

professionals...<br />

How do you talk directly to patients<br />

BJ: We help patients understand their disease and<br />

improve their experience. The TAP (Treatment,<br />

BENOÎT CHARDON<br />

HEAD OF FACIAL AESTHETICS<br />

41


PARTNERS<br />

A professional commitment<br />

With the Internet and new forms of<br />

media, the dependence of patients<br />

on a healthcare professional’s advice<br />

has changed. Like elsewhere,<br />

proactive self-education and<br />

shared responsibility are strong<br />

trends in dermatology.<br />

Partnering with professionals<br />

<strong>Galderma</strong> shares with healthcare professionals<br />

the mission of finding the<br />

right solutions for the changing needs<br />

of patients. A key part of that goal is<br />

developing partnerships with these<br />

professionals, to help them understand<br />

and better explain treatment benefits to<br />

patients who are more aware of their<br />

condition than before. Dermatologists<br />

are the most highly qualified medical<br />

professionals to deal with skin conditions,<br />

but there are many other healthcare<br />

providers who help patients find<br />

the right treatments for their needs.<br />

Among them, general practitioners,<br />

pediatricians, plastic surgeons, oncologists<br />

and gynecologists are increasingly<br />

treating skin conditions. Nurses are in<br />

constant contact with patients. Pharmacists<br />

play a key role in ensuring that<br />

the right products and solutions reach<br />

the patient, particularly in the case of<br />

Self-medication.<br />

<strong>Galderma</strong> engages with all of these<br />

professionals in a transparent and<br />

open way. Clinical studies provide<br />

a very practical point of contact<br />

with healthcare professionals. They<br />

offer physicians a firsthand view<br />

on <strong>Galderma</strong> treatments and their<br />

effectiveness. The company’s diligence<br />

on pharmacovigilance is another<br />

valuable contact point.<br />

Helping future practitioners<br />

Programs sponsored by the company<br />

are essential to the relationship with<br />

professionals. With the guidance<br />

of the Medical Affairs department,<br />

Helping healthcare professionals understand<br />

and better explain treatment benefits to patients.<br />

<strong>Galderma</strong> is supporting a number of<br />

initiatives to provide valuable services<br />

helping physicians in their daily<br />

practice of dermatology. Furthermore,<br />

the company is also committed to<br />

supporting a high level of education for<br />

dermatology residents. The residents’<br />

program (see box on the right side),<br />

which the company supports through<br />

the European Dermatology Forum, is<br />

a seminar that puts future practitioners<br />

in touch with leading authorities in<br />

dermatology. Another initiative, which<br />

<strong>Galderma</strong> supports in the United States,<br />

helps student residents prepare for their<br />

final board examination in dermatology.<br />

Improving professional experience<br />

In the Aesthetic & Corrective field,<br />

training physicians in procedures is<br />

central and provides ample resources<br />

for better understanding of their<br />

needs. Some are medical, such as<br />

demonstrating how physicians should<br />

use new product injection techniques<br />

for better results and an enhanced<br />

patient experience. But change is<br />

also afoot in the way physicians run<br />

their aesthetic practice. These courses<br />

provided by <strong>Galderma</strong>, part of the<br />

Alliance Service Program, help<br />

professionals improve their practice<br />

management and patient service.<br />

A new generation<br />

of European<br />

Dermatologists<br />

The European Dermatology<br />

Forum (EDF) organizes<br />

Euroderm Excellence, an<br />

annual training program<br />

for European Residents in<br />

dermatology. <strong>Galderma</strong> is<br />

the exclusive sponsor of this<br />

program that provides<br />

strong academic value for<br />

students, bringing qualitative<br />

and practical knowledge<br />

to them. The course gathers<br />

the best dermatology<br />

residents from European<br />

countries. This 4-day<br />

training program in practical<br />

clinical dermatology deals<br />

with all aspects of research<br />

and practical skills. Since<br />

the beginning, over 1,400<br />

students and 100 of the most<br />

famous teachers have<br />

joined this international<br />

training course. It is a great<br />

opportunity for all<br />

participants to develop<br />

their professional network<br />

and further their skills and<br />

education. This event is<br />

shared across universities<br />

all over Europe, and the 10 th<br />

anniversary will be<br />

celebrated in 2013.<br />

45 %<br />

OF DERMATOLOGY DRUGS<br />

IN NORTH AMERICA ARE PRESCRIBED<br />

BY DERMATOLOGISTS, 33%<br />

BY GENERAL PRACTITIONERS<br />

AND 19% BY PEDIATRICIANS.<br />

Source: Wolters Kluwer.<br />

19%<br />

IN JAPAN, ACNE-RELATED<br />

PATIENT CONSULTATION RATES<br />

JUMPED FROM 14% TO 19%,<br />

FOLLOWING AN ACNE AWARENESS<br />

PROGRAM SPONSORED BY<br />

GALDERMA.<br />

30,000<br />

PEOPLE IN CANADA<br />

ARE MEMBERS OF THE<br />

CETAPHIL SKINCARE CLUB.<br />

The purpose of <strong>Galderma</strong>'s<br />

Harmony Program is to teaching<br />

aesthetic physicians to achieve<br />

good, balanced results with<br />

2 to 3 injections, versus up to 10.<br />

1,000<br />

THE AVERAGE NUMBER OF<br />

DAILY CONTACTS BETWEEN<br />

HEALTHCARE PROFESSIONALS<br />

AND GALDERMA’S<br />

SALES FORCE IN GERMANY.<br />

42<br />

43


PARTNERS<br />

Likewise, <strong>Galderma</strong>’s Harmony program<br />

offers a complete holistic diagnostic<br />

approach so that physicians can<br />

listen to patients better and understand<br />

what they expect from an aesthetic<br />

consultation.<br />

Providing reliable<br />

information<br />

Communicating with patients is part<br />

of <strong>Galderma</strong>’s commitment. This includes<br />

educating them, helping them<br />

consult a doctor and understanding<br />

their disease and its treatment. With<br />

the Internet, patients are exposed to a<br />

huge amount of information, not all of<br />

it accurate or complete. The company<br />

works with medical institutions and patient<br />

advocacy groups all over the world<br />

to provide patients with the most appropriate<br />

and reliable information.<br />

Treatment compliance is a big issue.<br />

Reaching out online<br />

To encourage new means of exchange<br />

and interactions amongst dermatologists<br />

and healthcare professionals, <strong>Galderma</strong><br />

supports online educational platforms and<br />

services. Among them, Dermquest.com<br />

is a website dedicated to practicing and<br />

future dermatologists. It features one of the<br />

Ensuring that the patient follows prescriptions<br />

precisely, in the right quantity<br />

and frequency, is essential. Often,<br />

the answer lies in product innovation.<br />

Offering Epiduo in a pump format has<br />

improved acne treatment compliance<br />

for teenagers. A mobile application allows<br />

Epiduo patients to track progress<br />

and share with their practitioners. The<br />

growing importance of Self-medication<br />

has prompted <strong>Galderma</strong> to step up its<br />

efforts in patient education. Initiatives<br />

such as online Cetaphil clubs have<br />

built large communities. Sometimes,<br />

people do not know that there is a<br />

medical solution for what ails them.<br />

In Germany, “Skin Health Days” are an<br />

important disease awareness campaign<br />

about rosacea, which informs those<br />

suffering from that condition on how<br />

it can be treated. Feedback has been<br />

overwhelming.<br />

largest image bank with more than 23,000<br />

photos available, expert opinions, case<br />

notes and resources relevant to the practice<br />

of dermatology. A panel of respected<br />

international dermatologists sits on the<br />

editorial board and helps continuously<br />

improving the platform in order to meet the<br />

needs of its members. Derm101.com offers<br />

access to the most current research about<br />

Building confidence<br />

Helping people acquire a better awareness<br />

of skin conditions and treatments<br />

contributes to building a virtual circle<br />

between patients and healthcare professionals.<br />

Ultimately, positive patient experiences<br />

delivered via the right solution<br />

prescribed or recommended by wellinformed<br />

healthcare professionals are<br />

what count most at <strong>Galderma</strong>. Good<br />

experiences and testimonials serve as<br />

reminders that people are at the heart<br />

of everything the company does.<br />

diagnosis and treatment of skin diseases,<br />

and the platform is also tailored to meet the<br />

specific needs of pediatricians and family<br />

physicians practicing dermatology. The<br />

new mobile applications in both English<br />

and Spanish make this platform even more<br />

accessible and helpful in the daily practice.<br />

More than 50,000 physicians in the world<br />

are already members.<br />

Caring for the Littlest Patients<br />

Dr. Manju Elizabeth George<br />

is pediatric dermatologist<br />

in Palm Beach Gardens,<br />

Florida. She is boardcertified<br />

in adult and<br />

pediatric dermatology.<br />

What new dermatological<br />

needs are you now seeing<br />

in your practice<br />

In my practice I am now<br />

encountering younger<br />

children (ages 8-10) and<br />

adolescents with acne.<br />

Also, there are many infants<br />

and children with atopic<br />

dermatitis (eczema),<br />

whose parents are highly<br />

knowledgeable: they<br />

prefer organic and natural<br />

products, they know<br />

about parabens and are<br />

environmentally aware.<br />

Is it difficult for patients<br />

to follow treatment<br />

protocol<br />

Yes, at times it can<br />

be difficult because<br />

medications and treatment<br />

protocol can be<br />

complicated. I often<br />

provide handouts and write<br />

out instructions clearly,<br />

numbered in order.<br />

Very often, I show parents<br />

how to apply a medication.<br />

I always ask them to call<br />

the office if they have<br />

any questions and<br />

tell them, "Things should<br />

be getting better, not<br />

worse so please call me.”<br />

How do you work<br />

to improve<br />

patient outcomes<br />

I often tell patients,<br />

"I can give you all the<br />

products you want but if<br />

you don't use them it<br />

doesn't matter". If patients<br />

like the product, they will<br />

use it. Patient satisfaction<br />

and tolerability are key.<br />

How do you work<br />

with <strong>Galderma</strong><br />

I work with <strong>Galderma</strong> in<br />

developing acne education<br />

in the pediatric world,<br />

for providers who may be<br />

seeing acne first line<br />

in their office. I really enjoy<br />

talking to the community<br />

about something<br />

we can all prevent.<br />

What does interaction<br />

with <strong>Galderma</strong> bring you<br />

as a physician<br />

<strong>Galderma</strong> is providing me<br />

with all the resources I need<br />

as a practitioner: studies<br />

and handouts help me<br />

understand a particular<br />

product. I also learn from<br />

other pediatric<br />

dermatologists and<br />

pediatricians and this<br />

interaction really makes me<br />

a better physician. We all<br />

learn from each other.<br />

pediatricdermpb.com<br />

"I really enjoy talking to the<br />

community about something we<br />

can all prevent."<br />

DR. MANJU ELIZABETH GEORGE,<br />

PEDIATRIC DERMATOLOGIST<br />

CLOSE TO<br />

PHARMACISTS<br />

<strong>Galderma</strong> takes special pride<br />

in working closely with pharmacists.<br />

As one-stop providers<br />

for many solutions and products,<br />

pharmacies not only distribute Prescription<br />

products, naturally, but<br />

also the fast-growing category of<br />

Self-medication solutions, which<br />

pharmacists recommend to patients<br />

and consumers. In Brazil, for example,<br />

<strong>Galderma</strong> has developed a close<br />

partnership with pharmacies, offering<br />

a variety of services in about<br />

3,000 pharmacies. With over 425<br />

events in <strong>2012</strong>, impacting almost<br />

7,500 pharmacists and their assistants<br />

in the different categories and<br />

brands of <strong>Galderma</strong> products, the<br />

company has shown its long-term<br />

commitment to this relationship.<br />

Special Cetaphil and Dermotivin<br />

corners were set up and pharmacists<br />

received training sessions for<br />

Loceryl. Many new or emerging<br />

markets, such as Brazil or China,<br />

rely increasingly on Self-medication<br />

brands; <strong>Galderma</strong> is helping pharmacists<br />

better serve their customers<br />

while delivering high-quality training<br />

and materials.<br />

44<br />

45


INTERNATIONAL<br />

TODD ZAVODNICK<br />

SENIOR REGIONAL<br />

DIRECTOR LATIN AMERICA<br />

THREE EXECUTIVES DISCUSS HOW<br />

GLOBAL STRATEGY WAS ALIGNED<br />

WITH LOCAL BUSINESS MODELS TO<br />

BOOST GROWTH IN <strong>2012</strong>.<br />

How did you overcome market challenges <br />

Lee Heeson: In light of a challenging economy and loss<br />

of exclusivity, generating demand through our promoted<br />

brands across the 3 businesses was key. By focusing<br />

on cornerstone brands in Self-medication – Loceryl,<br />

Cetaphil and Benzac – and through talent acquisition<br />

and development, we successfully started the journey<br />

to create the dermatology category in pharmacies. The<br />

total value proposition of our world-class facial injectables<br />

portfolio, injector training and practice development<br />

support enabled us to drive market share gain in<br />

the A&C market. Finally, leadership development was<br />

a major focus with particular emphasis on strategic vision<br />

and agility.<br />

What is driving growth in your areas <br />

Todd Zavodnick: Latin America is a region where<br />

our main focus is to drive brand development and also<br />

shape and expand the overall market with initiatives<br />

across the three businesses. We expect strong double<br />

digit growth from all three business units within the<br />

current 10-year plan horizon. A key focus for us in Latin<br />

America is the expansion of the Aesthetic & Corrective<br />

marketplace, as today only 39% of physicians and<br />

surgeons are participating in non-invasive Aesthetic<br />

& Corrective procedures. We are executing numerous<br />

training initiatives to help grow the market in quantity,<br />

but at the same time ensuring they are quality injectors,<br />

achieving successful, repeatable outcomes over time.<br />

The commitment to our people and their development<br />

is of the utmost importance to achieve our objectives<br />

for today and tomorrow.<br />

What have been the strong points in your region <br />

Kamal Abbasi: Firstly the ‘can do’ attitude prevailing<br />

across the APAC region. The Asian economic boom and<br />

demographic shift, along with the increase of disposable<br />

income, and higher expectation on quality are benefiting<br />

our existing brands and is key for the future portfolio.<br />

It is expected that China will soon be the second<br />

biggest pharmaceutical market in the world. Restylane<br />

is successful and growing fast, with an Aesthetic &<br />

Corrective business in China showing strong potential.<br />

We also sold 5 million units of Cetaphil in China –the<br />

second highest performance in units after the U.S.<br />

Australia, our most successful affiliate to date, has<br />

become a benchmark for us in our 3 business strategy<br />

execution. In Korea, Cetaphil, recommended by<br />

dermatologists, took advantage of a business model<br />

including innovative online presence.<br />

...around<br />

the world.<br />

LEE HEESON<br />

SENIOR REGIONAL DIRECTOR<br />

EUROPE, MIDDLE-EAST, AFRICA<br />

KAMAL ABBASI<br />

SENIOR REGIONAL<br />

DIRECTOR ASIA-PACIFIC<br />

47


INTERNATIONAL<br />

Positioned<br />

for worldwide growth<br />

Following a year of growth in <strong>2012</strong>,<br />

<strong>Galderma</strong> is preparing for another<br />

year of promising results driven<br />

by innovation. It is also a time of<br />

geographic expansion, with<br />

products available in more than 70<br />

countries and improved coverage<br />

in areas where the company was<br />

already present.<br />

A complete spectrum<br />

of solutions<br />

<strong>Galderma</strong>’s global strategy relies on the<br />

simple principle of bringing innovative<br />

Prescription, Self-medication and<br />

Aesthetic & Corrective solutions to patients<br />

and customers in every market<br />

where there is a need. <strong>Galderma</strong> aims to<br />

strengthen its presence with patients<br />

and healthcare professionals by means<br />

of a vast portfolio of innovative medical<br />

solutions for everyone, at every age.<br />

This strategy then determines the company’s<br />

structure, notably as seen in the<br />

creation of new global business units.<br />

Strong brands are <strong>Galderma</strong>’s key asset.<br />

Four of them are ranked in the Top 20<br />

in the dermatology Prescription segment<br />

(1) . Epiduo is the most prescribed<br />

branded topical acne agent in the<br />

world (2) . Oracea, the first systemic treatment<br />

for rosacea, has met with huge<br />

success of sales in countries where it has<br />

been introduced. Loceryl, originally a<br />

Prescription brand, illustrates the potential<br />

of re-categorizing products as<br />

Self-medication: in Germany, sales of<br />

Loceryl have risen sharply since this<br />

treatment for fungal nail infections was<br />

made available over-the-counter in<br />

pharmacies. In the Aesthetic & Correctiveaera,<br />

<strong>Galderma</strong> can rely on a complete<br />

spectrum of solutions for medical<br />

practitioners, with its hyaluronic acidbased<br />

dermal fillers (Restylane and<br />

Emervel), a botulinum toxin type A<br />

(Azzalure), and complementary products<br />

such as Pliaglis and Metvix.<br />

<strong>Galderma</strong> is strongly focusing on new markets,<br />

particularly Asia and Latin America.<br />

Continued expansion<br />

In <strong>2012</strong>, the Company recorded overall<br />

sales growth of 12.9% based on reported<br />

figures, with particularly good results<br />

in Germany, China and Australia.<br />

Mature markets generally consolidated<br />

their performance in <strong>2012</strong>. In North<br />

America, the dermatology market<br />

transformed in <strong>2012</strong>: reshaping of the<br />

competitive landscape, healthcare<br />

changes and generics exposure for<br />

branded drugs. In this challenging environment,<br />

<strong>Galderma</strong> continued its expansion<br />

during a year marked by five<br />

product launches and three registrations<br />

in both the United States and<br />

Canada, where <strong>Galderma</strong> is a leader in<br />

the Prescription market with strong<br />

growing brands. As recessionary<br />

Europe tightens its public medical coverage,<br />

Germany leveraged commercial<br />

efforts and advertising campaigns.<br />

Focusing on emerging markets<br />

There is a clear demarcation between<br />

mature countries and the bustling<br />

emergent markets, which are a strong<br />

focus for <strong>Galderma</strong>. Asia and Latin<br />

America are still in growth mode as<br />

markets take shape. Opportunities<br />

abound, both through the launch of<br />

products already available elsewhere<br />

China:<br />

a clear priority<br />

The company’s objectives in<br />

China are clear: to reinforce a<br />

leading Aesthetic &<br />

Corrective business while<br />

accelerating the Selfmedication<br />

and Prescription<br />

categories through<br />

developing local organizational<br />

and production<br />

capacities. A&C and Selfmedication<br />

are strong growth<br />

drivers. In A&C, Restylane has<br />

drawn more customers<br />

through increased brand<br />

equity and geographical<br />

coverage. Cetaphil continued<br />

to grow fast via increased<br />

distribution to drugstores<br />

and chain pharmacies. The<br />

Self-medication market holds<br />

great promise for switch<br />

products based on<br />

Prescription formulas, such<br />

as Loceryl Nail Lacquer. The<br />

Prescription portfolio is being<br />

actively developed and will<br />

add significant growth<br />

opportunities moving<br />

forward. In <strong>2012</strong>, <strong>Galderma</strong><br />

doubled its sales in this<br />

strategic market.<br />

No. 1<br />

US DERMATOLOGISTS RECOGNIZED<br />

GALDERMA AS NO. 1 DERMATOLOGICAL<br />

COMPANY FOR SEVEN CONSECUTIVE YEARS.<br />

Source: SDI Company Image Survey.<br />

Results in Dermatology, 2011.<br />

No. 2<br />

BRAZIL WAS GALDERMA’S<br />

SECOND LARGEST MARKET<br />

AFTER THE US IN <strong>2012</strong>.<br />

Source: Company data, at the end<br />

of <strong>2012</strong>, at comparable rates.<br />

8%<br />

THE COMPANY’S<br />

GLOBAL HEADCOUNT<br />

INCREASE IN <strong>2012</strong>.<br />

58<br />

MILLION EUROS <strong>2012</strong> GALDERMA<br />

SALES IN GREATER CHINA (1) .<br />

17%<br />

GALDERMA GREW OVER 17%<br />

IN GERMANY DESPITE CHALLENGING<br />

MARKET CONDITIONS (1) .<br />

(1) Source: Company data, at the end<br />

of <strong>2012</strong>, at comparable rates.<br />

48<br />

49


INTERNATIONAL<br />

and through investing in new regions,<br />

such as South East Asia. Among the leading<br />

market-building opportunities are<br />

Singapore, the Philippines and Indonesia,<br />

(one of the most highly populated<br />

countries in the world), followed by Malaysia<br />

and Thailand.<br />

Powerful opportunities<br />

In Asia, and perhaps around the world,<br />

China presents the highest potential for<br />

growth. With three-digit sales growth in<br />

<strong>2012</strong>, China is set to become the<br />

world’s second-biggest market for<br />

pharmaceuticals in the next five years.<br />

<strong>Galderma</strong> has been operating there for<br />

several years, and <strong>2012</strong> marked the beginning<br />

of its expansion in this area,<br />

with the inauguration of an affiliate,<br />

and sales doubled in <strong>2012</strong>. Australia<br />

also performed very well, with a strategy<br />

based on the three businesses and<br />

Dysport, Cetaphil and Epiduo as key<br />

growth drivers. In Latin America, the<br />

rise of the middle class eager to spend<br />

on medical and consumer products to<br />

improve wellness has mirrored <strong>Galderma</strong>’s<br />

capacity for training physicians on<br />

treatment solutions. Both new markets<br />

and brands are expanding rapidly. Brazil<br />

represents the largest potential, reporting<br />

60% of the region’s total revenue<br />

and high opportunity across<br />

categories but many other markets,<br />

such as Mexico, are showing a strong<br />

increase in patient-driven needs.<br />

Responsible growth<br />

Because the company now serves nearly<br />

7% of the world’s dermatology market<br />

(1) and is investing in high potential<br />

markets, it is poised for further growth.<br />

The organic growth strategy is complemented<br />

by its external growth strategy.<br />

For example, in December, the brand<br />

announced the acquisition of the Swiss<br />

laboratory Spirig, the dermatology<br />

market leader in Switzerland. In <strong>2012</strong>,<br />

for the first time in the history of<br />

<strong>Galderma</strong>, more than half of sales were<br />

generated outside the United States: the<br />

company has truly become international.<br />

<strong>Galderma</strong> is more conscious than<br />

ever of its increased responsibilities towards<br />

patients and stakeholders, and of<br />

the importance of driving a business<br />

with compliance and respect.<br />

(1) Source: IMS data - D+J1A+J2A (dermatology<br />

only), MAT December <strong>2012</strong> – 39 countries.<br />

(2) Source: IMS Health - Monthly Midas database,<br />

all countries selected - Topical anti acne market -<br />

Nov.<strong>2012</strong> MAT, retail Rx Market - at sales manufacturer<br />

local currency dollar value.<br />

x2 over 120%<br />

THE COMPANY’S GROWTH IN CHINA IN <strong>2012</strong>.<br />

THE NUMBER OF EMPLOYEES<br />

IN THE ASIA PACIFIC REGION<br />

MORE THAN DOUBLED IN <strong>2012</strong>.<br />

CHINA IS SET TO BECOME THE WORLD’S 2ND<br />

PHARMACEUTICALS MARKET IN THE NEXT 5 YEARS.<br />

Source: Company data, at the end of <strong>2012</strong>, at comparable rates.<br />

Transformation and<br />

reinforcement in the US<br />

With about 600 employees,<br />

<strong>Galderma</strong>’s number one market<br />

continues to expand, generating sales<br />

of around $1 billion. The company<br />

made news in the US in <strong>2012</strong> with four<br />

product launches (Epiduo, Metrogel,<br />

Differin 0.3% pumps and Cetaphil<br />

Dermacontrol for acne-prone skin),<br />

two registrations and ten FDA<br />

consultations while championing<br />

compliance and safety. A leader in the<br />

US Prescription market, <strong>Galderma</strong>’s<br />

brand growth and performance has<br />

surpassed demand with Clobex Spray,<br />

Epiduo and Oracea. The Selfmedication<br />

category was also<br />

reinforced thanks to the continued<br />

strength of flagship brand Cetaphil<br />

– one product is sold every second -<br />

and the successful launch of Cetaphil<br />

Dermacontrol among the dermatology<br />

and pediatric community.<br />

The supplement approved by<br />

the FDA for Pliaglis, a topical<br />

anesthetic as well as the comeback<br />

of Tri-Luma, treating pigmentary<br />

disorders marked new steps<br />

reinforcing <strong>Galderma</strong>’s presence<br />

in the Aesthetic & Corrective area.<br />

<strong>Galderma</strong>’s dedicated Managed Care<br />

team promotes quality healthcare for<br />

dermatology patients by partnering<br />

with managed care organizations,<br />

insurers and third-party payers.<br />

The company actively supports<br />

dermatologic and pediatric<br />

organizations via direct, unrestricted<br />

grants and donations amounting to<br />

$20 million in the last five years. Last<br />

but not least, US-based dermatologists<br />

have recognized <strong>Galderma</strong> as the No.1<br />

dermatological company for seven<br />

consecutive years (3) .<br />

(3) SDI Company Image Survey — Results<br />

in Dermatology, 2011.<br />

Brazil:<br />

Three-category leader<br />

Brazil is a standout example of how<br />

<strong>Galderma</strong> shapes local markets<br />

by responding to local needs with<br />

a complete portfolio and three<br />

businesses at play. In the Prescription<br />

market, Epiduo consolidated its<br />

leadership as the first topical acne<br />

treatment. The third “Acne Day”<br />

in São Paulo was a success, with<br />

700 physicians attending. Clobex,<br />

Avicis and Loceryl significantly gained<br />

market share. The Self-medication<br />

products lead in four of the six market<br />

segments where they are present,<br />

taking the leadership for the first time<br />

in the moisturizer market with 22.4%<br />

market share, thanks to the support of<br />

a dedicated sales team covering 3,000<br />

pharmacies. Aquaclin was launched as<br />

the first OTC brand for acne treatment.<br />

As part of <strong>Galderma</strong>’s scientific<br />

studies support, the first Brazilian<br />

epidemiological study in<br />

onychomycosis “ONO” was<br />

presented. In Aesthetic & Corrective,<br />

Dysport is the leading brand on<br />

the botulinum toxin dermatology<br />

market, with 54% of market share.<br />

Restylane reached record sales<br />

of 100,000 units. The symposium<br />

addressing the global approach<br />

of facial anatomy and treatment<br />

with Dysport and Restylane drew<br />

3,500 participants during the National<br />

Brazilian Congress. The Alliance<br />

service platform in the aesthetic<br />

area was launched adding significant<br />

value to the brands with<br />

a cluster management model.<br />

These results were possible due to<br />

a complete professional relationship<br />

program. Among many other<br />

initiatives, the ‘Fellowship Program’<br />

reached 600 fellows, supporting<br />

various scientific projects and<br />

initiatives.<br />

Sources: IMS, CUP, SAFE System, Research<br />

- A&C Census.<br />

50<br />

51


INTERNATIONAL<br />

<strong>Galderma</strong> worldwide<br />

PARIS<br />

FRANCE<br />

CORPORATE SERVICES<br />

UPPSALA<br />

SWEDEN<br />

R&D AND PRODUCTION<br />

ASIA-PACIFIC<br />

AUSTRALIA<br />

CHINA<br />

HONG KONG<br />

INDIA<br />

JAPAN<br />

PHILIPPINES<br />

SOUTH KOREA<br />

SINGAPORE<br />

TAIWAN<br />

FORT WORTH<br />

TEXAS, USA<br />

NORTH AMERICA<br />

HEADQUARTERS<br />

GALDERMA IS<br />

EXPANDING ITS<br />

INTERNATIONAL<br />

PRESENCE, COVERING<br />

MORE THAN 70<br />

COUNTRIES TODAY.<br />

BAIE D'URFÉ<br />

CANADA<br />

PRODUCTION<br />

PRINCETON<br />

NEW JERSEY, USA<br />

R&D<br />

SOPHIA ANTIPOLIS<br />

FRANCE<br />

R&D<br />

ALBY-SUR-CHÉRAN<br />

FRANCE<br />

PRODUCTION<br />

LAUSANNE<br />

SWITZERLAND<br />

GLOBAL HEADQUARTERS<br />

TOKYO<br />

JAPAN<br />

R&D<br />

EUROPE - MIDDLE EAST<br />

AFRICA<br />

BELGIUM<br />

FRANCE<br />

GERMANY<br />

GREECE<br />

ITALY<br />

POLAND<br />

PORTUGAL<br />

RUSSIA<br />

SOUTH AFRICA<br />

SPAIN<br />

SWEDEN<br />

SWITZERLAND<br />

THE NETHERLANDS<br />

UNITED KINGDOM<br />

LATIN AMERICA<br />

ARGENTINA<br />

BRAZIL<br />

CHILE<br />

COLOMBIA<br />

MEXICO<br />

VENEZUELA<br />

NORTH AMERICA<br />

CANADA<br />

UNITED STATES OF AMERICA<br />

With 31 affiliates and exclusive representatives<br />

throughout the world,<br />

<strong>Galderma</strong> is developing markets<br />

in high potential regions while<br />

answering global needs in its three<br />

businesses: Prescription, Self-medication<br />

and Aesthetic & Corrective<br />

medical solutions.<br />

FIND ALL GALDERMA OFFICES<br />

AROUND THE WORLD<br />

ON WWW.GALDERMA.COM<br />

HORTOLÂNDIA<br />

BRAZIL<br />

PRODUCTION<br />

52<br />

53


Key brands<br />

<strong>Galderma</strong> locations<br />

VISIT ALL THE AFFILIATES WEBSITES ON WWW.GALDERMA.COM<br />

HEADQUARTERS<br />

SWITZERLAND<br />

GALDERMA SA<br />

Avenue Gratta-Paille 2<br />

1018 LAUSANNE<br />

Tel.: 41 21 642 78 00<br />

CORPORATE SERVICES<br />

FRANCE<br />

GALDERMA<br />

INTERNATIONAL S.A.S.<br />

Tour Europlaza La Défense 4<br />

20 avenue André Prothin<br />

92927 La Défense Cedex<br />

Tel.: 33 1 58 86 45 45<br />

SWITZERLAND<br />

GALDERMA SA<br />

Avenue Gratta-Paille 2<br />

1018 LAUSANNE<br />

Tel.: 41 21 642 78 00<br />

R&D<br />

FRANCE<br />

GALDERMA R&D S.N.C.<br />

Les Templiers<br />

2400, route des Colles<br />

06410 Biot<br />

Tel.: 33 4 93 95 70 70<br />

JAPAN<br />

GALDERMA KK (Japan)<br />

9th Floor, Sumitomo Fudosan<br />

Iidabashi No.3 Building<br />

13-1 Nishi-Gokencho<br />

Shinjuku-ku<br />

Tokyo 162-0812<br />

Tel.: 81 3 5229 6900<br />

SWEDEN<br />

Q-MED AB<br />

Seminariegatan 21<br />

Visitors: Fyrisvallsgatan 7<br />

752 28 Uppsala<br />

Tel.: 46 18 474 90 00<br />

UNITED STATES<br />

GALDERMA R&D LLC<br />

5 Cedar Brook Drive - Suite 1<br />

Cranbury, NJ 08512<br />

Tel.: 1 609 409 77 01<br />

PRODUCTION SITES<br />

BRAZIL<br />

GALDERMA BRASIL Ltda.<br />

Rodovia SP 101<br />

Campinas-Monte Mor, Km 9<br />

Condominio Techtown<br />

CEP 13186-904<br />

Hortolândia-SP<br />

Tel.: 55 19 3045 6900<br />

CANADA<br />

GALDERMA PRODUCTION<br />

CANADA INC<br />

19400 Trans-Canada Hwy<br />

Baie d'Urfé, Québec H9X 3S4<br />

TEL.: 1 514 457 33 66<br />

FRANCE<br />

LABORATOIRES<br />

GALDERMA S.A.S.<br />

Zone Industrielle - Touvière<br />

74540 Alby sur Chéran<br />

Tel.: 33 1 58 86 45 45<br />

SWEDEN<br />

Q-MED AB<br />

Seminariegatan 21<br />

Visitors: Fyrisvallsgatan 7<br />

752 28 Uppsala<br />

Tel.: 46 18 474 90 00<br />

AFFILIATES<br />

ARGENTINA<br />

GALDERMA ARGENTINA S.A.<br />

Juramento 1775 8° Piso<br />

(C1428DNA)<br />

Ciudad de Buenos Aires<br />

Tel.: 54 11 4124 0454<br />

AUSTRALIA / NEW ZEALAND<br />

GALDERMA AUSTRALIA<br />

(PTY) LTD.<br />

Suite 4, 13B Narabang Way<br />

Belrose NSW 2085<br />

Tel.: 61 2 9479 0600<br />

BELGIUM<br />

GALDERMA BELGILUX BN<br />

p/a Multiburo<br />

Keivitplein 20C/12<br />

2018 Antwerpen<br />

Tel.: 32 3 897 19 00<br />

BRAZIL<br />

GALDERMA BRASIL LTDA.<br />

R. Surubim, 373 - 4th floor<br />

Cid. Monções - São Paulo /<br />

SP 04571-050<br />

Tel.: 55 11 3524 6300<br />

CANADA<br />

GALDERMA CANADA INC.<br />

105 Commerce Valley Drive<br />

West - Suite 300<br />

Thornhill, Ontario L3T 7W3<br />

Tel.: 1 905 762 2500<br />

CHILE<br />

LABORATORIOS GALDERMA<br />

CHILE LTDA.<br />

Mc Iver N 440 -<br />

Office N 701<br />

Santiago Centro<br />

Tel.: 56 2480 7500<br />

CHINA<br />

GALDERMA INTERNATIONAL<br />

3708 Lippo Plaza<br />

No. 222 Middle Huaihai Rd.<br />

Shanghai 200021 - P.R.China<br />

Tel.: 86 21 2315 9666<br />

COLOMBIA<br />

GALDERMA COLOMBIA S.A.<br />

Carrera 14 N93 B-32<br />

Oficina 504 - Bogota, DC<br />

Tel.: 57 1622 7560 ext 201<br />

FRANCE<br />

GALDERMA<br />

INTERNATIONAL SAS<br />

Tour Europlaza - La Défense 4<br />

20, Avenue André Prothin<br />

92927 La Défense Cedex<br />

Tel.: 33 1 5 8 86 45 45<br />

GERMANY<br />

GALDERMA LABORATORIUM<br />

GMBH<br />

Georg-Glock-Strasse 8<br />

40474 Düsseldorf<br />

Tel.: 49 211 58 601 00<br />

GREECE<br />

GALDERMA HELLAS TRADE<br />

OF PHARMACEUTICAL<br />

PRODUCTS S.A.<br />

Pendelis Avenue 37A<br />

15235 Vrilissia Attica<br />

Tel.: 30 210 81 04 190<br />

HONG KONG<br />

GALDERMA HONG KONG LTD.<br />

Suite 3501-02, 35/F,<br />

Cambridge House, Taikoo<br />

Place, 979 King's Road<br />

Island East, Hong Kong<br />

Tel.: 852 28240333<br />

INDIA<br />

GALDERMA INDIA PVT. LTD.<br />

23, Steelmade Industrial Estate,<br />

2nd Floor - Marol Village,<br />

Andheri (E) - Mumbai 400 059<br />

Tel.: 91 22 6726 1818<br />

ITALY<br />

GALDERMA ITALIA S.p.A.<br />

Centro Direzionale Colleoni<br />

Palazzo Taurus - Ingresso 1<br />

20864 Agrate Brianza (MB)<br />

Tel.: 39 039 63 46 91<br />

JAPAN<br />

GALDERMA KK (Japan)<br />

9th Floor, Sumitomo Fudosan<br />

Iidabashi No.3 Building<br />

13-1 Nishi-Gokencho<br />

Shinjyuku-ku<br />

Tokyo 162-0812<br />

Tel.: 81 3 5229 6900<br />

MEXICO<br />

GALDERMA MEXICO S.A.<br />

de CV Mariano Escobedo<br />

N°. 476 - Piso 10, Torre Polanco<br />

Col. Anzures<br />

Delegación Miguel Hidalgo<br />

11590 México, D.F.<br />

Tel.: 52 55 9126 2000<br />

PHILIPPINES<br />

GALDERMA<br />

PHILIPPINES INC.<br />

Unit 3001 Atlanta Centre<br />

31 Annapolis Street<br />

Greenhills, San Juan<br />

Metro Manila 1502<br />

Tel.: 63 2 470 8000<br />

POLAND<br />

GALDERMA POLSKA Sp.z.o.o.<br />

ul. Laczyny 4<br />

02-820 Warsaw<br />

Tel.: 48 22 331 21 80<br />

PORTUGAL<br />

GALDERMA INTERNATIONAL<br />

Sucursal em Portugal<br />

R. Dr. Antonio Loureiro<br />

- Borges, n7 - 6 Andar -<br />

Arquiparque - Miraflores<br />

1495 - 131 Alges<br />

Tel.: 351 21 315 19 40/41<br />

RUSSIA<br />

GALDERMA LLC.<br />

Leningradskiy prospect 31A,<br />

building 1 - Business Center<br />

Monarkh Tower - 21st floor<br />

125284, Moscow<br />

Tel.: 7 495 540 5017<br />

SINGAPORE<br />

GALDERMA SINGAPORE<br />

PVT. LTD.<br />

1 Kim Seng Promenade<br />

#14-10, Great World City West<br />

Tower - Singapore 237994<br />

Tel.: 65 6838 9360<br />

SOUTH AFRICA<br />

GALDERMA LABORATORIES<br />

SOUTH AFRICA (PTY) LTD.<br />

Wedgefield Office Park<br />

17 Muswell Road South<br />

Bryanston - Phase 2, Block<br />

D, 1st Floor - P.O. Box 71150 -<br />

Bryanston 2021<br />

Tel.: 27 11 706 23 39<br />

SOUTH KOREA<br />

GALDERMA KOREA Ltd.<br />

6F, 7F Bando Building<br />

26 Gromurae-Ro 10-Gil<br />

Seocho-Gu, Seoul, 137-802<br />

Tel.: 82 2 6717 2000<br />

SPAIN<br />

LABORATORIOS<br />

GALDERMA S.A.<br />

C/ Agustín de Foxá, 29 - 4 Pl.<br />

28036 Madrid<br />

Tel.: 34 902 02 7595<br />

SWEDEN<br />

GALDERMA NORDIC AB<br />

Seminariegatan 21<br />

752 28 Uppsala<br />

Tel.: 46 18 444 0330<br />

SWITZERLAND<br />

GALDERMA S.A.<br />

Postfach 492 - 6330 Cham<br />

Tel.: 41 41 7803828<br />

TAIWAN<br />

GALDERMA HK LTD<br />

Taiwan Branch<br />

4-6, 9F, N° 17, Sec. 1<br />

Chengde Rd., Datong Dist.<br />

Taipei City 103<br />

Tel.: 886 22 555 8850<br />

THE NETHERLANDS<br />

GALDERMA BENELUX BV<br />

Postbus 2892 -<br />

3000 CW Rotterdam<br />

Visitors: Weena 723 C7.082<br />

Rotterdam<br />

Tel.: 31 183 69 19 19<br />

UNITED KINGDOM<br />

GALDERMA (UK) LTD.<br />

Meridien House, 1st Floor<br />

69 - 71 Clarendon Road<br />

Watford, Hertfordshire<br />

WD17 1DS<br />

Tel.: 44 1923 208 950<br />

UNITED STATES<br />

GALDERMA<br />

LABORATORIES L.P.<br />

14501 North Freeway<br />

Fort Worth, TX 76177<br />

Tel.: 1 817 961 5000<br />

VENEZUELA<br />

LABORATORIOS GALDERMA<br />

VENEZUELA S.A.<br />

Urbanizacion Sorocaima<br />

Calle Altagracia<br />

Edificio Procter & Gamble,<br />

Nivel Plaza, Mezzanina Sector<br />

La Trinidad - ZP 1080,<br />

Caracas - Edo. Miranda<br />

Tel.: 58 212 820 83 80<br />

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