Continuous Micro Reactor Technology for Drug Substance Synthesis:

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Analytical Sampling <strong>for</strong> Online Applications
Why Use Advanced Flow <strong>Reactor</strong>s High Throughput Experimentation For… Discovery and screening Process development Process optimization Process control Production • Eliminate chemical engineering production problems related to scaling up batch systems • Increase production through use of many parallel microreactors to achieve volume
Page 1: Continuous Micro Reactor Technology
Page 5 and 6: Relative Intensity Batch Runs at Di
Page 7 and 8: Product Yield vs. Temperature PCA A
Page 9 and 10: Challenges To Using AF Reactors •
Page 11 and 12: AF Reactor and Raman Analyzer • 4
Page 13 and 14: Design of Experiments Information
Page 15 and 16: NeSSI Ballprobe - Raman/NIR/UV Ball
Page 17 and 18: What does NeSSI Provide • Simple
Page 19 and 20: NeSSI and Raman Probe Images
Page 21 and 22: 3D Plot of Raman Reaction Data (Low
Page 23 and 24: Normalized Signal Intensity Normali
Page 25 and 26: FDA Project - Phase 2 Nov. 2010 - O
Page 27 and 28: Corning ® Advanced-Flow TM LF Low-
Page 29 and 30: Esterification of Benzoic Acid and
Page 31 and 32: Phase 2 - QbD Envisioned • Proces
Page 33 and 34: Thermo/C2V Fast Micro-GC http://www
Page 35: Thanks • U.S. Food and Drug Admin

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